International review of neurobiology最新文献_第9页

Covid-19 and Parkinson's disease: Nursing care, vaccination and impact on advanced therapies. Covid-19与帕金森病:护理、疫苗接种及其对先进疗法的影响

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/bs.irn.2022.04.005

Anna Roszmann, Aleksandra M Podlewska, Yue Hui Lau, Iro Boura, Annette Hand

引用次数: 4

Is inferior olive central to the pathophysiology of essential tremor? No. 下橄榄是特发性震颤的病理生理中枢吗?不。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-03-21 DOI: 10.1016/bs.irn.2022.02.010

Mario Manto

{"title":"Is inferior olive central to the pathophysiology of essential tremor? No.","authors":"Mario Manto","doi":"10.1016/bs.irn.2022.02.010","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.02.010","url":null,"abstract":"Essential tremor (ET) represents one of the commonest movement disorder worldwide and is the most common tremor disorder. ET manifests with various combinations of motor and nonmotor symptoms. The clinical hallmark is a kinetic tremor of upper limbs. Historically, the pathogenesis of ET has been based on the hypothesis of an overactivity of the inferior olive (inferior olive hypothesis: IOH) where the inferior olive would act as the central pace-maker of ET, resulting in impaired electrophysiological discharges of the olivo-cerebellar tract. The absence of structural alterations in post-mortem studies of the inferior olive is a striking argument against the IOH. Furthermore, neuroimaging studies point towards the implication of the cerebello-thalamo-cerebral pathway rather than the IO, and the harmaline model which has been considered as an animal model of ET presents important weaknesses. By contrast, a series of experiments by Louis et al. have provided convincing evidence of impaired wiring of the Purkinje cell microcircuitry and progressive neurodegeneration of the cerebellar cortex. The Purkinje neuron appears as the primary culprit (Purkinjopathy). The cerebellar cortex hypothesis (CCH) has solid neuropathological signatures, unlike the purely physiological IOH. Rather than a dysregulatory electrophysiological disorder suggested by IOH, ET is a clinical-pathological entity similar to late onset neurodegenerative disorders such as Parkinson's disease or Alzheimer's disease. The CCH emphasizes the need to develop novel therapeutic strategies in order to maintain or promote the cerebellar reserve. The modern reconceptualization of ET in a genuine cerebellar disorder is cleaning the IOH to the light of histopathological studies. ET falls in the large basket of the neurodegenerative diseases and we have entered into a novel formulation of the disease pathogenesis with direct impacts on future therapies.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":" ","pages":"167-187"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40396849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The microbiota-gut-brain axis in Huntington's disease. 亨廷顿氏病的微生物群-肠-脑轴。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-10-28 DOI: 10.1016/bs.irn.2022.06.005

Chloe J Love, Bethany A Masson, Carolina Gubert, Anthony J Hannan

引用次数: 4

More than a participant in trials of cell and gene therapy: Hearing the voices of people living with neurodegenerative diseases. 不仅仅是参与细胞和基因治疗的试验:倾听神经退行性疾病患者的声音。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-10-21 DOI: 10.1016/bs.irn.2022.09.007

Emma L Lane, Lyndsey Isaacs, Soania Mathur

{"title":"More than a participant in trials of cell and gene therapy: Hearing the voices of people living with neurodegenerative diseases.","authors":"Emma L Lane, Lyndsey Isaacs, Soania Mathur","doi":"10.1016/bs.irn.2022.09.007","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.09.007","url":null,"abstract":"With the advent of novel advanced therapy medicinal products (ATMPs) for neurodegenerative diseases, their pathway to clinical trials and the therapeutic landscape has highlighted some new challenges, many of which are outlined in other chapters of this volume. The practical considerations of all these aspects from basic research and animal models through to clinical trials and eventual clinical implementation are significant. By and large, the major voices surrounding these challenges are the scientists and clinical teams who both develop the interventions and design and deliver the clinical trials to test these novel ATMPs. Their expertise is of course essential, but there is a key voice that can add considerable benefit to the pipeline, that of the lived experience of the disease being treated and the new intervention being considered. While still in their relative infancy in neurodegenerative disease, some ATMPs are already in clinical application in other disease areas, mainly cancer and inherited disorders. This more advanced status has raised some interesting questions about the role of the patient voice across all aspects of the therapeutic research and clinical delivery pipeline. This chapter highlights what has been learnt from the patient voice in their understanding and perspectives of ATMPs and in their experiences of clinical trials in neurodegenerative diseases to date. We discuss when, and how, including people living with neurodegenerative disease is of value in the development and implementation of ATMPs and the questions this collaborative effort can allow us to answer.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":" ","pages":"281-312"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40704455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges of cell therapies for retinal diseases. 视网膜疾病细胞疗法的挑战。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-10-21 DOI: 10.1016/bs.irn.2022.09.004

Monville Christelle, Morizur Lise, Karim Ben M'Barek

引用次数: 0

Sex differences in neurovascular disorders. 神经血管疾病的性别差异。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-07-30 DOI: 10.1016/bs.irn.2022.07.001

Cheryl Carcel, Valeria Caso, Diana Aguiar de Sousa, Else Charlotte Sandset

引用次数: 0

Parkinson's disease and Covid-19: Is there an impact of ethnicity and the need for palliative care. 帕金森病和Covid-19:种族和姑息治疗需求是否有影响?

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-04-27 DOI: 10.1016/bs.irn.2022.03.004

Katarina Rukavina, Victor McConvey, Kallol Ray Chaudhuri, Janis Miyasaki

{"title":"Parkinson's disease and Covid-19: Is there an impact of ethnicity and the need for palliative care.","authors":"Katarina Rukavina, Victor McConvey, Kallol Ray Chaudhuri, Janis Miyasaki","doi":"10.1016/bs.irn.2022.03.004","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.03.004","url":null,"abstract":"Under the traditional models of care for People with Parkinson's Disease (PD, PwP), many of their needs remain unmet and a substantial burden of motor and non-motor symptoms they experience may not be tackled sufficiently. An introduction of palliative care (PC) interventions early in the course of PD offers profound benefits: it may improve quality of life of patients, their families and caregivers through the prevention and relief of medical symptoms, while, at the same time, emphasizing their emotional needs and spiritual wellbeing, establishing goals of care, and engaging in the advance care planning (ACP). The ongoing Coronavirus Disease 2019 (Covid-19) pandemic poses an unprecedented set of challenges for PwP and has in many ways (both directly and indirectly) magnified their suffering, thus rapidly raising the demand for PC interventions. Covid-19, as well as the repercussions of prolonged mobility restrictions and limited health-care access might exacerbate the severity of PD motor symptoms and interact negatively with a range of non-motor symptoms, with a detrimental effect on quality of life. Greater motor disability, higher amount of levodopa-induced motor fluctuations with an increased daily off-time, fatigue, anxiety, depression, sleep disturbances, pain and worsening of cognitive complaints might dominate the clinical presentation in PwP during the Covid-19 pandemic, alongside raising psychological and spiritual concerns and anticipatory grief. Here, we aim to provide a foundation for pragmatic and clinically orientated PC approach to improve quality of life and relieve suffering of PwP in the context of the current, ongoing Covid-19 pandemic.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":" ","pages":"229-249"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33493601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Management strategies of sexual dysfunctions in Parkinson's disease. 帕金森病患者性功能障碍的治疗策略。

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/bs.irn.2021.12.004

D. Urso, V. Leta, K. Rukavina

引用次数: 0

The pathophysiology of sexual dysfunction in Parkinson's disease: An overview. 帕金森病患者性功能障碍的病理生理学:综述。

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/bs.irn.2022.01.001

L. Batzu, N. Titova, K. Bhattacharyya, K. Chaudhuri

引用次数: 1

Challenges in progressing cell therapies to the clinic for Huntington's disease: A review of the progress made with pluripotent stem cell derived medium spiny neurons. 将亨廷顿氏症细胞疗法推向临床所面临的挑战：多能干细胞衍生中刺神经元进展回顾。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-10-08 DOI: 10.1016/bs.irn.2022.09.003

Patricia Garcia Jareño, Oliver J M Bartley, Sophie V Precious, Anne E Rosser, Mariah J Lelos

{"title":"Challenges in progressing cell therapies to the clinic for Huntington's disease: A review of the progress made with pluripotent stem cell derived medium spiny neurons.","authors":"Patricia Garcia Jareño, Oliver J M Bartley, Sophie V Precious, Anne E Rosser, Mariah J Lelos","doi":"10.1016/bs.irn.2022.09.003","DOIUrl":"10.1016/bs.irn.2022.09.003","url":null,"abstract":"Huntington's disease (HD) is a hereditary, neurodegenerative disorder characterized by a triad of symptoms: motor, cognitive and psychiatric. HD is caused by a genetic mutation, expansion of the CAG repeat in the huntingtin gene, which results in loss of medium spiny neurons (MSNs) of the striatum. Cell replacement therapy (CRT) has emerged as a possible therapy for HD, aiming to replace those cells lost to the disease process and alleviate its symptoms. Initial pre-clinical studies used primary fetal striatal cells to provide proof-of-principal that CRT can bring about functional recovery on some behavioral tasks following transplantation into HD models. Alternative donor cell sources are required if CRT is to become a viable therapeutic option and human pluripotent stem cell (hPSC) sources, which have undergone differentiation toward the MSNs lost to the disease process, have proved to be strong candidates. The focus of this chapter is to review work conducted on the functional assessment of animals following transplantation of hPSC-derived MSNs. We discuss different ways that graft function has been assessed, and the results that have been achieved to date. In addition, this chapter presents and discusses challenges that remain in this field.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"166 ","pages":"1-48"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9115880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0