International Reviews of Immunology最新文献_第10页

Indoleamine 2, 3-Dioxygenase: A Professional Immunomodulator and Its Potential Functions in Immune Related Diseases. 吲哚胺2,3 -双加氧酶:一种专业免疫调节剂及其在免疫相关疾病中的潜在功能

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2020-10-29 DOI: 10.1080/08830185.2020.1836176

Fahimeh Heidari, Amin Ramezani, Nasrollah Erfani, Mahboobeh Razmkhah

{"title":"Indoleamine 2, 3-Dioxygenase: A Professional Immunomodulator and Its Potential Functions in Immune Related Diseases.","authors":"Fahimeh Heidari, Amin Ramezani, Nasrollah Erfani, Mahboobeh Razmkhah","doi":"10.1080/08830185.2020.1836176","DOIUrl":"https://doi.org/10.1080/08830185.2020.1836176","url":null,"abstract":"Indoleamine 2, 3-dioxygenase (IDO) as an intracellular cytosolic enzyme converts tryptophan (Trp) to N-formyl kynurenine which leads to proinflammatory T-cell apoptosis and prevention of immune cells maturation via decreasing the level of cellular energy. Trp catabolism products such as kynurenine increase the recruitment of regulatory T cells and induce immune tolerance in dendritic cells. IDO expression can locally suppress immunity in the tumor microenvironment and tumor progression actively recruits IDO expressing cells in tumor-draining lymph nodes. Also, tumor infiltrating Tregs' activity leads to IDO expression in the tumor microenvironment. In this review, we described the immunomodulatory function of IDO and IDO-based therapeutic strategies for immune related diseases. According to positive-feedback loop between Tregs and IDO in the tumor microenvironment, IDO can be targeted as a promising immunostimulatory approach for immunotherapy of cancer. However, several studies revealed controversial consequences for influences of IDO in immunity. Considering the common concept, IDO1 and also IDO2 repress the function of T lymphocytes, while inactivation of IDO results in aggravation of some autoimmune diseases. Eventually, the extensive evaluation of IDO function in immunomodulatory procedure can help achieve IDO inhibitors as optimal drugs to inhibit tumor growth without motivating autoimmunity.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2020.1836176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38645052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Innate immunity: Trained immunity and innate allorecognition against the allograft. 先天免疫:针对同种异体移植物的训练免疫和先天异体识别。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-05-03 DOI: 10.1080/08830185.2021.1921175

Mohammad Mirzakhani, Mehdi Shahbazi, Sara Shamdani, Sina Naserian, Mousa Mohammadnia-Afrouzi

引用次数: 7

Adverse rare events to vaccines for COVID-19: From hypersensitivity reactions to thrombosis and thrombocytopenia. COVID-19疫苗的罕见不良事件:从过敏反应到血栓形成和血小板减少。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-07-12 DOI: 10.1080/08830185.2021.1939696

Natalija Novak, Leticia Tordesillas, Beatriz Cabanillas

{"title":"Adverse rare events to vaccines for COVID-19: From hypersensitivity reactions to thrombosis and thrombocytopenia.","authors":"Natalija Novak, Leticia Tordesillas, Beatriz Cabanillas","doi":"10.1080/08830185.2021.1939696","DOIUrl":"10.1080/08830185.2021.1939696","url":null,"abstract":"Vaccines for the prevention of coronavirus disease 2019 (COVID-19) started to be developed since the initiation of the COVID-19 pandemic. Up to now, four vaccines have been authorized by international agencies such as European Medicines Agency (EMA). Two are DNA vaccines (ChAdOx1 nCov-19 and Ad26.COV2.S) and two mRNA vaccines (BNT162b2 and mRNA-1273). The administration of the vaccines has been associated with a strong decrease in the infections by SARS-CoV-2 and deaths associated with it. However, in parallel to these results, some rare adverse events have also been described. In that sense, events of thrombosis, thrombocytopenia, and hemorrhage have been described in close temporal proximity to the administration of the DNA vaccines ChAdOx1 nCov-19 and Ad26.COV2.S, but also mRNA vaccines. Recent scientific reports have been released with updated information on the possible association of thrombotic thrombocytopenia and COVID-19 vaccines. On the other hand, since the initiation of the vaccination campaigns, adverse hypersensitivity reactions have been described after mRNA and DNA vaccines administration for COVID-19. Although globally these adverse events are rare, a high proportion of the world population will be exposed to these vaccines. For that reason, their safety and tolerance should be carefully considered. In this review, we provide an updated review of the last scientific findings that can explain the rare side effects that the vaccines for COVID-19 can produce.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2021.1939696","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39176410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Lipopolysaccharides derived from gram-negative bacterial pool of human gut microbiota promote inflammation and obesity development. 来源于人体肠道菌群革兰氏阴性菌群的脂多糖促进炎症和肥胖的发展。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-11-02 DOI: 10.1080/08830185.2021.1996573

Liyu Du, Xi Lei, Jie Wang, Li Wang, Qingping Zhong, Xiang Fang, Pan Li, Bing Du, Yutao Wang, Zhenlin Liao

引用次数: 14

Yin and yang of immunological memory in controlling infections: Overriding self defence mechanisms. 免疫记忆在控制感染中的阴阳作用:超越自我防御机制。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-04-19 DOI: 10.1080/08830185.2021.1912037

Roshan Kumar Roy, Rakhi Yadav, Aklank Jain, Vishwas Tripathi, Manju Jain, Sandhya Singh, Hridayesh Prakash

{"title":"Yin and yang of immunological memory in controlling infections: Overriding self defence mechanisms.","authors":"Roshan Kumar Roy, Rakhi Yadav, Aklank Jain, Vishwas Tripathi, Manju Jain, Sandhya Singh, Hridayesh Prakash","doi":"10.1080/08830185.2021.1912037","DOIUrl":"https://doi.org/10.1080/08830185.2021.1912037","url":null,"abstract":"Immunological memory is critical for host immunity and decisive for individual to respond exponentially to previously encountered infection. Both T and B cell memory are known to orchestrate immunological memory with their central and effector memory arms contributing in prolonged immunity/defence mechanisms of host. While central memory helps in maintaining prolonged immunity for a particular infection, effector memory helps in keeping local/seasonal infection in control. In addition to this, generation of long-lived plasma cells is pivotal for generating neutralizing antibodies which can enhance recall and B cell memory to control re-infection. In view of this, scaling up memory response is one of the major objectives for the expected outcome of vaccination. In this line, this review deals with the significance of memory cells, molecular pathways of their development, maintenance, epigenetic regulation and negative regulation in various infections. We have also highlighted the significance of both T and B cell memory responses in the vaccination approaches against range of infections which is not fully explored so far.[Box: see text].","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2021.1912037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38893373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Tuberculosis vaccine BCG: the magical effect of the old vaccine in the fight against the COVID-19 pandemic. 结核病疫苗卡介苗:老疫苗在抗击新冠肺炎大流行中的神奇作用。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-05-07 DOI: 10.1080/08830185.2021.1922685

Ashok Aspatwar, Wenping Gong, Shuyong Wang, Xueqiong Wu, Seppo Parkkila

{"title":"Tuberculosis vaccine BCG: the magical effect of the old vaccine in the fight against the COVID-19 pandemic.","authors":"Ashok Aspatwar, Wenping Gong, Shuyong Wang, Xueqiong Wu, Seppo Parkkila","doi":"10.1080/08830185.2021.1922685","DOIUrl":"https://doi.org/10.1080/08830185.2021.1922685","url":null,"abstract":"Bacillus Calmette-Guérin (BCG) is a live attenuated M. bovis vaccine that was developed about 100 years ago by Albert Calmette and Camille Guérin. Many countries have been using the vaccine for decades against tuberculosis (TB). The World Health Organization (WHO) recommends a single dose of BCG for infants in TB endemic as well as leprosy high risk countries, and globally almost 130 million infants are vaccinated yearly. The role of BCG is well known in reducing neonatal and childhood death rates. Epidemiological and retrospective cross-sectional studies demonstrated that the BCG vaccination protects the children against respiratory tract infections and lowers the risk of malaria in children. In addition, BCG enhances IFN-γ and IL-10 levels, thus providing immunity against respiratory tract infection even in elderly people. The BCG is also known to provide nonspecific innate immunity against viruses and parasites, through an innate immune mechanism termed 'trained immunity' and is defined as the immunological recall of the innate immune system by epigenetic reprogramming. Based on these studies it is suggested that the BCG has the potential to act as a protective agent against COVID-19. Further proven safety records of BCG in humans, its adjuvant activity and low-cost manufacturing make it an attractive option to stop the pandemic and reduce the COVID-19 related mortality. In this review we discuss the heterologous effects of BCG, induction of trained immunity and its implication in development of a potential vaccine against COVID-19 pandemic.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2021.1922685","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38958953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Exploring the pathways of inflammation and coagulopathy in COVID-19: A narrative tour into a viral rabbit hole. 探索 COVID-19 炎症和凝血病变的途径：病毒兔子洞的叙事之旅

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-10-22 DOI: 10.1080/08830185.2021.1993211

Nitsan Landau, Yehuda Shoenfeld, Liat Negru, Gad Segal

{"title":"Exploring the pathways of inflammation and coagulopathy in COVID-19: A narrative tour into a viral rabbit hole.","authors":"Nitsan Landau, Yehuda Shoenfeld, Liat Negru, Gad Segal","doi":"10.1080/08830185.2021.1993211","DOIUrl":"10.1080/08830185.2021.1993211","url":null,"abstract":"Worldwide COVID-19 pandemic has taken a huge toll of morbidity and mortality. In selected patients, classified as severe, the overwhelming inflammatory state imposed by this infection is accompanied by a hypercoagulable state, hallmarked by a unique pattern; a marked increase in D-dimer, out of proportion to other markers of coagulopathy. In this review, we turn a spotlight to this phenomenon, offering a unified conceptual model depicting the leading hypotheses of coagulopathy in COVID-19. The key players of the coagulation cascades accompanying the COVID-19 inflammation malfunction on virtually every level; tissue factor expression is amplified, physiological anti-coagulant pathways (anti-thrombin, protein C and S, and the inhibitor of the tissue factor pathway) are impaired and fibrinolysis is inhibited. Components of autoimmunity, the complement system amongst others, further contribute to the pathology. As data continue to gather, our model offers a pathophysiological overview of COVID-19 coagulopathy, defined by the resultant histopathology: either intra-vascular or extra-vascular. We hope this review will facilitate understanding and serve as a lead point to future therapeutic directives.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544671/pdf/IIRI_0_1993211.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39540870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune metabolism: a bridge of dendritic cells function. 免疫代谢:树突状细胞功能的桥梁。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-04-01 DOI: 10.1080/08830185.2021.1897124

Yuting Sun, Liyu Zhou, Weikai Chen, Linhui Zhang, Hongbo Zeng, Yunxia Sun, Jun Long, Dongping Yuan

引用次数: 6

The ubiquitous role of spleen tyrosine kinase (Syk) in gut diseases: From mucosal immunity to targeted therapy. 脾酪氨酸激酶(Syk)在肠道疾病中的普遍作用:从粘膜免疫到靶向治疗。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-08-06 DOI: 10.1080/08830185.2021.1962860

Wenbin Gong, Peizhao Liu, Tao Zheng, Xiuwen Wu, Yun Zhao, Jianan Ren

{"title":"The ubiquitous role of spleen tyrosine kinase (Syk) in gut diseases: From mucosal immunity to targeted therapy.","authors":"Wenbin Gong, Peizhao Liu, Tao Zheng, Xiuwen Wu, Yun Zhao, Jianan Ren","doi":"10.1080/08830185.2021.1962860","DOIUrl":"https://doi.org/10.1080/08830185.2021.1962860","url":null,"abstract":"Spleen tyrosine kinase (Syk) is a cytoplasmic non-receptor protein tyrosine kinase expressed in a variety of cells and play crucial roles in signal transduction. Syk mediates downstream signaling by recruiting to the dually phosphorylated immunoreceptor tyrosine-based activation motifs (ITAMs) of the transmembrane adaptor molecule or the receptor chain itself. In gut diseases, Syk is observed to be expressed in intestinal epithelial cells, monocytes/macrophages, dendritic cells and mast cells. Activation of Syk in these cells can modulate intestinal mucosal immune response by promoting inflammatory cytokines and chemokines production, thus regulating gut homeostasis. Due to the restriction of specificity and selectivity for the development of Syk inhibitors, only a few such inhibitors are available in gut diseases, including intestinal ischemia/reperfusion damage, infectious disease, inflammatory bowel disease, etc. The promising outcomes of Syk inhibitors from both preclinical and clinical studies have shown to attenuate the progression of gut diseases thereby indicating a great potential in the development of Syk targeted therapy for treatment of gut diseases. This review depicts the characterization of Syk, summarizes the signal pathways of Syk, and discusses its potential targeted therapy for gut diseases.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2021.1962860","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39281443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antibody Response against SARS-CoV-2 Infection: Implications for Diagnosis, Treatment and Vaccine Development. 针对SARS-CoV-2感染的抗体反应:对诊断、治疗和疫苗开发的影响

IF 5 4区医学

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-09-08 DOI: 10.1080/08830185.2021.1929205

Alessandra Mallano, Alessandro Ascione, Michela Flego

引用次数: 11