血小板细胞外囊泡:自身免疫性疾病的黑暗与光明

IF 4.3 4区 医学 Q2 IMMUNOLOGY
International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2023-06-23 DOI:10.1080/08830185.2023.2225551
Jingru Chen, Miao Wang, Ying Zhang, Fenglin Zhu, Yanqiu Xu, Guoxiang Yi, Runxiu Zheng, Bin Wu
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引用次数: 0

摘要

自身免疫性疾病的特点是免疫耐受被破坏,导致炎症和不可逆的终末器官组织损伤。血小板胞外囊泡是血液循环中的重要细胞元素,通过炎症细胞、免疫细胞及其分泌因子之间的细胞间通讯和相互作用,积极参与炎症和免疫反应。因此,血小板胞外囊泡是自身免疫性疾病病理过程的 "加速器";然而,血小板胞外囊泡的这一系列强大功能也促使自身免疫性疾病的治疗策略取得了新进展。在这篇综述中,我们更新了基于血小板胞外囊泡在自身免疫性疾病中沟通功能的基本机制。我们还关注了血小板胞外囊泡在治疗自身免疫性疾病中的潜在作用。最近的一些研究发现,抗血小板聚集药物、特异性生物制剂可以减少血小板胞外囊泡的释放。血小板胞外囊泡还可以作为载体将药物输送到靶细胞。血小板胞外囊泡可以将微RNA转移到其他细胞,从而调节免疫炎症反应,因此我们似乎可以尝试抑制血小板胞外囊泡转录所携带的微RNA,并调节靶细胞,从而治疗自身免疫性疾病。希望本文提供的信息能为自身免疫性疾病患者带来希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Platelet extracellular vesicles: Darkness and light of autoimmune diseases.

Autoimmune diseases are characterized by a breakdown of immune tolerance, leading to inflammation and irreversible end-organ tissue damage. Platelet extracellular vesicles are cellular elements that are important in blood circulation and actively participate in inflammatory and immune responses through intercellular communication and interactions between inflammatory cells, immune cells, and their secreted factors. Therefore, platelet extracellular vesicles are the "accelerator" in the pathological process of autoimmune diseases; however, this robust set of functions of platelet extracellular vesicles has also prompted new advances in therapeutic strategies for autoimmune diseases. In this review, we update fundamental mechanisms based on platelet extracellular vesicles communication function in autoimmune diseases. We also focus on the potential role of platelet extracellular vesicles for the treatment of autoimmune diseases. Some recent studies have found that antiplatelet aggregation drugs, specific biological agents can reduce the release of platelet extracellular vesicles. Platelet extracellular vesicles can also serve as vehicles to deliver drugs to targeted cells. It seems that we can try to silence or inhibit microRNA carried by platelet extracellular vesicles transcription and regulate the target cells to treat autoimmune diseases as platelet extracellular vesicles can transfer microRNA to other cells to regulate immune-inflammatory responses. Hopefully, the information presented here will provide hope for patients with autoimmune diseases.

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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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