Impact of sleep deprivation on dynamic functional connectivity states.

Q2 Medicine

Handbook of clinical neurology Pub Date : 2025-01-01 DOI:10.1016/B978-0-323-90918-1.00012-5

Elisabetta Fasiello, Andrea Galbiati, Luigi Ferini-Strambi

引用次数: 0

Abstract

Sleep deprivation (SD) is an experimental procedure to study the effects of sleep loss on the human brain. Neuroimaging techniques, such as functional magnetic resonance imaging (fMRI) and electroencephalography (EEG), have been pivotal in studying these effects. The present chapter aims to retrace the state of the art regarding the literature that examines the SD effects on the brain through functional connectivity (FC) evaluated in fMRI and EEG settings, separately. Specifically, we focused on the cognitive domains mainly affected by sleep loss and the underlying brain connectivity alterations. SD disrupts homeostatic and circadian processes, negatively affecting cognitive and cerebral functionality explored through FC. All evidence confirms the detrimental role of SD on brain connectivity impacting several resting-state networks and resulting in cognitive impairments. To conclude, SD may offer useful insights into pathogenic mechanisms likely resembling those induced by chronic sleep loss that might find their application in the clinical context.

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睡眠剥夺对动态功能连接状态的影响

睡眠剥夺（SD）是一种研究睡眠缺失对人脑影响的实验程序。神经成像技术，如功能磁共振成像（fMRI）和脑电图（EEG），已经成为研究这些影响的关键。本章旨在回顾在功能磁共振成像和脑电图设置中分别通过功能连接（FC）评估SD对大脑的影响的文献的最新进展。具体来说，我们关注的是主要受睡眠不足和潜在的大脑连接改变影响的认知领域。SD破坏体内平衡和昼夜节律过程，对认知和大脑功能产生负面影响。所有证据都证实了SD对大脑连接的有害作用，影响了几个静息状态网络，导致认知障碍。综上所述，睡眠障碍可能为研究类似于慢性睡眠不足的致病机制提供有用的见解，这些机制可能会在临床环境中得到应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Handbook of clinical neurology Medicine-Neurology (clinical)

CiteScore

4.10

自引率

0.00%

发文量

302

期刊介绍： The Handbook of Clinical Neurology (HCN) was originally conceived and edited by Pierre Vinken and George Bruyn as a prestigious, multivolume reference work that would cover all the disorders encountered by clinicians and researchers engaged in neurology and allied fields. The first series of the Handbook (Volumes 1-44) was published between 1968 and 1982 and was followed by a second series (Volumes 45-78), guided by the same editors, which concluded in 2002. By that time, the Handbook had come to represent one of the largest scientific works ever published. In 2002, Professors Michael J. Aminoff, François Boller, and Dick F. Swaab took on the responsibility of supervising the third (current) series, the first volumes of which published in 2003. They have designed this series to encompass both clinical neurology and also the basic and clinical neurosciences that are its underpinning. Given the enormity and complexity of the accumulating literature, it is almost impossible to keep abreast of developments in the field, thus providing the raison d''être for the series. The series will thus appeal to clinicians and investigators alike, providing to each an added dimension. Now, more than 140 volumes after it began, the Handbook of Clinical Neurology series has an unparalleled reputation for providing the latest information on fundamental research on the operation of the nervous system in health and disease, comprehensive clinical information on neurological and related disorders, and up-to-date treatment protocols.