International Journal of Retina and Vitreous最新文献

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Effect of internal limiting membrane surgical techniques on the idiopathic and refractory management of macular holes: a systematic review and meta-analysis. 内限制膜手术技术对特发性和难治性黄斑孔治疗的影响:系统回顾和荟萃分析。
IF 1.9
International Journal of Retina and Vitreous Pub Date : 2024-06-21 DOI: 10.1186/s40942-024-00564-2
Miguel A Quiroz-Reyes, Erick A Quiroz-Gonzalez, Miguel A Quiroz-Gonzalez, Virgilio Lima-Gomez
{"title":"Effect of internal limiting membrane surgical techniques on the idiopathic and refractory management of macular holes: a systematic review and meta-analysis.","authors":"Miguel A Quiroz-Reyes, Erick A Quiroz-Gonzalez, Miguel A Quiroz-Gonzalez, Virgilio Lima-Gomez","doi":"10.1186/s40942-024-00564-2","DOIUrl":"10.1186/s40942-024-00564-2","url":null,"abstract":"<p><p>Macular holes (MHs), including atraumatic idiopathic and refractory MHs, affect central vision acuity due to full-thickness defects in the retinal tissue. The existing controversy regarding the pathophysiology and management of MHs has significantly improved with the implementation of internal limiting membrane (ILM) surgical techniques and improved MH closure rates. Thus, to determine the effect of ILM techniques on large idiopathic and refractory MH management, the present study systematically reviewed 5910 original research articles extracted from online literature databases, including PubMed, Cochrane, Google Scholar, and Embase, following the PRISMA guidelines. The primary outcome measures were MH closure rate and postoperative visual acuity. A total of 23 randomized controlled trials (RCTs) with adequate patient information and information on the effect of ILM peeling, inverted ILM flaps, autologous retinal transplantation (ART), and ILM insertion techniques on large idiopathic and refractory MH patients were retrieved and analyzed using RevMan software (version 5.3) provided by the Cochrane Collaboration. Statistical risk of bias analysis was also conducted on the selected sources using RoB2, which showed a low risk of bias in the included studies. A meta-analysis indicated that the inverted ILM flap technique had a significantly greater MH closure rate for primary MH than the other treatment methods (OR = 3. 22, 95% CI 1.34-7.43; p = 0.01). Furthermore, the findings showed that the inverted ILM flap group had significantly better postoperative visual acuity than did the other treatment options for patients with idiopathic MH (WMD = - 0.13; 95% CI = 0.22-0.09; p = 0.0002). The ILM peeling technique had the second highest statistical significance for MH closure rates in patients with idiopathic MH (OR = 2. 72, 95% CI: 1.26-6.32; p = 0.016). In refractory MHs, autologous retinal transplant (ART) and multilayer ILM plug (MIP) techniques improve the closure rate and visual function; human amniotic membrane grafting (hAMG) provides a high degree of anatomical outcomes but disappointing visual results. This study demonstrated the reliability and effectiveness of ILM techniques in improving the functional and anatomical outcomes of large idiopathic and refractory MH surgery. These findings will help clinicians choose the appropriate treatment technique for patients with idiopathic and refractory MH.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Image quality comparison of AirDoc portable retina camera versus eyer in a diabetic retinopathy screening program. 在糖尿病视网膜病变筛查项目中,AirDoc 便携式视网膜照相机与 eyer 的图像质量比较。
IF 2.3
International Journal of Retina and Vitreous Pub Date : 2024-06-14 DOI: 10.1186/s40942-024-00559-z
Rodrigo Brant, Luis Filipe Nakayama, Talita Virgínia Fernandes de Oliveira, Juliana Angelica Estevão de Oliveira, Lucas Zago Ribeiro, Gabriela Dalmedico Richter, Rafael Rodacki, Fernando Marcondes Penha
{"title":"Image quality comparison of AirDoc portable retina camera versus eyer in a diabetic retinopathy screening program.","authors":"Rodrigo Brant, Luis Filipe Nakayama, Talita Virgínia Fernandes de Oliveira, Juliana Angelica Estevão de Oliveira, Lucas Zago Ribeiro, Gabriela Dalmedico Richter, Rafael Rodacki, Fernando Marcondes Penha","doi":"10.1186/s40942-024-00559-z","DOIUrl":"10.1186/s40942-024-00559-z","url":null,"abstract":"<p><strong>Background: </strong>Diabetic retinopathy (DR) stands as the foremost cause of preventable blindness in adults. Despite efforts to expand DR screening coverage in the Brazilian public healthcare system, challenges persist due to various factors including social, medical, and financial constraints. Our objective was to evaluate the quality of images obtained with the AirDoc, a novel device, compared to Eyer portable camera which has already been clinically validated.</p><p><strong>Methods: </strong>Images were captured by two portable retinal devices: AirDoc and Eyer. The included patients had their fundus images obtained in a screening program conducted in Blumenau, Santa Catarina. Two retina specialists independently assessed image's quality. A comparison was performed between both devices regarding image quality and the presence of artifacts.</p><p><strong>Results: </strong>The analysis included 129 patients (mean age of 61 years), with 29 (43.28%) male and an average disease duration of 11.1 ± 8 years. In Ardoc, 21 (16.28%) images were classified as poor quality, with 88 (68%) presenting artifacts; in Eyer, 4 (3.1%) images were classified as poor quality, with 94 (72.87%) presenting artifacts.</p><p><strong>Conclusions: </strong>Although both Eyer and AirDoc devices show potential as screening tools, the AirDoc images displayed higher rates of ungradable and low-quality images, that may directly affect the DR and DME grading. We must acknowledge the limitations of our study, including the relatively small sample size. Therefore, the interpretations of our analyses should be approached with caution, and further investigations with larger patient cohorts are warranted to validate our findings.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141320848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of optical coherence tomography biomarker probability detection in central serous chorioretinopathy by using an artificial intelligence-based biomarker detector. 利用基于人工智能的生物标记检测器分析中心性浆液性脉络膜视网膜病变的光学相干断层扫描生物标记概率检测。
IF 2.3
International Journal of Retina and Vitreous Pub Date : 2024-05-31 DOI: 10.1186/s40942-024-00560-6
Lorenzo Ferro Desideri, Rodrigo Anguita, Lieselotte E Berger, Helena M A Feenstra, Davide Scandella, Raphael Sznitman, Camiel J F Boon, Elon H C van Dijk, Martin S Zinkernagel
{"title":"Analysis of optical coherence tomography biomarker probability detection in central serous chorioretinopathy by using an artificial intelligence-based biomarker detector.","authors":"Lorenzo Ferro Desideri, Rodrigo Anguita, Lieselotte E Berger, Helena M A Feenstra, Davide Scandella, Raphael Sznitman, Camiel J F Boon, Elon H C van Dijk, Martin S Zinkernagel","doi":"10.1186/s40942-024-00560-6","DOIUrl":"10.1186/s40942-024-00560-6","url":null,"abstract":"<p><strong>Aim: </strong>To adopt a novel artificial intelligence (AI) optical coherence tomography (OCT)-based program to identify the presence of biomarkers associated with central serous chorioretinopathy (CSC) and whether these can differentiate between acute and chronic central serous chorioretinopathy (aCSC and cCSC).</p><p><strong>Methods: </strong>Multicenter, observational study with a retrospective design enrolling treatment-naïve patients with aCSC and cCSC. The diagnosis of aCSC and cCSC was established with multimodal imaging and for the current study subsequent follow-up visits were also considered. Baseline OCTs were analyzed by an AI-based platform (Discovery® OCT Fluid and Biomarker Detector, RetinAI AG, Switzerland). This software allows to detect several different biomarkers in each single OCT scan, including subretinal fluid (SRF), intraretinal fluid (IRF), hyperreflective foci (HF) and flat irregular pigment epithelium detachment (FIPED). The presence of SRF was considered as a necessary inclusion criterion for performing biomarker analysis and OCT slabs without SRF presence were excluded from the analysis.</p><p><strong>Results: </strong>Overall, 160 eyes of 144 patients with CSC were enrolled, out of which 100 (62.5%) eyes were diagnosed with cCSC and 60 eyes (34.5%) with aCSC. In the OCT slabs showing presence of SRF the presence of biomarkers was found to be clinically relevant (> 50%) for HF and FIPED in aCSC and cCSC. HF had an average percentage of 81% (± 20) in the cCSC group and 81% (± 15) in the aCSC group (p = 0.4295) and FIPED had a mean percentage of 88% (± 18) in cCSC vs. 89% (± 15) in the aCSC (p = 0.3197).</p><p><strong>Conclusion: </strong>We demonstrate that HF and FIPED are OCT biomarkers positively associated with CSC when present at baseline. While both HF and FIPED biomarkers could aid in CSC diagnosis, they could not distinguish between aCSC and cCSC at the first visit. AI-assisted biomarker detection shows promise for reducing invasive imaging needs, but further validation through longitudinal studies is needed.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using 2% PVPI topical solution for serial intravitreous injections and ocular surface findings: a case control study. 使用 2% PVPI 局部溶液进行连续玻璃体内注射与眼表发现:一项病例对照研究。
IF 2.3
International Journal of Retina and Vitreous Pub Date : 2024-05-29 DOI: 10.1186/s40942-024-00557-1
José Henrique Casemiro, Ana Paula Miyagusko Taba Oguido, Antonio Marcelo Barbante Casella
{"title":"Using 2% PVPI topical solution for serial intravitreous injections and ocular surface findings: a case control study.","authors":"José Henrique Casemiro, Ana Paula Miyagusko Taba Oguido, Antonio Marcelo Barbante Casella","doi":"10.1186/s40942-024-00557-1","DOIUrl":"10.1186/s40942-024-00557-1","url":null,"abstract":"<p><strong>Background: </strong>The use of povidone-iodine for ocular surface asepsis is widespread for intravitreal injections. They became frequent procedures, leading to serial exposure of patients' eyes to iodinated solutions. In this study, we investigate the changes in the ocular surface in patients submitted to repeated use of povidine for intravitreal injection of anti-VEGF asepsis, analyzing Ocular Surface Disease Index, non-invasive break up time, blinking quality, lipid layer, meniscus height and osmolarity.</p><p><strong>Methods: </strong>This case-control study included 34 individuals (68 eyes), 14 males, 20 females aged 48 to 94. Inclusion criteria were individuals who received application of 2% povidone-iodine eyedrops for intravitreal injections treatment with the non-treated contralateral eye used as control. Ocular surface examinations were performed at a single occasion. A pre-intravitreal injection asepsis protocol with povidone-iodine was applied. All statistical analysis was performed using the STATA® 18.0 Software and a p-value = 0.05 was considered as the statistical significance value in all tests.</p><p><strong>Results: </strong>The median number of IVIs in treated eyes was 12 (range 6-20). The results in treated eyes compared with untreated eyes were respectively : median OSDI 16 (IQR 6-39) and 12.5 (IQR 8-39) (p = 0.380); mean NIBUT 10.30 (SD ± 2.62) and 10.78 (SD ± 2.92) ( s, p = 0.476); median blinking quality 100 (IQR 100) and 100 (IQR 100 ) (%, p = 0.188); median lipid layer 87 (IQR 77-90) and 86 (IQR 74-100) (nm, p = 0.451); median meniscus height 0.22 (IQR 0.19-0,31) and 0.24 (IQR 0.20-0.27) (mm, p = 0.862), median Meibomian gland atrophy 33 (IQR 24-45) and 31.5 (IQR 25-39) (%, p = 0.524); and mean osmolarity 306.6 (SD ± 21.13) and 313.8 (SD ± 29) (mOsm, p = 0.297). There was no statistically significant relationship between the repetitive use of 2% iodinated solution and signs or symptoms compatible with dry eye syndrome in this group of patients.</p><p><strong>Conclusions: </strong>The findings suggest that 2% povidone iodine is a safe and efficacious agent for ocular surface antisepsis during intravitreal injections, not leading to substantial ocular surface modifications. This conclusion supports the continued use of povidone iodine in routine ophthalmic procedures without increased risk of inducing dry eye syndrome.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11134966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Near vision in patients with DME and RVO treated with aflibercept and correlation with NEI VFQ-25 questionnaire. 用阿弗利贝赛治疗 DME 和 RVO 患者的近视力以及与 NEI VFQ-25 问卷的相关性。
IF 2.3
International Journal of Retina and Vitreous Pub Date : 2024-05-23 DOI: 10.1186/s40942-024-00558-0
Zuzana Anwarzai Sulavikova, Zuzana Sustykevicova, Marek Kacerik, Vladimir Krasnik
{"title":"Near vision in patients with DME and RVO treated with aflibercept and correlation with NEI VFQ-25 questionnaire.","authors":"Zuzana Anwarzai Sulavikova, Zuzana Sustykevicova, Marek Kacerik, Vladimir Krasnik","doi":"10.1186/s40942-024-00558-0","DOIUrl":"10.1186/s40942-024-00558-0","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study is to evaluate near and distance visual acuity (VA) and their correlation with the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) outcomes in patients with diabetic macular edema (DME) and macular edema due to retinal vein occlusion (RVO) treated with aflibercept.</p><p><strong>Methods: </strong>In this prospective study, we included 87 eyes of patients diagnosed with DME (n = 61) and RVO (n = 26), who received aflibercept treatment and were followed until the 8th injection. Near VA was examined on the 1st, 2nd, 3rd, 4th, 6th, and 8th injection, and patients completed the NEI VFQ-25 on the 1st, 4th, and 8th aflibercept injection.</p><p><strong>Results: </strong>The mean near VA at baseline in all eyes was 0.89 ± 0.12 logMAR. With every administration, there was a statistically significant improvement; on the 4th (0.70 ± 0.19; p = 0.000) and the 8th application (0.60 ± 0.19; p = 0.000). At baseline, the mean NEI VFQ-25 total score was 71 ± 14%, and improved to 81 ± 13% (p = 0.000) on the 8th injection. The most significant score gain was recorded in the near VA subscale (+ 20 ± 14%, p = 0.000). There was no statistically significant difference between DME and RVO group in the questionnaire or near VA outcomes.</p><p><strong>Conclusion: </strong>Aflibercept treatment resulted in a remarkable improvement of near vision by 4 lines of logMAR optotype after the 8th application. The near vision questionnaire subscale, initially scoring the lowest, exhibited the greatest gain during the treatment period. This underscores the importance of near vision and reading ability for patients with DME and RVO.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11112959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A pilot cost-analysis study comparing AI-based EyeArt® and ophthalmologist assessment of diabetic retinopathy in minority women in Oslo, Norway. 一项试点成本分析研究,比较了基于人工智能的 EyeArt® 和眼科医生对挪威奥斯陆少数民族妇女糖尿病视网膜病变的评估。
IF 2.3
International Journal of Retina and Vitreous Pub Date : 2024-05-23 DOI: 10.1186/s40942-024-00547-3
Mia Karabeg, Goran Petrovski, Silvia Nw Hertzberg, Maja Gran Erke, Dag Sigurd Fosmark, Greg Russell, Morten C Moe, Vallo Volke, Vidas Raudonis, Rasa Verkauskiene, Jelizaveta Sokolovska, Inga-Britt Kjellevold Haugen, Beata Eva Petrovski
{"title":"A pilot cost-analysis study comparing AI-based EyeArt® and ophthalmologist assessment of diabetic retinopathy in minority women in Oslo, Norway.","authors":"Mia Karabeg, Goran Petrovski, Silvia Nw Hertzberg, Maja Gran Erke, Dag Sigurd Fosmark, Greg Russell, Morten C Moe, Vallo Volke, Vidas Raudonis, Rasa Verkauskiene, Jelizaveta Sokolovska, Inga-Britt Kjellevold Haugen, Beata Eva Petrovski","doi":"10.1186/s40942-024-00547-3","DOIUrl":"10.1186/s40942-024-00547-3","url":null,"abstract":"<p><strong>Background: </strong>Diabetic retinopathy (DR) is the leading cause of adult blindness in the working age population worldwide, which can be prevented by early detection. Regular eye examinations are recommended and crucial for detecting sight-threatening DR. Use of artificial intelligence (AI) to lessen the burden on the healthcare system is needed.</p><p><strong>Purpose: </strong>To perform a pilot cost-analysis study for detecting DR in a cohort of minority women with DM in Oslo, Norway, that have the highest prevalence of diabetes mellitus (DM) in the country, using both manual (ophthalmologist) and autonomous (AI) grading. This is the first study in Norway, as far as we know, that uses AI in DR- grading of retinal images.</p><p><strong>Methods: </strong>On Minority Women's Day, November 1, 2017, in Oslo, Norway, 33 patients (66 eyes) over 18 years of age diagnosed with DM (T1D and T2D) were screened. The Eidon - True Color Confocal Scanner (CenterVue, United States) was used for retinal imaging and graded for DR after screening had been completed, by an ophthalmologist and automatically, using EyeArt Automated DR Detection System, version 2.1.0 (EyeArt, EyeNuk, CA, USA). The gradings were based on the International Clinical Diabetic Retinopathy (ICDR) severity scale [1] detecting the presence or absence of referable DR. Cost-minimization analyses were performed for both grading methods.</p><p><strong>Results: </strong>33 women (64 eyes) were eligible for the analysis. A very good inter-rater agreement was found: 0.98 (P < 0.01), between the human and AI-based EyeArt grading system for detecting DR. The prevalence of DR was 18.6% (95% CI: 11.4-25.8%), and the sensitivity and specificity were 100% (95% CI: 100-100% and 95% CI: 100-100%), respectively. The cost difference for AI screening compared to human screening was $143 lower per patient (cost-saving) in favour of AI.</p><p><strong>Conclusion: </strong>Our results indicate that The EyeArt AI system is both a reliable, cost-saving, and useful tool for DR grading in clinical practice.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11112837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic and non-diabetic retinopathy: associated factors and anatomical correlation. 糖尿病和非糖尿病视网膜病变中玻璃体色素上皮衍生因子和血管内皮生长因子的水平:相关因素和解剖学关联。
IF 2.3
International Journal of Retina and Vitreous Pub Date : 2024-05-21 DOI: 10.1186/s40942-024-00556-2
Rami Al-Dwairi, Tamam El-Elimat, Abdelwahab Aleshawi, Ahmed Al Sharie, Seren Al Beiruti, Abdallah K Sharayah, Mohammed Allouh
{"title":"Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic and non-diabetic retinopathy: associated factors and anatomical correlation.","authors":"Rami Al-Dwairi, Tamam El-Elimat, Abdelwahab Aleshawi, Ahmed Al Sharie, Seren Al Beiruti, Abdallah K Sharayah, Mohammed Allouh","doi":"10.1186/s40942-024-00556-2","DOIUrl":"10.1186/s40942-024-00556-2","url":null,"abstract":"<p><strong>Background: </strong>This study aims to investigate the factors affecting the vitreous levels of pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VGEF) among patients with pars plana vitrectomy (PPV). Also, this study correlates the levels of PEDF with RRD characteristics.</p><p><strong>Methods: </strong>All patients who were scheduled for PPV for any indication were included in the study. They were divided into a case group which included patients with advanced PDR and a control group which included the remaining diagnoses. During the PPV, an undiluted vitreous sample was taken and the enzyme-linked immunosorbent assay method was utilized to measure the levels of VEGF and PEDF.</p><p><strong>Results: </strong>Eighty eyes were involved. Patients diagnosed with advanced PDR and endophthalmitis exhibited higher levels of VEGF. PEDF was affected inversely by the age of the patients and PEDF levels were higher in RRD and endophthalmitis cases. In patients with RRD, the level of PEDF was higher if the tear was found inferiorly, if the macula was detached, and with a longer duration of RRD.</p><p><strong>Conclusions: </strong>This study highlights the clinical importance of those biomarkers. Anti-VEGF-based treatment is the mainstay against PDR. PEDF may show a promising predictive values regarding patients with RRD.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11106866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing code-free deep learning models to expert-designed models for detecting retinal diseases from optical coherence tomography. 比较无代码深度学习模型和专家设计的模型,从光学相干断层扫描中检测视网膜疾病。
IF 2.3
International Journal of Retina and Vitreous Pub Date : 2024-04-26 DOI: 10.1186/s40942-024-00555-3
Samir Touma, Badr Ait Hammou, Fares Antaki, Marie Carole Boucher, Renaud Duval
{"title":"Comparing code-free deep learning models to expert-designed models for detecting retinal diseases from optical coherence tomography.","authors":"Samir Touma, Badr Ait Hammou, Fares Antaki, Marie Carole Boucher, Renaud Duval","doi":"10.1186/s40942-024-00555-3","DOIUrl":"https://doi.org/10.1186/s40942-024-00555-3","url":null,"abstract":"<p><strong>Background: </strong>Code-free deep learning (CFDL) is a novel tool in artificial intelligence (AI). This study directly compared the discriminative performance of CFDL models designed by ophthalmologists without coding experience against bespoke models designed by AI experts in detecting retinal pathologies from optical coherence tomography (OCT) videos and fovea-centered images.</p><p><strong>Methods: </strong>Using the same internal dataset of 1,173 OCT macular videos and fovea-centered images, model development was performed simultaneously but independently by an ophthalmology resident (CFDL models) and a postdoctoral researcher with expertise in AI (bespoke models). We designed a multi-class model to categorize video and fovea-centered images into five labels: normal retina, macular hole, epiretinal membrane, wet age-related macular degeneration and diabetic macular edema. We qualitatively compared point estimates of the performance metrics of the CFDL and bespoke models.</p><p><strong>Results: </strong>For videos, the CFDL model demonstrated excellent discriminative performance, even outperforming the bespoke models for some metrics: area under the precision-recall curve was 0.984 (vs. 0.901), precision and sensitivity were both 94.1% (vs. 94.2%) and accuracy was 94.1% (vs. 96.7%). The fovea-centered CFDL model overall performed better than video-based model and was as accurate as the best bespoke model.</p><p><strong>Conclusion: </strong>This comparative study demonstrated that code-free models created by clinicians without coding expertise perform as accurately as expert-designed bespoke models at classifying various retinal pathologies from OCT videos and images. CFDL represents a step forward towards the democratization of AI in medicine, although its numerous limitations must be carefully addressed to ensure its effective application in healthcare.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11055378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140850557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence in chorioretinal pathology through fundoscopy: a comprehensive review 人工智能在眼底镜检查脉络膜视网膜病理学中的应用:综述
IF 2.3
International Journal of Retina and Vitreous Pub Date : 2024-04-23 DOI: 10.1186/s40942-024-00554-4
Matthew Driban, Audrey Yan, A. Selvam, J. Ong, K. Vupparaboina, Jay Chhablani
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引用次数: 0
Management, risk factors and treatment outcomes of rhegmatogenous retinal detachment associated with giant retinal tears: scoping review 与巨大视网膜裂孔相关的流变性视网膜脱离的管理、风险因素和治疗效果:范围界定综述
IF 2.3
International Journal of Retina and Vitreous Pub Date : 2024-04-23 DOI: 10.1186/s40942-024-00552-6
Miguel A. Quiroz-Reyes, Zaheer-Ud-Din Babar, R. Hussain, Zhe Chi Loh, E. Quiroz-Gonzalez, M. A. Quiroz-Gonzalez, V. Lima-Gómez
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引用次数: 0
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