早期生活压力和青少年成瘾的易感性。

3区 医学 Q2 Medicine
International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2021-10-09 DOI:10.1016/bs.irn.2021.08.007
K E Tschetter, L B Callahan, S A Flynn, S Rahman, T P Beresford, P J Ronan
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引用次数: 6

摘要

早期生活压力(ELS)是发展成许多精神疾病的一个危险因素。青春期是这些疾病和物质使用障碍(SUDs)发病的特别脆弱时期。在这里,我们讨论ELS及其对青少年的影响,特别是sud,以及它们与奖赏和应激神经回路信号系统分子变化的相关性。利用新生儿ELS的母亲分离(MS)模型,我们研究了一系列包括“药物寻求”表型的行为。然后我们研究了这种表型发展的潜在机制。促肾上腺皮质激素释放因子(CRF)和血清素(5-HT)被广泛认为与包括成瘾在内的“压力诱发”疾病有关。在这里,我们发现ELS导致药物寻求表型的发展,表明成瘾易感性增加,并伴随在扩展的脑奖励/应激神经回路中CRF和5-HT系统成分的性别依赖性上调。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early life stress and susceptibility to addiction in adolescence.

Early life stress (ELS) is a risk factor for developing a host of psychiatric disorders. Adolescence is a particularly vulnerable period for the onset of these disorders and substance use disorders (SUDs). Here we discuss ELS and its effects in adolescence, especially SUDs, and their correlates with molecular changes to signaling systems in reward and stress neurocircuits. Using a maternal separation (MS) model of neonatal ELS, we studied a range of behaviors that comprise a "drug-seeking" phenotype. We then investigated potential mechanisms underlying the development of this phenotype. Corticotropin releasing factor (CRF) and serotonin (5-HT) are widely believed to be involved in "stress-induced" disorders, including addiction. Here, we show that ELS leads to the development of a drug-seeking phenotype indicative of increased susceptibility to addiction and concomitant sex-dependent upregulation of CRF and 5-HT system components throughout extended brain reward/stress neurocircuits.

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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
75
审稿时长
>12 weeks
期刊介绍: Published since 1959, International Review of Neurobiology is a well-established series appealing to neuroscientists, clinicians, psychologists, physiologists and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
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