The emerging role of the microbiome in Alzheimer's disease.

3区 医学 Q2 Medicine
Caroline Wasén, Ella Simonsen, Millicent N Ekwudo, Martin R Profant, Laura M Cox
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引用次数: 4

Abstract

Alzheimer's disease (AD) is the most prevalent form of dementia and can be influenced by genetic and environmental factors. Recent studies suggest that the intestinal microbiota is altered in AD patients when compared to healthy individuals and may play a role in disease onset and progression. Aging is the greatest risk factor for AD, and age-related changes in the microbiota can affect processes that contribute to cognitive decline. The microbiota may affect AD by modulating peripheral and central immunity or by secreting factors that influence neurogenesis or neuronal cell death. Finally, probiotic and dietary interventions that target the microbiome may have therapeutic potential to prevent or treat AD.

微生物组在阿尔茨海默病中的新作用。
阿尔茨海默病(AD)是最常见的痴呆症形式,可受遗传和环境因素的影响。最近的研究表明,与健康个体相比,AD患者的肠道微生物群发生了改变,并可能在疾病的发生和进展中发挥作用。衰老是阿尔茨海默病的最大危险因素,与年龄相关的微生物群变化会影响导致认知能力下降的过程。微生物群可能通过调节外周和中枢免疫或通过分泌影响神经发生或神经元细胞死亡的因子来影响AD。最后,针对微生物组的益生菌和饮食干预可能具有预防或治疗AD的治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
75
审稿时长
>12 weeks
期刊介绍: Published since 1959, International Review of Neurobiology is a well-established series appealing to neuroscientists, clinicians, psychologists, physiologists and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
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