International Journal of Retina and Vitreous最新文献

{"title":"\"Setting the standard\": an analysis of different acquisition patterns for macular OCT-angiography.","authors":"Ramkailash Gujar, Giulia Gregori, Rosa Dolz-Marco, Alessio Muzi, Jay Chhablani, Daniela Fruttini, Lorenzo Mangoni, Clara Rizzo, Cesare Mariotti, Marco Lupidi","doi":"10.1186/s40942-025-00653-w","DOIUrl":"10.1186/s40942-025-00653-w","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to determine the optimal OCT angiography (OCT-A) scanning pattern using the SPECTRALIS HRA-OCT2 device to evaluate macular microvasculature perfusion in healthy subjects.</p><p><strong>Methods: </strong>Healthy subjects were imaged using the SPECTRALIS OCT-A Module (Heidelberg Engineering) with the following scanning protocols: 10ºX10º-512 ART 7 [P1], 10ºX10º-256 ART 5 [P2], 10ºX10º-512 ART 5 [P3], and 15ºX10º-256 ART 5 [P4], all centered on the macula. Vessel perfusion density (VPD) and vessel length density (VLD) of the superficial vascular complex (SVC) were calculated using ImageJ software to evaluate the differences between scanning patterns. Three additional 10ºx1º, ART 7 high-density images were also obtained using the in-built software (SP-X1701 Update 3, based on Heyex Software Version 1.9.215.0 H) in the macular area and the VPD and VLD for all the three10ºx1º pattern size images with the corresponding area of pattern 1 image[P1]. Two retinal specialists conducted a blind qualitative assessment of the foveal avascular zone and image quality.</p><p><strong>Results: </strong>Twenty eyes from 20 consecutive healthy patients were included in the study. The mean VPD for P1, P2, P3, and P4 were 35.60, 31.67, 31.18, and 31.16, respectively. Mean VLD for P1, P2, P3, and P4 were 7.54, 5.86, 6.74, and 4.40, respectively. Significant differences were found between P1 and the other patterns for both the VPD and VLD, but not between P2, P3, and P4. VPD and VLD for 10ºx1º high-density images were 33.20 and 4.61, respectively, with significant VLD differences compared to P1, but not for VPD. P1 scored the highest and P4 the lowest in the qualitative assessments.</p><p><strong>Conclusions: </strong>The 10ºX10º-512 ART 7 pattern showed statistically significant qualitative superiority and appeared optimal for blood flow detection with reduced noise in quantitative assessments.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"28"},"PeriodicalIF":1.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Impact of duration of treatments with metformin and sulfonylureas, individually or in combination, on diabetic retinopathy among newly diagnosed type 2 diabetic patients: a pooled cohort's analysis.","authors":"Mansour Bahardoust, Yadollah Mehrabi, Farzad Hadaegh, Davood Khalili, Ali Delpisheh","doi":"10.1186/s40942-025-00658-5","DOIUrl":"10.1186/s40942-025-00658-5","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"27"},"PeriodicalIF":1.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical management and long-term follow-up of ocular hypotony associated with peripheral circumferential retinal detachment.","authors":"Leandro Cabral Zacharias, Lívia da Silva Conci, Davi Paraguassu de Sousa Martins, Rony Carlos Preti, Leonardo Proveti Cunha, Mario Luiz Ribeiro Monteiro","doi":"10.1186/s40942-025-00648-7","DOIUrl":"10.1186/s40942-025-00648-7","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the surgical management and long-term follow-up of hypotony related to post-vitrectomy peripheral circumferential retinal detachment (PCD).</p><p><strong>Methods: </strong>Eyes diagnosed with hypotony secondary to PCD after pars plana vitrectomy were retrospectively reviewed. The patient demographic data, complications, management, and treatment outcomes were collected and analyzed.</p><p><strong>Results: </strong>Four eyes were included in this study. The median preoperative best-corrected visual acuity (BCVA) was 20/200 and the mean preoperative intraocular pressure (IOP) was 4.5 mmHg. One case had rubeosis iridis. All eyes underwent peripheral retinectomy to remove the detached retina and release ciliary body traction. Complete retinal reattachment was achieved in all eyes. The final BCVA ranged from 20/200 to 20/50 and regression of rubeosis iridis was observed. Mean IOP improved to 12,25 mmHg at 12 months after the retinectomy. The mean follow- up time was 5 years (range 2-7 years).</p><p><strong>Conclusion: </strong>Aggressive dissection and 360º trimming of the anterior retina is helpful to relieve ciliary body traction and remove ischemic tissue, restoring minimally adequate aqueous production in cases of hypotony related to PCD.</p><p><strong>Trial registration: </strong>This retrospective study was approved by the Institutional Review Board, under registration number 77599724.7.0000.0068.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"26"},"PeriodicalIF":1.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New minimally invasive technique for repositioning of a subluxated retropupillary iris-claw IOL using needle-assisted fixation.","authors":"Celso Costa, Nuno Gouveia, Pedro Fonseca, Miguel Raimundo, Joaquim Murta, João Figueira","doi":"10.1186/s40942-025-00651-y","DOIUrl":"10.1186/s40942-025-00651-y","url":null,"abstract":"<p><strong>Purpose: </strong>This paper presents a modification of the needle-assisted retropupillary fixation technique for iris-claw intraocular lenses (IOLs). We introduce a novel, minimally invasive reenclavation technique for managing subluxated retropupillary iris-claw IOLs.</p><p><strong>Methods: </strong>The technique was successfully performed on four patients diagnosed with subluxated retropupillary iris-claw IOLs. This approach involved a novel, minimally invasive reenclavation technique that utilized three needles: one long, straight translimbal needle crossing the anterior chamber and two needles introduced through the pars plana to reposition and securely reenclavate the IOL.</p><p><strong>Results: </strong>All patients experienced immediate and significant visual recovery, with their baseline visual acuities reestablished postoperatively. Importantly, no post-operative complications were observed during the six-month follow-up period, highlighting the safety and efficacy of the technique.</p><p><strong>Conclusion: </strong>Our novel, minimally invasive technique for reenclavation of iris-claw IOLs, employing just three needles, eliminates the need for trocar insertion, infusion cannulas, or sutures. This approach offers significant advantages, including a shorter operative time and minimal surgical manipulation, leading to faster patient recovery and fewer complications.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"25"},"PeriodicalIF":1.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: OCT biomarkers as predictors of visual improvement in diabetic macular edema eyes receiving dexamethasone implants.","authors":"Giacomo Visioli, Ludovico Alisi, Elvia Mastrogiuseppe, Giuseppe Maria Albanese, Enrico Romano, Ludovico Iannetti, Marta Armentano, Francesca Giovannetti, Magda Gharbiya","doi":"10.1186/s40942-025-00644-x","DOIUrl":"10.1186/s40942-025-00644-x","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"24"},"PeriodicalIF":1.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Postoperative endophthalmitis treatment with antibiotics associated or not with pars plana vitrectomy: a randomized clinical trial.","authors":"Vinicius Campos Bergamo, Luis Filipe Nakayama, Nilva Simeren Bueno de Moraes, Ivan Maynart Tavares, Mauro Silveira De Queiroz Campos, Ana Luisa Hofling-Lima, Maurício Maia","doi":"10.1186/s40942-025-00647-8","DOIUrl":"10.1186/s40942-025-00647-8","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"23"},"PeriodicalIF":1.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-resolution optical coherence tomography in pigmented choroidal lesions.","authors":"Damian Jaggi, Shalin G Aeberhard, Dmitri Artemiev, Martin S Zinkernagel, Florian M Heussen","doi":"10.1186/s40942-025-00645-w","DOIUrl":"10.1186/s40942-025-00645-w","url":null,"abstract":"<p><strong>Purpose: </strong>Evaluating High-Resolution Optical Coherence Tomography (HR-OCT) versus standard spectral domain OCT in pigmented choroidal lesions.</p><p><strong>Methods: </strong>We screened a total of 40 subjects with pigmented choroidal lesions. Lesions were imaged on HR-OCT and standard OCT devices with and without enhanced depth imaging (EDI) mode. Images were graded for qualitative and quantitative aspects, like choriocapillaris compression and width, choroidal reflectivity and thickness, amongst others.</p><p><strong>Results: </strong>32 of the 40 subjects could be included in the image analysis, the rest were excluded due to insufficient imaging. HR-OCT EDI mode allowed visualization of the posterior choroidal extent in 11 lesions (11/32 = 34.4%) versus in six (6/32; 18.8%), four (4/30; 13.3%), and five cases (5/30; 16.7%) in normal HR-OCT (n = 32), standard OCT (n = 30) and OCT EDI mode (n = 30), respectively, albeit not significantly different. Choriocapillaris compression was evident in 10 cases on HR-OCT and equally visible in all imaging modes. Mean choriocapillaris thickness ranged from 11.6 to 13.9 microns (SD range 3.84-4.33), and compressed choriocapillaris thickness similarly ranged from a mean of 7.1 to 7.8 microns (SD range 2.20-3.55). Image quality declined significantly towards the periphery in three out of four modes (p = 0.0077 to p = 0.29).</p><p><strong>Conclusions: </strong>HR-OCT may provide better visibility of retinal and choroidal structures in pigmented choroidal lesions, although image quality is reduced in attempting to image peripheral lesions.</p><p><strong>Translational relevance: </strong>The prototype HR-OCT offers insights into clinical features of pigmented choroidal lesions that are not apparent on conventional OCT imaging. This supports the development of HR-OCTolution OCT devices.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"22"},"PeriodicalIF":1.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of cigarette smoking on retinal thickness and choroidal vascularity index: a systematic review and meta-analysis.","authors":"Miguel A Quiroz-Reyes, Erick A Quiroz-Gonzalez, Miguel A Quiroz-Gonzalez, Virgilio Lima-Gomez","doi":"10.1186/s40942-025-00646-9","DOIUrl":"10.1186/s40942-025-00646-9","url":null,"abstract":"<p><strong>Background: </strong>Smoking increases oxidative stress, affecting the vascular endothelium by decreasing the antioxidant vitamin C and disrupting regular nitric oxide activity. It reduces blood flow in the retina and choroid due to increased vascular resistance and compromised choroidal blood flow regulation compared to nonsmokers. This systematic review and meta-analysis aimed to elucidate the impact of cigarette smoking on retinal thickness and the choroidal vascularity index (CVI).</p><p><strong>Methods: </strong>A comprehensive literature search was performed across multiple databases, including Web of Science, Medline, PubMed, and Embase, adhering to the PRISMA and MOOSE guidelines. Observational studies were selected to explore the relationships between smoking and ocular parameters such as CVI, full-retinal, and choroidal thickness. Two independent reviewers conducted the data extraction and quality assessment using a modified Newcastle-Ottawa scale. Statistical analysis was performed using a random-effects model.</p><p><strong>Results: </strong>Four out of the 743 identified articles, involving 702 eyes, met the inclusion criteria. The analysis revealed a significant reduction in the CVI among smokers (SMD: -0.61, 95% CI: -0.78 to -0.43, p < 0.00001), indicating compromised choroidal vascularity. In contrast, the impact of smoking on subfoveal choroidal thickness (SFCT) was not statistically significant (mean difference: 3.88 μm, 95% CI: -7.34 to 15.10, p = 0.50), with high heterogeneity (I² = 79%). Additionally, the full-retinal thickness (FRT) did not show a significant difference between smokers and nonsmokers.</p><p><strong>Conclusion: </strong>Cigarette smoking negatively affects choroidal vascularity, as indicated by a significant reduction in CVI. However, its impact on FRT and SFCT remains unclear and requires further research. These findings highlight the importance of smoking cessation for eye health and suggest that CVI is a valuable noninvasive biomarker for monitoring vascular changes in smokers.</p><p><strong>Trial registration: </strong>PROSPERO registration number: CRD42024627478.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"21"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinocytoma: understanding pathogenesis, diagnosis, and treatment approaches.","authors":"Maysa Al-Hussaini, Sarah Al Sharie, Hala Sultan, Mona Mohammad, Yacoub A Yousef","doi":"10.1186/s40942-025-00642-z","DOIUrl":"10.1186/s40942-025-00642-z","url":null,"abstract":"<p><p>Retinocytoma, or retinoma, is a rare benign intraocular tumor primarily affecting the retina. It is often considered a precursor or a differentiated form of retinoblastoma, a malignant retinal tumor predominantly seen in children. Despite its non-aggressive nature and excellent prognosis, retinocytoma remains a significant area of interest due to its implications for genetic counseling, early detection, and management of ocular tumors. The pathogenesis of retinocytoma is closely linked to mutations in the RB1 gene, which plays a vital role in regulating the cell cycle. The detection of RB1 mutations in peripheral blood indicates germline disease, substantially elevating the risk of bilateral retinoblastoma development. Despite its benign nature, retinocytoma necessitates vigilant monitoring due to its potential to transform into retinoblastoma. Current treatment strategies primarily focus on observation and regular follow-up. However, more aggressive treatments are considered if malignant transformation is suspected. The prognosis is generally favorable, with most patients maintaining good visual acuity and a low risk of progression to retinoblastoma. We aim to present an up-to-date review on epidemiology, clinical features, pathogenesis, macroscopic and histopathological features, diagnostic criteria, prognosis, and management strategies.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"20"},"PeriodicalIF":1.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the role of electrostatic force, van der Waals force, and osmotic pressure in retinal function and barrier integrity.","authors":"Khayry Al-Shami, Jafar Shatnawi, Khaled Qasagsah, Salman Almurabi, Ghayda' Shatnawi, Tasnim Darawsheh, Shahed Karaja","doi":"10.1186/s40942-025-00643-y","DOIUrl":"10.1186/s40942-025-00643-y","url":null,"abstract":"<p><p>The retina's intricate interplay of forces and structures, with a focus on the retinal pigment epithelium (RPE) and photoreceptors, is essential for retinal health and function. Among these forces, electrostatic forces play a crucial role, working alongside van der Waals forces and oncotic pressure to maintain the retina's attachment to the RPE and ensure the integrity of the blood-retina barrier (BRB). The composition of the interphotoreceptor matrix (IPM), influenced by molecules like Retbindin secreted by rod photoreceptors, further modulates these forces, affecting processes like visual pigment regeneration and metabolite exchange. In the context of retinal tissue engineering and new technologies for support and cells-based treatments, electrostatic forces are harnessed to optimize nutrient supply to transplanted RPE cells by reducing pore size in electrospun polymer membranes. Scaffold-based strategies for retinal repair also utilize electrostatic, hydrophobic, van der Waals, and hydrogen bonding forces to enhance cell adhesion and growth, mimicking the basement membrane. Understanding the complex dynamics of these forces in retinal-RPE interactions holds promise for innovative treatments for retinal disorders, emphasizing the intricate balance between electrostatic forces, van der Waals forces, oncotic pressure, and more. These insights open exciting avenues for research and therapeutic interventions in ophthalmology. Additionally, van der Waals forces are explored in the context of cell adhesion, and their potential role in retinal health is discussed, particularly in relation to melanin's protective properties against blue light-induced damage. Tissue engineering approaches, both scaffold-free and scaffold-based, are discussed, highlighting the importance of physical surface treatments and adhesive forces in preserving engineered RPE tissue. Overall, this abstract provides a comprehensive overview of the multifaceted role of electrostatic and other forces in retinal biology and their implications for future research and clinical applications in ophthalmology.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"19"},"PeriodicalIF":1.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11837441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}