{"title":"聚焦非运动症状和 Covid-19。","authors":"Silvia Rota, Iro Boura, Yi-Min Wan, Claudia Lazcano-Ocampo, Mayela Rodriguez-Violante, Angelo Antonini, Kallol Ray Chaudhuri","doi":"10.1016/bs.irn.2022.04.001","DOIUrl":null,"url":null,"abstract":"<p><p>The Coronavirus Disease 2019 (Covid-19) pandemic has profoundly affected the quality of life (QoL) and health of the general population globally over the past 2 years, with a clear impact on people with Parkinson's Disease (PwP, PD). Non-motor symptoms have been widely acknowledged to hold a vital part in the clinical spectrum of PD, and, although often underrecognized, they significantly contribute to patients' and their caregivers' QoL. Up to now, there have been numerous reports of newly emerging or acutely deteriorating non-motor symptoms in PwP who had been infected by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), while some of these symptoms, like fatigue, pain, depression, anxiety and cognitive impairment, have also been identified as part of the long-COVID syndrome due to their persistent nature. The subjacent mechanisms, mediating the appearance or progression of non-motor symptoms in the context of Covid-19, although probably multifactorial in origin, remain largely unknown. Such mechanisms might be, at least partly, related solely to the viral infection per se or the lifestyle changes imposed during the pandemic, as many of the non-motor symptoms seem to be prevalent even among Covid-19 patients without PD. Here, we summarize the available evidence and implications of Covid-19 in non-motor PD symptoms in the acute and chronic, if applicable, phase of the infection, with a special reference on studies of PwP.</p>","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":" ","pages":"103-133"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270874/pdf/","citationCount":"0","resultStr":"{\"title\":\"Spotlight on non-motor symptoms and Covid-19.\",\"authors\":\"Silvia Rota, Iro Boura, Yi-Min Wan, Claudia Lazcano-Ocampo, Mayela Rodriguez-Violante, Angelo Antonini, Kallol Ray Chaudhuri\",\"doi\":\"10.1016/bs.irn.2022.04.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The Coronavirus Disease 2019 (Covid-19) pandemic has profoundly affected the quality of life (QoL) and health of the general population globally over the past 2 years, with a clear impact on people with Parkinson's Disease (PwP, PD). Non-motor symptoms have been widely acknowledged to hold a vital part in the clinical spectrum of PD, and, although often underrecognized, they significantly contribute to patients' and their caregivers' QoL. Up to now, there have been numerous reports of newly emerging or acutely deteriorating non-motor symptoms in PwP who had been infected by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), while some of these symptoms, like fatigue, pain, depression, anxiety and cognitive impairment, have also been identified as part of the long-COVID syndrome due to their persistent nature. The subjacent mechanisms, mediating the appearance or progression of non-motor symptoms in the context of Covid-19, although probably multifactorial in origin, remain largely unknown. Such mechanisms might be, at least partly, related solely to the viral infection per se or the lifestyle changes imposed during the pandemic, as many of the non-motor symptoms seem to be prevalent even among Covid-19 patients without PD. Here, we summarize the available evidence and implications of Covid-19 in non-motor PD symptoms in the acute and chronic, if applicable, phase of the infection, with a special reference on studies of PwP.</p>\",\"PeriodicalId\":14468,\"journal\":{\"name\":\"International review of neurobiology\",\"volume\":\" \",\"pages\":\"103-133\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270874/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International review of neurobiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/bs.irn.2022.04.001\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/7/9 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International review of neurobiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/bs.irn.2022.04.001","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/7/9 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
在过去两年中,2019 年冠状病毒病(Covid-19)大流行对全球普通人群的生活质量和健康产生了深远影响,对帕金森病(PwP,PD)患者的影响也非常明显。人们普遍认为,非运动症状在帕金森病的临床表现中占有重要地位,尽管往往未得到充分认识,但它们对患者及其护理人员的 QoL 有着重要影响。迄今为止,已有大量关于感染严重急性呼吸系统综合征冠状病毒-2(SARS-CoV-2)的残疾人出现新的或急性恶化的非运动症状的报道,而其中一些症状,如疲劳、疼痛、抑郁、焦虑和认知障碍,由于其持续性,也被认为是长期慢性阻塞性脑损伤综合征的一部分。尽管 Covid-19 可能是由多种因素引起的,但导致非运动症状出现或发展的次要机制在很大程度上仍不为人所知。这些机制可能(至少部分)仅与病毒感染本身或大流行期间生活方式的改变有关,因为许多非运动症状似乎在没有帕金森病的 Covid-19 患者中也很普遍。在此,我们总结了 Covid-19 病毒感染急性期和慢性期(如适用)非运动性帕金森病症状的现有证据和影响,并特别提到了对帕金森病患者的研究。
The Coronavirus Disease 2019 (Covid-19) pandemic has profoundly affected the quality of life (QoL) and health of the general population globally over the past 2 years, with a clear impact on people with Parkinson's Disease (PwP, PD). Non-motor symptoms have been widely acknowledged to hold a vital part in the clinical spectrum of PD, and, although often underrecognized, they significantly contribute to patients' and their caregivers' QoL. Up to now, there have been numerous reports of newly emerging or acutely deteriorating non-motor symptoms in PwP who had been infected by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), while some of these symptoms, like fatigue, pain, depression, anxiety and cognitive impairment, have also been identified as part of the long-COVID syndrome due to their persistent nature. The subjacent mechanisms, mediating the appearance or progression of non-motor symptoms in the context of Covid-19, although probably multifactorial in origin, remain largely unknown. Such mechanisms might be, at least partly, related solely to the viral infection per se or the lifestyle changes imposed during the pandemic, as many of the non-motor symptoms seem to be prevalent even among Covid-19 patients without PD. Here, we summarize the available evidence and implications of Covid-19 in non-motor PD symptoms in the acute and chronic, if applicable, phase of the infection, with a special reference on studies of PwP.
期刊介绍:
Published since 1959, International Review of Neurobiology is a well-established series appealing to neuroscientists, clinicians, psychologists, physiologists and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.