Biological underpinnings of sex differences in neurological disorders.

3区 医学 Q2 Medicine
International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-07-30 DOI:10.1016/bs.irn.2022.06.009
Katarzyna Winek, Yonat Tzur, Hermona Soreq
{"title":"Biological underpinnings of sex differences in neurological disorders.","authors":"Katarzyna Winek,&nbsp;Yonat Tzur,&nbsp;Hermona Soreq","doi":"10.1016/bs.irn.2022.06.009","DOIUrl":null,"url":null,"abstract":"<p><p>The importance of sex differences in neurological disorders has been increasingly acknowledged in recent clinical and basic research studies, but the complex biology and genetics underlying sex-linked biological heterogeneity and its brain-to-body impact remained incompletely understood. Men and women differ substantially in their susceptibility to certain neurological diseases, in the severity of symptoms, prognosis as well as the nature and efficacy of their response to treatments. The detailed mechanisms underlying these differences, especially at the molecular level, are being addressed in many studies but leave a lot to be further revealed. Here, we provide an overview of recent advances in our understanding of how sex differences in the brain and brain-body signaling contribute to neurological disorders and further present some future prospects entailed in terms of diagnostics and therapeutics.</p>","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"164 ","pages":"27-67"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International review of neurobiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/bs.irn.2022.06.009","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/7/30 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

The importance of sex differences in neurological disorders has been increasingly acknowledged in recent clinical and basic research studies, but the complex biology and genetics underlying sex-linked biological heterogeneity and its brain-to-body impact remained incompletely understood. Men and women differ substantially in their susceptibility to certain neurological diseases, in the severity of symptoms, prognosis as well as the nature and efficacy of their response to treatments. The detailed mechanisms underlying these differences, especially at the molecular level, are being addressed in many studies but leave a lot to be further revealed. Here, we provide an overview of recent advances in our understanding of how sex differences in the brain and brain-body signaling contribute to neurological disorders and further present some future prospects entailed in terms of diagnostics and therapeutics.

神经疾病中性别差异的生物学基础。
在最近的临床和基础研究中,性别差异在神经系统疾病中的重要性已得到越来越多的承认,但复杂的生物学和遗传学背后的性别相关的生物异质性及其对大脑对身体的影响仍未完全了解。男性和女性在对某些神经系统疾病的易感性、症状的严重程度、预后以及对治疗的反应的性质和效果方面存在很大差异。这些差异背后的详细机制,特别是在分子水平上,正在许多研究中得到解决,但还有很多有待进一步揭示。在这里,我们概述了我们对大脑和脑-体信号的性别差异如何导致神经系统疾病的理解的最新进展,并进一步提出了诊断和治疗方面的一些未来前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
5.90
自引率
0.00%
发文量
75
审稿时长
>12 weeks
期刊介绍: Published since 1959, International Review of Neurobiology is a well-established series appealing to neuroscientists, clinicians, psychologists, physiologists and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信