{"title":"Emotion: An evolutionary model of lateralization in the human brain.","authors":"Guido Gainotti","doi":"10.1016/B978-0-443-15646-5.00001-4","DOIUrl":"https://doi.org/10.1016/B978-0-443-15646-5.00001-4","url":null,"abstract":"<p><p>Since several reviews have recently discussed the lateralization of emotions, this chapter will take into account the possible evolutionary meaning of this lateralization. The organization of the chapter will be based on the following steps. I will first propose that emotions must be considered as a complex adaptive system, complementary to the more phylogenetically advanced cognitive system. Second, I will remind historical aspects and consolidated results on the lateralization of emotions. Then I will discuss the phylogenetic aspects of the problem, trying to evaluate if emotional asymmetries concern only humans and some nonhuman primates or are part of a continuum between humans and many phylogenetically distant animal species. After having reviewed various aspects of emotional lateralization across different animal species and (more specifically) in nonhuman primates, I will propose a general model of hemispheric asymmetries in the human brain, based on theoretical models and empiric data. Theoretical models stem from the influence that the presence or the absence of language can have on concomitant hemispheric functions, whereas supporting neuropsychologic data have been gathered in patients with unilateral brain damage.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"208 ","pages":"421-432"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interhemispheric differences in visual attention.","authors":"Carlo Alberto Marzi","doi":"10.1016/B978-0-443-15646-5.00028-2","DOIUrl":"https://doi.org/10.1016/B978-0-443-15646-5.00028-2","url":null,"abstract":"<p><p>The chapter explores the difference between the cerebral hemispheres in the three categories of attention described in the fundamental classification of Posner and Petersen: Alerting, Orienting, and Executive Functions. The first section is concerned with the brain localization of visuospatial attention as studied in brain-damaged patients, mainly hemineglect and callosum-sectioned patients. Other important results have been provided more recently by means of brain imaging studies of cortical and subcortical attention networks. Most of these studies have shown a clear dominance of the right hemisphere (RH) in visuospatial attention, but there are some exceptions. Accordingly, the second section concerns the role of the left hemisphere (LH) in visuospatial attention. A third section describes the contribution of attention to interhemispheric communication. A fourth section is focused on a discussion of the existence of hemispheric asymmetries not only in conscious but also in unconscious attention. Further, a fifth section concerns the effects of emotion on hemispheric differences in visuospatial attention. Finally, the last section briefly discusses the controversial evidence concerning laterality in executive functions.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"208 ","pages":"115-125"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Seeing and visualizing across the hemispheres.","authors":"Selene Schintu, Paolo Bartolomeo","doi":"10.1016/B978-0-443-15646-5.00019-1","DOIUrl":"https://doi.org/10.1016/B978-0-443-15646-5.00019-1","url":null,"abstract":"<p><p>Despite our subjective experience of a largely symmetric visual world, the human brain exhibits varying patterns and degrees of hemispheric asymmetry in distinct processes of visual cognition. This chapter reviews behavioral and neuroimaging evidence from neurotypical individuals and neurological patients, concerning functional asymmetries between the right hemisphere (RH) and the left hemisphere (LH) in visual object processing and mental imagery. Hierarchical perception shows RH preference for global processing and LH preference for local processing. At later stages of visual object processing, RH-based circuits exhibit a relative advantage in terms of perceptual integration, with a subsequent shift toward LH-based circuits for processing at higher conceptual and semantic levels. In voluntary visual mental imagery, circuits in the LH ventral temporal cortex play a pivotal role in transitioning from object meaning to simulated visualization. These hemispheric asymmetries in visual object processing might, in part, be influenced by the overall need to minimize wiring, coupled with the presence of distinct specialized networks within each hemisphere, such as the RH attention networks and the LH language networks. From a broader viewpoint, the evidence examined in this chapter indicates that visual object processing involves the interactions of large-scale cortical circuits within and between the hemispheres.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"208 ","pages":"481-497"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renata Cristina Mendes Ferreira, Francieli S Ruiz, Marco Túlio de Mello
{"title":"Human sleep and immunity: The role of circadian patterns.","authors":"Renata Cristina Mendes Ferreira, Francieli S Ruiz, Marco Túlio de Mello","doi":"10.1016/B978-0-323-90918-1.00003-4","DOIUrl":"https://doi.org/10.1016/B978-0-323-90918-1.00003-4","url":null,"abstract":"<p><p>It is well established that sleep promotes health and welfare. Literature data suggests that sleep is a recurrent resting state that performs multiple biological functions, such as memory consolidation and regulation of glucose, lipid metabolism, energy metabolism, eating behavior, and blood pressure, besides, regulating the immune system. These immunological functions depend on regular sleep and circadian rhythms, as both impact the magnitude of immune responses. Circadian rhythm is the 24-h internal clock in our brain that regulates cycles of alertness and sleepiness by responding to light changes in our environment. It encompasses physical and behavioral daily oscillations. Sleep deprivation and circadian misalignment affect immunity, and both have been related to adverse health effects and chronic diseases. Studies have shown that individuals with regular and consistent sleep patterns have a more effective immune response. Thus, understanding how sleep disturbance will affect the immune response is vital in developing interventions to prevent the health burden of irregular sleep patterns and circadian misalignment, favoring a homeostatic immune defense to microbial or inflammatory insults. Therefore, the scope of this chapter is to explore evidence that regular circadian rhythms and sleep patterns are needed for optimal resistance to infectious challenges.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"206 ","pages":"93-103"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gliotransmission in physiologic and pathologic conditions.","authors":"Eunji Cheong, C Justin Lee","doi":"10.1016/B978-0-443-19104-6.00003-6","DOIUrl":"https://doi.org/10.1016/B978-0-443-19104-6.00003-6","url":null,"abstract":"<p><p>This chapter explores the roles of gliotransmission in physiologic and pathologic conditions, including psychiatric and neurologic disorders. Gliotransmission, facilitated by astrocytes through the release of gliotransmitters such as glutamate, d-serine, and GABA, regulates neuronal activity and synaptic transmission. Under physiologic conditions, astrocytic gliotransmission maintains the balance of tonic excitation and inhibition, influencing synaptic plasticity and cognitive functions. In psychiatric disorders, the chapter examines how dysregulated gliotransmission contributes to major depression and schizophrenia. In major depression, changes in astrocytic glutamate and adenosine signaling impact mood regulation and cognitive functions. Schizophrenia involves complex astrocyte-neuron interactions, with dysregulated astrocytic activity affecting synaptic function and contributing to symptoms. The chapter also delves into neurologic disorders. In Alzheimer disease, aberrant GABA release from reactive astrocytes impairs memory and cognitive functions. Parkinson disease features alterations in glutamatergic and GABAergic systems, affecting motor and nonmotor symptoms. Epilepsy involves a disruption in the balance between excitatory and inhibitory neurotransmission, with astrocytic GABA accumulation helping to maintain neuronal stability. Autism spectrum disorder (ASD) is linked to imbalances in glutamatergic and GABAergic neurotransmission, underlying sensory, cognitive, and social impairments. Overall, the chapter underscores the pivotal role of gliotransmission in maintaining neural homeostasis and highlights its potential as a therapeutic target in various disorders.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"209 ","pages":"93-116"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Foreword.","authors":"Michael J Aminoff, François Boller, Dick F Swaab","doi":"10.1016/B978-0-443-19104-6.09999-X","DOIUrl":"https://doi.org/10.1016/B978-0-443-19104-6.09999-X","url":null,"abstract":"","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"209 ","pages":"ix"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Emerging ethical issues in patients with disorders of consciousness: A clinical guide.","authors":"James L Bernat, Joseph J Fins","doi":"10.1016/B978-0-443-13408-1.00001-4","DOIUrl":"https://doi.org/10.1016/B978-0-443-13408-1.00001-4","url":null,"abstract":"<p><p>Clinicians who manage patients with disorders of consciousness (DoC) commonly encounter challenging ethical issues. Consciousness disorders include the vegetative state, the minimally conscious state, and covert consciousness resulting from cognitive-motor dissociation. The practice landscape of ethical issues encompasses making the correct diagnosis; making and communicating an accurate prognosis despite irreducible uncertainty; conducting effective shared decision-making with a lawful surrogate decision-maker to deliver goal-concordant care; providing optimal medical, rehabilitative, and palliative care across the spectrum of care sites: acute inpatient, neurorehabilitative, chronic, and palliative; respecting the human rights of and advocating for DoC patient, an historically under-served population and, when appropriate, properly participating in decisions to withhold or withdraw life-sustaining therapy. Research and translational issues in DoC patients include the challenges posed by emerging diagnostics and therapeutics and their prudential integration into clinical practice in the service of patients and their families. Our conceptual analysis of these ethical issues and our practical advice to address them comprise the subject material of this chapter.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"207 ","pages":"217-236"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neuroglia in autism spectrum disorders.","authors":"Vivi M Heine, Stephanie Dooves","doi":"10.1016/B978-0-443-19102-2.00006-5","DOIUrl":"https://doi.org/10.1016/B978-0-443-19102-2.00006-5","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is characterized by difficulties in social interaction, communication, and repetitive behavior, typically diagnosed during early childhood and attributed to altered neuronal network connectivity. Several genetic and environmental risk factors contribute to ASD, including pre- or early life immune activation, which can trigger microglial and astroglial reactivity, impacting early neurodevelopment. In ASD, astrocytes show altered glutamate metabolism, directly influencing neuronal network activity, while microglia display impaired synaptic pruning, an essential developmental process for the refinement of neuronal connections. Additionally, reduced myelination in specific cortical and subcortical regions may affect brain connectivity in ASD, with white matter integrity correlating with the severity of the disorder, suggesting an important role for oligodendrocytes and myelin in ASD. This chapter provides an overview of current literature on the role of neuroglia cells in ASD, with a focus on immune activation, glutamate signaling, synaptic pruning, and myelination.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"210 ","pages":"303-311"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hemispheric asymmetries in face recognition in health and dysfunction.","authors":"Marlene Behrmann","doi":"10.1016/B978-0-443-15646-5.00010-5","DOIUrl":"https://doi.org/10.1016/B978-0-443-15646-5.00010-5","url":null,"abstract":"<p><p>A defining characteristic of the human brain is that, notwithstanding the clear anatomic similarities, the two cerebral hemispheres have several different functional superiorities. The focus of this chapter is on the hemispheric asymmetry associated with the function of face identity processing, a finely tuned and expert behavior for almost all humans that is acquired incidentally from birth and continues to be refined through early adulthood. The first section lays out the well-accepted doctrine that face perception is a product of the right hemisphere, a finding based on longstanding behavioral data from healthy adult human observers. Data are then presented from neuropsychologic studies conducted with individuals with prosopagnosia, which is either acquired after a lesion to the right hemisphere or is developmental in nature with no obvious lesion. The second section reviews data on the neural correlates of face perception, gathered using a host of imaging methodologies all the way from electroencephalography (EEG) through functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) studies to transcranial magnetic stimulation and intracranial depth recording. The penultimate section reviews empirical findings that track the emergence of the hemispheric asymmetry for faces, and offers a theoretical proposal that lays out possible origins of the adult asymmetry profile. Lastly, the hemispheric asymmetry associated with the perception of emotional face expression is considered. While considerable progress has been made in understanding the functional organization of the human cerebral cortex and its biases and asymmetries, much remains to be determined and the many inconsistencies remain to be reconciled in future research.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"208 ","pages":"433-447"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hemispheric asymmetry in neurodegenerative diseases.","authors":"Stefano F Cappa","doi":"10.1016/B978-0-443-15646-5.00009-9","DOIUrl":"https://doi.org/10.1016/B978-0-443-15646-5.00009-9","url":null,"abstract":"<p><p>Hemispheric asymmetry in pathologic involvement is frequently observed in neurodegenerative disorders (NDD) and is responsible for differences in cognitive and motor clinical manifestations in individual patients. While asymmetry is modest in typical Alzheimer disease (AD), atypical AD presentations with prominent language impairment [logopenic/phonologic variant of primary progressive aphasia (L/Phv-PPA)] are associated with prevalent involvement of the language-dominant hemisphere. Similarly, in the frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) spectrum, the semantic (Sv) and nonfluent/agrammatic (Nf/Av) variants of PPA are due to asymmetric pathology involving the language-dominant hemisphere. A reversed (typically right-sided) pattern of asymmetry is often found in conditions associated with prominent disorders of behavior and social cognition (i.e., behavioral variant of frontotemporal degeneration-Bv FTD). Asymmetry is generally modest and less consistent in NDD with prevalent motor manifestations, such as Parkinson disease (PD). Overall, the pattern of hemispheric involvement reflects the network-specific selectivity of NDD and is compatible with the spreading of pathology along connection pathways.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"208 ","pages":"101-112"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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