Chemokines: A key driver for inflammation in protozoan infection.

IF 4.3 4区 医学 Q2 IMMUNOLOGY
International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2023-11-19 DOI:10.1080/08830185.2023.2281566
Rubika Chauhan, Mrinalini Tiwari, Amrendra Chaudhary, Reva Sharan Thakur, Veena Pande, Jyoti Das
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引用次数: 0

Abstract

Chemokines belong to the group of small proteins within the cytokine family having strong chemo-attractant properties. In most cases, the strong immuno-modulatory role of chemokines is crucial for generating the immune response against pathogens in various protozoan diseases. In this review, we have given a brief update on the classification, characterization, homeostasis, transcellular migration, and immuno-modulatory role of chemokines. Here we will evaluate the potential role of chemokines and their regulation in various protozoan diseases. There is a significant direct relationship between parasitic infection and the recruitment of effector cells of the immune response. Chemokines play an indispensable role in mediating several defense mechanisms against infection, such as leukocyte recruitment and the generation of innate and cell-mediated immunity that aids in controlling/eliminating the pathogen. This process is controlled by the chemotactic movement of chemokines induced as a primary host immune response. We have also addressed that chemokine expressions during infection are time-dependent and orchestrated in a systematic pattern that ultimately assists in generating a protective immune response. Taken together, this review provides a systematic understanding of the complexity of chemokines profiles during protozoan disease conditions and the rationale of targeting chemokines for the development of therapeutic strategies.

趋化因子:原生动物感染炎症的关键驱动因素。
趋化因子属于细胞因子家族中的一组小蛋白,具有很强的趋化特性。在大多数情况下,趋化因子的强大免疫调节作用对于产生针对各种原生动物疾病病原体的免疫应答至关重要。在这篇综述中,我们简要介绍了趋化因子的分类、特征、稳态、跨细胞迁移和免疫调节作用。在这里,我们将评估趋化因子及其调控在各种原生动物疾病中的潜在作用。寄生虫感染与免疫应答效应细胞的募集之间存在着重要的直接关系。趋化因子在介导几种抵抗感染的防御机制中发挥着不可或缺的作用,例如白细胞募集和先天免疫和细胞介导免疫的产生,有助于控制/消除病原体。这一过程是由趋化因子的趋化运动所控制的,这是一种主要的宿主免疫反应。我们还指出,趋化因子在感染期间的表达是时间依赖性的,并以一种系统的模式进行编排,最终有助于产生保护性免疫反应。综上所述,本综述提供了对原虫疾病条件下趋化因子谱复杂性的系统理解,以及针对趋化因子制定治疗策略的基本原理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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