International review of neurobiology最新文献_第2页

What have we learned about the biology of dystonia from deep brain stimulation? 我们从深部脑刺激学到了什么关于肌张力障碍的生物学知识?

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2023.05.008

Vidailhet Marie

引用次数: 0

The metabotropic glutamate receptor 5 as a biomarker for psychiatric disorders. 代谢性谷氨酸受体5作为精神疾病的生物标志物。

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2022.10.007

Ruth H Asch, Ansel T Hillmer, Stephen R Baldassarri, Irina Esterlis

{"title":"The metabotropic glutamate receptor 5 as a biomarker for psychiatric disorders.","authors":"Ruth H Asch, Ansel T Hillmer, Stephen R Baldassarri, Irina Esterlis","doi":"10.1016/bs.irn.2022.10.007","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.10.007","url":null,"abstract":"The role of glutamate system in the etiology and pathophysiology of psychiatric disorders has gained considerable attention in the past two decades, including dysregulation of the metabotropic glutamatergic receptor subtype 5 (mGlu5). Thus, mGlu5 may represent a promising therapeutic target for psychiatric conditions, particularly stress-related disorders. Here, we describe mGlu5 findings in mood disorders, anxiety, and trauma disorders, as well as substance use (specifically nicotine, cannabis, and alcohol use). We highlight insights gained from positron emission tomography (PET) studies, where possible, and discuss findings from treatment trials, when available, to explore the role of mGlu5 in these psychiatric disorders. Through the research evidence reviewed in this chapter, we make the argument that, not only is dysregulation of mGlu5 evident in numerous psychiatric disorders, potentially functioning as a disease \"biomarker,\" the normalization of glutamate neurotransmission via changes in mGlu5 expression and/or modulation of mGlu5 signaling may be a needed component in treating some psychiatric disorders or symptoms. Finally, we hope to demonstrate the utility of PET as an important tool for investigating mGlu5 in disease mechanisms and treatment response.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"168 ","pages":"265-310"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9441951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

What can epidemiological studies teach on the pathophysiology of adult-onset isolated dystonia? 流行病学研究对成人发病的孤立性肌张力障碍的病理生理学有什么启示?

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2023.05.015

Davide Martino

{"title":"What can epidemiological studies teach on the pathophysiology of adult-onset isolated dystonia?","authors":"Davide Martino","doi":"10.1016/bs.irn.2023.05.015","DOIUrl":"https://doi.org/10.1016/bs.irn.2023.05.015","url":null,"abstract":"Several demographic and environmental factors may play an important role in determining the risk of developing adult-onset isolated dystonia (AOID) and/or modifying its course. However, epidemiologic studies have provided to date only partial insight on the disease mechanisms that are actively influenced by these factors. The age-related increase in female predominance in both patients diagnosed with AOID and subjects carrying its putative mediational phenotype suggests sexual dimorphism that has been demonstrated for mechanisms related to blepharospasm and cervical dystonia. The opposite relationship that spread and spontaneous remission of AOID have with age suggests age-related decline of compensatory mechanisms that protect from the progression of AOID. Epidemiological studies focusing on environmental risk factors yielded associations only with specific forms of AOID, even for those factors that are not likely to predispose exclusively to specific focal forms (for example, only writing dystonia was found associated with head trauma, and only blepharospasm with coffee intake). Other factors show biological plausibility of their mechanistic role for specific forms, e.g., dry eye syndrome or sunlight exposure for blepharospasm, scoliosis for cervical dystonia, repetitive writing for writing dystonia. Overall, the relationship between environment and AOID remains complex and incompletely defined. Both hypothesis-driven preclinical studies and well-designed cross-sectional or prospective clinical studies are still necessary to decipher this intricate relationship.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"169 ","pages":"21-60"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9854052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of metabotropic glutamate receptors in neurobehavioral effects associated with methamphetamine use. 代谢性谷氨酸受体在与甲基苯丙胺使用相关的神经行为效应中的作用。

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2022.10.005

Peter U Hámor, Lori A Knackstedt, Marek Schwendt

{"title":"The role of metabotropic glutamate receptors in neurobehavioral effects associated with methamphetamine use.","authors":"Peter U Hámor, Lori A Knackstedt, Marek Schwendt","doi":"10.1016/bs.irn.2022.10.005","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.10.005","url":null,"abstract":"Metabotropic glutamate (mGlu) receptors are expressed throughout the central nervous system and act as important regulators of drug-induced neuroplasticity and behavior. Preclinical research suggests that mGlu receptors play a critical role in a spectrum of neural and behavioral consequences arising from methamphetamine (meth) exposure. However, an overview of mGlu-dependent mechanisms linked to neurochemical, synaptic, and behavioral changes produced by meth has been lacking. This chapter provides a comprehensive review of the role of mGlu receptor subtypes (mGlu1-8) in meth-induced neural effects, such as neurotoxicity, as well as meth-associated behaviors, such as psychomotor activation, reward, reinforcement, and meth-seeking. Additionally, evidence linking altered mGlu receptor function to post-meth learning and cognitive deficits is critically evaluated. The chapter also considers the role of receptor-receptor interactions involving mGlu receptors and other neurotransmitter receptors in meth-induced neural and behavioral changes. Taken together, the literature indicates that mGlu5 regulates the neurotoxic effects of meth by attenuating hyperthermia and possibly through altering meth-induced phosphorylation of the dopamine transporter. A cohesive body of work also shows that mGlu5 antagonism (and mGlu2/3 agonism) reduce meth-seeking, though some mGlu5-blocking drugs also attenuate food-seeking. Further, evidence suggests that mGlu5 plays an important role in extinction of meth-seeking behavior. In the context of a history of meth intake, mGlu5 also co-regulates aspects of episodic memory, with mGlu5 stimulation restoring impaired memory. Based on these findings, we propose several avenues for the development of novel pharmacotherapies for Methamphetamine Use Disorder based on the selective modulation mGlu receptor subtype activity.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"168 ","pages":"177-219"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9441950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface. 前言。

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/S0074-7742(23)00009-0

Lori A Knackstedt, Marek Schwendt

引用次数: 0

Clinical features of dystonia and the science of classification. 肌张力障碍的临床特征及分型科学。

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2023.05.006

Alberto Albanese

引用次数: 0

Dystonia and tremor: Do they have a shared biology? 肌张力障碍和震颤:它们有共同的生物学特征吗?

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2023.04.002

Abhishek Lenka, Sanjay Pandey

引用次数: 0

The role of mGlu receptors in susceptibility to stress-induced anhedonia, fear, and anxiety-like behavior. mGlu受体在应激性快感缺乏、恐惧和焦虑样行为易感性中的作用。

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2022.10.006

Cassandra G Modrak, Courtney S Wilkinson, Harrison L Blount, Marek Schwendt, Lori A Knackstedt

{"title":"The role of mGlu receptors in susceptibility to stress-induced anhedonia, fear, and anxiety-like behavior.","authors":"Cassandra G Modrak, Courtney S Wilkinson, Harrison L Blount, Marek Schwendt, Lori A Knackstedt","doi":"10.1016/bs.irn.2022.10.006","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.10.006","url":null,"abstract":"Stress and trauma exposure contribute to the development of psychiatric disorders such as post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) in a subset of people. A large body of preclinical work has found that the metabotropic glutamate (mGlu) family of G protein-coupled receptors regulate several behaviors that are part of the symptom clusters for both PTSD and MDD, including anhedonia, anxiety, and fear. Here, we review this literature, beginning with a summary of the wide variety of preclinical models used to assess these behaviors. We then summarize the involvement of Group I and II mGlu receptors in these behaviors. Bringing together this extensive literature reveals that mGlu5 signaling plays distinct roles in anhedonia, fear, and anxiety-like behavior. mGlu5 promotes susceptibility to stress-induced anhedonia and resilience to stress-induced anxiety-like behavior, while serving a fundamental role in the learning underlying fear conditioning. The medial prefrontal cortex, basolateral amygdala, nucleus accumbens, and ventral hippocampus are key regions where mGlu5, mGlu2, and mGlu3 regulate these behaviors. There is strong support that stress-induced anhedonia arises from decreased glutamate release and post-synaptic mGlu5 signaling. Conversely, decreasing mGlu5 signaling increases resilience to stress-induced anxiety-like behavior. Consistent with opposing roles for mGlu5 and mGlu2/3 in anhedonia, evidence suggests that increased glutamate transmission may be therapeutic for the extinction of fear learning. Thus, a large body of literature supports the targeting of pre- and post-synaptic glutamate signaling to ameliorate post-stress anhedonia, fear, and anxiety-like behavior.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"168 ","pages":"221-264"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9506939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Physiology of dystonia: Human studies. 肌张力障碍的生理学：人体研究。

3区医学

International review of neurobiology Pub Date : 2023-01-01 Epub Date: 2023-05-26 DOI: 10.1016/bs.irn.2023.05.007

Petra Fischer, Dan Piña-Fuentes, Panagiotis Kassavetis, Anna Sadnicka

引用次数: 0

Dystonia and Parkinson's disease: Do they have a shared biology? 肌张力障碍和帕金森氏症:它们有共同的生物学特征吗?

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2023.05.001

Elie Matar, Kailash Bhatia

引用次数: 0