International Journal of Retina and Vitreous最新文献

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Short and long-term impact of intravitreal anti-VEGF therapy interruption in retinal vein occlusion during the COVID-19 pandemic: functional outcomes and AI-based fluid analysis of macular edema. COVID-19大流行期间视网膜静脉闭塞玻璃体内抗vegf治疗中断的短期和长期影响:黄斑水肿的功能结局和基于人工智能的液体分析
IF 2.4
International Journal of Retina and Vitreous Pub Date : 2025-08-05 DOI: 10.1186/s40942-025-00717-x
Emmanuelle Moret, Jennifer Cattaneo, Adham Elwakil, Andrea Montesel, Mattia Tommasoni, Chiara M Eandi
{"title":"Short and long-term impact of intravitreal anti-VEGF therapy interruption in retinal vein occlusion during the COVID-19 pandemic: functional outcomes and AI-based fluid analysis of macular edema.","authors":"Emmanuelle Moret, Jennifer Cattaneo, Adham Elwakil, Andrea Montesel, Mattia Tommasoni, Chiara M Eandi","doi":"10.1186/s40942-025-00717-x","DOIUrl":"10.1186/s40942-025-00717-x","url":null,"abstract":"<p><strong>Background: </strong>The aim of the study is to investigate the short- and long-term effects of delayed intravitreal anti-VEGF injections (IVI) for macular edema (ME) in retinal vein occlusion (RVO) patients during the first wave of the COVID-19 pandemic.</p><p><strong>Methods: </strong>This is a retrospective observational study analyzing a cohort of patients followed at the medical retina department of the Jules Gonin Eye Hospital. During the COVID-19 lockdown, treatment for patients with ME secondary to RVO was deferred due to emergency federal dispositions. The impact on best corrected visual acuity (BCVA) and on OCT changes (i.e. central subfield thickness (CST), intraretinal fluid (IRF), and subretinal fluid (SRF)) were assessed at several time points before and after the lockdown over a 2-year period. The OCT parameters were assessed by the mean of an artificial intelligence (AI) software (Discovery, RetinAI).</p><p><strong>Results: </strong>A total of 64 patients were included in the study. BCVA significantly decreased following a mean treatment delay of 10 weeks. However, BCVA returned to baseline levels after 6 months, with no significant differences observed after 2-years of follow-up. OCT analysis revealed an increase in CST, IRF and SRF following the treatment delay, which decreased and return to pre-lockdown values after 3 months. No significant differences in OCT parameters were observed at the two-year follow-up.</p><p><strong>Conclusion: </strong>The results of our study suggest that delaying IVI for RVO patients during the COVID-19 lockdown resulted in a temporary decline in BCVA and a recurrence of ME. However, these effects were not sustained long term, as both BCVA and ME control returned to baseline levels by 6 months, with no significant changes observed at the two-year follow-up.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"92"},"PeriodicalIF":2.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in retinal and choroidal thickness after carotid endarterectomy: a systematic review. 颈动脉内膜切除术后视网膜和脉络膜厚度的变化:一项系统综述。
IF 2.4
International Journal of Retina and Vitreous Pub Date : 2025-08-04 DOI: 10.1186/s40942-025-00713-1
Ana Cibrão-Pedroso, João Rocha-Neves, Rafael Vieira, João Barbosa Breda, André Ferreira
{"title":"Changes in retinal and choroidal thickness after carotid endarterectomy: a systematic review.","authors":"Ana Cibrão-Pedroso, João Rocha-Neves, Rafael Vieira, João Barbosa Breda, André Ferreira","doi":"10.1186/s40942-025-00713-1","DOIUrl":"10.1186/s40942-025-00713-1","url":null,"abstract":"<p><strong>Background: </strong>Carotid endarterectomy is a well-established procedure for enhancing cerebral perfusion in patients with internal carotid artery stenosis. As a multifactorial disease, carotid stenosis can have ocular implications, potentially affecting retinal and choroidal perfusion and contributing to visual dysfunction. This systematic review aims to evaluate changes in choroidal and retinal thickness after unilateral carotid endarterectomy, providing insight into the impact of the procedure on ocular perfusion.</p><p><strong>Methods: </strong>A comprehensive search was performed across PubMed, Scopus, and Web of Science up to July 2024, without restrictions on language or publication date. The inclusion criteria included original studies assessing retinal or choroidal thickness via optical coherence tomography before and after carotid endarterectomy in adults. Additional manual searches of reference lists and citation tracking were employed to ensure completeness. Study quality was appraised via the NHLBI tool for observational studies.</p><p><strong>Results: </strong>Six prospective observational studies involving 269 patients were included. Findings on choroidal thickness changes after carotid endarterectomy are heterogeneous. While two studies reported significant postoperative Choroidal Thickness increases-one within a week and another at three months-other studies reported no significant changes. One study suggested that higher degrees of carotid stenosis may blunt early Choroidal Thickness response. Retinal measurements were less consistently assessed; among the three studies that evaluated retinal nerve fibre layer and ganglion cell complex thickness, no consistent postoperative changes were observed. Overall, variability in study designs, Optical Coherence Tomography protocols, and follow-up durations limits comparability, precluding meta-analysis.</p><p><strong>Conclusions: </strong>This review highlights a potential association between carotid endarterectomy and improved ocular perfusion, as reflected by changes in choroidal thickness. However, inconsistencies across studies and limited data on retinal structural outcomes underscore the complexity of this relationship. These findings emphasize the need for larger, standardized studies to clarify the impact of carotid revascularization on the ocular microvasculature and guide future clinical practice.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"91"},"PeriodicalIF":2.4,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-year results of visual response following intravitreal novel anti-VEGF injection for diabetic macular edema in a Latino population. 新型抗血管内皮生长因子玻璃体内注射治疗糖尿病性黄斑水肿后一年的视觉反应结果
IF 2.4
International Journal of Retina and Vitreous Pub Date : 2025-08-01 DOI: 10.1186/s40942-025-00719-9
Guillermo Salcedo-Villanueva, Gisela Garcia-Sánchez, Claudia Palacio-Pastrana, Gerardo Gascón-Guzmán, Aureliano Moreno-Andrade, Oscar Olvera-Montaño, Patricia Muñoz-Villegas
{"title":"One-year results of visual response following intravitreal novel anti-VEGF injection for diabetic macular edema in a Latino population.","authors":"Guillermo Salcedo-Villanueva, Gisela Garcia-Sánchez, Claudia Palacio-Pastrana, Gerardo Gascón-Guzmán, Aureliano Moreno-Andrade, Oscar Olvera-Montaño, Patricia Muñoz-Villegas","doi":"10.1186/s40942-025-00719-9","DOIUrl":"10.1186/s40942-025-00719-9","url":null,"abstract":"<p><strong>Background: </strong>Diabetic macular edema (DME) is a leading cause of vision impairment. This study evaluated the effects of multiple anti-VEGF intravitreal injections, including a novel anti-VEGF PRO-169, on best-corrected visual acuity (BCVA) and central macular thickness (CMT) in Latino patients with DME.</p><p><strong>Methods: </strong>This is a multicenter, drug-agnostic interim analysis. Patients were randomized 1:1 to receive monthly injections for four months after a pro re nata intravitreal injection of either PRO-169 or ranibizumab over a one-year period.</p><p><strong>Results: </strong>A total of 278 eyes with DME were analyzed. The average age of the participants was 62.1 ± 7.4 years, with diabetes diagnosed at an average of 16.7 ± 8.4 years and DME detected 1.2 ± 1.6 years later. By week 48, patients with an initial BCVA letter score of < 69 experienced a gain of 13.1 ± 10.4 letters, with an injection frequency of 34.5 ± 6.9 days per injection. The group showed a reduction in CMT of -127 ± 153 μm, compared to a -82.2 ± 82.1 μm reduction in those with an initial BCVA between 69 and 78 letters (p = 0.016). Additionally, 49% of patients with an initial score < 69 letters improved their visual acuity to 20/40 or better, and 41.5% gained 15 or more letters.</p><p><strong>Conclusions: </strong>This interim analysis indicates the potential effectiveness of the anti-VEGF agents PRO-169 and ranibizumab, especially for patients with initial visual acuity < 69 letters. The final analysis will be essential for verifying the efficacy and safety of PRO-169. This study provides solid evidence to support ophthalmologists treating Latino patients with DME and likely improves patient care.</p><p><strong>Trial registration: </strong>NCT05217680 (clinicaltrials.gov).</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"89"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When less is more: the role of non-vitrectomized vitreous surgery in retinal diseases. 少即是多:非玻璃体切割玻璃体手术在视网膜疾病中的作用。
IF 2.4
International Journal of Retina and Vitreous Pub Date : 2025-08-01 DOI: 10.1186/s40942-025-00686-1
Andrew D Brown, Ahmed F Shakarchi, Muhammad Z Chauhan, Lindsay Chai-Chang, Daisy Alapat, Abdulrahman H Badawi, Ahmed B Sallam
{"title":"When less is more: the role of non-vitrectomized vitreous surgery in retinal diseases.","authors":"Andrew D Brown, Ahmed F Shakarchi, Muhammad Z Chauhan, Lindsay Chai-Chang, Daisy Alapat, Abdulrahman H Badawi, Ahmed B Sallam","doi":"10.1186/s40942-025-00686-1","DOIUrl":"10.1186/s40942-025-00686-1","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"90"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Internal 40-gauge microneedle drainage for the management of subretinal fluid in rhegmatogenous retinal detachment surgery. 孔源性视网膜脱离手术中40针内引流处理视网膜下积液。
IF 2.4
International Journal of Retina and Vitreous Pub Date : 2025-07-31 DOI: 10.1186/s40942-025-00709-x
Gregor S Reiter, Jenna Krivit, Run Zhou Ye, Raymond Iezzi
{"title":"Internal 40-gauge microneedle drainage for the management of subretinal fluid in rhegmatogenous retinal detachment surgery.","authors":"Gregor S Reiter, Jenna Krivit, Run Zhou Ye, Raymond Iezzi","doi":"10.1186/s40942-025-00709-x","DOIUrl":"10.1186/s40942-025-00709-x","url":null,"abstract":"<p><strong>Purpose: </strong>To describe outcomes for internal microneedle drainage for the management of residual subretinal fluid (SRF) during pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD).</p><p><strong>Methods: </strong>Retrospective review of patients undergoing PPV for RRD using a 40-gauge angled and beveled microneedle (Incyto, South Korea) for the aspiration and drainage of SRF during fluid/air exchange. The microneedle is inserted through the neurosensory retina into the bleb of residual SRF, removed from the subretinal space and placed onto the retina or adjacent to the subretinal entry site. Visual acuity (VA) and safety outcomes are reported.</p><p><strong>Results: </strong>Thirteen eyes from 13 patients with a median age (Q1 - Q3) of 61.12 (52.03-63.81) were included. Median visual acuity (VA) at baseline was 0.52 (0.24-0.8) logMAR (approx. 20/66) and significantly improved to 0.1 (0.02-0.26) logMAR (approx. 20/25) at the last available follow-up time point (p = 0.0167). Macula-off RRD had significantly worse VA at baseline 0.58 (0.3-1.0) logMAR (approx. 20/76) compared to macula-on RRD 0.15 (0.105-0.25) logMAR (approx. 20/28), p = 0.0196) but improved significantly to the last available follow-up (p = 0.0391), matching those with macula-on RRD. The use of microneedle drainage was safe and resulted in an attached retina in all 13 (100%) cases without adverse events.</p><p><strong>Conclusions: </strong>Microneedle drainage is safe, while patient outcomes are excellent. The complete aspiration of SRF might reduce complications associated with PPV for RRD and optimize visual outcomes.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"88"},"PeriodicalIF":2.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal parameter analysis and diagnostic potentail exploration in familial exudative vitreoretinopathy using ultra-widefield fundus photography. 超广角眼底摄影对家族性渗出性玻璃体视网膜病变视网膜参数分析及诊断潜力探讨。
IF 2.4
International Journal of Retina and Vitreous Pub Date : 2025-07-30 DOI: 10.1186/s40942-025-00716-y
Jiayu Li, Shaochi Zhang, Xiaolong Qi, Chanjuan Wang, Wen Zhang, Rui Li, Caihong Sun, Keyan Liu, Xiaolu Li, Wenjuan Zhuang
{"title":"Retinal parameter analysis and diagnostic potentail exploration in familial exudative vitreoretinopathy using ultra-widefield fundus photography.","authors":"Jiayu Li, Shaochi Zhang, Xiaolong Qi, Chanjuan Wang, Wen Zhang, Rui Li, Caihong Sun, Keyan Liu, Xiaolu Li, Wenjuan Zhuang","doi":"10.1186/s40942-025-00716-y","DOIUrl":"10.1186/s40942-025-00716-y","url":null,"abstract":"<p><strong>Background: </strong>Familial Exudative Vitreoretinopathy (FEVR) is a monogenic disorder causing retinal vascular impairment, often underdiagnosed due to its variable presentation and reliance on invasive methods like fundus fluorescein angiography (FFA). Through the utilization of non-invasive ultra-widefield fundus photography (UWFFP), this research explored both the diagnostic potential of integrated retinal parameters for the detection of FEVR, and their characteristic changes during the early stage progression.</p><p><strong>Methods: </strong>Retinal parameters were systematically extracted and quantified from UWFFP of 114 FEVR patients and 114 matched controls using the EVision AI cloud platform. Comparative statistical analyses were performed to identify significant intergroup differences between FEVR and control cohorts, and assess intra-group variations among FEVR subgroups. Based on parameters that showed significant differences between the FEVR group and the control group and had an impact on the FEVR group, a diagnostic model was constructed. Receiver operating characteristic (ROC) curves were plotted to determine the diagnostic potential of these parameters. In addition, subgroup analysis within the FEVR group was conducted to clarify the relationship between retinal parameters and disease staging.</p><p><strong>Results: </strong>Significant differences were observed in 25 retinal parameters between the FEVR group and the control group, with the horizontal cup-to-disc ratio, vertical cup-to-disc ratio, optic disc-to-macula distance, and vascular density demonstrating potential diagnostic efficacy. Subgroup analysis within the FEVR group revealed that as the disease stage advanced and severity increased, the optic disc and cup diameters decreased, the optic disc-to-macula distance increased, and the vascular fractal dimension and vascular density parameters declined.</p><p><strong>Conclusions: </strong>UWFFP and automated retinal parameter analysis offer promising tools for early FEVR diagnosis, with specific structural and vascular markers providing diagnostic potential. Further large-scale studies are needed to validate these findings and refine diagnostic models.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"87"},"PeriodicalIF":2.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of epiretinal membrane peeling on steroid dependency in uveitic eyes: a retrospective analysis. 视网膜前膜剥离对黄斑眼类固醇依赖的影响:回顾性分析。
IF 2.4
International Journal of Retina and Vitreous Pub Date : 2025-07-29 DOI: 10.1186/s40942-025-00712-2
Verena Schöneberger, Julia Schirrwagen, Claudia Brockmann, Thomas A Fuchsluger, Friederike Schaub
{"title":"Impact of epiretinal membrane peeling on steroid dependency in uveitic eyes: a retrospective analysis.","authors":"Verena Schöneberger, Julia Schirrwagen, Claudia Brockmann, Thomas A Fuchsluger, Friederike Schaub","doi":"10.1186/s40942-025-00712-2","DOIUrl":"10.1186/s40942-025-00712-2","url":null,"abstract":"<p><strong>Background: </strong>Secondary epiretinal membranes (sERM) are common in uveitis and often associated with cystoid macular edema (CME), which increases the need for anti-inflammatory treatment. While surgical removal can improve anatomical and visual outcomes, its effect on intraocular inflammation and steroid requirement remains unclear. This study evaluates whether vitrectomy with ERM peeling can reduce the need for postoperative steroid therapy in uveitic eyes.</p><p><strong>Methods: </strong>This retrospective single-center study reviewed 67 eyes of 67 patients with history of uveitis who underwent sERM peeling between 11/2002 and 04/2023. Demographic data, uveitis classification (SUN), spectral domain optical coherence tomography (SD-OCT) findings, and pre-/postoperative steroid requirements were analyzed. Statistical significance testing was performed using a paired two-tailed t-test.</p><p><strong>Results: </strong>Of the 67 eyes, 50.7% were right eyes, and 65.7% of patients were female. Mean age at timepoint of surgery was 63.1 ± 13.6 years, with 53.7% phakic eyes. Uveitis was classified as anterior (17.9%), intermediate (44.8%), posterior (31.3%), and panuveitis (6.0%). Steroid therapy was reduced in 28.4% of patients, remained unchanged in 56.7%, and increased in 14.9%. Preoperatively, cystoid macular edema (CME) was present in 41.4% of the 58 available SD-OCT scans. Postoperatively, retinal thickness, macular volume, and total retinal volume decreased significantly (p < 0.001). Postoperative CME was found in 31.3% in first postoperative SD-OCT and was newly observed in 6.0%, while 62.7% showed no CME.</p><p><strong>Conclusions: </strong>ERM peeling in uveitic eyes does not guarantee functional improvement or a consistent reduction in steroid dependency. While approximately one-third of patients benefited from reduced steroid use-particularly those with preoperative CME-the majority showed no change, and a subset required intensified therapy due to postoperative inflammation or CME recurrence. Careful patient selection remains essential.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"86"},"PeriodicalIF":2.4,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-related macular degeneration, subretinal drusenoid deposits, and cuticular and calcified drusen in black and hispanic subjects. 年龄相关性黄斑变性,视网膜下结节样沉积,角质层和钙化结节在黑人和西班牙裔受试者。
IF 2.4
International Journal of Retina and Vitreous Pub Date : 2025-07-28 DOI: 10.1186/s40942-025-00710-4
John M Tan, Yang Fei, Liang Wang, Oscar Otero-Marquez, Tasin R Bhuiyan, J Fernando Arevalo, Gareth M C Lema, Roland Theodore Smith
{"title":"Age-related macular degeneration, subretinal drusenoid deposits, and cuticular and calcified drusen in black and hispanic subjects.","authors":"John M Tan, Yang Fei, Liang Wang, Oscar Otero-Marquez, Tasin R Bhuiyan, J Fernando Arevalo, Gareth M C Lema, Roland Theodore Smith","doi":"10.1186/s40942-025-00710-4","DOIUrl":"10.1186/s40942-025-00710-4","url":null,"abstract":"<p><strong>Background: </strong>Subretinal drusenoid deposits (SDDs), cuticular drusen, and calcified drusen have been linked to rapid progression of age-related macular degeneration (AMD). SDDs have also been linked to high-risk vascular diseases (HRVDs). However, SDDs, cuticular drusen, and calcified drusen have not been reported in Black and Hispanic populations. We report that these drusen phenotypes occur in Black and Hispanic AMD patients.</p><p><strong>Methods: </strong>Twenty-three Black and Hispanic AMD subjects were identified in a published cross-sectional study of 200 AMD subjects. Spectral-domain optical coherence tomography, near-infrared reflectance imaging, and lipid profiles were obtained in the parent study. Masked readers assigned subjects into 2 groups: SDDs, present with or without drusen, and drusen only, as in the parent study. Calcified and cuticular drusen were independently identified. Subjects were assigned by health history questionnaires into those with or without HRVDs, defined as: cardiac valve defect (i.e., aortic stenosis), myocardial defect (i.e., myocardial infarction), and stroke/transient ischemic attack.</p><p><strong>Results: </strong>10/23 subjects were in the SDD group (3 Black and 7 Hispanic subjects), 13 of 23 were in the drusen only group. 4/23 subjects were identified with cuticular drusen (1 Black and 3 Hispanic subjects) and 4/23 subjects were identified with calcified drusen (2 Black and 2 Hispanic Subjects). All subjects had respective phenotypes indistinguishable from that of White subjects. 3/10 SDD subjects had HRVDs.</p><p><strong>Conclusions: </strong>We report, for the first time to our knowledge, that subretinal drusenoid deposits, calcified drusen, and cuticular drusen are present in some AMD patients who identify as Black or Hispanic. A strong association of SDDs with HRVDs was discovered in the parent study. These diseases are known to be over-represented in these under-served populations. SDDs, calcified drusen, and cuticular drusen also confer high risk for progression to advanced AMD. A diligent search for these drusen phenotypes in minority patients with AMD or with HRVDs is thus warranted. Further studies of larger cohorts of Black and Hispanic AMD subjects are needed to better assess associations of these drusen subtypes with life threatening diseases.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"85"},"PeriodicalIF":2.4,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Twin and triplet discordance in retinopathy of prematurity: a call to integrate genomic, placental, and environmental determinants. 早产儿视网膜病变的双胞胎和三胞胎不一致:呼吁整合基因组,胎盘和环境决定因素。
IF 2.4
International Journal of Retina and Vitreous Pub Date : 2025-07-28 DOI: 10.1186/s40942-025-00714-0
Zahra Sharifi, Mojtaba Heydari, Mohammadkarim Johari, Shayan Yousufzai
{"title":"Twin and triplet discordance in retinopathy of prematurity: a call to integrate genomic, placental, and environmental determinants.","authors":"Zahra Sharifi, Mojtaba Heydari, Mohammadkarim Johari, Shayan Yousufzai","doi":"10.1186/s40942-025-00714-0","DOIUrl":"10.1186/s40942-025-00714-0","url":null,"abstract":"<p><strong>Background: </strong>Retinopathy of prematurity (ROP) is a major cause of preventable blindness in preterm infants, especially in multiple births such as twins and triplets. Although the incidence of ROP in these groups is well-documented, the discordance in disease severity among siblings has not been thoroughly investigated. This study aimed to quantify the discordance of ROP in twins and triplets and to identify associated predictive factors.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at the Poostchi ROP Clinic in southern Iran, involving 339 preterm infants from twin and triplet pregnancies undergoing screening for ROP. Data were collected on demographic, clinical, and ROP-specific variables, including gestational age (GA), birth weight (BW), duration of oxygen therapy, and ROP stage. Discordance was defined as a difference in ROP stage between siblings. Stepwise Poisson regression was employed to identify predictors of discordance.</p><p><strong>Results: </strong>ROP discordance was observed in 88 neonates (26.0%), comprising 52 twins and 36 triplets. GA emerged as the only significant predictor of ROP severity (prevalence ratio = 0.90, 95% CI: 0.83-0.97, p = 0.012). No other variables, including BW, sex, or medical interventions, demonstrated significant associations. A post-hoc power analysis revealed limited statistical power for detecting subtle effects or rare events, indicating the necessity for larger studies.</p><p><strong>Conclusion: </strong>ROP discordance was present in over one-quarter of neonates from multiple births, with GA as the primary influencing factor. The multifactorial nature of discordance highlights the need for larger, multicenter studies that incorporate genetic, placental, and prenatal data to optimize individualized neonatal care and prevent vision loss in this high-risk population.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"84"},"PeriodicalIF":2.4,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term optical coherence tomography changes and visual outcomes after vitrectomy for epiretinal proliferation: lamellar holes and full-thickness macular holes. 玻璃体切除术后视网膜上增生的长期光学相干断层扫描变化和视力结果:板层孔和全层黄斑孔。
IF 2.4
International Journal of Retina and Vitreous Pub Date : 2025-07-24 DOI: 10.1186/s40942-025-00711-3
Tarin T Tanji, Jae Young Heo, Terrence Murphy, Vivek Chaturvedi
{"title":"Long-term optical coherence tomography changes and visual outcomes after vitrectomy for epiretinal proliferation: lamellar holes and full-thickness macular holes.","authors":"Tarin T Tanji, Jae Young Heo, Terrence Murphy, Vivek Chaturvedi","doi":"10.1186/s40942-025-00711-3","DOIUrl":"10.1186/s40942-025-00711-3","url":null,"abstract":"<p><strong>Background: </strong>Epiretinal proliferation (ERP) is an extension of preretinal tissue, creating a thin, semi-translucent layer of fibrous tissue on the retina. ERP has been recently associated with degenerative lamellar macular holes (DLMH) and full-thickness macular holes (FTMH). The proposed surgery for patients has been vitrectomy and ERM peeling, but there is no consensus on whether DLMH is a stable condition or should be resolved with surgical treatment. The purpose was to investigate optical coherence tomography (OCT) changes and visual outcomes of degenerative LMH and FTMH secondary to ERP after pars plana vitrectomy (PPV) and internal limiting membrane (ILM) peeling.</p><p><strong>Methods: </strong>This retrospective case series evaluated 14 eyes with DLMH and eight eyes with FTMH. All 22 eyes were associated with ERP and treated with PPV with ILM peeling. Best-corrected visual acuity (BCVA, in logMAR), OCT findings, including presence of foveal bump and ellipsoid zone integrity, were documented. Wilcoxon signed-rank tests were used for numerical data. Statistical significance was based on a value of p < 0.05.</p><p><strong>Results: </strong>Among the 14 DLMH cases, the mean Snellen equivalent VA was 20/75 at baseline; 20/59 at the 4-12-month postoperative period; and 20/56 at the final follow-up visit. For the eight FTMH cases, the mean Snellen equivalent VA was 20/94 at baseline; 20/45 at the 4-12-month postoperative period; and 20/38 at the final follow-up visit. Compared to baseline VA, FTMH cases demonstrated a statistically significant improvement in the 4-12-month postoperative VA (p < 0.05) and in the final postoperative VA (p < 0.05). Among all cases, a strong correlation was observed between baseline logMAR and change in logMAR from baseline to final follow-up (R<sup>2</sup> = 0.671).</p><p><strong>Conclusion: </strong>This study demonstrated that surgical intervention led to improved visual and anatomic outcomes in patients with DLMH and FTMH, with a correlation between baseline VA and postoperative visual outcomes. The results suggest that patients with worse preoperative VA experienced the greatest benefit in visual outcome from PPV and ILM peeling. Future studies would look at the timing of when to ideally intervene to improve anatomic and visual outcomes.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"83"},"PeriodicalIF":2.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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