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International review of neurobiology最新文献

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Is essential tremor a family of diseases or a syndrome? A syndrome. 特发性震颤是一系列疾病还是一种综合征?一个综合症。
3区 医学
International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-03-21 DOI: 10.1016/bs.irn.2022.02.002
Sanjay Pandey
{"title":"Is essential tremor a family of diseases or a syndrome? A syndrome.","authors":"Sanjay Pandey","doi":"10.1016/bs.irn.2022.02.002","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.02.002","url":null,"abstract":"<p><p>In a consensus statement, a task force of the \"International Parkinson and Movement Disorder Society\" (IPMDS) has recently proposed a two axes classification for tremor: axis I (clinical manifestations) and axis II (etiology). In the axis, I, the clinical features of tremor in a given patient are specified in terms of medical history, tremor characteristics, associated signs, and laboratory tests for some tremors leading to the discovery of axis 2 etiologies. Based on axis I sign and symptoms a specific clinical syndrome is diagnosed which have been categorized as isolated tremor syndrome (a syndrome consisting only of tremor) and combined tremor syndrome (consisting of tremor and other systemic or neurological signs). The IPMDS task force defined essential tremor as an isolated tremor syndrome of bilateral upper limb action tremor of at least 3years duration with or without a tremor in other locations (e.g., head, voice or lower limbs) in absence of other neurological signs, such as dystonia, ataxia, or parkinsonism. Patients with neurological signs of uncertain significance (such as impaired tandem gait, questionable dystonic posturing, or memory impairment) are classified as essential tremor plus. In this paper, the author will make the argument that essential tremor is a syndrome with multiple causes.</p>","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":" ","pages":"31-59"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40396050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing GABA inhibition is the next generation of medications for essential tremor. 增强GABA抑制是治疗特发性震颤的新一代药物。
3区 医学
International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-03-21 DOI: 10.1016/bs.irn.2022.02.007
William Ondo
{"title":"Enhancing GABA inhibition is the next generation of medications for essential tremor.","authors":"William Ondo","doi":"10.1016/bs.irn.2022.02.007","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.02.007","url":null,"abstract":"<p><p>γ-Aminobutyric acid (GABA) is the most prevalent inhibitory CNS neurotransmitter. Activating GABA-A receptors hyperpolarizes cells via Cl<sup>-</sup> influx, which inhibits action potentials. Although the exact pathophysiologies of tremor are incompletely understood, proposed neuroanatomy extensively implicates GABA pathways. Pathological studies and imaging studies also show GABA abnormalities in patients with ET. Most importantly, medications that activate GABA-A receptors, such as primidone, often improve tremor. Ongoing clinical trials and physiology research should further refine potential future GABAergic targets and treatments, which are currently the most promising targets for pharmacological intervention.</p>","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":" ","pages":"317-334"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40396051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Prevalence and outcomes of Covid-19 in Parkinson's disease: Acute settings and hospital. 帕金森病中Covid-19的患病率和结局：急性环境和医院
3区 医学
International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-04-20 DOI: 10.1016/bs.irn.2022.03.001
Conor Fearon, Alfonso Fasano
{"title":"Prevalence and outcomes of Covid-19 in Parkinson's disease: Acute settings and hospital.","authors":"Conor Fearon, Alfonso Fasano","doi":"10.1016/bs.irn.2022.03.001","DOIUrl":"10.1016/bs.irn.2022.03.001","url":null,"abstract":"<p><p>The global explosion of COVID-19 necessitated the rapid dissemination of information regarding SARS-CoV-2. Hence, COVID-19 prevalence and outcome data in Parkinson's disease patients were disseminated at a time when we only had part of the picture. In this chapter we firstly discuss the current literature on the prevalence of COVID-19 in people with PD. We then discuss outcomes from COVID-19 in people with PD, specifically risk of hospitalization and mortality. Finally, we discuss specific contributing and confounding factors which may put PD patients at higher or lower risk from COVID-19.</p>","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"165 ","pages":"35-62"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10360067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The emerging role of the microbiome in Alzheimer's disease. 微生物组在阿尔茨海默病中的新作用。
3区 医学
International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/bs.irn.2022.09.001
Caroline Wasén, Ella Simonsen, Millicent N Ekwudo, Martin R Profant, Laura M Cox
{"title":"The emerging role of the microbiome in Alzheimer's disease.","authors":"Caroline Wasén,&nbsp;Ella Simonsen,&nbsp;Millicent N Ekwudo,&nbsp;Martin R Profant,&nbsp;Laura M Cox","doi":"10.1016/bs.irn.2022.09.001","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.09.001","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most prevalent form of dementia and can be influenced by genetic and environmental factors. Recent studies suggest that the intestinal microbiota is altered in AD patients when compared to healthy individuals and may play a role in disease onset and progression. Aging is the greatest risk factor for AD, and age-related changes in the microbiota can affect processes that contribute to cognitive decline. The microbiota may affect AD by modulating peripheral and central immunity or by secreting factors that influence neurogenesis or neuronal cell death. Finally, probiotic and dietary interventions that target the microbiome may have therapeutic potential to prevent or treat AD.</p>","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"167 ","pages":"101-139"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170863/pdf/nihms-1891687.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9445244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Is essential tremor a disorder of primary GABA dysfunction? Yes. 特发性震颤是原发性GABA功能障碍的一种疾病吗?是的。
3区 医学
International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/bs.irn.2022.02.005
Alexandre Gironell
{"title":"Is essential tremor a disorder of primary GABA dysfunction? Yes.","authors":"Alexandre Gironell","doi":"10.1016/bs.irn.2022.02.005","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.02.005","url":null,"abstract":"<p><p>Dysfunction in gamma-aminobutyric acid (GABA) neurotransmission has emerged as a prime suspect for the underlying neurochemical dysfunction in essential tremor (ET). This dysfunction has been termed the GABA hypothesis. We review findings to date supporting the 4 steps in this hypothesis in studies of cerebrospinal fluid, pathology, genetics, animal models, imaging, computational models, and human drugs, while not overlooking the evidence of negative studies and controversies. It remains to be elucidated whether reduced GABAergic tone is a primary contributing factor to ET pathophysiology, a consequence of altered Purkinje cell function, or even a result of Purkinje cell death. More studies are clearly needed to confirm both the neurodegenerative nature of ET and the reduction in GABA activity in the cerebellum. Also necessary is to test further therapies to enhance GABA transmission specifically focused on the cerebellar area.</p>","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"163 ","pages":"259-284"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446196/pdf/nihms-1828378.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9504142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Treatment paradigms in Parkinson's Disease and Covid-19. 帕金森病和Covid-19的治疗模式。
3区 医学
International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/bs.irn.2022.03.002
Iro Boura, Lucia Batzu, Espen Dietrichs, Kallol Ray Chaudhuri
{"title":"Treatment paradigms in Parkinson's Disease and Covid-19.","authors":"Iro Boura,&nbsp;Lucia Batzu,&nbsp;Espen Dietrichs,&nbsp;Kallol Ray Chaudhuri","doi":"10.1016/bs.irn.2022.03.002","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.03.002","url":null,"abstract":"<p><p>People with Parkinson's Disease (PwP) may be at higher risk for complications from the Coronavirus Disease 2019 (Covid-19) due to older age and to the multi-faceted nature of Parkinson's Disease (PD) per se, presenting with a variety of motor and non-motor symptoms. Those on advanced therapies may be particularly vulnerable. Taking the above into consideration, along with the potential multi-systemic impact of Covid-19 on affected patients and the complications of hospitalization, we are providing an evidence-based guidance to ensure a high standard of care for PwP affected by Covid-19 with varying severity of the condition. Adherence to the dopaminergic medication of PwP, without abrupt modifications in dosage and frequency, is of utmost importance, while potential interactions with newly introduced drugs should always be considered. Treating physicians should be cautious to acknowledge and timely address any potential complications, while consultation by a neurologist, preferably with special knowledge on movement disorders, is advised for patients admitted in non-neurological wards. Non-pharmacological approaches, including the patient's mobilization, falls prevention, good sleep hygiene, emotional support, and adequate nutritional and fluid intake, are essential and the role of telemedicine services should be strengthened and encouraged.</p>","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"165 ","pages":"135-171"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9226129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Scales and assessments of sexual dysfunction. 性功能障碍的量表和评估。
3区 医学
International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/bs.irn.2021.12.002
C. Rodríguez-Blázquez, M. Forjaz
{"title":"Scales and assessments of sexual dysfunction.","authors":"C. Rodríguez-Blázquez, M. Forjaz","doi":"10.1016/bs.irn.2021.12.002","DOIUrl":"https://doi.org/10.1016/bs.irn.2021.12.002","url":null,"abstract":"","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"162 1","pages":"35-52"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54086227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex and age differences in migraine treatment and management strategies. 偏头痛治疗和管理策略的性别和年龄差异。
3区 医学
International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-08-10 DOI: 10.1016/bs.irn.2022.07.003
Elena R Lebedeva
{"title":"Sex and age differences in migraine treatment and management strategies.","authors":"Elena R Lebedeva","doi":"10.1016/bs.irn.2022.07.003","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.07.003","url":null,"abstract":"<p><p>Migraine is one of the leading causes of disability worldwide, especially in women younger than 50 years old. Migraine has three times higher prevalence in women than in men and tends to decrease after the menopausal transition. Migraine has different clinical features in people of different ages. Clinical symptoms and factors associated with migraine can be various in women and men. Women have special types of migraine, such as pure menstrual migraine and menstrually related migraine. Besides, clinical symptoms of migraine can change during pregnancy, postpartum and lactation. Women are significantly more often than men consulting a doctor because of migraine. These features of migraine lead to different treatment and management strategies in females and males of different ages. Migraine therefore is a disorder that demonstrates the necessity of a personalization of healthcare-ensuring the proper treatment for the right patient, at the right time. Considering all the available literature and guidelines, in this chapter several strategies for management of acute and prophylactic treatments of migraine, according to sex and age differences, are discussed. The purpose of this chapter is to provide a useful piece of information improving the treatment and management of migraine.</p>","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"164 ","pages":"309-347"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33445993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
History and development of sex- and gender sensitive medicine (SGSM). 性别和性别敏感医学(SGSM)的历史和发展。
3区 医学
International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-07-25 DOI: 10.1016/bs.irn.2022.06.008
Eva Becher, Sabine Oertelt-Prigione
{"title":"History and development of sex- and gender sensitive medicine (SGSM).","authors":"Eva Becher,&nbsp;Sabine Oertelt-Prigione","doi":"10.1016/bs.irn.2022.06.008","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.06.008","url":null,"abstract":"<p><p>Sex- and gender-sensitive medicine has evolved from a feminist approach into an innovative cross-cutting approach to doing medicine. In the present chapter we define what sex and gender are in the context of biomedical research and describe the history of the development of this scientific approach. Looking back at crucial events in the U.S.A., Canada and Europe, we will outline how a structural framework has been established, ready to be filled with clinical and applied knowledge and to change the practice of medicine for decades to come.</p>","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"164 ","pages":"1-25"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33446049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Sex and gender differences in movement disorders: Parkinson's disease, essential tremor, dystonia and chorea. 运动障碍的性别和性别差异:帕金森病、特发性震颤、肌张力障碍和舞蹈病。
3区 医学
International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-08-05 DOI: 10.1016/bs.irn.2022.06.010
Gennarina Arabia, Antonio De Martino, Elena Moro
{"title":"Sex and gender differences in movement disorders: Parkinson's disease, essential tremor, dystonia and chorea.","authors":"Gennarina Arabia,&nbsp;Antonio De Martino,&nbsp;Elena Moro","doi":"10.1016/bs.irn.2022.06.010","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.06.010","url":null,"abstract":"<p><p>Sex and gender-based differences in epidemiology, clinical features and therapeutical responses are emerging in several movement disorders, even though they are still not widely recognized. In this chapter, we summarize the most relevant evidence concerning these differences in Parkinson's disease, essential tremor, dystonia and chorea. Indeed, both sex-related biological (hormonal levels fluctuations) and gender-related variables (socio-cultural and environmental factors) may differently impact symptoms manifestation and severity, phenotype and disease progression of movement disorders on men and women. Moreover, sex differences in treatment responses should be taken into account in any therapeutical planning. Physicians need to be aware of these major differences between men and women that will eventually have a major impact on better tailoring prevention, treatment, or even delaying progression of the most common movement disorders.</p>","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"164 ","pages":"101-128"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33446050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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