International review of neurobiology最新文献_第4页

Reduction of neuronal hyperexcitability with modulation of T-type calcium channel or SK channel in essential tremor. 特发性震颤中t型钙通道或SK通道调节对神经元高兴奋性的影响。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-05-02 DOI: 10.1016/bs.irn.2022.02.008

Aparna Wagle Shukla

{"title":"Reduction of neuronal hyperexcitability with modulation of T-type calcium channel or SK channel in essential tremor.","authors":"Aparna Wagle Shukla","doi":"10.1016/bs.irn.2022.02.008","DOIUrl":"10.1016/bs.irn.2022.02.008","url":null,"abstract":"Essential tremor is one of the most prevalent movement disorders. Propranolol and primidone are the first-line pharmacological therapies. They provide symptomatic control in less than 50% of patients. Topiramate, alprazolam, clonazepam, gabapentin, and botulinum toxin injections are the next line of treatments. These medications lead to modest improvements and are therefore commonly used as add-on agents. Surgical therapies, including deep brain stimulation (DBS) surgery and focused ultrasound beam targeted to the thalamus, are considered for treating tremor refractory to medications and lead to greater than 75% improvements in tremor symptoms. However, DBS is a costly and an invasive procedure; some patients report tolerance to benefits. Focused ultrasound therapy leading to brain lesions is associated with a possibility for permanent clinical deficits. Therefore, research efforts to develop the next generation of oral medications with greater benefits and lesser adverse effects are warranted. There is considerable evidence that the increased functions of calcium channels (P/Q-type and T-type channels) and reduced functions of calcium-activated potassium channels (SK channels) located in the neuronal membranes lead to tremor oscillations. Consequently, many new pharmacological studies have targeted these channels to leverage better clinical outcomes. The current review will discuss the pathophysiology, the specific importance of these channels, and the early clinical experience of using compounds targeting these channels to treat essential tremor.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":" ","pages":"335-355"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40396052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex and gender differences in epilepsy. 癫痫的性别差异。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-08-10 DOI: 10.1016/bs.irn.2022.06.012

Lauren Hophing, Paulina Kyriakopoulos, Esther Bui

引用次数: 3

Is essential tremor a degenerative disorder or an electric disorder? Degenerative disorder. 特发性震颤是一种退行性疾病还是一种电性疾病?退行性疾病。

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/bs.irn.2022.02.003

Phyllis L Faust

{"title":"Is essential tremor a degenerative disorder or an electric disorder? Degenerative disorder.","authors":"Phyllis L Faust","doi":"10.1016/bs.irn.2022.02.003","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.02.003","url":null,"abstract":"Essential tremor (ET) is a highly prevalent neurologic disease and is the most common of the many tremor disorders. ET is a progressive condition with marked clinical heterogeneity, associated with a spectrum of both motor and non-motor features. However, its disease mechanisms remain poorly understood. Much debate has centered on whether ET should be considered a degenerative disorder, with underlying pathological changes in brain causing progressive disease manifestations, or an electric disorder, with overactivity of intrinsically oscillatory motor networks that occur without underlying structural brain abnormalities. Converging data from clinical, neuroimaging and pathological studies in ET now provide considerable evidence for the neurodegenerative hypothesis. A major turning point in this debate is that rigorous tissue-based studies have recently identified a series of structural changes in the ET cerebellum. Most of these pathological changes are centered on the Purkinje cell and connected neuronal populations, which can result in partial loss of Purkinje cells and circuitry reorganizations that would disturb cerebellar function. There is significant overlap in clinical and pathological features of ET with other disorders of cerebellar degeneration, and an increased risk of developing other degenerative diseases in ET. The combined implication of these studies is that ET could be degenerative. The evidence in support of the degenerative hypothesis is presented.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"163 ","pages":"65-101"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846862/pdf/nihms-1858942.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9165994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

How important is the inferior olive in essential tremor? An evolving story. 下橄榄在特发性震颤中有多重要?一个不断发展的故事。

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/s0074-7742(22)00055-1

Sheng-Han Kuo, Elan D Louis

引用次数: 0

Essential tremor as a harbinger: What is the cognitive fallout of having essential tremor? 特发性震颤的先兆:特发性震颤对认知的影响是什么?

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/s0074-7742(22)00057-5

Elan D Louis, Sheng-Han Kuo

引用次数: 0

Diagnostic work up: Laboratory and biomarkers. 诊断工作:实验室和生物标志物。

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/bs.irn.2021.12.003

Gustav Cedergren Weber, P. Odin

引用次数: 0

Covid-19 and Parkinsonism Covid-19和帕金森病

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/s0074-7742(22)x0005-6

引用次数: 4

Early life stress and susceptibility to addiction in adolescence. 早期生活压力和青少年成瘾的易感性。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2021-10-09 DOI: 10.1016/bs.irn.2021.08.007

K E Tschetter, L B Callahan, S A Flynn, S Rahman, T P Beresford, P J Ronan

引用次数: 6

Alcohol, inflammation, and blood-brain barrier function in health and disease across development. 酒精、炎症和血脑屏障功能在健康和疾病发展中的作用。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2021-08-11 DOI: 10.1016/bs.irn.2021.06.009

A S Vore, T Deak

引用次数: 10

Is essential tremor a family of diseases or a syndrome? A family of diseases. 特发性震颤是一系列疾病还是一种综合征?一个疾病家族。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-03-23 DOI: 10.1016/bs.irn.2022.02.001

Giulietta M Riboldi, Steven J Frucht

引用次数: 0