International Reviews of Immunology最新文献_第10页

Acute post-streptococcal glomerulonephritis: analysis of the pathogenesis. 急性链球菌感染后肾小球肾炎的发病机制分析。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2021-01-01 Epub Date: 2020-10-08 DOI: 10.1080/08830185.2020.1830083

Jesús Mosquera, Adriana Pedreañez

{"title":"Acute post-streptococcal glomerulonephritis: analysis of the pathogenesis.","authors":"Jesús Mosquera, Adriana Pedreañez","doi":"10.1080/08830185.2020.1830083","DOIUrl":"https://doi.org/10.1080/08830185.2020.1830083","url":null,"abstract":"Abstract Increasing evidence supports a central role of the immune system in acute post streptococcal glomerulonephritis (APSGN), but the current view of how streptococcal biology affects immunity, and vice versa, remains to be clarified. Renal glomerular immune complex deposition is critical in the initiation of APSGN; however, mechanisms previous to immune complex formation could modulate the initiation and the progression of the disease. Initial and late renal events involved in the nephritis can also be related to host factors and streptococcal factors. In this review we describe the mechanisms reported for the APSGN pathogenesis, the interactions of streptococcal products with renal cells and leukocytes, the possible effects of different nephritogenic antigens in the renal environment and the possibility that APSGN is not just due to a single streptococcal antigen and its antibody; instead, kidney damage may be the result of different factors acting at the same time related to both streptococcus and host factors. Addressing these points should help us to better understand APSGN physiopathology.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"40 6","pages":"381-400"},"PeriodicalIF":5.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2020.1830083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38467248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

The concept revolution of gut barrier: from epithelium to endothelium. 肠屏障的概念革命:从上皮到内皮。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2021-01-01 Epub Date: 2020-11-03 DOI: 10.1080/08830185.2020.1841185

Song Liu, Peng Song, Feng Sun, Shichao Ai, Qiongyuan Hu, Wenxian Guan, Meng Wang

{"title":"The concept revolution of gut barrier: from epithelium to endothelium.","authors":"Song Liu, Peng Song, Feng Sun, Shichao Ai, Qiongyuan Hu, Wenxian Guan, Meng Wang","doi":"10.1080/08830185.2020.1841185","DOIUrl":"https://doi.org/10.1080/08830185.2020.1841185","url":null,"abstract":"Gut barrier controls the food tolerance as well as host defense against potential hazards. The gut epithelium has been extensively studied for its importance in the structure and function of gut barrier. Recently, a new concept of barrier, named gut vascular barrier (GVB) has been discovered in both mice and human. Subsequent studies identified the morphological characteristics of GVB, the involved signaling events and its association with clinical diseases. In current study, we will summarize recent breakthroughs of GVB, with particular attentions to the molecular basis of GVB dysfunction. We will perform bioinformatics analysis to compare the transcriptional profiles of endothelium between blood and lymphatic vessels, healthy and inflammatory bowel diseases (IBD), healthy and colorectal cancer in the absence or presence of liver metastasis. We will further discuss the significance of impaired GVB in associated diseases, including vascular diseases, IBD and cancer metastasis. Our study will provide insights into the new concept of gut barrier, and promote the development of new strategies toward the vascular endothelium in the management of various diseases.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"40 6","pages":"401-408"},"PeriodicalIF":5.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2020.1841185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38560903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Relevance of glycans in the interaction between T lymphocyte and the antigen presenting cell. 聚糖在T淋巴细胞和抗原提呈细胞相互作用中的相关性。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2021-01-01 Epub Date: 2020-11-18 DOI: 10.1080/08830185.2020.1845331

Wilton Gómez-Henao, Eda Patricia Tenorio, Francisco Raúl Chávez Sanchez, Miguel Cuéllar Mendoza, Ricardo Lascurain Ledezma, Edgar Zenteno

{"title":"Relevance of glycans in the interaction between T lymphocyte and the antigen presenting cell.","authors":"Wilton Gómez-Henao, Eda Patricia Tenorio, Francisco Raúl Chávez Sanchez, Miguel Cuéllar Mendoza, Ricardo Lascurain Ledezma, Edgar Zenteno","doi":"10.1080/08830185.2020.1845331","DOIUrl":"https://doi.org/10.1080/08830185.2020.1845331","url":null,"abstract":"The immunological synapse promotes receptors and ligands interaction in the contact interface between the T lymphocyte and the antigen presenting cell; glycosylation of the proteins involved in this biological process favors regulation of molecular interactions and development of the T lymphocyte effector response. Glycans in the immunological synapse influence cellular and molecular processes such as folding, expression, and structural stability of proteins, they also mediate ligand-receptor interaction and propagation of the intracellular signaling or inhibition of uncontrolled cellular activation that could lead to the development of autoimmunity, among others. It has been suggested that altered glycosylation of proteins that participate in the immunological synapse affects the signaling processes and cell proliferation, as well as exacerbation of the effector mechanisms of T cells that trigger systemic damage and autoimmunity. Understanding the role of glycans in the immune response has allowed for advances in the development of immunotherapies in different fields through the controlled and specific activation of the immune response. This review describes the structural and biological aspects of glycans associated with some molecules present in the immunological synapse, providing information that allows understanding the function of glycosylation in the interaction between the T lymphocyte and the antigen-presenting cell, as well as its impact on signaling and development regulation of T lymphocytes effector response.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"40 4","pages":"274-288"},"PeriodicalIF":5.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2020.1845331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38615738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Eye on the Enigmatic Link: Dysbiotic Oral Pathogens in Ocular Diseases; The Flip Side. 神秘联系之眼:眼部疾病的口腔益生菌另一面。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2021-01-01 Epub Date: 2020-11-12 DOI: 10.1080/08830185.2020.1845330

Pachiappan Arjunan

{"title":"Eye on the Enigmatic Link: Dysbiotic Oral Pathogens in Ocular Diseases; The Flip Side.","authors":"Pachiappan Arjunan","doi":"10.1080/08830185.2020.1845330","DOIUrl":"https://doi.org/10.1080/08830185.2020.1845330","url":null,"abstract":"Mouth and associated structures were regarded as separate entities from the rest of the body. However, there is a paradigm shift in this conception and oral health is now considered as a fundamental part of overall well-being. In recent years, the subject of oral-foci of infection has attained a resurgence in terms of systemic morbidities while limited observations denote the implication of chronic oral inflammation in the pathogenesis of eye diseases. Hitherto, there is a paucity for mechanistic insights underlying the reported link between periodontal disease (PD) and ocular comorbidities. In light of prevailing scientific evidence, this review article will focus on the understudied theme, that is, the impact of oral dysbiosis in the induction and/or progression of inflammatory eye diseases like diabetic retinopathy, scleritis, uveitis, glaucoma, age-related macular degeneration (AMD). Furthermore, the plausible mechanisms by which periodontal microbiota may trigger immune dysfunction in the Oro-optic-network and promote the development of PD-associated AMD have been discussed.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"40 6","pages":"409-432"},"PeriodicalIF":5.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2020.1845330","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38698671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Unfolding the Role of Splicing Factors and RNA Debranching in AID Mediated Antibody Diversification. 剪接因子和RNA脱支在AID介导的抗体分化中的作用。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2021-01-01 Epub Date: 2020-09-14 DOI: 10.1080/08830185.2020.1815725

Ankit Jaiswal, Amit Kumar Singh, Anubhav Tamrakar, Prashant Kodgire

{"title":"Unfolding the Role of Splicing Factors and RNA Debranching in AID Mediated Antibody Diversification.","authors":"Ankit Jaiswal, Amit Kumar Singh, Anubhav Tamrakar, Prashant Kodgire","doi":"10.1080/08830185.2020.1815725","DOIUrl":"https://doi.org/10.1080/08830185.2020.1815725","url":null,"abstract":"Activated B-cells diversify their antibody repertoire via somatic hypermutation (SHM) and class switch recombination (CSR). SHM is restricted to the variable region, whereas, CSR is confined to the constant region of immunoglobulin (Ig) genes. Activation-induced cytidine deaminase (AID) is a crucial player in the diversification of antibodies in the activated B-cell. AID catalyzes the deamination of cytidine (C) into uracil (U) at Ig genes. Subsequently, low fidelity repair of U:G mismatches may lead to mutations. Transcription is essential for the AID action, as it provides a transient single-strand DNA substrate. Since splicing is a co-transcriptional event, various splicing factors or regulators influence the transcription. Numerous splicing factors are known to regulate the AID targeting, function, Ig transcription, and AID splicing, which eventually influence antibody diversification processes. Splicing regulator SRSF1-3, a splicing isoform of serine arginine-rich splicing factor (SRSF1), and CTNNBL1, a spliceosome interacting factor, interact with AID and play a critical role in SHM. Likewise, a splicing regulator polypyrimidine tract binding protein-2 (PTBP2) and the debranching enzyme (DBR1) debranches primary switch transcripts which later forms G-quadruplex structures, and the S region guide RNAs direct AID to S region DNA. Moreover, AID shows several alternate splicing isoforms, like AID devoid of exon-4 (AIDΔE4) that is expressed in various pathological conditions. Interestingly, RBM5, a splicing regulator, is responsible for the skipping of AID exon 4. In this review, we discuss the role and significance of splicing factors in the AID mediated antibody diversification.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"40 4","pages":"289-306"},"PeriodicalIF":5.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2020.1815725","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38474882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pathogenesis guided therapeutic management of COVID-19: an immunological perspective. 新冠肺炎发病机制指导下的治疗管理:免疫学视角

IF 5 4区医学

International Reviews of Immunology Pub Date : 2021-01-01 Epub Date: 2020-10-28 DOI: 10.1080/08830185.2020.1840566

Ashutosh Kumar, Pranav Prasoon, Prakash S Sekhawat, Vikas Pareek, Muneeb A Faiq, Chiman Kumari, Ravi K Narayan, Maheswari Kulandhasamy, Kamla Kant

引用次数: 11

Association between TNF-α and IFN-γ levels and severity of acute viral bronchiolitis. TNF-α和IFN-γ水平与急性病毒性细支气管炎严重程度的关系

IF 5 4区医学

International Reviews of Immunology Pub Date : 2021-01-01 Epub Date: 2021-02-22 DOI: 10.1080/08830185.2021.1889534

Carolina Frizzera Dias, Maurício Menegatti Rigo, Daniele Cristovao Escouto, Bárbara Porto, Rita Mattiello

{"title":"Association between TNF-α and IFN-γ levels and severity of acute viral bronchiolitis.","authors":"Carolina Frizzera Dias, Maurício Menegatti Rigo, Daniele Cristovao Escouto, Bárbara Porto, Rita Mattiello","doi":"10.1080/08830185.2021.1889534","DOIUrl":"https://doi.org/10.1080/08830185.2021.1889534","url":null,"abstract":"Acute bronchiolitis caused by the respiratory syncytial virus triggers an inflammatory response with the production and release of several pro-inflammatory cytokines. Evidence suggests that their levels are associated with the severity of the infection. This systematic review and meta-analysis aim to assess whether the levels of TNF-α and IFN-γ are associated with the severity of acute viral bronchiolitis. We searched MEDLINE libraries (via PUBMED), EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Scientific Electronic Library Online (SciELO), Latin American Caribbean Health Sciences Literature (LILACS), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, and the gray literature through April 2020. Random effect models were used for general and subgroup analysis. In total, six studies were included with a total of 744 participants. The mean TNF-α levels between the severe group did not differ from the control group 0.14 (95% CI: -0.53 to 0.82, I2 = 91%, p < 0.01); the heterogeneity was high. The results remained insignificant when the analyses were performed including only studies with high quality 0.25 (95% CI: -0.46 to 0.96, I2 = 92%, p < 0.01) I2 = 95%, p = 0.815), when TNF-α was nasal 0.60 (95% CI: -0.49 to 1.69), I2 = 94%, p < 0.01), or serum -0.08 (95% CI: -0.48 to 0.31), I2 = 29%, p = 0.24). In the analysis of studies measuring IFN-γ, there was also no significance of -0.67 (95% CI: -1.56 to 0.22, I2 = 76%, p = 0.04). In conclusion, this meta-analysis suggests that the most severe patients do not have different mean TNF-α and IFN-γ values than patients with mild disease, but the heterogeneity of the studies was high. Supplemental data for this article is available online at https://doi.org/10.1080/08830185.2021.1889534.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"40 6","pages":"433-440"},"PeriodicalIF":5.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2021.1889534","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25393313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Molecular Diagnostic Tools for the Detection of SARS-CoV-2. SARS-CoV-2检测分子诊断工具

IF 5 4区医学

International Reviews of Immunology Pub Date : 2021-01-01 Epub Date: 2021-01-13 DOI: 10.1080/08830185.2020.1871477

Manali Datta, Desh Deepak Singh, Afsar R Naqvi

{"title":"Molecular Diagnostic Tools for the Detection of SARS-CoV-2.","authors":"Manali Datta, Desh Deepak Singh, Afsar R Naqvi","doi":"10.1080/08830185.2020.1871477","DOIUrl":"https://doi.org/10.1080/08830185.2020.1871477","url":null,"abstract":"The pandemic causing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has globally infected more than 50 million people and ∼1.2 million have succumbed to this deadly pathogen. With the vaccine trials still in clinical phases, mitigation of Coronavirus Disease 2019 (COVID-19) relies primarily on robust virus detection methods and subsequent quarantine measures. Hence, the importance of rapid, affordable and reproducible virus testing will serve the need to identify and treat infected subjects in a timely manner. Based on the type of diagnostic assay, the primary targets are viral genome (RNA) and encoded proteins. Currently, COVID-19 detection is performed using various molecular platforms as well as serodiagnostics that exhibit approximately 71% sensitivity. These methods encounter several limitations including sensitivity, specificity, availability of skilled expertise and instrument access. Saliva-based COVID-19 diagnostics are emerging as a superior alternative to nasal swabs because of the ease of sample collection, no interaction during sampling, and high viral titers during early stages of infection. In addition, SARS-CoV-2 is detected in the environment as aerosols associated with suspended particulate matter. Designing virus detection strategies in diverse samples will allow timely monitoring of virus spread in humans and its persistence in the environment. With the passage of time, advanced technologies are overcoming limitations associated with detection. Enhanced sensitivity and specificity of next-generation diagnostics are key features enabling improved prognostic care. In this comprehensive review, we analyze currently adopted advanced technologies and their concurrent use in the development of diagnostics for SARS-CoV-2 detection.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"40 1-2","pages":"143-156"},"PeriodicalIF":5.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2020.1871477","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39150934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Manipulation of Inflammasome: A Promising Approach Towards Immunotherapy of Lung Cancer. 炎性体的操作:肺癌免疫治疗的一种有前途的方法。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2021-01-01 Epub Date: 2021-01-29 DOI: 10.1080/08830185.2021.1876044

Rupak Dey Sarkar, Samraj Sinha, Nabendu Biswas

{"title":"Manipulation of Inflammasome: A Promising Approach Towards Immunotherapy of Lung Cancer.","authors":"Rupak Dey Sarkar, Samraj Sinha, Nabendu Biswas","doi":"10.1080/08830185.2021.1876044","DOIUrl":"https://doi.org/10.1080/08830185.2021.1876044","url":null,"abstract":"Chronic inflammation has emerged as a key player at different stages of cancer development. A prominent signaling pathway for acute and chronic inflammation is the activation of the caspase-1 inflammasomes. These are complexes that assemble on activation of certain nucleotide-binding domain, leucine-rich repeat containing proteins (NLRs), AIM2-like receptors (ALRs), or pyrin due to activation via PAMPs or DAMPs. Of these, five complexes-NLRP1, NLRP3, NLRC4, Pyrin, and AIM2 are of importance in the context of cancer for their activities in modulating immune responses, cell proliferation, and apoptosis. Inflammasomes have emerged as clinically relevant in multiple forms of cancer making them highly promising targets for cancer therapy. As lungs are a tissue niche that is prone to inflammation owing to its exposure to external substances, inflammasomes play a vital role in the development and pathogenesis of lung cancer. Therefore, manipulation of inflammasome by various immunomodulatory means could prove a full-proof strategy for the treatment of lung cancer. Here, in this review, we tried to explore the various strategies to target the inflammasomes for the treatment of lung cancer.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"40 3","pages":"171-182"},"PeriodicalIF":5.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2021.1876044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38791575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

IL-27, a pleiotropic cytokine for fine-tuning the immune response in cancer. IL-27，一种微调癌症免疫反应的多效细胞因子。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2021-01-01 Epub Date: 2020-11-04 DOI: 10.1080/08830185.2020.1840565

Zahra Beizavi, Mahshid Zohouri, Morvarid Asadipour, Abbas Ghaderi

{"title":"IL-27, a pleiotropic cytokine for fine-tuning the immune response in cancer.","authors":"Zahra Beizavi, Mahshid Zohouri, Morvarid Asadipour, Abbas Ghaderi","doi":"10.1080/08830185.2020.1840565","DOIUrl":"https://doi.org/10.1080/08830185.2020.1840565","url":null,"abstract":"Interleukin (IL)-27, a member of the IL-6/IL-12 family, has an important role in modulating inflammation in partnership with innate and adaptive immune cells. IL-27 binding to IL-27R starts downstream signaling based on the target cells. It can instigate inflammation by inducing CD4+ T cell proliferation, Th1 polarization, cytotoxic T cell activation, generation of the natural killer cell, and macrophage and dendritic cell activation. However, by inducing programmed cell death and suppression of effector cells, IL-27 can suppress inflammation and return the immune response to hemostasis. Altogether, IL-27 displays multifaceted dual functions, which may result in either pro- or anti-inflammatory effects. Recent investigations indicated the antitumor activity of IL-27 via inducing Th1, and CTL responses and generating NK cells. On the other hand, IL-27 also can promote tumor cells' proliferation, survival, and angiogenesis. In the present review, we'll discuss recent advances concerning the role of IL-27 in inflammatory diseases such as infections, autoimmune diseases with a focus on cancer.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":"40 5","pages":"319-329"},"PeriodicalIF":5.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08830185.2020.1840565","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38565359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17