International review of neurobiology最新文献

Metabotropic glutamate receptors in Parkinson's disease. 帕金森病中的代谢性谷氨酸受体

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2022.10.001

Cynthia Kwan, Woojin Kang, Esther Kim, Sébastien Belliveau, Imane Frouni, Philippe Huot

{"title":"Metabotropic glutamate receptors in Parkinson's disease.","authors":"Cynthia Kwan, Woojin Kang, Esther Kim, Sébastien Belliveau, Imane Frouni, Philippe Huot","doi":"10.1016/bs.irn.2022.10.001","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.10.001","url":null,"abstract":"Parkinson's disease (PD) is a complex disorder that leads to alterations in multiple neurotransmitter systems, notably glutamate. As such, several drugs acting at glutamatergic receptors have been assessed to alleviate the manifestation of PD and treatment-related complications, culminating with the approval of the N-methyl-d-aspartate (NMDA) antagonist amantadine for l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia. Glutamate elicits its actions through several ionotropic and metabotropic (mGlu) receptors. There are 8 sub-types of mGlu receptors, with sub-types 4 (mGlu4) and 5 (mGlu5) modulators having been tested in the clinic for endpoints pertaining to PD, while sub-types 2 (mGlu2) and 3 (mGlu3) have been investigated in pre-clinical settings. In this book chapter, we provide an overview of mGlu receptors in PD, with a focus on mGlu5, mGlu4, mGlu2 and mGlu3 receptors. For each sub-type, we review, when applicable, their anatomical localization and possible mechanisms underlying their efficacy for specific disease manifestation or treatment-induced complications. We then summarize the findings of pre-clinical studies and clinical trials with pharmacological agents and discuss the potential strengths and limitations of each target. We conclude by offering some perspectives on the potential use of mGlu modulators in the treatment of PD.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"168 ","pages":"1-31"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9441949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The interaction of membrane estradiol receptors and metabotropic glutamate receptors in adaptive and maladaptive estradiol-mediated motivated behaviors in females. 膜雌二醇受体和代谢性谷氨酸受体在雌性适应性和非适应性雌二醇介导的动机行为中的相互作用。

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2022.11.001

Caroline S Johnson, Paul G Mermelstein

{"title":"The interaction of membrane estradiol receptors and metabotropic glutamate receptors in adaptive and maladaptive estradiol-mediated motivated behaviors in females.","authors":"Caroline S Johnson, Paul G Mermelstein","doi":"10.1016/bs.irn.2022.11.001","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.11.001","url":null,"abstract":"Estrogen receptors were initially identified as intracellular, ligand-regulated transcription factors that result in genomic change upon ligand binding. However, rapid estrogen receptor signaling initiated outside of the nucleus was also known to occur via mechanisms that were less clear. Recent studies indicate that these traditional receptors, estrogen receptor α and estrogen receptor β, can also be trafficked to act at the surface membrane. Signaling cascades from these membrane-bound estrogen receptors (mERs) can rapidly alter cellular excitability and gene expression, particularly through the phosphorylation of CREB. A principal mechanism of neuronal mER action has been shown to occur through glutamate-independent transactivation of metabotropic glutamate receptors (mGlu), which elicits multiple signaling outcomes. The interaction of mERs with mGlu has been shown to be important in many diverse functions in females, including driving motivated behaviors. Experimental evidence suggests that a large part of estradiol-induced neuroplasticity and motivated behaviors, both adaptive and maladaptive, occurs through estradiol-dependent mER activation of mGlu. Herein we will review signaling through estrogen receptors, both \"classical\" nuclear receptors and membrane-bound receptors, as well as estradiol signaling through mGlu. We will focus on how the interactions of these receptors and their downstream signaling cascades are involved in driving motivated behaviors in females, discussing a representative adaptive motivated behavior (reproduction) and maladaptive motivated behavior (addiction).","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"168 ","pages":"33-91"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9441953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of metabotropic glutamate receptor 8 in neuropsychiatric and neurological disorders. 代谢性谷氨酸受体8在神经精神和神经系统疾病中的作用。

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2022.10.003

Li-Min Mao, Nirav Mathur, Karina Shah, John Q Wang

{"title":"Roles of metabotropic glutamate receptor 8 in neuropsychiatric and neurological disorders.","authors":"Li-Min Mao, Nirav Mathur, Karina Shah, John Q Wang","doi":"10.1016/bs.irn.2022.10.003","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.10.003","url":null,"abstract":"Metabotropic glutamate (mGlu) receptors are G protein-coupled receptors. Among eight mGlu subtypes (mGlu1-8), mGlu8 has drawn increasing attention. This subtype is localized to the presynaptic active zone of neurotransmitter release and is among the mGlu subtypes with high affinity for glutamate. As a Gi/o-coupled autoreceptor, mGlu8 inhibits glutamate release to maintain homeostasis of glutamatergic transmission. mGlu8 receptors are expressed in limbic brain regions and play a pivotal role in modulating motivation, emotion, cognition, and motor functions. Emerging evidence emphasizes the increasing clinical relevance of abnormal mGlu8 activity. Studies using mGlu8 selective agents and knockout mice have revealed the linkage of mGlu8 receptors to multiple neuropsychiatric and neurological disorders, including anxiety, epilepsy, Parkinson's disease, drug addiction, and chronic pain. Expression and function of mGlu8 receptors in some limbic structures undergo long-lasting adaptive changes in animal models of these disorders, which may contribute to the remodeling of glutamatergic transmission critical for the pathogenesis and symptomatology of brain illnesses. This review summarizes the current understanding of mGlu8 biology and the possible involvement of the receptor in several common psychiatric and neurological disorders.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"168 ","pages":"349-366"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162486/pdf/nihms-1896074.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9732971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The functional anatomy of dystonia: Recent developments. 肌张力障碍的功能解剖学:最新进展。

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2023.04.004

Daniel T Corp, Jordan Morrison-Ham, H A Jinnah, Juho Joutsa

引用次数: 2

Experimental pharmacology: Targeting metabolic pathways. 实验药理学：针对代谢途径。

3区医学

International review of neurobiology Pub Date : 2023-01-01 Epub Date: 2023-07-11 DOI: 10.1016/bs.irn.2023.05.005

Vincenzo Leuzzi, Serena Galosi

引用次数: 0

How does botulinum toxin really work? 肉毒杆菌毒素究竟是如何起作用的?

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2023.05.003

Daniele Belvisi, Giorgio Leodori, Matteo Costanzo, Antonella Conte, Alfredo Berardelli

引用次数: 1

Sex differences and hormonal regulation of metabotropic glutamate receptor synaptic plasticity. 代谢型谷氨酸受体突触可塑性的性别差异和激素调控

3区医学

International review of neurobiology Pub Date : 2023-01-01 Epub Date: 2022-11-11 DOI: 10.1016/bs.irn.2022.10.002

Carly B Fabian, Marianne L Seney, Max E Joffe

{"title":"Sex differences and hormonal regulation of metabotropic glutamate receptor synaptic plasticity.","authors":"Carly B Fabian, Marianne L Seney, Max E Joffe","doi":"10.1016/bs.irn.2022.10.002","DOIUrl":"10.1016/bs.irn.2022.10.002","url":null,"abstract":"Striking sex differences exist in presentation and incidence of several psychiatric disorders. For example, major depressive disorder is more prevalent in women than men, and women who develop alcohol use disorder progress through drinking milestones more rapidly than men. With regards to psychiatric treatment responses, women respond more favorably to selective serotonin reuptake inhibitors than men, whereas men have better outcomes when prescribed tricyclic antidepressants. Despite such well-documented biases in incidence, presentation, and treatment response, sex as a biological variable has long been neglected in preclinical and clinical research. An emerging family of druggable targets for psychiatric diseases, metabotropic glutamate (mGlu) receptors are G-protein coupled receptors broadly distributed throughout the central nervous system. mGlu receptors confer diverse neuromodulatory actions of glutamate at the levels of synaptic plasticity, neuronal excitability, and gene transcription. In this chapter, we summarize the current preclinical and clinical evidence for sex differences in mGlu receptor function. We first highlight basal sex differences in mGlu receptor expression and function and proceed to describe how gonadal hormones, notably estradiol, regulate mGlu receptor signaling. We then describe sex-specific mechanisms by which mGlu receptors differentially modulate synaptic plasticity and behavior in basal states and models relevant for disease. Finally, we discuss human research findings and highlight areas in need of further research. Taken together, this review emphasizes how mGlu receptor function and expression can differ across sex. Gaining a more complete understanding of how sex differences in mGlu receptor function contribute to psychiatric diseases will be critical in the development of novel therapeutics that are effective in all individuals.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"168 ","pages":"311-347"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9932602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in targeting neurotransmitter systems in dystonia. 肌张力障碍靶向神经递质系统的研究进展。

3区医学

International review of neurobiology Pub Date : 2023-01-01 Epub Date: 2023-07-05 DOI: 10.1016/bs.irn.2023.06.002

Dora Steel, Kimberley M Reid, Antonio Pisani, Ellen J Hess, Susan Fox, Manju A Kurian

{"title":"Advances in targeting neurotransmitter systems in dystonia.","authors":"Dora Steel, Kimberley M Reid, Antonio Pisani, Ellen J Hess, Susan Fox, Manju A Kurian","doi":"10.1016/bs.irn.2023.06.002","DOIUrl":"10.1016/bs.irn.2023.06.002","url":null,"abstract":"Dystonia is characterised as uncontrolled, often painful involuntary muscle contractions that cause abnormal postures and repetitive or twisting movements. These movements can be continuous or sporadic and affect different parts of the body and range in severity. Dystonia and its related conditions present a huge cause of neurological morbidity worldwide. Although therapies are available, achieving optimal symptom control without major unwanted effects remains a challenge. Most pharmacological treatments for dystonia aim to modulate the effects of one or more neurotransmitters in the central nervous system, but doing so effectively and with precision is far from straightforward. In this chapter we discuss the physiology of key neurotransmitters, including dopamine, noradrenaline, serotonin (5-hydroxytryptamine), acetylcholine, GABA, glutamate, adenosine and cannabinoids, and their role in dystonia. We explore the ways in which existing pharmaceuticals as well as novel agents, currently in clinical trial or preclinical development, target dystonia, and their respective advantages and disadvantages. Finally, we discuss current and emerging genetic therapies which may be used to treat genetic forms of dystonia.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"169 ","pages":"217-258"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9858730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adult-onset focal dystonias: To lump or split. 成人发病局灶性肌张力障碍:肿块或分裂。

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2023.04.001

H A Jinnah, Giovanni DeFazio

引用次数: 1

Physiology of Dystonia: Animal Studies. 肌张力障碍生理学:动物研究。

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2023.05.004

Alejandro G Rey Hipolito, Meike E van der Heijden, Roy V Sillitoe

{"title":"Physiology of Dystonia: Animal Studies.","authors":"Alejandro G Rey Hipolito, Meike E van der Heijden, Roy V Sillitoe","doi":"10.1016/bs.irn.2023.05.004","DOIUrl":"https://doi.org/10.1016/bs.irn.2023.05.004","url":null,"abstract":"Dystonia is currently ranked as the third most prevalent motor disorder. It is typically characterized by involuntary muscle over- or co-contractions that can cause painful abnormal postures and jerky movements. Dystonia is a heterogenous disorder-across patients, dystonic symptoms vary in their severity, body distribution, temporal pattern, onset, and progression. There are also a growing number of genes that are associated with hereditary dystonia. In addition, multiple brain regions are associated with dystonic symptoms in both genetic and sporadic forms of the disease. The heterogeneity of dystonia has made it difficult to fully understand its underlying pathophysiology. However, the use of animal models has been used to uncover the complex circuit mechanisms that lead to dystonic behaviors. Here, we summarize findings from animal models harboring mutations in dystonia-associated genes and phenotypic animal models with overt dystonic motor signs resulting from spontaneous mutations, neural circuit perturbations, or pharmacological manipulations. Taken together, an emerging picture depicts dystonia as a result of brain-wide network dysfunction driven by basal ganglia and cerebellar dysfunction. In the basal ganglia, changes in dopaminergic, serotonergic, noradrenergic, and cholinergic signaling are found across different animal models. In the cerebellum, abnormal burst firing activity is observed in multiple dystonia models. We are now beginning to unveil the extent to which these structures mechanistically interact with each other. Such mechanisms inspire the use of pre-clinical animal models that will be used to design new therapies including drug treatments and brain stimulation.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"169 ","pages":"163-215"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9854058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0