Alcohol, inflammation, and blood-brain barrier function in health and disease across development.

3区医学 Q2 Medicine

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2021-08-11 DOI:10.1016/bs.irn.2021.06.009

A S Vore, T Deak

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引用次数: 10

Abstract

Alcohol is the most commonly used drug of abuse in the world and binge drinking is especially harmful to the brain, though the mechanisms by which alcohol compromises overall brain health remain somewhat elusive. A number of brain diseases and pathological states are accompanied by perturbations in Blood-Brain Barrier (BBB) function, ultimately exacerbating disease progression. The BBB is critical for coordinating activity between the peripheral immune system and the brain. Importantly, BBB integrity is responsive to circulating cytokines and other immune-related signaling molecules, which are powerfully modulated by alcohol exposure. This review will highlight key cellular components of the BBB; discuss mechanisms by which permeability is achieved; offer insight into methodological approaches for assessing BBB integrity; and forecast how alcohol-induced changes in the peripheral and central immune systems might influence BBB function in individuals with a history of binge drinking and ultimately Alcohol Use Disorders (AUD).

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酒精、炎症和血脑屏障功能在健康和疾病发展中的作用。

酒精是世界上最常用的滥用药物，酗酒对大脑尤其有害，尽管酒精损害大脑整体健康的机制仍然有些难以捉摸。许多脑疾病和病理状态都伴随着血脑屏障(BBB)功能的紊乱，最终加剧了疾病的进展。血脑屏障对于协调外周免疫系统和大脑之间的活动至关重要。重要的是，血脑屏障的完整性是对循环细胞因子和其他免疫相关信号分子的反应，这些分子是由酒精暴露强有力地调节的。本综述将重点介绍血脑屏障的关键细胞成分;讨论实现渗透率的机制;对评估血脑屏障完整性的方法学方法提供见解;并预测酒精引起的外周和中枢免疫系统的变化如何影响有酗酒史和最终酒精使用障碍(AUD)的个体的血脑屏障功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International review of neurobiology NEUROSCIENCES-

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Published since 1959, International Review of Neurobiology is a well-established series appealing to neuroscientists, clinicians, psychologists, physiologists and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.