Handbook of clinical neurology最新文献

Impact of sleep deprivation on dynamic functional connectivity states. 睡眠剥夺对动态功能连接状态的影响

Handbook of clinical neurology Pub Date : 2025-01-01 DOI: 10.1016/B978-0-323-90918-1.00012-5

Elisabetta Fasiello, Andrea Galbiati, Luigi Ferini-Strambi

引用次数: 0

Preface.

Handbook of clinical neurology Pub Date : 2025-01-01 DOI: 10.1016/B978-0-323-90918-1.09990-1

Luigi Ferini-Strambi, Christian Cajochen

引用次数: 0

Sleep and circadian rhythms after traumatic brain injury.

Handbook of clinical neurology Pub Date : 2025-01-01 DOI: 10.1016/B978-0-323-90918-1.00004-6

Narges Kalantari, Nadia Gosselin

{"title":"Sleep and circadian rhythms after traumatic brain injury.","authors":"Narges Kalantari, Nadia Gosselin","doi":"10.1016/B978-0-323-90918-1.00004-6","DOIUrl":"https://doi.org/10.1016/B978-0-323-90918-1.00004-6","url":null,"abstract":"Traumatic brain injury (TBI) is a serious public health concern and is one of the major causes of death and chronic disability in young individuals. Sleep-wake disturbances are among the most persistent and debilitating consequences of TBI and are reported by 50%-70% of TBI patients regardless of TBI severity. Excessive daytime sleepiness, fatigue, hypersomnia, and insomnia are the most common sleep disturbances in TBI patients. Post-TBI sleep-wake disturbances are often associated with pain, anxiety, depression, and posttraumatic stress disorder. They may exacerbate cognitive impairment following TBI, reduce community integration, and delay recovery and return to normal life. Changes in sleep architecture following TBI have been reported in the literature but cannot fully explain the extent and intensity of the sleep-wake disturbances reported by TBI patients. The alteration in the circadian timing system is another factor that may partially account for the presence of post-TBI sleep-wake disturbances. Current literature supports cognitive behavioral therapy and sleep hygiene education, light therapy, and certain pharmacologic interventions for treating sleep disturbances in TBI patients. Due to heterogeneous consequences of TBI, early screening and individualized approaches to treatment must be prioritized to improve sleep in TBI patients and consequently speed up recovery.","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"206 ","pages":"125-140"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhythms of light: Understanding the role of circadian timing in alertness and cognitive performance.

Handbook of clinical neurology Pub Date : 2025-01-01 DOI: 10.1016/B978-0-323-90918-1.00016-2

Renske Lok

{"title":"Rhythms of light: Understanding the role of circadian timing in alertness and cognitive performance.","authors":"Renske Lok","doi":"10.1016/B978-0-323-90918-1.00016-2","DOIUrl":"https://doi.org/10.1016/B978-0-323-90918-1.00016-2","url":null,"abstract":"The nonimage-forming effects of light are pivotal in regulating cognitive functions, including alertness, sustained attention, and higher-order cognitive processes. These cognitive domains are deeply influenced by the sleep-wake cycle, which are governed by two key processes: the homeostatic process, which builds sleep pressure during wakefulness, and the circadian process, which aligns with environmental light cues to regulate wakefulness and sleep. When these processes fall out of sync-a condition known as circadian misalignment-alertness, sustained attention, and cognitive performance can suffer significantly. This misalignment is often observed in shift workers, individuals experiencing jet lag, and those with circadian rhythm sleep disorders. However, strategic light exposure can help mitigate these cognitive impairments by realigning circadian rhythms, enhancing wakefulness during desired periods, and facilitating sleep when needed. This chapter examines the complex interplay between light, circadian rhythms, the sleep-wake cycle, and cognitive functioning, offering a comprehensive exploration of how these factors shape cognitive performance throughout the day and under conditions of circadian misalignment. It also discusses the broader implications of these interactions for cognitive health and performance.","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"206 ","pages":"17-26"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep and circadian dysfunction in Parkinson disease: New perspective and opportunities for treatment.

Handbook of clinical neurology Pub Date : 2025-01-01 DOI: 10.1016/B978-0-323-90918-1.00002-2

Yun Shen, Chun-Feng Liu

{"title":"Sleep and circadian dysfunction in Parkinson disease: New perspective and opportunities for treatment.","authors":"Yun Shen, Chun-Feng Liu","doi":"10.1016/B978-0-323-90918-1.00002-2","DOIUrl":"https://doi.org/10.1016/B978-0-323-90918-1.00002-2","url":null,"abstract":"Sleep and circadian dysfunction are common nonmotor symptoms in patients with Parkinson disease (PD). Sleep and circadian dysfunction usually have a significant negative impact on quality of life and may also serve as markers to identify patients in the preclinical stage of PD. Sleep disturbances have different types in PD such as insomnia, excessive daytime sleepiness, rapid eye movement sleep behavior disorders, restless legs syndrome, and sleep-disordered breathing. Because PD has a variety of clinical manifestations, sleep disorders and circadian dysfunction are most easy to be overlooked. The management of sleep and circadian dysfunction in patients with PD is complex as these conditions are heterogeneous; therefore, treatment plans must be individualized and directed at the underlying cause(s). Therefore, screening for and managing sleep and circadian dysfunction are important in clinical practice, and looking for new perspective and opportunities for treatment of them may improve the quality of life of PD patients. Therefore, screening for and managing sleep and circadian dysfunction are important in clinical practice. Looking for new perspective and opportunities for treatment will likely improve the quality of life of PD patients.","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"206 ","pages":"193-209"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of light on biological functions and human sleep.

Handbook of clinical neurology Pub Date : 2025-01-01 DOI: 10.1016/B978-0-323-90918-1.00008-3

Christine Blume, Mirjam Münch

{"title":"Effects of light on biological functions and human sleep.","authors":"Christine Blume, Mirjam Münch","doi":"10.1016/B978-0-323-90918-1.00008-3","DOIUrl":"https://doi.org/10.1016/B978-0-323-90918-1.00008-3","url":null,"abstract":"The nonvisual effects of light in humans are mainly conveyed by a subset of retinal ganglion cells that contain the pigment melanopsin which renders them intrinsically photosensitive (= intrinsically photosensitive retinal ganglion cells, ipRGCs). They have direct connections to the main circadian clock in the suprachiasmatic nuclei (SCN) of the hypothalamus and modulate a variety of physiological processes, pineal melatonin secretion, autonomic functions, cognitive processes such as attention, and behavior, including sleep and wakefulness. This is because efferent projections from the SCN reach other hypothalamic nuclei, the pineal gland, thalamus, basal forebrain, and the brainstem. The ipRGCs also directly impact the prefrontal cortex and the perihabenular nucleus (mood). In particular, light suppresses the secretion of melatonin in a dose-dependent manner, mainly depending on irradiance and spectral composition of light. There is evidence that exposure to light-emitting devices from luminaires and screens before bedtime can impact on sleep onset latency, sleep duration, and sleep quality. Likewise, light exposure during daytime modulates sleep architecture, duration, and sleep quality during the subsequent night. Therefore, the integration of acute, circadian, and long-term effects of light together influence sleep-wake quality and behavior in healthy individuals, as well as in patients with psychiatric or medical disorders.","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"206 ","pages":"3-16"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep and circadian rhythms modeling: From hypothalamic regulatory networks to cortical dynamics and behavior.

Handbook of clinical neurology Pub Date : 2025-01-01 DOI: 10.1016/B978-0-323-90918-1.00013-7

Svetlana Postnova, Paula Sanz-Leon

{"title":"Sleep and circadian rhythms modeling: From hypothalamic regulatory networks to cortical dynamics and behavior.","authors":"Svetlana Postnova, Paula Sanz-Leon","doi":"10.1016/B978-0-323-90918-1.00013-7","DOIUrl":"https://doi.org/10.1016/B978-0-323-90918-1.00013-7","url":null,"abstract":"Sleep and circadian rhythms are regulated by dynamic physiologic processes that operate across multiple spatial and temporal scales. These include, but are not limited to, genetic oscillators, clearance of waste products from the brain, dynamic interplay among brain regions, and propagation of local dynamics across the cortex. The combination of these processes, modulated by environmental cues, such as light-dark cycles and work schedules, represents a complex multiscale system that regulates sleep-wake cycles and brain dynamics. Physiology-based mathematical models have successfully explained the mechanisms underpinning dynamics at specific scales and are a useful tool to investigate interactions across multiple scales. They can help answer questions such as how do electroencephalographic (EEG) features relate to subthalamic neuron activity? Or how are local cortical dynamics regulated by the homeostatic and circadian mechanisms? In this chapter, we review two types of models that are well-positioned to consider such interactions. Part I of the chapter focuses on the subthalamic sleep regulatory networks and a model of arousal dynamics capable of predicting sleep, circadian rhythms, and cognitive outputs. Part II presents a model of corticothalamic circuits, capable of predicting spatial and temporal EEG features. We then discuss existing approaches and unsolved challenges in developing unified multiscale models.","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"206 ","pages":"37-58"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian rhythm disorders in the blind.

Handbook of clinical neurology Pub Date : 2025-01-01 DOI: 10.1016/B978-0-323-90918-1.00007-1

Maria Antonia Quera-Salva, Sarah Hartley, Karol Uscamaita

引用次数: 0

Advanced sleep phase syndrome: Role of genetics and aging.

Handbook of clinical neurology Pub Date : 2025-01-01 DOI: 10.1016/B978-0-323-90918-1.00005-8

Rosalia Silvestri, Biancamaria Guarnieri

{"title":"Advanced sleep phase syndrome: Role of genetics and aging.","authors":"Rosalia Silvestri, Biancamaria Guarnieri","doi":"10.1016/B978-0-323-90918-1.00005-8","DOIUrl":"https://doi.org/10.1016/B978-0-323-90918-1.00005-8","url":null,"abstract":"Advanced sleep phase (ASP) is seldom brought to medical attention because many individuals easily adapt to their early chronotype, especially if it emerges before the age of 30 and is present in a first-degree relative. In this case, the disorder is considered familial (FASP) and is mostly discovered coincidentally in the presence of other sleep disorders, mainly obstructive sleep apnea syndrome (OSAS). The prevalence of FASP is currently estimated to be between 0.21% and 0.5%. Autosomal dominant mutations in circadian clock genes like PER2, CK1, PER3, CRY2, TIMELESS, and DEC2 have been linked to FASP, some with pleiotropic effects influencing other health aspects like migraine and depression. Early morning awakening is, instead, more common among older individuals, occurring in almost 4% of cases, without considering associated comorbidities. Advanced sleep-wake phase disorder (ASWPD) is characterized by a consistent and distressing anticipation of sleep-wake timing, affecting almost 1% of middle-aged individuals. On average, women have a shorter circadian period than men, making them more susceptible to ASWPD, albeit no significant gender discrepancies have been observed. Age-related alterations in circadian rhythms are exacerbated and compounded by neurodegenerative disorders, impacting the suprachiasmatic nucleus (SCN), sensitivity to light, and light responsiveness in those affected. Conflicting data has surfaced regarding the protective or detrimental effects of ASWPD in studies on aging, mild cognitive impairment (MCI), and diverse dementia conditions.","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"206 ","pages":"61-70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Foreword. 前言

Handbook of clinical neurology Pub Date : 2025-01-01 DOI: 10.1016/B978-0-323-90918-1.09991-3

Michael J Aminoff, François Boller, Dick F Swaab

引用次数: 0