特发性震颤是原发性GABA功能障碍的一种疾病吗?是的。

3区 医学 Q2 Medicine
Alexandre Gironell
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引用次数: 1

摘要

γ -氨基丁酸(GABA)神经传递功能障碍已成为原发性震颤(ET)潜在神经化学功能障碍的主要怀疑。这种功能障碍被称为GABA假说。我们回顾了迄今为止在脑脊液、病理学、遗传学、动物模型、成像、计算模型和人类药物研究中支持这一假设的4个步骤的发现,同时也没有忽视负面研究和争议的证据。gaba能张力降低是ET病理生理的主要因素,还是浦肯野细胞功能改变的结果,甚至是浦肯野细胞死亡的结果,仍有待阐明。显然需要更多的研究来证实ET的神经退行性和小脑中GABA活性的降低。同样有必要测试进一步的治疗方法,以增强GABA的传递,特别是集中在小脑区域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is essential tremor a disorder of primary GABA dysfunction? Yes.

Dysfunction in gamma-aminobutyric acid (GABA) neurotransmission has emerged as a prime suspect for the underlying neurochemical dysfunction in essential tremor (ET). This dysfunction has been termed the GABA hypothesis. We review findings to date supporting the 4 steps in this hypothesis in studies of cerebrospinal fluid, pathology, genetics, animal models, imaging, computational models, and human drugs, while not overlooking the evidence of negative studies and controversies. It remains to be elucidated whether reduced GABAergic tone is a primary contributing factor to ET pathophysiology, a consequence of altered Purkinje cell function, or even a result of Purkinje cell death. More studies are clearly needed to confirm both the neurodegenerative nature of ET and the reduction in GABA activity in the cerebellum. Also necessary is to test further therapies to enhance GABA transmission specifically focused on the cerebellar area.

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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
75
审稿时长
>12 weeks
期刊介绍: Published since 1959, International Review of Neurobiology is a well-established series appealing to neuroscientists, clinicians, psychologists, physiologists and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
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