The involvement of the cholinergic system in Parkinson disease.

Q2 Medicine

Handbook of clinical neurology Pub Date : 2025-01-01 DOI:10.1016/B978-0-443-19088-9.00001-9

Jacopo Pasquini, David J Brooks, Nicola Pavese

引用次数: 0

Abstract

In Parkinson disease (PD), cholinergic dysfunction develops in the early stages of the neurodegenerative process and progresses over time. Basal forebrain cholinergic system dysfunction is historically linked to cognitive decline in the dementia spectrum, and its pathophysiologic role in PD-related cognitive impairment has now been well established. However, cholinergic system dysfunction is also linked to several other manifestations of PD, such as gait difficulties, REM sleep behavior disorder (RBD), neuropsychiatric manifestations such as depression and visual hallucinations, and olfactory dysfunction. Furthermore, disruption of the striatal intrinsic cholinergic system, which modulates dopamine release, has been linked to cardinal motor manifestations and dyskinesia. Manifestations of cognitive decline, gait problems, falls, and RBD tend to cluster in a subset of people with PD, so that a "cholinergic phenotype" has been proposed. In this chapter, the involvement of the cholinergic system and its clinical correlates in PD will be discussed.

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胆碱能系统在帕金森病中的作用。

在帕金森病（PD）中，胆碱能功能障碍出现在神经退行性过程的早期阶段，并随着时间的推移而发展。基底前脑胆碱能系统功能障碍历来与痴呆症谱系中的认知能力下降有关，其在pd相关认知障碍中的病理生理作用现已得到很好的证实。然而，胆碱能系统功能障碍也与PD的其他几种表现有关，如步态困难、快速眼动睡眠行为障碍（RBD）、神经精神表现，如抑郁和视觉幻觉，以及嗅觉功能障碍。此外，调节多巴胺释放的纹状体内在胆碱能系统的破坏与主要运动表现和运动障碍有关。认知能力下降、步态问题、跌倒和RBD的表现倾向于聚集在PD患者的一个子集中，因此提出了“胆碱能表型”。在本章中，将讨论胆碱能系统及其临床相关因素在帕金森病中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Handbook of clinical neurology Medicine-Neurology (clinical)

CiteScore

4.10

自引率

0.00%

发文量

302

期刊介绍： The Handbook of Clinical Neurology (HCN) was originally conceived and edited by Pierre Vinken and George Bruyn as a prestigious, multivolume reference work that would cover all the disorders encountered by clinicians and researchers engaged in neurology and allied fields. The first series of the Handbook (Volumes 1-44) was published between 1968 and 1982 and was followed by a second series (Volumes 45-78), guided by the same editors, which concluded in 2002. By that time, the Handbook had come to represent one of the largest scientific works ever published. In 2002, Professors Michael J. Aminoff, François Boller, and Dick F. Swaab took on the responsibility of supervising the third (current) series, the first volumes of which published in 2003. They have designed this series to encompass both clinical neurology and also the basic and clinical neurosciences that are its underpinning. Given the enormity and complexity of the accumulating literature, it is almost impossible to keep abreast of developments in the field, thus providing the raison d''être for the series. The series will thus appeal to clinicians and investigators alike, providing to each an added dimension. Now, more than 140 volumes after it began, the Handbook of Clinical Neurology series has an unparalleled reputation for providing the latest information on fundamental research on the operation of the nervous system in health and disease, comprehensive clinical information on neurological and related disorders, and up-to-date treatment protocols.