痴呆症的性别差异。

3区 医学 Q2 Medicine
International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-08-02 DOI:10.1016/bs.irn.2022.07.002
Patrick Salwierz, Carly Davenport, Vishaal Sumra, M Florencia Iulita, Maria Teresa Ferretti, Maria Carmela Tartaglia
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引用次数: 2

摘要

痴呆症的格局发生了惊人的范式转变。对神经退行性变和蛋白质病变的理解的进步改变了我们治疗认知障碍患者的方法。首先,最近的研究表明,导致痴呆症的各种蛋白质病变早在出现任何明显症状之前就开始积累了。这巩固了诊断的紧迫性,因为它发生在这些疾病的病理生理学非常晚。其次,准确的诊断需要提供有针对性的治疗,也就是精准医疗。有了后一点,认识到一个人的各种因素需要考虑,因为它们可能影响疾病的表现和进展,已经上升到最前沿。除了种族和年龄之外,其中两个因素是生理性别和社会性别(社会结构),因为两者都对疾病的表现有巨大的影响。本章将涵盖已知的和有待了解的关于性和社会性别与痴呆的一些主要原因的相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sex and gender differences in dementia.

The dementia landscape has undergone a striking paradigm shift. The advances in understanding of neurodegeneration and proteinopathies has changed our approach to patients with cognitive impairment. Firstly, it has recently been shown that the various proteinopathies that are the cause of the dementia begin to build up long before the appearance of any obvious symptoms. This has cemented the idea that there is an urgency in diagnosis as it occurs very late in the pathophysiology of these diseases. Secondly, that accurate diagnosis is required to deliver targeted therapies, that is precision medicine. With this latter point, the realization that various factors of a person need to be considered as they may impact the presentation and progression of disease has risen to the forefront. Two of these factors aside from race and age are biological sex and gender (social construct), as both can have tremendous impact on manifestation of disease. This chapter will cover what is known and remains to be known on the interaction of sex and gender with some of the major causes of dementia.

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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
75
审稿时长
>12 weeks
期刊介绍: Published since 1959, International Review of Neurobiology is a well-established series appealing to neuroscientists, clinicians, psychologists, physiologists and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
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