International Reviews of Immunology最新文献_第5页

FAM26F: An Enigmatic Protein Having a Complex Role in the Immune System. FAM26F:一种在免疫系统中具有复杂作用的神秘蛋白。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2016.1206098

Uzma Malik, Aneela Javed

{"title":"FAM26F: An Enigmatic Protein Having a Complex Role in the Immune System.","authors":"Uzma Malik, Aneela Javed","doi":"10.1080/08830185.2016.1206098","DOIUrl":"https://doi.org/10.1080/08830185.2016.1206098","url":null,"abstract":"Mammalian immune system is a complex amalgam of diverse cellular and noncellular components such as cytokines, receptors and co-receptors. FAM26F (family with sequence similarity 26, member F) is a recently identified tetraspanin-like membrane glycoprotein which is predicted to make homophilic interactions and potential synapses between several immune cells including CD4+, CD8+, NK, dendritic cells and macrophages. Various whole transcriptome analyses have demonstrated the differential expression of FAM26F in several bacterial, viral and parasitic infections, in certain pathophysiological conditions such as liver and heart transplantation, and in various cancers. The complete understanding of transcriptional regulation of FAM26F is in its infancy however it is up regulated by various stimulants such as polyI:C, LPS, INF gamma and TNF alpha, and via various proposed pathways including TLR3, TLR4 IFN-β and Dectin-1. These pathways can merge in STAT1 activation. The synergistic expression of FAM26F on both NK-cells and myeloid dendritic cells is required to activate NK-cells against tumors via its cytoplasmic tail, thus emphasizing therapeutic potential of FAM26F for NK sensitive tumors. Current review provides a comprehensive basis to propose that FAM26F expression level is at least a hallmark for IFN-γ-lead immune responses and thus can proficiently be regarded as an early diagnostic marker. Future investigation dissecting the role of FAM26F in activation of various immune cell populations in local amplification by cell-cell contact is crucial to provide the missing link imperative for elucidating the relevance of this protein in immune responses.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"42 4","pages":"247-257"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2016.1206098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9633157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Diversity of T cells in the skin: Novel insights. 皮肤中T细胞的多样性:新的见解。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2021.1985116

Natalija Novak, Leticia Tordesillas, Beatriz Cabanillas

{"title":"Diversity of T cells in the skin: Novel insights.","authors":"Natalija Novak, Leticia Tordesillas, Beatriz Cabanillas","doi":"10.1080/08830185.2021.1985116","DOIUrl":"https://doi.org/10.1080/08830185.2021.1985116","url":null,"abstract":"T cells populate the skin to provide an effective immunosurveillance against external insults and to maintain tissue homeostasis. Most cutaneous T cells are αβ T cells, however, γδ T cells also exist although in much lower frequency. Different subsets of αβ T cells can be found in the skin, such as short-lived effector T cells, central memory T cells, effector memory T cells, and tissue-resident memory T cells. Their differential biology, function, and location provide an ample spectrum of immune responses in the skin. Foxp3+ memory regulatory T cells have a pivotal role in maintaining homeostasis in the skin and their dysregulation has been linked with different skin pathologies. The skin also contains populations of non-classical T cells, such as γδ T cells, NK T cells, and MR1-restricted T cells. Their role in skin homeostasis and response to pathogens has been well established in the past years, however, there is also growing evidence of their role in mediating allergic skin inflammation and promoting sensitization to allergens. In this review, we provide an updated overview on the different subsets of T cells that populate the skin with a specific focus on their role in allergic skin inflammation.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"42 3","pages":"185-198"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9447609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The potential targets in immunotherapy of atherosclerosis. 动脉粥样硬化免疫治疗的潜在靶点。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2021.1988591

Azin Aghamajidi, Melika Gorgani, Faezeh Shahba, Zahra Shafaghat, Nazanin Mojtabavi

引用次数: 1

Antibody engineering and its therapeutic applications. 抗体工程及其治疗应用。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2021.1960986

Divya Kandari, Rakesh Bhatnagar

{"title":"Antibody engineering and its therapeutic applications.","authors":"Divya Kandari, Rakesh Bhatnagar","doi":"10.1080/08830185.2021.1960986","DOIUrl":"https://doi.org/10.1080/08830185.2021.1960986","url":null,"abstract":"As a natural function, antibodies defend the host from infected cells and pathogens by recognizing their pathogenic determinants. Antibodies (Abs) gained wide acceptance with an enormous impact on human health and have predominantly captured the arena of bio-therapeutics and bio-diagnostics. The scope of Ab-based biologics is vast, and it is likely to solve many unmet clinical needs in future. The majority of attention is now devoted to developing innovative technologies for manufacturing and engineering Abs, better suited to satisfy human needs. The advent of Ab engineering technologies (AET) led to phenomenal developments leading to the generation of Abs-/Ab-derived molecules with desirable functional properties proportional to their expanding requirements. Evolution brought by AET, from the naturally occurring Ab forms to several advanced Ab formats and derivatives, was much needed as it is of great interest to the pharmaceutical industry. Thus, numerous advancements in AET have propelled success in therapeutic Ab development, along with the potential for ever-increasing improvements. Unique characteristics of Abs, such as its diversity, specificity, structural integrity and an array of possible applications, together inspire continuous innovation in the field. Overall, the AET could assist in conquer of several limitations of Abs in terms of their applicability in the field of therapeutics, diagnostics and research; AET has so far led to the production of next-generation Abs, which have revolutionized these arenas. Here in this review, we discuss the various distinguished engineering platforms for Ab development and the progress in modern therapeutics by the so-called \"next-generation Abs.\"","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"42 2","pages":"156-183"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2021.1960986","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9455709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Pathophysiological functions of self-derived DNA. 自源DNA的病理生理功能。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2022.2070616

Daisuke Ori, Taro Kawai

引用次数: 0

Dysregulated metabolism: A friend-to-foe skewer of macrophages. 代谢失调:巨噬细胞的友对敌串。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2022.2095374

Keywan Mortezaee, Jamal Majidpoor

引用次数: 10

Role of natural killer and B cell interaction in inducing pathogen specific immune responses. 自然杀手和B细胞相互作用在诱导病原体特异性免疫反应中的作用。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2023.2172406

Nikunj Tandel, Sushmita Negi, Sarat K Dalai, Rajeev K Tyagi

{"title":"Role of natural killer and B cell interaction in inducing pathogen specific immune responses.","authors":"Nikunj Tandel, Sushmita Negi, Sarat K Dalai, Rajeev K Tyagi","doi":"10.1080/08830185.2023.2172406","DOIUrl":"https://doi.org/10.1080/08830185.2023.2172406","url":null,"abstract":"The innate lymphoid cell (ILC) system comprising of the circulating and tissue-resident cells is known to clear infectious pathogens, establish immune homeostasis as well as confer antitumor immunity. Human natural killer cells (hNKs) and other ILCs carry out mopping of the infectious pathogens and perform cytolytic activity regulated by the non-adaptive immune system. The NK cells generate immunological memory and rapid recall response tightly regulated by the adaptive immunity. The interaction of NK and B cell, and its role to induce the pathogen specific immunity is not fully understood. Hence, present article sheds light on the interaction between NK and B cells and resulting immune responses in the infectious diseases. The immune responses elicited by the NK-B cell interaction is of particular importance for developing therapeutic vaccines against the infectious pathogens. Further, experimental evidences suggest the immune-response driven by NK cell population elicits the host-specific antibodies and memory B cells. Also, recently developed humanized immune system (HIS) mice and their importance in to understanding the NK-B cell interaction and resulting pathogen specific immunity has been discussed.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"42 4","pages":"304-322"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9572823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Molecular mechanisms of ferroptosis and their role in inflammation. 铁下垂的分子机制及其在炎症中的作用。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2021.2016739

Feng Wang, Jingya He, Ruxiao Xing, Tong Sha, Bin Sun

引用次数: 15

Host-directed antileishmanial interventions: Harvesting unripe fruits to reach fruition. 宿主导向的抗利什曼干预:收获未成熟的果实以达到结果。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 DOI: 10.1080/08830185.2022.2047670

Anuradha Seth, Susanta Kar

{"title":"Host-directed antileishmanial interventions: Harvesting unripe fruits to reach fruition.","authors":"Anuradha Seth, Susanta Kar","doi":"10.1080/08830185.2022.2047670","DOIUrl":"https://doi.org/10.1080/08830185.2022.2047670","url":null,"abstract":"Leishmaniasis is an exemplary paradigm of immune evasion, fraught with the perils of limited clinical assistance, escalating costs of treatment and made worse with the lack of suitable vaccine. While drugs remain central to large-scale disease control, the growing emergence of parasite resistance necessitates the need for combination therapy involving host-directed immunological agents. Also, since prolonged disease progression is associated with strong immune suppression of the host, augmentation of host immunity via restoration of the immunoregulatory circuit involving antigen-presenting cells and T-cells, activation of macrophage function and/or CD4+ T helper 1 cell differentiation may serve as an ideal approach to resolve severe cases of leishmaniasis. As such, therapies that embody a synergistic approach that involve direct killing of the parasite in addition to elevating host immunity are likely to pave the way for widespread elimination of leishmaniasis in the future. With this review, we aim to recapitulate the various immunotherapeutic agents found to hold promise in antileishmanial treatment both in vitro and in vivo. These include parasite-specific antigens, dendritic cell-targeted therapy, recombinant inhibitors of various components intrinsic to immune cell signaling and agonists or antagonists to immune cells and cytokines. We also summarize their abilities to direct therapeutic skewing of the host cell-immune response and review their potential to combat the disease either alone, or as adjunct modalities.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"42 3","pages":"217-236"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9807567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

SARS-CoV-2 variants and COVID-19 vaccines: Current challenges and future strategies. SARS-CoV-2变体和COVID-19疫苗:当前挑战和未来战略

IF 5 4区医学

International Reviews of Immunology Pub Date : 2023-01-01 Epub Date: 2022-05-28 DOI: 10.1080/08830185.2022.2079642

Wenping Gong, Seppo Parkkila, Xueqiong Wu, Ashok Aspatwar

{"title":"SARS-CoV-2 variants and COVID-19 vaccines: Current challenges and future strategies.","authors":"Wenping Gong, Seppo Parkkila, Xueqiong Wu, Ashok Aspatwar","doi":"10.1080/08830185.2022.2079642","DOIUrl":"10.1080/08830185.2022.2079642","url":null,"abstract":"The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global threat. Despite strict control measures implemented worldwide and immunization using novel vaccines, the pandemic continues to rage due to emergence of several variants of SARS-CoV-2 with increased transmission and immune escape. The rapid spread of variants of concern (VOC) in the recent past has created a massive challenge for the control of COVID-19 pandemic via the currently used vaccines. Vaccines that are safe and effective against the current and future variants of SARS-CoV-2 are essential in controlling the COVID-19 pandemic. Rapid production and massive rollout of next-generation vaccines against the variants are key steps to control the COVID-19 pandemic and to help us return to normality. Coordinated surveillance of SARS-CoV-2, rapid redesign of new vaccines and extensive vaccination are needed to counter the current SARS-CoV-2 variants and prevent the emergence of new variants. In this article, we review the latest information on the VOCs and variants of interest (VOIs) and present the information on the clinical trials that are underway on evaluating the effectiveness of COVID-19 vaccines on VOCs. We also discuss the current challenges posed by the VOCs in controlling the COVID-19 pandemic and future strategies to overcome the threat posed by the highly virulent and rapidly transmissible variants of SARS-CoV2.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"1 1","pages":"393-414"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46254001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23