COVID-19背景下干扰素反应和NAD+调节的新见解

IF 4.3 4区医学 Q2 IMMUNOLOGY

International Reviews of Immunology Pub Date : 2022-01-01 DOI:10.1080/08830185.2021.1961768

Nada J Habeichi, Cynthia Tannous, Andriy Yabluchanskiy, Raffaele Altara, Mathias Mericskay, George W Booz, Fouad A Zouein

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引用次数: 7

摘要

由严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2)引起的COVID-19大流行在全球造成了巨大的死亡率。在开发疫苗的同时，医学界也在探索遏制这种大流行的新策略。更好地了解SARS-CoV-2细胞感染的分子后果可能会导致更有效和更安全的治疗方法。本文讨论了SARS-CoV-2在调节干扰素(IFN)分泌和导致线粒体NAD+耗竭方面的潜在影响，这可能与COVID-19的致命表现直接相关。本文讨论了sars - cov -2感染后先天免疫反应失衡和线粒体功能障碍的已知或推测，以及在COVID-19大流行背景下，适时使用IFN治疗和NAD+增强治疗的潜在益处。

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Insights into the modulation of the interferon response and NAD⁺ in the context of COVID-19.

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in dramatic worldwide mortality. Along with developing vaccines, the medical profession is exploring new strategies to curb this pandemic. A better understanding of the molecular consequences of SARS-CoV-2 cellular infection could lead to more effective and safer treatments. This review discusses the potential underlying impact of SARS-CoV-2 in modulating interferon (IFN) secretion and in causing mitochondrial NAD⁺ depletion that could be directly linked to COVID-19's deadly manifestations. What is known or surmised about an imbalanced innate immune response and mitochondrial dysfunction post-SARS-CoV-2 infection, and the potential benefits of well-timed IFN treatments and NAD⁺ boosting therapies in the context of the COVID-19 pandemic are discussed.

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来源期刊

International Reviews of Immunology 医学-免疫学

CiteScore

11.00

自引率

4.00%

发文量

期刊介绍： This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).