Peri-adolescent exposure to (meth)amphetamine in animal models.

3区 医学 Q2 Medicine
International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2021-08-20 DOI:10.1016/bs.irn.2021.06.011
T J Phillips, S J Aldrich
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引用次数: 0

Abstract

Experimentation with psychoactive drugs is often initiated in the peri-adolescent period, but knowledge of differences in the outcomes of peri-adolescent- vs adult-initiated exposure is incomplete. We consider the existing animal research in this area for (meth)amphetamines. Established for a number of phenotypes, is lower sensitivity of peri-adolescents than adults to acute effects of (meth)amphetamines, including neurotoxic effects of binge-level exposure. More variable are data for long-term consequences of peri-adolescent exposure on motivational and cognitive traits. Moreover, investigations often exclude an adult-initiated exposure group critical for answering questions about outcomes unique to peri-adolescent initiation. Despite this, it is clear from the animal research that (meth)amphetamine exposure during the peri-adolescent period, whether self- or other-administered, impacts brain motivational circuitry and cognitive function, and alters adult sensitivity to other drugs and natural rewards. Such consequences occurring in humans have the potential to predispose toward unfortunate and potentially disastrous family, social and livelihood outcomes.

在动物模型中,青春期前后暴露于(冰毒)安非他明。
精神活性药物的实验通常是在青春期前后开始的,但是关于青春期前后与成年后接触的结果差异的知识是不完整的。我们考虑现有的动物研究在这一领域的(冰毒)安非他明。在许多表型中,青少年对(冰毒)安非他明的急性影响的敏感性低于成年人,包括大量暴露的神经毒性影响。更多的变量是关于青春期前后接触对动机和认知特征的长期影响的数据。此外,调查经常排除成人开始接触的群体,这对于回答关于青春期周围开始接触的独特结果的问题至关重要。尽管如此,从动物研究中可以清楚地看出,在青少年时期,无论是自我还是他人给予的(冰毒)安非他明,都会影响大脑的动机回路和认知功能,并改变成人对其他药物和自然奖励的敏感性。这种发生在人类身上的后果有可能导致不幸和潜在灾难性的家庭、社会和生计结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
75
审稿时长
>12 weeks
期刊介绍: Published since 1959, International Review of Neurobiology is a well-established series appealing to neuroscientists, clinicians, psychologists, physiologists and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
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