International Reviews of Immunology最新文献_第5页

Dysregulated metabolism: A friend-to-foe skewer of macrophages. 代谢失调:巨噬细胞的友对敌串。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2022.2095374

Keywan Mortezaee, Jamal Majidpoor

引用次数: 10

Molecular mechanisms of ferroptosis and their role in inflammation. 铁下垂的分子机制及其在炎症中的作用。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2021.2016739

Feng Wang, Jingya He, Ruxiao Xing, Tong Sha, Bin Sun

引用次数: 15

Role of natural killer and B cell interaction in inducing pathogen specific immune responses. 自然杀手和B细胞相互作用在诱导病原体特异性免疫反应中的作用。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2023.2172406

Nikunj Tandel, Sushmita Negi, Sarat K Dalai, Rajeev K Tyagi

{"title":"Role of natural killer and B cell interaction in inducing pathogen specific immune responses.","authors":"Nikunj Tandel, Sushmita Negi, Sarat K Dalai, Rajeev K Tyagi","doi":"10.1080/08830185.2023.2172406","DOIUrl":"https://doi.org/10.1080/08830185.2023.2172406","url":null,"abstract":"The innate lymphoid cell (ILC) system comprising of the circulating and tissue-resident cells is known to clear infectious pathogens, establish immune homeostasis as well as confer antitumor immunity. Human natural killer cells (hNKs) and other ILCs carry out mopping of the infectious pathogens and perform cytolytic activity regulated by the non-adaptive immune system. The NK cells generate immunological memory and rapid recall response tightly regulated by the adaptive immunity. The interaction of NK and B cell, and its role to induce the pathogen specific immunity is not fully understood. Hence, present article sheds light on the interaction between NK and B cells and resulting immune responses in the infectious diseases. The immune responses elicited by the NK-B cell interaction is of particular importance for developing therapeutic vaccines against the infectious pathogens. Further, experimental evidences suggest the immune-response driven by NK cell population elicits the host-specific antibodies and memory B cells. Also, recently developed humanized immune system (HIS) mice and their importance in to understanding the NK-B cell interaction and resulting pathogen specific immunity has been discussed.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9572823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Host-directed antileishmanial interventions: Harvesting unripe fruits to reach fruition. 宿主导向的抗利什曼干预:收获未成熟的果实以达到结果。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2022.2047670

Anuradha Seth, Susanta Kar

{"title":"Host-directed antileishmanial interventions: Harvesting unripe fruits to reach fruition.","authors":"Anuradha Seth, Susanta Kar","doi":"10.1080/08830185.2022.2047670","DOIUrl":"https://doi.org/10.1080/08830185.2022.2047670","url":null,"abstract":"Leishmaniasis is an exemplary paradigm of immune evasion, fraught with the perils of limited clinical assistance, escalating costs of treatment and made worse with the lack of suitable vaccine. While drugs remain central to large-scale disease control, the growing emergence of parasite resistance necessitates the need for combination therapy involving host-directed immunological agents. Also, since prolonged disease progression is associated with strong immune suppression of the host, augmentation of host immunity via restoration of the immunoregulatory circuit involving antigen-presenting cells and T-cells, activation of macrophage function and/or CD4+ T helper 1 cell differentiation may serve as an ideal approach to resolve severe cases of leishmaniasis. As such, therapies that embody a synergistic approach that involve direct killing of the parasite in addition to elevating host immunity are likely to pave the way for widespread elimination of leishmaniasis in the future. With this review, we aim to recapitulate the various immunotherapeutic agents found to hold promise in antileishmanial treatment both in vitro and in vivo. These include parasite-specific antigens, dendritic cell-targeted therapy, recombinant inhibitors of various components intrinsic to immune cell signaling and agonists or antagonists to immune cells and cytokines. We also summarize their abilities to direct therapeutic skewing of the host cell-immune response and review their potential to combat the disease either alone, or as adjunct modalities.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9807567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

SARS-CoV-2 variants and COVID-19 vaccines: Current challenges and future strategies. SARS-CoV-2变体和COVID-19疫苗:当前挑战和未来战略

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 Epub Date: 2022-05-28 DOI: 10.1080/08830185.2022.2079642

Wenping Gong, Seppo Parkkila, Xueqiong Wu, Ashok Aspatwar

{"title":"SARS-CoV-2 variants and COVID-19 vaccines: Current challenges and future strategies.","authors":"Wenping Gong, Seppo Parkkila, Xueqiong Wu, Ashok Aspatwar","doi":"10.1080/08830185.2022.2079642","DOIUrl":"10.1080/08830185.2022.2079642","url":null,"abstract":"The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global threat. Despite strict control measures implemented worldwide and immunization using novel vaccines, the pandemic continues to rage due to emergence of several variants of SARS-CoV-2 with increased transmission and immune escape. The rapid spread of variants of concern (VOC) in the recent past has created a massive challenge for the control of COVID-19 pandemic via the currently used vaccines. Vaccines that are safe and effective against the current and future variants of SARS-CoV-2 are essential in controlling the COVID-19 pandemic. Rapid production and massive rollout of next-generation vaccines against the variants are key steps to control the COVID-19 pandemic and to help us return to normality. Coordinated surveillance of SARS-CoV-2, rapid redesign of new vaccines and extensive vaccination are needed to counter the current SARS-CoV-2 variants and prevent the emergence of new variants. In this article, we review the latest information on the VOCs and variants of interest (VOIs) and present the information on the clinical trials that are underway on evaluating the effectiveness of COVID-19 vaccines on VOCs. We also discuss the current challenges posed by the VOCs in controlling the COVID-19 pandemic and future strategies to overcome the threat posed by the highly virulent and rapidly transmissible variants of SARS-CoV2.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46254001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Pyroptosis in neurodegenerative diseases: What lies beneath the tip of the iceberg? 神经退行性疾病中的焦亡:冰山一角下隐藏着什么?

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2022.2052064

Mengli Yue, Li Xiao, Rui Yan, Xinyi Li, Wei Yang

引用次数: 2

Regulatory Effects of Clock and Bmal1 on Circadian Rhythmic TLR Expression. 时钟和Bmal1对TLR昼夜节律表达的调控作用。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2021.1931170

Xu-Li Fan, Ying Song, Dong-Xu Qin, Pei-Yao Lin

引用次数: 6

Disparities in positive results and dissemination of randomized controlled trials in immuno-oncology. 免疫肿瘤学随机对照试验阳性结果的差异和传播。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2022.2088744

Cheng Xu, Shu Zhang, Guang-Li Zhu, Kai-Bin Yang, Yuan Zhang, Yan-Ping Mao, Ling-Long Tang, Qing Liu, Ying Huang, Jun Ma

{"title":"Disparities in positive results and dissemination of randomized controlled trials in immuno-oncology.","authors":"Cheng Xu, Shu Zhang, Guang-Li Zhu, Kai-Bin Yang, Yuan Zhang, Yan-Ping Mao, Ling-Long Tang, Qing Liu, Ying Huang, Jun Ma","doi":"10.1080/08830185.2022.2088744","DOIUrl":"https://doi.org/10.1080/08830185.2022.2088744","url":null,"abstract":"Background: This cross-sectional and longitudinal analysis aimed to demonstrate the disparities in positive results and dissemination patterns of randomized controlled trials (RCTs) in global immuno-oncology (IO).Methods: Phase II-IV RCTs with results reported by article publications registered on ClinicalTrials.gov in 2007-2018 studying immune checkpoint inhibitors (ICIs), adoptive cell transfer, cancer vaccines, and immune modulators were included.Results: Twenty-eight percent of trials were positive (72 of 258), most of which were pharma-sponsored and focused on ICI and multiple IO therapies in lung cancer, melanoma, and multiple cancer types. The recent period of trial start year, upfront registration, large sample size, high strictness score on corticosteroid/infection-related criteria, and survival endpoints were associated with positive results. Trials from Mainland China had a faster publication timeline of positive results but lacked study diversity or full reporting of negative results compared with US and multinational trials. Compared with phase II trials, phase III-IV trials had a higher average proportion of positive results (28.9% vs. 22.2%) and a more stable change over the past decade (23.65% vs. 49.24%). Positive trials yielded more secondary manuscripts (10 vs. 4), a shorter publication process of approximately two years (P < 0.001), and a superiority in the dissemination of journals with an h-index >90 (P < 0.001) compared with negative trials.Conclusion: Disparities in positive result dissemination are widespread in IO RCTs and affected by trial features. We proposed improvements in upfront registration, procedural integrity, and adequate inclusion of rival trials reporting negative results within the earlier two years in future reviews.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9825036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysregulated translational factors and epigenetic regulations orchestrate in B cells contributing to autoimmune diseases. 失调的翻译因子和表观遗传调控在B细胞中协调促进自身免疫性疾病。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2021.1964498

Ming Yang, Ping Yi, Jiao Jiang, Ming Zhao, Haijing Wu, Qianjin Lu

{"title":"Dysregulated translational factors and epigenetic regulations orchestrate in B cells contributing to autoimmune diseases.","authors":"Ming Yang, Ping Yi, Jiao Jiang, Ming Zhao, Haijing Wu, Qianjin Lu","doi":"10.1080/08830185.2021.1964498","DOIUrl":"https://doi.org/10.1080/08830185.2021.1964498","url":null,"abstract":"B cells play a crucial role in antigen presentation, antibody production and pro-/anti-inflammatory cytokine secretion in adaptive immunity. Several translational factors including transcription factors and cytokines participate in the regulation of B cell development, with the cooperation of epigenetic regulations. Autoimmune diseases are generally characterized with autoreactive B cells and high-level pathogenic autoantibodies. The success of B cell depletion therapy in mouse model and clinical trials has proven the role of B cells in pathogenesis of autoimmune diseases. The failure of B cell tolerance in immune checkpoints results in accumulated autoreactive naïve B (BN) cells with aberrant B cell receptor signaling and dysregulated B cell response, contributing to self-antibody-mediated autoimmune reaction. Dysregulation of translational factors and epigenetic alterations in B cells has been demonstrated to correlate with aberrant B cell compartment in autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, primary Sjögren's syndrome, multiple sclerosis, diabetes mellitus and pemphigus. This review is intended to summarize the interaction of translational factors and epigenetic regulations that are involved with development and differentiation of B cells, and the mechanism of dysregulation in the pathogenesis of autoimmune diseases.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9459169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The role of sialic acid-binding immunoglobulin-like-lectin-1 (siglec-1) in immunology and infectious disease. 唾液酸结合免疫球蛋白样凝集素-1 (siglec1)在免疫学和感染性疾病中的作用。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2021.1931171

Shane Prenzler, Santosh Rudrawar, Mario Waespy, Sørge Kelm, Shailendra Anoopkumar-Dukie, Thomas Haselhorst

{"title":"The role of sialic acid-binding immunoglobulin-like-lectin-1 (siglec-1) in immunology and infectious disease.","authors":"Shane Prenzler, Santosh Rudrawar, Mario Waespy, Sørge Kelm, Shailendra Anoopkumar-Dukie, Thomas Haselhorst","doi":"10.1080/08830185.2021.1931171","DOIUrl":"https://doi.org/10.1080/08830185.2021.1931171","url":null,"abstract":"Siglec-1, also known as Sialoadhesin (Sn) and CD169 is highly conserved among vertebrates and with 17 immunoglobulin-like domains is Siglec-1 the largest member of the Siglec family. Expression of Siglec-1 is found primarily on dendritic cells (DCs), macrophages and interferon induced monocyte. The structure of Siglec-1 is unique among siglecs and its function as a receptor is also different compared to other receptors in this class as it contains the most extracellular domains out of all the siglecs. However, the ability of Siglec-1 to internalize antigens and to pass them on to lymphocytes by allowing dendritic cells and macrophages to act as antigen presenting cells, is the main reason that has granted Siglec-1's key role in multiple human disease states including atherosclerosis, coronary artery disease, autoimmune diseases, cell-cell signaling, immunology, and more importantly bacterial and viral infections. Enveloped viruses for example have been shown to manipulate Siglec-1 to increase their virulence by binding to sialic acids present on the virus glycoproteins allowing them to spread or evade immune response. Siglec-1 mediates dissemination of HIV-1 in activated tissues enhancing viral spread via infection of DC/T-cell synapses. Overall, the ability of Siglec-1 to bind a variety of target cells within the immune system such as erythrocytes, B-cells, CD8+ granulocytes and NK cells, highlights that Siglec-1 is a unique player in these essential processes.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9459175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5