International Journal of Retina and Vitreous最新文献

{"title":"Surgical prognosis in epiretinal membrane: 12-month outcomes after membrane peeling in a 5-year cohort with OCT biomarkers.","authors":"Piero Barrera-Arshavin, Álvaro Bofill-Ramirez, Antonia Bayo-Burgos, Eduardo Urrejola-Irarrazabal, Josefina Camelio-Opazo, Juan Ignacio Verdaguer-Diaz, María José Rivas-Figueroa, Luis Filsecker-López, José Manuel López-Astaburuaga, Sergio Zacharías-Santamaría, Jorge Orellana-Rios, Efraín Pérez-Argandoña","doi":"10.1186/s40942-026-00853-y","DOIUrl":"https://doi.org/10.1186/s40942-026-00853-y","url":null,"abstract":"<p><strong>Background: </strong>To determine the functional and anatomical outcomes at 12 months after pars plana vitrectomy (PPV) for epiretinal membrane (ERM) and the independent prognostic value of preoperative biomarkers in optical coherence tomography (OCT).</p><p><strong>Methods: </strong>Five-year analytical study of 340 eyes with ERM in stages (Govetto G2-4). Best-corrected visual acuity (BCVA) logMAR and OCT were evaluated at baseline, 1, 3, 6, and 12 months. The primary objective was to determine the change in BCVA at 12 months (ΔlogMAR 12 m - baseline). Univariate tests, ANCOVA, longitudinal mixed linear models, and logistic regression were applied for gain ≥ 0.2 logMAR. The models were adjusted for baseline VA, age, sex, aetiology, surgical technique, and analysis of biomarkers in OCT.</p><p><strong>Results: </strong>Baseline VA was 0.54 ± 0.44 logMAR (approximate Snellen equivalent: 20/70); distribution according to G2 (n = 166), G3 (n = 146), G4 (n = 28). VA improved significantly at 12 months (Wilcoxon p < 0.001), equivalent to 11-12 ETDRS letters. Secondary ERMs showed greater unadjusted gain than idiopathic ones, but aetiology was not an independent predictor after adjustment. The surgical technique was not independently associated with VA at 12 months (β=+0.031 logMAR; 95% CI; p = 0.408) or with responder status (OR 1.18; 95% CI; p = 0.625). By severity, advanced stages had worse baseline visual acuity (VA) and greater absolute gains (Kruskal-Wallis H = 7.61; p = 0.0223), although with lower final VA compared to lesser stages. Baseline VA was the dominant predictor in all models (β=-0.766; 95% CI; p < 0.001). Among preoperative biomarkers, COST line disruption independently increased the probability of response (OR = 2.08; 95% CI; p = 0.013). DRIL, EZ disruption, and central bouquet alterations did not reach significance after adjustment. Mixed models confirmed early improvement, maintained up to 12 months. Kaplan-Meier showed faster time to response in advanced stages.</p><p><strong>Conclusions: </strong>PPV for ERM achieves significant improvement at 12 months. Baseline VA is the main determinant of prognosis. According to Govetto's classification, the greatest gain occurs in advanced stages, but with lower final VA. The COST line emerges as the only preoperative biomarker with independent prognostic value for achieving ≥ 0.2 logMAR; the others provide limited utility when baseline VA is considered.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and risk factors of retinopathy of prematurity in artificial reproductive technology conceived preterm infants in China.","authors":"Shufen Chen, Shuhui Chen, Yuzhen Zhu, Yuxuan Lai, Guihua Xu","doi":"10.1186/s40942-026-00859-6","DOIUrl":"https://doi.org/10.1186/s40942-026-00859-6","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular pharmacokinetics of tivozanib eye drops in patients with neovascular age-related macular degeneration: comparison with phase 1 trials of oral tivozanib in solid tumors.","authors":"Shinya Horita, Mayumi Saki, Sotaro Takigawa, Yasumasa Kanai, Kenta Murotani, Fumi Gomi","doi":"10.1186/s40942-026-00848-9","DOIUrl":"10.1186/s40942-026-00848-9","url":null,"abstract":"<p><p>Intravitreal anti-vascular endothelial growth factor (VEGF) therapy is the standard treatment for neovascular age-related macular degeneration (nAMD) but is invasive and burdensome for patients. To overcome these obstacles, tivozanib, a pan-VEGF receptor inhibitor approved for renal cell carcinoma, is in development as eye drops. The phase 1 study of a 3-week administration of tivozanib eye drops showed a preferable safety profile and exploratory efficacy signs in Japanese patients with nAMD. During eye drop administration, two drug delivery pathways affect ocular pharmacokinetics, either directly through the ocular tissues or through systemic circulation. To assess the ocular pharmacokinetics of tivozanib eye drops, we conducted an integrated analysis of systemic adverse event occurrence and systemic exposure in patients with nAMD treated with tivozanib eye drops and in patients with cancer treated with oral tivozanib, using previous phase 1 study results. Systemic exposure was significantly lower with tivozanib eye drops versus oral tivozanib, with no drug-related hypertension due to the systemic pan-VEGF receptor inhibition observed, suggesting systemic VEGF receptors are not fully inhibited by tivozanib. Exploratory efficacy signs in patients with nAMD after short-term use of tivozanib eye drops also suggest tivozanib might reach the retina and inhibit VEGF receptors, although further long-term efficacy studies are warranted. Given the integrated analysis, we hypothesize that tivozanib eye drops could predominantly be delivered to the posterior eye segment through the ocular tissues, with limited contribution by the systemic drug delivery pathway. This hypothesis provides meaningful insights into the ocular pharmacokinetics of tivozanib eye drops.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13085304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical outcomes of familial exudative vitreoretinopathy-associated retinal detachment: a systematic review and meta-analysis.","authors":"Ahmed B Sallam, Hashem Abu Serhan, Ahmad Alazzam, Ahmad Barakat, Anas Alamoudi, Raed Alnutaifi, Nagi Ahmed, Taima'a Al-Awaysheh, Mohd Salim Harun Gigani","doi":"10.1186/s40942-026-00850-1","DOIUrl":"https://doi.org/10.1186/s40942-026-00850-1","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of retinal imaging with presence of inner limiting membrane pores in idiopathic epiretinal gliosis.","authors":"Denise Vogt, Nikolina Durdevic, Azza Dammak, Ricarda G Schumann, Andrea Govetto, Mario R Romano, Efstathios Vounotrypidis, Melih Parlak, Armin Wolf","doi":"10.1186/s40942-026-00849-8","DOIUrl":"10.1186/s40942-026-00849-8","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13081236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effect of gas and silicone oil tamponades on visual outcomes in the surgical treatment of rhegmatogenous retinal detachment.","authors":"Tural Galbinur, Ayan Mammadkhanova, Hafiz Gahramanov, Ulkar Galbinur, Ayan Galbinur, Gunay Aslanova, Pasha Musayev","doi":"10.1186/s40942-026-00851-0","DOIUrl":"https://doi.org/10.1186/s40942-026-00851-0","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracameral antibiotic prophylaxis and surgical expertise: key determinants in endophthalmitis after cataract surgery.","authors":"Vinicius Campos Bergamo, Luis Filipe Nakayama, Nilva Simeren Bueno de Moraes, Caio Vinicius Saito Regatieri, Ivan Maynart Tavares, Mauro Silveira de Queiroz Campos, Ana Luisa Hofling-Lima, Maurício Maia","doi":"10.1186/s40942-026-00845-y","DOIUrl":"https://doi.org/10.1186/s40942-026-00845-y","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Off-label intravitreal eculizumab for geographic atrophy: report of the first two cases.","authors":"Rodrigo Jorge, Marcelo G B Rego, Arthur S Zupelli, Rodrigo T Calado","doi":"10.1186/s40942-026-00842-1","DOIUrl":"10.1186/s40942-026-00842-1","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications of silicone oil in vitreoretinal surgery: a narrative review of clinical and experimental evidence.","authors":"Rosa Lomelino Pinheiro, Filipe Henriques, Mun Faria, Elisa Julião Campos, Carlos Marques-Neves","doi":"10.1186/s40942-026-00847-w","DOIUrl":"https://doi.org/10.1186/s40942-026-00847-w","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relaxing retinectomy and autologous retinal transplant for complex retinal detachment with macular hole: a case series.","authors":"Rami Madani, Armin Wolf, Jad Madani, Michael F Ward, Matthew Cohen, Ferris Bayasi, Tarek Alasil","doi":"10.1186/s40942-026-00843-0","DOIUrl":"https://doi.org/10.1186/s40942-026-00843-0","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}