探索中性粒细胞在感染性和非感染性肺部疾病中的作用。

IF 4.3 4区 医学 Q2 IMMUNOLOGY
International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2023-06-24 DOI:10.1080/08830185.2023.2222769
Alisha Arora, Archana Singh
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引用次数: 1

摘要

随着全球环境的变化,呼吸系统疾病正日益威胁着全世界人民的健康。这些疾病与免疫系统的表现密切相关。在先天性免疫系统中,中性粒细胞是一道重要的免疫防御屏障。它们是最先被招募到感染部位的细胞之一,在各种肺部疾病的发病机制中起着至关重要的作用。中性粒细胞的迁移和活化可直接或间接导致炎症,而这种炎症对清除病原体和解决感染至关重要。然而,实现这一目标所涉及的免疫病理机制非常复杂,人们对其了解不多。尽管有研究集中探讨了中性粒细胞在多种呼吸系统疾病中的作用,但要完全了解中性粒细胞参与这些呼吸系统疾病的复杂性及其发病机制,还有很长的路要走。在本文中,我们回顾了相关文献,全面介绍了中性粒细胞在感染性呼吸系统疾病(包括冠状病毒病(COVID-19)等病毒性呼吸系统疾病和肺结核等细菌性肺部疾病)以及慢性阻塞性肺疾病(COPD)和哮喘等非感染性疾病中的作用的最新进展。此外,还讨论了未来的研究方向和治疗目标,以供进一步探讨。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the role of neutrophils in infectious and noninfectious pulmonary disorders.

With the change in global environment, respiratory disorders are becoming more threatening to the health of people all over the world. These diseases are closely linked to performance of immune system. Within the innate arm of immune system, Neutrophils are an important moiety to serve as an immune defense barrier. They are one of the first cells recruited to the site of infection and plays a critical role in pathogenesis of various pulmonary diseases. It is established that the migration and activation of neutrophils can lead to inflammation either directly or indirectly and this inflammation caused is very crucial for the clearance of pathogens and resolution of infection. However, the immunopathological mechanisms involved to carry out the same is very complex and not well understood. Despite there being studies concentrating on the role of neutrophils in multiple respiratory diseases, there is still a long way to go in order to completely understand the complexity of the participation of neutrophils and mechanisms involved in the development of these respiratory diseases. In the present article, we have reviewed the literature to comprehensively provide an insight in the current development and advancements about the role of neutrophils in infectious respiratory disorders including viral respiratory disorders such as Coronavirus disease (COVID-19) and bacterial pulmonary disorders with a focused review on pulmonary tuberculosis as well as in noninfectious disorders like Chronic obstructive pulmonary disease (COPD) and asthma. Also, future directions into research and therapeutic targets have been discussed for further exploration.

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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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