International Journal of Retina and Vitreous最新文献

{"title":"Correction: OCT biomarkers as predictors of visual improvement in diabetic macular edema eyes receiving dexamethasone implants.","authors":"Giacomo Visioli, Ludovico Alisi, Elvia Mastrogiuseppe, Giuseppe Maria Albanese, Enrico Romano, Ludovico Iannetti, Marta Armentano, Francesca Giovannetti, Magda Gharbiya","doi":"10.1186/s40942-025-00644-x","DOIUrl":"10.1186/s40942-025-00644-x","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"24"},"PeriodicalIF":1.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Postoperative endophthalmitis treatment with antibiotics associated or not with pars plana vitrectomy: a randomized clinical trial.","authors":"Vinicius Campos Bergamo, Luis Filipe Nakayama, Nilva Simeren Bueno de Moraes, Ivan Maynart Tavares, Mauro Silveira De Queiroz Campos, Ana Luisa Hofling-Lima, Maurício Maia","doi":"10.1186/s40942-025-00647-8","DOIUrl":"10.1186/s40942-025-00647-8","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"23"},"PeriodicalIF":1.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-resolution optical coherence tomography in pigmented choroidal lesions.","authors":"Damian Jaggi, Shalin G Aeberhard, Dmitri Artemiev, Martin S Zinkernagel, Florian M Heussen","doi":"10.1186/s40942-025-00645-w","DOIUrl":"10.1186/s40942-025-00645-w","url":null,"abstract":"<p><strong>Purpose: </strong>Evaluating High-Resolution Optical Coherence Tomography (HR-OCT) versus standard spectral domain OCT in pigmented choroidal lesions.</p><p><strong>Methods: </strong>We screened a total of 40 subjects with pigmented choroidal lesions. Lesions were imaged on HR-OCT and standard OCT devices with and without enhanced depth imaging (EDI) mode. Images were graded for qualitative and quantitative aspects, like choriocapillaris compression and width, choroidal reflectivity and thickness, amongst others.</p><p><strong>Results: </strong>32 of the 40 subjects could be included in the image analysis, the rest were excluded due to insufficient imaging. HR-OCT EDI mode allowed visualization of the posterior choroidal extent in 11 lesions (11/32 = 34.4%) versus in six (6/32; 18.8%), four (4/30; 13.3%), and five cases (5/30; 16.7%) in normal HR-OCT (n = 32), standard OCT (n = 30) and OCT EDI mode (n = 30), respectively, albeit not significantly different. Choriocapillaris compression was evident in 10 cases on HR-OCT and equally visible in all imaging modes. Mean choriocapillaris thickness ranged from 11.6 to 13.9 microns (SD range 3.84-4.33), and compressed choriocapillaris thickness similarly ranged from a mean of 7.1 to 7.8 microns (SD range 2.20-3.55). Image quality declined significantly towards the periphery in three out of four modes (p = 0.0077 to p = 0.29).</p><p><strong>Conclusions: </strong>HR-OCT may provide better visibility of retinal and choroidal structures in pigmented choroidal lesions, although image quality is reduced in attempting to image peripheral lesions.</p><p><strong>Translational relevance: </strong>The prototype HR-OCT offers insights into clinical features of pigmented choroidal lesions that are not apparent on conventional OCT imaging. This supports the development of HR-OCTolution OCT devices.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"22"},"PeriodicalIF":1.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of cigarette smoking on retinal thickness and choroidal vascularity index: a systematic review and meta-analysis.","authors":"Miguel A Quiroz-Reyes, Erick A Quiroz-Gonzalez, Miguel A Quiroz-Gonzalez, Virgilio Lima-Gomez","doi":"10.1186/s40942-025-00646-9","DOIUrl":"10.1186/s40942-025-00646-9","url":null,"abstract":"<p><strong>Background: </strong>Smoking increases oxidative stress, affecting the vascular endothelium by decreasing the antioxidant vitamin C and disrupting regular nitric oxide activity. It reduces blood flow in the retina and choroid due to increased vascular resistance and compromised choroidal blood flow regulation compared to nonsmokers. This systematic review and meta-analysis aimed to elucidate the impact of cigarette smoking on retinal thickness and the choroidal vascularity index (CVI).</p><p><strong>Methods: </strong>A comprehensive literature search was performed across multiple databases, including Web of Science, Medline, PubMed, and Embase, adhering to the PRISMA and MOOSE guidelines. Observational studies were selected to explore the relationships between smoking and ocular parameters such as CVI, full-retinal, and choroidal thickness. Two independent reviewers conducted the data extraction and quality assessment using a modified Newcastle-Ottawa scale. Statistical analysis was performed using a random-effects model.</p><p><strong>Results: </strong>Four out of the 743 identified articles, involving 702 eyes, met the inclusion criteria. The analysis revealed a significant reduction in the CVI among smokers (SMD: -0.61, 95% CI: -0.78 to -0.43, p < 0.00001), indicating compromised choroidal vascularity. In contrast, the impact of smoking on subfoveal choroidal thickness (SFCT) was not statistically significant (mean difference: 3.88 μm, 95% CI: -7.34 to 15.10, p = 0.50), with high heterogeneity (I² = 79%). Additionally, the full-retinal thickness (FRT) did not show a significant difference between smokers and nonsmokers.</p><p><strong>Conclusion: </strong>Cigarette smoking negatively affects choroidal vascularity, as indicated by a significant reduction in CVI. However, its impact on FRT and SFCT remains unclear and requires further research. These findings highlight the importance of smoking cessation for eye health and suggest that CVI is a valuable noninvasive biomarker for monitoring vascular changes in smokers.</p><p><strong>Trial registration: </strong>PROSPERO registration number: CRD42024627478.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"21"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinocytoma: understanding pathogenesis, diagnosis, and treatment approaches.","authors":"Maysa Al-Hussaini, Sarah Al Sharie, Hala Sultan, Mona Mohammad, Yacoub A Yousef","doi":"10.1186/s40942-025-00642-z","DOIUrl":"10.1186/s40942-025-00642-z","url":null,"abstract":"<p><p>Retinocytoma, or retinoma, is a rare benign intraocular tumor primarily affecting the retina. It is often considered a precursor or a differentiated form of retinoblastoma, a malignant retinal tumor predominantly seen in children. Despite its non-aggressive nature and excellent prognosis, retinocytoma remains a significant area of interest due to its implications for genetic counseling, early detection, and management of ocular tumors. The pathogenesis of retinocytoma is closely linked to mutations in the RB1 gene, which plays a vital role in regulating the cell cycle. The detection of RB1 mutations in peripheral blood indicates germline disease, substantially elevating the risk of bilateral retinoblastoma development. Despite its benign nature, retinocytoma necessitates vigilant monitoring due to its potential to transform into retinoblastoma. Current treatment strategies primarily focus on observation and regular follow-up. However, more aggressive treatments are considered if malignant transformation is suspected. The prognosis is generally favorable, with most patients maintaining good visual acuity and a low risk of progression to retinoblastoma. We aim to present an up-to-date review on epidemiology, clinical features, pathogenesis, macroscopic and histopathological features, diagnostic criteria, prognosis, and management strategies.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"20"},"PeriodicalIF":1.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the role of electrostatic force, van der Waals force, and osmotic pressure in retinal function and barrier integrity.","authors":"Khayry Al-Shami, Jafar Shatnawi, Khaled Qasagsah, Salman Almurabi, Ghayda' Shatnawi, Tasnim Darawsheh, Shahed Karaja","doi":"10.1186/s40942-025-00643-y","DOIUrl":"10.1186/s40942-025-00643-y","url":null,"abstract":"<p><p>The retina's intricate interplay of forces and structures, with a focus on the retinal pigment epithelium (RPE) and photoreceptors, is essential for retinal health and function. Among these forces, electrostatic forces play a crucial role, working alongside van der Waals forces and oncotic pressure to maintain the retina's attachment to the RPE and ensure the integrity of the blood-retina barrier (BRB). The composition of the interphotoreceptor matrix (IPM), influenced by molecules like Retbindin secreted by rod photoreceptors, further modulates these forces, affecting processes like visual pigment regeneration and metabolite exchange. In the context of retinal tissue engineering and new technologies for support and cells-based treatments, electrostatic forces are harnessed to optimize nutrient supply to transplanted RPE cells by reducing pore size in electrospun polymer membranes. Scaffold-based strategies for retinal repair also utilize electrostatic, hydrophobic, van der Waals, and hydrogen bonding forces to enhance cell adhesion and growth, mimicking the basement membrane. Understanding the complex dynamics of these forces in retinal-RPE interactions holds promise for innovative treatments for retinal disorders, emphasizing the intricate balance between electrostatic forces, van der Waals forces, oncotic pressure, and more. These insights open exciting avenues for research and therapeutic interventions in ophthalmology. Additionally, van der Waals forces are explored in the context of cell adhesion, and their potential role in retinal health is discussed, particularly in relation to melanin's protective properties against blue light-induced damage. Tissue engineering approaches, both scaffold-free and scaffold-based, are discussed, highlighting the importance of physical surface treatments and adhesive forces in preserving engineered RPE tissue. Overall, this abstract provides a comprehensive overview of the multifaceted role of electrostatic and other forces in retinal biology and their implications for future research and clinical applications in ophthalmology.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"19"},"PeriodicalIF":1.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11837441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative endophthalmitis treatment with antibiotics associated or not with pars plana vitrectomy: a randomized clinical trial.","authors":"Vinicius Campos Bergamo, Luis Filipe Nakayama, Nilva Simeren Bueno de Moraes, Ivan Maynart Tavares, Mauro Silveira De Queiroz Campos, Ana Luisa Hofling-Lima, Maurício Maia","doi":"10.1186/s40942-025-00640-1","DOIUrl":"10.1186/s40942-025-00640-1","url":null,"abstract":"<p><strong>Background: </strong>Postoperative endophthalmitis (PSE) is a severe ocular complication that can lead to irreversible vision loss or even globe atrophy. The Endophthalmitis Vitrectomy Study (EVS) historically guided PSE management but is increasingly questioned due to advances in pars plana vitrectomy (PPV) techniques and its narrow focus on cataract surgery. This study aimed to compare PPV followed by intravitreal antibiotic injection at the end of surgery (PPV + IVAIES) with intravitreal antibiotic injection alone (IVAI) in managing PSE.</p><p><strong>Methods: </strong>This randomized clinical trial included 35 pseudophakic patients with PSE following cataract extraction, anti-vascular endothelial growth factor (anti-VEGF) injections, or glaucoma surgeries. Participants were randomized to receive either PPV + IVAIES (n = 12) or IVAI (n = 23). Best-corrected visual acuity (BCVA) was assessed at baseline and days 7, 30, 60, and 90 post-intervention. Clinical worsening, defined as lack of improvement or progression of symptoms within 48-72 h, guided retreatment protocols. Group A (PPV + IVAIES) received repeat IVAI if required, while Group B (IVAI) underwent delayed PPV with repeat IVAI. Statistical significance was assessed using repeated measures ANOVA and logistic regression.</p><p><strong>Results: </strong>Both groups showed significant BCVA improvement (p < 0.001). PPV + IVAIES resulted in faster recovery, with superior BCVA at day 7 (p = 0.019) and day 30 (p = 0.041). Retreatment was required in 39.1% of the IVAI group but not in the PPV + IVAIES group (p = 0.015). Subgroup analysis indicated a trend toward better early outcomes with early PPV (p = 0.029).</p><p><strong>Conclusions: </strong>Early PPV + IVAIES provides faster visual recovery and reduces retreatment rates compared to IVAI alone. Multicenter studies are warranted to confirm these findings and refine clinical guidelines. Trial registration ClinicalTrials.gov identifier: NCT04192994.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"18"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of hypertensive retinopathy and its associated factors among adult hypertensive patients attending at Comprehensive Specialized Hospitals in Northwest Ethiopia, 2024, a multicenter cross-sectional study.","authors":"Yitayal Abebe Gudayneh, Abebech Fikade Shumye, Abebech Tewabe Gelaye, Melkamu Temeselew Tegegn","doi":"10.1186/s40942-025-00631-2","DOIUrl":"10.1186/s40942-025-00631-2","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertensive retinopathy refers to changes in the retinal microvasculature resulting from elevated blood pressure, and the global burden ranges from 2 to 85%. However, there was no evidence on prevalence and associated factors of hypertensive retinopathy among adult hypertensive patients in the study area even in Ethiopia.</p><p><strong>Objective: </strong>The aim of this study was to investigate prevalence of hypertensive retinopathy and associated factors in adult hypertensive patients attending at Comprehensive Specialized Hospitals in Northwest Ethiopia in 2024.</p><p><strong>Methods: </strong>Multicenter hospital-based cross-sectional study was conducted in Northwest Ethiopia Comprehensive specialized hospitals from June, 07 to August, 07, 2024. A multistage sampling technique with an interval of 3 was applied to select 696 study participants. Data were collected through personal interviews, review of medical records and eye examinations. Data were entered into the Kobo Toolbox and then transferred to STATA version 17 for analysis. Bivariable and then multivariable binary logistic regression models were fitted to determine factors associated with hypertensive retinopathy. Variables with a P-value of less than 0.05 at multivariable analysis were considered statistically significant.</p><p><strong>Result: </strong>A total of 696 (95.34%) participants were included in the study. The prevalence of hypertensive retinopathy was 57.47%(95%CI: 53.75, 61.10). Age > 74 years (AOR = 4.24, 95%CI = 1.54,11.64), heart disease(AOR = 5.38, 95%CI = 1.86,15.58), duration of hypertension > 5years (AOR = 12.66, 95%CI = 3.88,41.29), dyslipidemia (AOR = 3.44,95%CI = 1.59-7.45), uncontrolled current levels of hypertension (AOR = 40.03, 95%CI = 17.19,93.18), poor adherence of hypertensive medications (AOR = 1.84, 95%CI = 1.12,3.03) and diabetes (AOR = 3.56, 95%CI = 1.49,5.99) were positively associated with hypertensive retinopathy.</p><p><strong>Conclusion: </strong>-The prevalence of hypertensive retinopathy is high among systemic hypertensive patients seen in Northwest Ethiopia comprehensive specialized hospitals and independently associated with older age, longer duration of hypertension, heart disease, diabetes, dyslipidemia, poor adherence of hypertension medications and uncontrolled hypertension. Early diagnosis and treatment of hypertension was recommended to prevent target organ complications.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"17"},"PeriodicalIF":1.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic oxidative stress levels and their associations with the risk of neovascular age-related macular degeneration and treatment response.","authors":"Maiko Abe, Hiroshi Kunikata, Naoko Aizawa, Masayuki Yasuda, Fumihiko Nitta, Toshiaki Abe, Toru Nakazawa","doi":"10.1186/s40942-025-00632-1","DOIUrl":"10.1186/s40942-025-00632-1","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association between oxidative stress (OS) and both the risk of neovascular age-related macular degeneration (nAMD) and the treatment response to intravitreal anti-vascular endothelial growth factor injections (anti-VEGF IVIs).</p><p><strong>Methods: </strong>This retrospective study included 46 treatment-naïve nAMD eyes of 46 patients (26 male and 20 female) who received anti-VEGF IVIs with a \"treat-and-extend\" regimen following an initial loading phase for one year. The patients were divided into two groups according to the total number of anti-VEGF IVIs administered during the year: the \"effective\" group and the \"resistant\" group. OS was evaluated by diacron reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and skin autofluorescence (SAF) at baseline. For comparison, 54 control subjects were recruited.</p><p><strong>Results: </strong>There were no significant differences in d-ROM or BAP levels between control subjects and nAMD patients, regardless of sex, whereas SAF levels were higher in nAMD patients overall and in male nAMD patients than in controls (P < 0.001 for both). The effective and resistant groups included 30 and 16 eyes, respectively. Among the male nAMD patients, the effective and resistant groups had similar baseline characteristics, including age, smoking history, visual acuity, and central macular thickness; however, the resistant group had higher SAF levels (effective vs. resistant: 2.3 vs. 2.6 arbitrary units [AU]; P = 0.02). This finding was further supported by a multiple logistic regression analysis, which showed that the odds ratio for SAF was 1.57 per 0.1 AU increase (P = 0.01).</p><p><strong>Conclusion: </strong>SAF levels were significantly higher in nAMD patients than in controls. The total number of anti-VEGF IVIs required over one year in male nAMD patients depended on SAF levels, suggesting that the SAF levels may serve as a potential biomarker for the response to anti-VEGF IVIs in nAMD.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"16"},"PeriodicalIF":1.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-clinic vitreous biopsy peel pack technique.","authors":"Charles DeBoer, Cindy Zhao, Prithvi Mruthyunjaya, Vinit B Mahajan, Karen M Wai, Steven R Sanislo","doi":"10.1186/s40942-025-00639-8","DOIUrl":"10.1186/s40942-025-00639-8","url":null,"abstract":"<p><strong>Background: </strong>Vitreous biopsy is a common technique used to guide management of acute endophthalmitis and help differentiate between infectious and inflammatory conditions. Currently, in-clinic vitreous biopsy is performed with a 25-gauge needle, without the ability to cut vitreous, potentially leading to reduced diagnostic yield. Recent work demonstrated the ability to perform vitreous biopsy with an off-the-shelf vitreous cutter. However, this was limited by complexity of assembly. Here, a technique using a single peel pack vitrectomy cutter is demonstrated for in-clinic vitreous biopsy.</p><p><strong>Methods: </strong>A 25-gauge vitreous cutter is opened from a peel pack. The drive line is identified, cut to length, and attached to a 10 mL syringe. A 1 mL syringe is attached to the aspiration line. After a trocar is used to place a cannula in the pars plana, the vitreous cutter is introduced into the eye. Cutting is performed by an assistant actuating the 10 mL syringe while the surgeon aspirates from the 1 mL syringe. After sample is collected, antimicrobials are injected if required and the cannula is removed.</p><p><strong>Results: </strong>A peel pack technique simplifies assembly for an in-clinic vitreous biopsy using a manually actuated cutter.</p><p><strong>Conclusion: </strong>We present a novel, improved, and simplified technique for vitreous tap using a vitreous cutter provided in a single peel pack, actuated by a single syringe with minimal assembly prior to use. This technique may be more accessible for clinicians than prior techniques and does not require a surgical console.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"15"},"PeriodicalIF":1.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}