International review of neurobiology最新文献_第10页

Considerations for clinical trial design and conduct in the evaluation of novel advanced therapeutics in neurodegenerative disease. 神经退行性疾病新型先进疗法评估中临床试验设计和实施的考虑。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-10-22 DOI: 10.1016/bs.irn.2022.09.006

Cheney J G Drew, Monica Busse

{"title":"Considerations for clinical trial design and conduct in the evaluation of novel advanced therapeutics in neurodegenerative disease.","authors":"Cheney J G Drew, Monica Busse","doi":"10.1016/bs.irn.2022.09.006","DOIUrl":"10.1016/bs.irn.2022.09.006","url":null,"abstract":"The recent advances in the development of potentially disease modifying cell and gene therapies for neurodegenerative disease has resulted in the production of a number of promising novel therapies which are now moving forward to clinical evaluation. The robust evaluation of these therapies pose a significant number of challenges when compared to more traditional evaluations of pharmacotherapy, which is the current mainstay of neurodegenerative disease symptom management. Indeed, there is an inherent complexity in the design and conduct of these trials at multiple levels. Here we discuss specific aspects requiring consideration in the context of investigating novel cell and gene therapies for neurodegenerative disease. This extends to overarching trial designs that could be employed and the factors that underpin design choices such outcome assessments, participant selection and methods for delivery of cell and gene therapies. We explore methods of data collection that may improve efficiency in trials of cell and gene therapy to maximize data sharing and collaboration. Lastly, we explore some of the additional context beyond efficacy evaluations that should be considered to ensure implementation across relevant healthcare settings.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"166 ","pages":"235-279"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9146700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence, clinical presentations and impact on relationship of sexual dysfunction in Parkinson's Disease 帕金森病的患病率、临床表现及对性功能障碍的影响

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/bs.irn.2021.12.001

Carsten Buhmann

引用次数: 1

Sex and gender differences in autoimmune demyelinating CNS disorders: Multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD) and myelin-oligodendrocyte-glycoprotein antibody associated disorder (MOGAD). 自身免疫性脱髓鞘性中枢神经系统疾病的性别差异:多发性硬化症(MS)、视神经脊髓炎谱系障碍(NMOSD)和髓鞘-少突胶质细胞-糖蛋白抗体相关疾病(MOGAD)。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-08-09 DOI: 10.1016/bs.irn.2022.06.011

Lara Diem, Helly Hammer, Robert Hoepner, Max Pistor, Jana Remlinger, Anke Salmen

{"title":"Sex and gender differences in autoimmune demyelinating CNS disorders: Multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD) and myelin-oligodendrocyte-glycoprotein antibody associated disorder (MOGAD).","authors":"Lara Diem, Helly Hammer, Robert Hoepner, Max Pistor, Jana Remlinger, Anke Salmen","doi":"10.1016/bs.irn.2022.06.011","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.06.011","url":null,"abstract":"Multiple sclerosis (MS), Neuromyelitis optica spectrum disorder (NMOSD) and Myelin-Oligodendrocyte-Glycoprotein antibody associated disorder (MOGAD) are demyelinating disorders of the central nervous system (CNS) of autoimmune origin. Here, we summarize general considerations on sex-specific differences in the immunopathogenesis and hormonal influences as well as key clinical and epidemiological elements. Gender-specific issues are widely neglected starting with the lacking separation of sex as a biological variable and gender comprising the sociocultural components. As for other autoimmune diseases, female preponderance is common in MS and NMOSD. However, sex distribution in MOGAD seems equal. As in MS, immunotherapy in NMOSD and MOGAD is crucial to prevent further disease activity. Therefore, we assessed data on sex differences of the currently licensed disease-modifying treatments for efficacy and safety. This topic seems widely neglected with only fragmented information resulting from post-hoc analyses of clinical trials or real-world post-marketing studies afflicted with lacking power and/or inherent sources of bias. In summary, biological hypotheses of sex differences including genetic factors, the constitution of the immune system and hormonal influences are based upon human and preclinical data, especially for the paradigmatic disease of MS whereas specific data for NMOSD and MOGAD are widely lacking. Epidemiological and clinical differences between men and women are well described for MS and to some extent for NMOSD, yet, with remaining contradictory findings. MOGAD needs further detailed investigation. Sex-specific analyses of safety and efficacy of long-term immunotherapies need to be addressed in future studies designed and powered to answer the pressing questions and to optimize and individualize treatment.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"164 ","pages":"129-178"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33446052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Role of the gut microbiome in multiple sclerosis: From etiology to therapeutics. 肠道微生物组在多发性硬化症中的作用：从病因到治疗。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-06-25 DOI: 10.1016/bs.irn.2022.06.001

Shailesh K Shahi, Meeta Yadav, Sudeep Ghimire, Ashutosh K Mangalam

{"title":"Role of the gut microbiome in multiple sclerosis: From etiology to therapeutics.","authors":"Shailesh K Shahi, Meeta Yadav, Sudeep Ghimire, Ashutosh K Mangalam","doi":"10.1016/bs.irn.2022.06.001","DOIUrl":"10.1016/bs.irn.2022.06.001","url":null,"abstract":"Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS that affects around one million people in the United States. Predisposition or protection from this disease is linked with both genetic and environmental factors. In recent years, gut microbiome has emerged as an important environmental factor in the pathobiology of MS. The gut microbiome supports various physiologic functions, including the development and maintenance of the host immune system, the perturbation of which is known as dysbiosis and has been linked with multiple diseases including MS. We and others have shown that people with MS (PwMS) have gut dysbiosis that is characterized by specific gut bacteria being enriched or depleted. Consequently, there is an emphasis on determining the mechanism(s) through which gut bacteria and/or their metabolites alter the course of MS through their ability to provide protection, predispose individuals, or promote disease progression. Improving our understanding of these mechanisms will allow us to harness the enormous potential of the gut microbiome as a diagnostic and/or therapeutic agent. In this chapter, we will discuss current advances in microbiome research in the context of MS, including a review of specific bacteria that are currently linked with this disease, potential mechanisms of disease pathogenesis, and the utility of microbiome-based therapy for PwMS.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":" ","pages":"185-215"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40707337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is essential tremor a degenerative or an electrical disorder? Electrical disorder. 特发性震颤是一种退行性疾病还是一种神经紊乱?电气障碍。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-03-21 DOI: 10.1016/bs.irn.2022.02.004

Hyun Joo Cho

引用次数: 0

Introduction: Unraveling the complex contributions of indigenous microbes to neurological health and disease. 介绍:揭示本地微生物对神经系统健康和疾病的复杂贡献。

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/S0074-7742(22)00138-6

Timothy R Sampson

引用次数: 1

Exploring sexual dysfunction in care homes. 探讨养老院的性功能障碍。

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/bs.irn.2021.12.005

Annette Hand, B. Hill

引用次数: 0

Covid-19 and Parkinson's disease: Acute clinical implications, long-COVID and post-COVID-19 parkinsonism. Covid-19 与帕金森病：急性临床影响、长期COVID和COVID-19后帕金森病。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-08-08 DOI: 10.1016/bs.irn.2022.04.004

Valentina Leta, Iro Boura, Daniel J van Wamelen, Mayela Rodriguez-Violante, Angelo Antonini, Kallol Ray Chaudhuri

{"title":"Covid-19 and Parkinson's disease: Acute clinical implications, long-COVID and post-COVID-19 parkinsonism.","authors":"Valentina Leta, Iro Boura, Daniel J van Wamelen, Mayela Rodriguez-Violante, Angelo Antonini, Kallol Ray Chaudhuri","doi":"10.1016/bs.irn.2022.04.004","DOIUrl":"10.1016/bs.irn.2022.04.004","url":null,"abstract":"The Coronavirus Disease 2019 (Covid-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has led to unprecedented challenges for the delivery of healthcare and has had a clear impact on people with chronic neurological conditions such as Parkinson's disease (PD). Acute worsening of motor and non-motor symptoms and long-term sequalae have been described during and after SARS-CoV-2 infections in people with Parkinson's (PwP), which are likely to be multifactorial in their origin. On the one hand, it is likely that worsening of symptoms has been related to the viral infection itself, whereas social restrictions imposed over the course of the Covid-19 pandemic might also have had such an effect. Twenty cases of post-Covid-19 para-infectious or post-infectious parkinsonism have been described so far where a variety of pathophysiological mechanisms seem to be involved; however, a Covid-19-induced wave of post-viral parkinsonism seems rather unlikely at the moment. Here, we describe the interaction between SARS-CoV-2 and PD in the short- and long-term and summarize the clinical features of post-Covid-19 cases of parkinsonism observed so far.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"165 ","pages":"63-89"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9226131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19: The cynosure of rise of Parkinson's disease. 2019冠状病毒病:帕金森病上升的前兆。

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/bs.irn.2022.06.007

Prashanth Lingappa Kukkle

引用次数: 0

Sex and gender differences in pain. 性别和性别在疼痛方面的差异。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-07-30 DOI: 10.1016/bs.irn.2022.06.013

Natalie R Osborne, Karen D Davis

{"title":"Sex and gender differences in pain.","authors":"Natalie R Osborne, Karen D Davis","doi":"10.1016/bs.irn.2022.06.013","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.06.013","url":null,"abstract":"Chronic pain affects 20% of adults and is one of the leading causes of disability worldwide. Women and girls are disproportionally affected by chronic pain. About half of chronic pain conditions are more common in women, with only 20% having a higher prevalence in men. There are also sex and gender differences in acute pain sensitivity. Pain is a subjective experience made up of sensory, cognitive, and emotional components. Consequently, there are multiple dimensions through which sex and gender can influence the pain experience. Historically, most preclinical pain research was conducted exclusively in male animals. However, recent studies that included females have revealed significant sex differences in the physiological mechanisms underlying pain, including sex specific involvement of different genes and proteins as well as distinct interactions between hormones and the immune system that influence the transmission of pain signals. Human neuroimaging has revealed sex and gender differences in the neural circuitry associated with pain, including sex specific brain alterations in chronic pain conditions. Clinical pain research suggests that gender can affect how an individual contextualizes and copes with pain. Gender may also influence the susceptibility to develop chronic pain. Sex and gender biases can impact how pain is perceived and treated clinically. Furthermore, the efficacy and side effects associated with different pain treatments can vary according to sex and gender. Therefore, preclinical and clinical research must include sex and gender analyses to understand basic mechanisms of pain and its relief, and to develop personalized pain treatment.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"164 ","pages":"277-307"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33445992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9