International review of neurobiology最新文献_第3页

Metabotropic glutamate receptors and cognition: From underlying plasticity and neuroprotection to cognitive disorders and therapeutic targets. 代谢性谷氨酸受体与认知:从潜在的可塑性和神经保护到认知障碍和治疗靶点。

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2022.10.004

Brandon K Hoglund, Vincent Carfagno, M Foster Olive, Jonna M Leyrer-Jackson

{"title":"Metabotropic glutamate receptors and cognition: From underlying plasticity and neuroprotection to cognitive disorders and therapeutic targets.","authors":"Brandon K Hoglund, Vincent Carfagno, M Foster Olive, Jonna M Leyrer-Jackson","doi":"10.1016/bs.irn.2022.10.004","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.10.004","url":null,"abstract":"Metabotropic glutamate (mGlu) receptors are G protein-coupled receptors that play pivotal roles in mediating the activity of neurons and other cell types within the brain, communication between cell types, synaptic plasticity, and gene expression. As such, these receptors play an important role in a number of cognitive processes. In this chapter, we discuss the role of mGlu receptors in various forms of cognition and their underlying physiology, with an emphasis on cognitive dysfunction. Specifically, we highlight evidence that links mGlu physiology to cognitive dysfunction across brain disorders including Parkinson's disease, Alzheimer's disease, Fragile X syndrome, post-traumatic stress disorder, and schizophrenia. We also provide recent evidence demonstrating that mGlu receptors may elicit neuroprotective effects in particular disease states. Lastly, we discuss how mGlu receptors can be targeted utilizing positive and negative allosteric modulators as well as subtype specific agonists and antagonist to restore cognitive function across these disorders.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"168 ","pages":"367-413"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9441952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-onset inherited dystonias versus late-onset idiopathic dystonias: Same or different biological mechanisms? 早发性遗传性肌张力障碍与晚发性特发性肌张力障碍:相同或不同的生物学机制?

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2023.05.002

Roberto Erro, Edoardo Monfrini, Alessio Di Fonzo

{"title":"Early-onset inherited dystonias versus late-onset idiopathic dystonias: Same or different biological mechanisms?","authors":"Roberto Erro, Edoardo Monfrini, Alessio Di Fonzo","doi":"10.1016/bs.irn.2023.05.002","DOIUrl":"https://doi.org/10.1016/bs.irn.2023.05.002","url":null,"abstract":"Dystonia syndromes encompass a heterogeneous group of movement disorders which might be differentiated by several clinical-historical features. Among the latter, age-at-onset is probably the most important in predicting the likelihood both for the symptoms to spread from focal to generalized and for a genetic cause to be found. Accordingly, dystonia syndromes are generally stratified into early-onset and late-onset forms, the former having a greater likelihood of being monogenic disorders and the latter to be possibly multifactorial diseases, despite being currently labeled as idiopathic. Nonetheless, there are several similarities between these two groups of dystonia, including shared pathophysiological and biological mechanisms. Moreover, there is also initial evidence of age-related modifiers of early-onset dystonia syndromes and of critical periods of vulnerability of the sensorimotor network, during which a combination of genetic and non-genetic insults is more likely to produce symptoms. Based on these lines of evidence, we reappraise the double-hit hypothesis of dystonia, which would accommodate both similarities and differences between early-onset and late-onset dystonia in a single framework.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"169 ","pages":"329-346"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9862917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dystonia genes and their biological pathways. 肌张力障碍基因及其生物学途径。

3区医学

International review of neurobiology Pub Date : 2023-01-01 DOI: 10.1016/bs.irn.2023.04.009

Alessio Di Fonzo, H A Jinnah, Michael Zech

{"title":"Dystonia genes and their biological pathways.","authors":"Alessio Di Fonzo, H A Jinnah, Michael Zech","doi":"10.1016/bs.irn.2023.04.009","DOIUrl":"https://doi.org/10.1016/bs.irn.2023.04.009","url":null,"abstract":"High-throughput sequencing has been instrumental in uncovering the spectrum of pathogenic genetic alterations that contribute to the etiology of dystonia. Despite the immense heterogeneity in monogenic causes, studies performed during the past few years have highlighted that many rare deleterious variants associated with dystonic presentations affect genes that have roles in certain conserved pathways in neural physiology. These various gene mutations that appear to converge towards the disruption of interconnected cellular networks were shown to produce a wide range of different dystonic disease phenotypes, including isolated and combined dystonias as well as numerous clinically complex, often neurodevelopmental disorder-related conditions that can manifest with dystonic features in the context of multisystem disturbances. In this chapter, we summarize the manifold dystonia-gene relationships based on their association with a discrete number of unifying pathophysiological mechanisms and molecular cascade abnormalities. The themes on which we focus comprise dopamine signaling, heavy metal accumulation and calcifications in the brain, nuclear envelope function and stress response, gene transcription control, energy homeostasis, lysosomal trafficking, calcium and ion channel-mediated signaling, synaptic transmission beyond dopamine pathways, extra- and intracellular structural organization, and protein synthesis and degradation. Enhancing knowledge about the concept of shared etiological pathways in the pathogenesis of dystonia will motivate clinicians and researchers to find more efficacious treatments that allow to reverse pathologies in patient-specific core molecular networks and connected multipathway loops.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"169 ","pages":"61-103"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10240056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabotropic glutamate receptor function and regulation of sleep-wake cycles. 促代谢谷氨酸受体的功能和睡眠-觉醒周期的调节。

3区医学

International review of neurobiology Pub Date : 2023-01-01 Epub Date: 2023-01-13 DOI: 10.1016/bs.irn.2022.11.002

Kimberly M Holter, Bethany E Pierce, Robert W Gould

{"title":"Metabotropic glutamate receptor function and regulation of sleep-wake cycles.","authors":"Kimberly M Holter, Bethany E Pierce, Robert W Gould","doi":"10.1016/bs.irn.2022.11.002","DOIUrl":"10.1016/bs.irn.2022.11.002","url":null,"abstract":"Metabotropic glutamate (mGlu) receptors are the most abundant family of G-protein coupled receptors and are widely expressed throughout the central nervous system (CNS). Alterations in glutamate homeostasis, including dysregulations in mGlu receptor function, have been indicated as key contributors to multiple CNS disorders. Fluctuations in mGlu receptor expression and function also occur across diurnal sleep-wake cycles. Sleep disturbances including insomnia are frequently comorbid with neuropsychiatric, neurodevelopmental, and neurodegenerative conditions. These often precede behavioral symptoms and/or correlate with symptom severity and relapse. Chronic sleep disturbances may also be a consequence of primary symptom progression and can exacerbate neurodegeneration in disorders including Alzheimer's disease (AD). Thus, there is a bidirectional relationship between sleep disturbances and CNS disorders; disrupted sleep may serve as both a cause and a consequence of the disorder. Importantly, comorbid sleep disturbances are rarely a direct target of primary pharmacological treatments for neuropsychiatric disorders even though improving sleep can positively impact other symptom clusters. This chapter details known roles of mGlu receptor subtypes in both sleep-wake regulation and CNS disorders focusing on schizophrenia, major depressive disorder, post-traumatic stress disorder, AD, and substance use disorder (cocaine and opioid). In this chapter, preclinical electrophysiological, genetic, and pharmacological studies are described, and, when possible, human genetic, imaging, and post-mortem studies are also discussed. In addition to reviewing the important relationships between sleep, mGlu receptors, and CNS disorders, this chapter highlights the development of selective mGlu receptor ligands that hold promise for improving both primary symptoms and sleep disturbances.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"168 ","pages":"93-175"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9441954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Essential tremor: Is this an electrical or a degenerative disorder? Or is it both? 特发性震颤:这是一种电性疾病还是退行性疾病?还是两者兼而有之?

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/s0074-7742(22)00053-8

Elan D Louis, Sheng-Han Kuo

引用次数: 0

Sex and gender differences in mild traumatic brain injury/concussion. 轻度创伤性脑损伤/脑震荡的性别差异。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-08-02 DOI: 10.1016/bs.irn.2022.07.004

Samaneh Chaychi, Eve Valera, Maria Carmela Tartaglia

引用次数: 6

Adolescent neuroimmune function and its interaction with alcohol. 青少年神经免疫功能及其与酒精的相互作用

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2021-10-04 DOI: 10.1016/bs.irn.2021.08.006

T L Doremus-Fitzwater, T Deak

{"title":"Adolescent neuroimmune function and its interaction with alcohol.","authors":"T L Doremus-Fitzwater, T Deak","doi":"10.1016/bs.irn.2021.08.006","DOIUrl":"https://doi.org/10.1016/bs.irn.2021.08.006","url":null,"abstract":"Adolescence is an evolutionarily conserved developmental period associated with behavioral change, including increased risk-taking and alcohol use. Experimentation with alcohol typically begins in adolescence and transitions to binge-like patterns of consumption. Alcohol exposure during adolescence can alter normative changes in brain structure and function. Understanding mechanisms by which ethanol impacts neurodevelopmental processes is important for preventing and ameliorating the deleterious consequences of adolescent alcohol abuse. This review focuses on the neuroimmune system as a key contributor to ethanol-induced changes in adolescent brain and behavior. After brief review of neuroimmune system development, acute and chronic effects of ethanol on adolescent neuroimmune functioning are addressed. Comparisons between stress/immunological challenges and ethanol on adolescent neuroimmunity are reviewed, as cross-sensitization is relevant during adolescence. The mechanisms by which ethanol alters neuroimmune functioning are then discussed, as they may portend development of neuropathological consequences and thus increase vulnerability to subsequent challenges and potentiate addictive behaviors.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"161 ","pages":"167-208"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204461/pdf/nihms-1812673.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39641942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Essential Tremor: Current Concepts and Controversies 特发性震颤:当前的概念和争议

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/s0074-7742(22)x0003-2

引用次数: 0

Reduction of neuronal hyperexcitability with modulation of T-type calcium channel or SK channel in essential tremor. 特发性震颤中t型钙通道或SK通道调节对神经元高兴奋性的影响。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-05-02 DOI: 10.1016/bs.irn.2022.02.008

Aparna Wagle Shukla

{"title":"Reduction of neuronal hyperexcitability with modulation of T-type calcium channel or SK channel in essential tremor.","authors":"Aparna Wagle Shukla","doi":"10.1016/bs.irn.2022.02.008","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.02.008","url":null,"abstract":"Essential tremor is one of the most prevalent movement disorders. Propranolol and primidone are the first-line pharmacological therapies. They provide symptomatic control in less than 50% of patients. Topiramate, alprazolam, clonazepam, gabapentin, and botulinum toxin injections are the next line of treatments. These medications lead to modest improvements and are therefore commonly used as add-on agents. Surgical therapies, including deep brain stimulation (DBS) surgery and focused ultrasound beam targeted to the thalamus, are considered for treating tremor refractory to medications and lead to greater than 75% improvements in tremor symptoms. However, DBS is a costly and an invasive procedure; some patients report tolerance to benefits. Focused ultrasound therapy leading to brain lesions is associated with a possibility for permanent clinical deficits. Therefore, research efforts to develop the next generation of oral medications with greater benefits and lesser adverse effects are warranted. There is considerable evidence that the increased functions of calcium channels (P/Q-type and T-type channels) and reduced functions of calcium-activated potassium channels (SK channels) located in the neuronal membranes lead to tremor oscillations. Consequently, many new pharmacological studies have targeted these channels to leverage better clinical outcomes. The current review will discuss the pathophysiology, the specific importance of these channels, and the early clinical experience of using compounds targeting these channels to treat essential tremor.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":" ","pages":"335-355"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40396052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Preface. 前言。

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/S0074-7742(22)00127-1

Emma L Lane, Cheney J G Drew, Mariah J Lelos

引用次数: 0