Vaccine design and development: Exploring the interface with computational biology and AI.

IF 4.3 4区医学 Q2 IMMUNOLOGY

International Reviews of Immunology Pub Date : 2024-07-10 DOI:10.1080/08830185.2024.2374546

Ananya, Darshan C Panchariya, Anandakrishnan Karthic, Surya Pratap Singh, Ashutosh Mani, Aakash Chawade, Sandeep Kushwaha

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引用次数: 0

Abstract

Computational biology involves applying computer science and informatics techniques in biology to understand complex biological data. It allows us to collect, connect, and analyze biological data at a large scale and build predictive models. In the twenty first century, computational resources along with Artificial Intelligence (AI) have been widely used in various fields of biological sciences such as biochemistry, structural biology, immunology, microbiology, and genomics to handle massive data for decision-making, including in applications such as drug design and vaccine development, one of the major areas of focus for human and animal welfare. The knowledge of available computational resources and AI-enabled tools in vaccine design and development can improve our ability to conduct cutting-edge research. Therefore, this review article aims to summarize important computational resources and AI-based tools. Further, the article discusses the various applications and limitations of AI tools in vaccine development.

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疫苗设计与开发：探索计算生物学和人工智能的接口。

计算生物学涉及在生物学中应用计算机科学和信息学技术来理解复杂的生物数据。它使我们能够大规模地收集、连接和分析生物数据，并建立预测模型。在二十一世纪，计算资源和人工智能（AI）已被广泛应用于生物科学的各个领域，如生物化学、结构生物学、免疫学、微生物学和基因组学，用于处理海量数据以做出决策，包括药物设计和疫苗开发等应用，这也是人类和动物福利的主要关注领域之一。了解疫苗设计和开发中可用的计算资源和人工智能工具，可以提高我们开展前沿研究的能力。因此，这篇综述文章旨在总结重要的计算资源和基于人工智能的工具。此外，文章还讨论了人工智能工具在疫苗开发中的各种应用和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Reviews of Immunology 医学-免疫学

CiteScore

11.00

自引率

4.00%

发文量

期刊介绍： This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).

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