早产儿视网膜病变的双胞胎和三胞胎不一致:呼吁整合基因组,胎盘和环境决定因素。

IF 2.4 Q2 OPHTHALMOLOGY
Zahra Sharifi, Mojtaba Heydari, Mohammadkarim Johari, Shayan Yousufzai
{"title":"早产儿视网膜病变的双胞胎和三胞胎不一致:呼吁整合基因组,胎盘和环境决定因素。","authors":"Zahra Sharifi, Mojtaba Heydari, Mohammadkarim Johari, Shayan Yousufzai","doi":"10.1186/s40942-025-00714-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Retinopathy of prematurity (ROP) is a major cause of preventable blindness in preterm infants, especially in multiple births such as twins and triplets. Although the incidence of ROP in these groups is well-documented, the discordance in disease severity among siblings has not been thoroughly investigated. This study aimed to quantify the discordance of ROP in twins and triplets and to identify associated predictive factors.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at the Poostchi ROP Clinic in southern Iran, involving 339 preterm infants from twin and triplet pregnancies undergoing screening for ROP. Data were collected on demographic, clinical, and ROP-specific variables, including gestational age (GA), birth weight (BW), duration of oxygen therapy, and ROP stage. Discordance was defined as a difference in ROP stage between siblings. Stepwise Poisson regression was employed to identify predictors of discordance.</p><p><strong>Results: </strong>ROP discordance was observed in 88 neonates (26.0%), comprising 52 twins and 36 triplets. GA emerged as the only significant predictor of ROP severity (prevalence ratio = 0.90, 95% CI: 0.83-0.97, p = 0.012). No other variables, including BW, sex, or medical interventions, demonstrated significant associations. A post-hoc power analysis revealed limited statistical power for detecting subtle effects or rare events, indicating the necessity for larger studies.</p><p><strong>Conclusion: </strong>ROP discordance was present in over one-quarter of neonates from multiple births, with GA as the primary influencing factor. The multifactorial nature of discordance highlights the need for larger, multicenter studies that incorporate genetic, placental, and prenatal data to optimize individualized neonatal care and prevent vision loss in this high-risk population.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"84"},"PeriodicalIF":2.4000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302786/pdf/","citationCount":"0","resultStr":"{\"title\":\"Twin and triplet discordance in retinopathy of prematurity: a call to integrate genomic, placental, and environmental determinants.\",\"authors\":\"Zahra Sharifi, Mojtaba Heydari, Mohammadkarim Johari, Shayan Yousufzai\",\"doi\":\"10.1186/s40942-025-00714-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Retinopathy of prematurity (ROP) is a major cause of preventable blindness in preterm infants, especially in multiple births such as twins and triplets. Although the incidence of ROP in these groups is well-documented, the discordance in disease severity among siblings has not been thoroughly investigated. This study aimed to quantify the discordance of ROP in twins and triplets and to identify associated predictive factors.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at the Poostchi ROP Clinic in southern Iran, involving 339 preterm infants from twin and triplet pregnancies undergoing screening for ROP. Data were collected on demographic, clinical, and ROP-specific variables, including gestational age (GA), birth weight (BW), duration of oxygen therapy, and ROP stage. Discordance was defined as a difference in ROP stage between siblings. Stepwise Poisson regression was employed to identify predictors of discordance.</p><p><strong>Results: </strong>ROP discordance was observed in 88 neonates (26.0%), comprising 52 twins and 36 triplets. GA emerged as the only significant predictor of ROP severity (prevalence ratio = 0.90, 95% CI: 0.83-0.97, p = 0.012). No other variables, including BW, sex, or medical interventions, demonstrated significant associations. A post-hoc power analysis revealed limited statistical power for detecting subtle effects or rare events, indicating the necessity for larger studies.</p><p><strong>Conclusion: </strong>ROP discordance was present in over one-quarter of neonates from multiple births, with GA as the primary influencing factor. The multifactorial nature of discordance highlights the need for larger, multicenter studies that incorporate genetic, placental, and prenatal data to optimize individualized neonatal care and prevent vision loss in this high-risk population.</p>\",\"PeriodicalId\":14289,\"journal\":{\"name\":\"International Journal of Retina and Vitreous\",\"volume\":\"11 1\",\"pages\":\"84\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302786/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Retina and Vitreous\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s40942-025-00714-0\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Retina and Vitreous","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s40942-025-00714-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:早产儿视网膜病变(ROP)是导致可预防的早产儿失明的主要原因,尤其是多胞胎,如双胞胎和三胞胎。虽然这些组中ROP的发病率有充分的记录,但兄弟姐妹之间疾病严重程度的不一致尚未得到彻底调查。本研究旨在量化双胞胎和三胞胎中ROP的不一致性,并确定相关的预测因素。方法:在伊朗南部的Poostchi ROP诊所进行了一项横断面研究,涉及339名接受ROP筛查的双胎和三胞胎早产儿。收集了人口统计学、临床和ROP特异性变量的数据,包括胎龄(GA)、出生体重(BW)、氧疗持续时间和ROP分期。不一致性被定义为兄弟姐妹之间ROP分期的差异。采用逐步泊松回归识别不一致的预测因子。结果:新生儿ROP不一致88例(26.0%),其中双胞胎52例,三胞胎36例。GA是ROP严重程度的唯一显著预测因子(患病率比= 0.90,95% CI: 0.83-0.97, p = 0.012)。没有其他变量,包括体重、性别或医疗干预,显示出显著的相关性。事后功效分析显示,检测细微影响或罕见事件的统计功效有限,这表明有必要进行更大规模的研究。结论:多胎新生儿ROP失调发生率超过1 / 4,GA为主要影响因素。不一致的多因素特性强调需要更大的、多中心的研究,包括遗传、胎盘和产前数据,以优化个性化的新生儿护理和预防这一高危人群的视力丧失。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Twin and triplet discordance in retinopathy of prematurity: a call to integrate genomic, placental, and environmental determinants.

Twin and triplet discordance in retinopathy of prematurity: a call to integrate genomic, placental, and environmental determinants.

Twin and triplet discordance in retinopathy of prematurity: a call to integrate genomic, placental, and environmental determinants.

Twin and triplet discordance in retinopathy of prematurity: a call to integrate genomic, placental, and environmental determinants.

Background: Retinopathy of prematurity (ROP) is a major cause of preventable blindness in preterm infants, especially in multiple births such as twins and triplets. Although the incidence of ROP in these groups is well-documented, the discordance in disease severity among siblings has not been thoroughly investigated. This study aimed to quantify the discordance of ROP in twins and triplets and to identify associated predictive factors.

Methods: A cross-sectional study was conducted at the Poostchi ROP Clinic in southern Iran, involving 339 preterm infants from twin and triplet pregnancies undergoing screening for ROP. Data were collected on demographic, clinical, and ROP-specific variables, including gestational age (GA), birth weight (BW), duration of oxygen therapy, and ROP stage. Discordance was defined as a difference in ROP stage between siblings. Stepwise Poisson regression was employed to identify predictors of discordance.

Results: ROP discordance was observed in 88 neonates (26.0%), comprising 52 twins and 36 triplets. GA emerged as the only significant predictor of ROP severity (prevalence ratio = 0.90, 95% CI: 0.83-0.97, p = 0.012). No other variables, including BW, sex, or medical interventions, demonstrated significant associations. A post-hoc power analysis revealed limited statistical power for detecting subtle effects or rare events, indicating the necessity for larger studies.

Conclusion: ROP discordance was present in over one-quarter of neonates from multiple births, with GA as the primary influencing factor. The multifactorial nature of discordance highlights the need for larger, multicenter studies that incorporate genetic, placental, and prenatal data to optimize individualized neonatal care and prevent vision loss in this high-risk population.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
3.50
自引率
4.30%
发文量
81
审稿时长
19 weeks
期刊介绍: International Journal of Retina and Vitreous focuses on the ophthalmic subspecialty of vitreoretinal disorders. The journal presents original articles on new approaches to diagnosis, outcomes of clinical trials, innovations in pharmacological therapy and surgical techniques, as well as basic science advances that impact clinical practice. Topical areas include, but are not limited to: -Imaging of the retina, choroid and vitreous -Innovations in optical coherence tomography (OCT) -Small-gauge vitrectomy, retinal detachment, chromovitrectomy -Electroretinography (ERG), microperimetry, other functional tests -Intraocular tumors -Retinal pharmacotherapy & drug delivery -Diabetic retinopathy & other vascular diseases -Age-related macular degeneration (AMD) & other macular entities
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信