International Journal of Retina and Vitreous最新文献

{"title":"The relationship of macular vessel density and foveal avascular zone with pulse wave velocity and central blood pressure in healthy adults: Persian cohort study.","authors":"Hamid Reza Heidarzadeh, Elaheh Ebrahimi Miandehi, Nasser Shoeibi, Mohammad Reza Ansari Astaneh, Seyedeh Maryam Hosseini, Majid Abrishami, Mehrdad Motamed Shariati, Saeid Eslami, Parnian Arjmand, Mojtaba Abrishami","doi":"10.1186/s40942-024-00616-7","DOIUrl":"10.1186/s40942-024-00616-7","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the correlation of macular vessel density (VD) and foveal avascular zone (FAZ) parameters measured on optical coherence tomography angiography (OCTA) with systemic arterial stiffness using pulse wave velocity (PWV), pulse wave analysis, arterial age, and central blood pressure (CBP) measurements in healthy subjects.</p><p><strong>Methods: </strong>In a comparative, cross-sectional, observational study, healthy adults who participated in the PERSIAN Cohort study at Mashhad University of Medical Sciences were included in this study. The study involved using a spectral domain OCTA device to obtain 3 × 3 and 6 × 6 mm scans of the macular superficial capillary plexus (SCP) VD, deep capillary plexus (DCP) VD, and FAZ vascular analysis. Additionally, we used the SphygmoCor XCEL System (AtCor, Itasca, IL) to analyze systemic vascular parameters like CBP and PWV.</p><p><strong>Results: </strong>The study included 296 healthy participants with a mean age of 39.2 ± 6.7 years, and 152 subjects (51.3%) were female. Female participants were found to have higher DCP VD and FAZ area values. Age showed a negative correlation with SCP and DCP VDs. PWV showed a negative correlation with parafoveal DCP VDs, but no correlation was observed between macular VDs and aortic diastolic and systolic pressures.</p><p><strong>Conclusion: </strong>In conclusion, age was found to have a negative impact on macular SCP and DCP VDs. In addition, higher arterial stiffness was found to correlate with a lower parafoveal DCP VD value. These findings suggest macular OCTA parameters may be used as early markers of systemic arterial disease.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"10 1","pages":"95"},"PeriodicalIF":1.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the role of exosomal derived regulatory noncoding RNAs as potential biomarkers for diabetic retinopathy: a systematic review.","authors":"Santosh Nandalal, Harshitha Venkatesan, Madhumitha Haridoss, Krithika Ramachandran, Raji Rajesh Lenin","doi":"10.1186/s40942-024-00615-8","DOIUrl":"10.1186/s40942-024-00615-8","url":null,"abstract":"<p><p>About one-third of individuals with diabetes develop diabetic retinopathy (DR), with one-tenth experiencing vision-threatening conditions such as diabetic macular edema (DME) or proliferative diabetic retinopathy (PDR). Current treatments only show recovery in 50% of cases, and the disease often remains asymptomatic. Therefore, novel early detection methods and new biomarkers are crucial. Our study aims to summarise evidence on the role of altered exosomal regulatory noncoding RNAs in DR, based on human studies. Observational studies delineating the different exosomal noncoding RNAs in DR were searched systematically from inception to June 2024 in PubMed-MEDLINE and SCOPUS databases. Preferred Reporting Items of Systematic Reviews and Meta-analysis (PRISMA) 2020 guidelines was used to conduct this systematic review (Prospero ID: CRD42023406724). We synthesised data from 13 human studies that assessed the expression of exosomal regulatory ncRNAs from individuals with DR. Among the 13 studies, nine focused on miRNA, while three examined lncRNA and one on circRNA. Although no common genes were identified across the studies, the review underscores the critical roles of exosomal noncoding RNAs in the pathogenesis of diabetic retinopathy, highlighting their potential as therapeutic targets. Future studies should aim for a unified approach in terms of sample selection, RNA analysis, and appropriate controls for a comprehension of exosomal expression patterns for early diagnosis of DR.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"10 1","pages":"93"},"PeriodicalIF":1.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11657862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal microvascular changes in systemic lupus erythematosus assessed by optical coherence tomography angiography.","authors":"André Ferreira, Luísa Viveiros, Raquel Faria, Francisca Bragança, Ana Carolina Abreu, Daniela Santos, Maria João Furtado, Miguel Lume, Pedro Menéres, José P Andrade","doi":"10.1186/s40942-024-00617-6","DOIUrl":"10.1186/s40942-024-00617-6","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the retinal microvasculature of Systemic Lupus Erythematosus (SLE) patients using Optical Coherence Tomography Angiography (OCTA).</p><p><strong>Methods: </strong>Twenty adult SLE patients without disease activity and no ocular manifestations were recruited and cross-sectionally assessed. A demographically similar cohort of healthy subjects was used for comparison. The main outcome is vascular density (VD). As secondary outcomes, foveal avascular zone (FAZ) parameters, total vessel length (TVL), vessel length density (VLD), vessel diameter and tortuosity, branchpoint density (BD) and fractal dimension (FD) were evaluated.</p><p><strong>Results: </strong>Forty eyes of 40 women (20 SLE patients and 20 healthy subjects) were enrolled with a mean ± SD age of 36.7 ± 9.9 years. In both the superficial and deep capillary plexuses, SLE patients presented significantly lower VD and TVL values, mean vessel diameter and FD (all p < 0.005). No significant differences were found in FAZ values. A negative correlation was found between age and FAZ parameters and between age and TVL, VLD and FD in the superficial capillary plexus (all p < 0.05).</p><p><strong>Conclusions: </strong>This study supports the evidence of subclinical retinal microvascular changes in adult SLE patients, providing a more comprehensive characterization of vascular changes. We found vessel diameter and length and FD are decreased in SLE.</p><p><strong>Trial registration: </strong>NCT05863689, 2023-10-19.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"10 1","pages":"94"},"PeriodicalIF":1.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11657433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phacovitrectomy vs. consecutive vitrectomy for idiopathic macular holes: short and long-term outcomes and OCT image quality assessment.","authors":"Vishma Prabhu, Priyanka Gandhi, Rupal Kathare, Kanika Godani, Prathiba Hande, Naresh Kumar Yadav, Jay Chhablani, Ramesh Venkatesh","doi":"10.1186/s40942-024-00614-9","DOIUrl":"10.1186/s40942-024-00614-9","url":null,"abstract":"<p><strong>Purpose: </strong>To compare short- and long-term anatomical, functional, and refractive outcomes between combined phacovitrectomy (PVS) and consecutive vitrectomy (CVS) for idiopathic macular holes (MHs). Also, to evaluate the role of preoperative optical coherence tomography (OCT) image quality in guiding surgical selection.</p><p><strong>Methods: </strong>This retrospective study analyzed 183 phakic MH eyes operated between 2012 and 23, with patients divided into PVS and CVS groups. Demographic and ocular data, MH features, visual acuity (VA), refraction changes and postoperative outcomes, and follow-up details were collected. Pre- and post-operative OCT scans were evaluated for MH characteristics, OCT image quality, and surgical outcomes at short-term (≤ 3 months) and long-term (≥ 5 years) intervals.</p><p><strong>Results: </strong>The study included 144 eyes in PVS group and 39 in CVS group. Median follow-up duration was 16 months for PVS group and 72 months for CVS group (p < 0.001). Both groups showed significant VA improvements and comparable MH closure rates at short-term follow-up. However, CVS group had significantly better postoperative VA at short-term (p = 0.001) and long-term (p = 0.017) intervals. The preoperative OCT quality index did not significantly differ between groups and was ineffective in assessing cataract grade or guiding surgical decisions. Both groups experienced a myopic refractive shift, with a higher magnitude in the PVS group (p = 0.04). Postoperative complications were similar between the groups.</p><p><strong>Conclusion: </strong>CVS achieves better long-term VA than PVS following MH repair, despite similar anatomical outcomes. Preoperative OCT quality index is not effective for guiding surgical decisions, and careful refractive planning is essential, especially for PVS patients, to address postoperative myopic shifts.</p><p><strong>Clinical trial registration number: </strong>Not applicable.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"10 1","pages":"92"},"PeriodicalIF":1.9,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choriocapillaris flow deficit is associated with disease duration in type 2 diabetic patients without retinopathy: a cross-sectional study.","authors":"Lourdes Vidal-Oliver, Elisa Herzig-de Almeida, Sabrina Spissinger, Robert P Finger","doi":"10.1186/s40942-024-00611-y","DOIUrl":"10.1186/s40942-024-00611-y","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus (DM) causes microvascular damage due to long-term hyperglycemia, even before the onset of retinal changes. We aimed to investigate the association between optical coherence tomography angiography (OCTA) metrics and disease duration in type 2 diabetic patients without retinopathy.</p><p><strong>Methods: </strong>Eighty-two eyes of 82 type 2 diabetic patients without diabetic retinopathy (DR) were included. Choriocapillaris flow deficit (CC FD%), vessel density (VD), vessel length density (VLD) in the superficial (SVP) and deep vascular plexus (DVP) were calculated and compared between different sectors of the macula. Foveal avascular zone circularity (FAZc) was also calculated. Linear regression was used to study the association of each vascular parameter with disease duration both in a univariate and multivariate design adjusting for age, sex, Hb1Ac and arterial hypertension.</p><p><strong>Results: </strong>CC FD% increased by 3.7, 2.3, 3.8 and 4.6% in the nasal, superior, temporal and inferior sectors per decade of disease duration, after adjusting for confounders. Mean values of VD and VLD in the SVP and DVP, as well as FAZc decreased with increased duration of DM, but the association was weaker. Only the VD in the superior and temporal sectors of the SVP were significant in the multivariate analysis (ß=-0.12 (95% CI -0.24 to -0.01) and - 0.13 (95%CI -0.25 to -0.002), respectively).</p><p><strong>Conclusion: </strong>CC FD% is independently associated with disease duration in type 2 diabetes independent of the presence of clinical retinopathy. Further longitudinal studies are needed to investigate the role of choroidal changes in predicting DR onset in order to individualize screening protocols.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"10 1","pages":"91"},"PeriodicalIF":1.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142728846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-reported visual function and in-depth swept-source optical coherence tomography features of cystoid macular edema in retinitis pigmentosa.","authors":"Celso Costa, Carlos Nogueira, Mário Soares, Silvia Simão, Pedro Melo, Rufino Silva, Joaquim Murta, João Pedro Marques","doi":"10.1186/s40942-024-00608-7","DOIUrl":"10.1186/s40942-024-00608-7","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate self-reported visual function in retinitis pigmentosa (RP) patients with and without cystoid macular edema (CME) and to explore associations between cystoid spaces (CS), retinal morphometric parameters, and clinical data using swept-source optical coherence tomography (SS-OCT).</p><p><strong>Methods: </strong>In this cross-sectional case-control study (1:3) conducted at an Inherited Retinal Degenerations referral center in Portugal, RP patients with and without CME (matched for age and gender) completed the Michigan Retinal Degeneration Questionnaire (MRDQ) and underwent SS-OCT. Morphometric analysis, including ellipsoid zone area (EZA), was performed by two independent graders. In the CME group, detailed CS analysis was conducted. Correlations between clinical data - age, gender, best-corrected visual acuity (BCVA) - and MRDQ domains were evaluated.</p><p><strong>Results: </strong>The study included 23 RP patients with CME (60.87% male, mean age 44.65 ± 13.58 years) and 69 without CME (49.28% male, mean age 47.94 ± 14.39 years). No significant differences were found between groups in almost all MRDQ domains, BCVA, or EZA. Age positively correlated with 4 MRDQ domains in both groups. BCVA negatively correlated with nearly all MRDQ domains. While EZA showed a negative correlation in both groups, it was significant only in RP without CME. In the CME group, centrally located, outer nuclear layer-involving and large CS were associated with worse BCVA but better EZA.</p><p><strong>Conclusion: </strong>MRDQ responses strongly correlated with clinical parameters. CME does not seem to affect self-reported visual function in RP patients, and CS may not worsen visual function. Thus, aggressive treatment of CME in RP may not be necessary.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"10 1","pages":"89"},"PeriodicalIF":1.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal and choroidal microvascular assessment of children receiving recombinant growth hormone therapy : Study design: a prospective observational comparative study.","authors":"Ismail Omar, Yousra Samir Fadle, Noura M Ibrahim El Bakry","doi":"10.1186/s40942-024-00610-z","DOIUrl":"10.1186/s40942-024-00610-z","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study is to evaluate the retinal and choroidal microvascular state in children with congenital isolated growth hormone deficiency (IGHD) and determine the effect of recombinant human growth hormone treatment on these structures compared with healthy controls.</p><p><strong>Methods: </strong>The study included children with IGHD under recombinant human GH treatment as group one and another group of healthy controls. Both groups were examined using optical coherence tomography angiography (OCTA). Data concerning superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC), and retinal thickness were recorded.</p><p><strong>Results: </strong>The study included two equal groups of 30 individuals. Both groups had no statistically significant differences in age, gender, weight, or spherical equivalent. However, subjects of group II were taller than those of group I (p = 0.011). OCTA images of the SCP, DCP, and CC vessel density revealed statistically non-significant differences between the two groups.</p><p><strong>Conclusion: </strong>Children receiving recombinant growth hormone therapy showed no changes in the retinal and choroidal microvasculature or macular thickness.</p><p><strong>Trial registration number: </strong>1094/03/2024 by Minia University Faculty of Medicine Institutional Review Board. Another registration number is UMIN000055654.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"10 1","pages":"90"},"PeriodicalIF":1.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of post-operative foveal location and microstructural changes after pars plana vitrectomy for rhegmatogenous retinal detachment using enhanced-depth imaging optical coherence tomography.","authors":"Mostafa Mahmoud Eid Al Azaizy, Hossam Eldin Mohamed Khalil, Mahmoud Leila, Nour Salah Akl, Sahar Ibrahim Mohammed","doi":"10.1186/s40942-024-00609-6","DOIUrl":"10.1186/s40942-024-00609-6","url":null,"abstract":"<p><strong>Background: </strong>Patients who had successful rhegmatogenous retinal detachment (RRD) surgery often complained of metamorphopsia due to postoperative fovea displacement and alteration of the foveal microstructure. The papillo-foveal distance (PFD) is correlated bilaterally. Therefore, PFD from the fellow healthy eye could be used to determine the change of foveal position in eyes with successful RRD repair. Ultra-high-resolution optical coherence tomography (UHR-OCT) could explain incomplete visual recovery by demonstrating foveal misalignment and changes in foveal microstructure. The rationale of the study is to assess the changes in the foveal location and microstructural layers after successful retinal reattachment and correlate them with visual dysfunction.</p><p><strong>Patients and methods: </strong>A prospective interventional cross-sectional controlled study included patients who had successful retinal reattachment and complained of defective vision or metamorphopsia. The primary outcome measure is to evaluate the post-operative foveal location. The secondary outcome measures are the assessment of metamorphopsia, the evaluation of the foveal microstructural changes, and the correlation between foveal shift, metamorphopsia, foveal microstructure, and visual function. We used a standard Amsler chart to detect subjective metamorphopsia and a modified Amsler chart to quantify metamorphopsia. We used the enhanced-depth imaging optical coherence tomography (EDI-OCT) to detect changes in PFD and the foveal microstructure. p < 0.05.</p><p><strong>Results: </strong>The study included 50 study eyes and 50 control eyes. The male gender constituted 70%. The mean age was 53 years. The mean baseline BCVA was 0.001. The incidence of foveal displacement was 70%. Disorganized retinal inner layers (DRIL) occurred in 56% of eyes, and disorganized retinal outer layers (DROL) occurred in 72% of eyes. The mean postoperative BCVA was 0.3. The subjective metamorphopsia was mild in 39%, moderate in 24%, severe in 33%, and very severe in 3% of eyes. The mean quantitative metamorphopsia was 587 mm. PVR correlated significantly with the foveal shift. DROL correlated significantly with subjective metamorphopsia. There was a statistically significant difference between subjective metamorphopsia and quantitative metamorphopsia.</p><p><strong>Conclusion: </strong>Foveal displacement and metamorphopsia after successful retinal reattachment pose significant morbidity. UHR-OCT is pivotal in evaluating the anatomical outcome after successful retinal re-attachment surgery and its relation to visual function.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"10 1","pages":"88"},"PeriodicalIF":1.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choroidal vascularity index in health and systemic diseases: a systematic review.","authors":"Mehrdad Motamed Shariati, Sahel Khazaei, Mariye Yaghoobi","doi":"10.1186/s40942-024-00607-8","DOIUrl":"10.1186/s40942-024-00607-8","url":null,"abstract":"<p><strong>Background: </strong>The choroid, a highly vascular structure within the eye, is significantly influenced by various systemic conditions. The advent of enhanced depth optical coherence tomography has improved our ability to evaluate choroidal pathophysiology. The choroidal vascularity index (CVI), a noninvasive and reliable tool, serves as an effective means of assessing the choroidal vascular structure. Recent studies have increasingly focused on exploring CVI alterations under different systemic conditions. This study aims to provide a comprehensive summary of the latest research findings in this area.</p><p><strong>Methods: </strong>A systematic literature review was conducted on October 1, 2023, using two databases, MEDLINE (via PubMed) and Scopus. Search terms were tailored specifically for each database to ensure a thorough exploration of relevant literature. The studies identified were qualitatively assessed, with particular emphasis on outcomes related to CVI and choroidal thickness.</p><p><strong>Results: </strong>A total of 48 studies were included in the review, encompassing a diverse range of systemic conditions such as diabetes, central nervous system disorders, cardiovascular diseases, autoimmune disorders, and infectious diseases. Notable reductions in CVI were observed in diabetic retinopathy, autoimmune diseases, and neurodegenerative disorders. Additionally, the review highlighted variations in CVI values related to the severity of systemic diseases, indicating its potential use as a biomarker for disease progression.</p><p><strong>Conclusion: </strong>This review highlights the significant correlation between variations in the choroidal vascularity index and diverse systemic conditions affecting hemodynamics. An enhanced understanding of CVI provides deeper insights into the pathophysiological mechanisms underlying these disorders and positions CVI as a promising biomarker for early detection and monitoring. Nevertheless, its clinical utility warrants careful assessment. Future research should address the potential limitations of CVI to fully capitalize on its diagnostic and prognostic potential.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"10 1","pages":"87"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is retinal vein occlusion highly associated with an increased risk of myocardial infarction? A systematic review and meta-analysis.","authors":"Kai-Yang Chen, Hoi-Chun Chan, Chi-Ming Chan","doi":"10.1186/s40942-024-00606-9","DOIUrl":"10.1186/s40942-024-00606-9","url":null,"abstract":"<p><strong>Background and objective: </strong>Retinal vein occlusion (RVO) and acute myocardial infarction (MI) are significant vascular events that impact patient health and mortality. Both conditions share common risk factors, such as hypertension, diabetes, and atherosclerosis. This study investigated the potential connection between RVO and MI, particularly among younger individuals, to improve preventive measures and management protocols.</p><p><strong>Method: </strong>A systematic review and meta-analysis were conducted, adhering to the PRISMA and MOOSE guidelines. Multiple databases, including PubMed, Scopus, MEDLINE, ScienceDirect, and ClinicalTrials.gov, were exhaustively searched until August 24, 2024. Studies were selected based on their reports of the association between RVO and MI risk. Quality assessment was performed using the Newcastle-Ottawa Quality Assessment Scale, and data were pooled using a random-effects model with hazard ratios and 95% confidence intervals.</p><p><strong>Result: </strong>Twelve studies comprising 371,817 participants were included. Meta-analysis revealed a pooled hazard ratio of 1.324 (95% CI, 1.238-1.415), indicating a significant association between RVO and increased MI risk (p = 0.0001). Subgroup analysis for central retinal vein occlusion (CRVO) showed a hazard ratio of 1.691 (95% confidence interval [CI] 1.142, 2.502, p = 0.009) with moderate heterogeneity (I² = 36%), whereas branch retinal vein occlusion (BRVO) yielded a non-significant hazard ratio of 1.167 (95% CI 0.843, 2.106, p = 0.444; I² = 33%). Publication bias was identified (Egger's test, p = 0.036) and addressed through trim-and-fill adjustment, maintaining statistical significance.</p><p><strong>Conclusion: </strong>Our meta-analysis shows a strong association between CRVO and a 69.1% increased risk of MI, while BRVO shows no significant correlation. Overall, RVO is linked to a 32.4% elevated risk of MI. Despite slight publication bias, adjusted analyses confirm reliability, indicating that improved cardiovascular monitoring for RVO patients, especially those with CRVO, is essential to mitigate MI risk.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"10 1","pages":"86"},"PeriodicalIF":1.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}