中枢神经系统胆碱能传递简史。

Q2 Medicine

Handbook of clinical neurology Pub Date : 2025-01-01 DOI:10.1016/B978-0-443-19088-9.00011-1

A Claudio Cuello, Ezio Giacobini

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引用次数: 0

摘要

本章提供了一个简明的事件演变的叙述，导致了目前广泛接受的胆碱能神经传递的概念。它讲述了一个世纪以来激烈的研究、技术创新和基础发现的传奇故事，突出了关键人物的贡献，他们在胆碱能传递的生理意义方面引发了持续的智力挑战和科学争论。此外，本章还描述了几十年来围绕电与化学神经传递假说的争论的解决方案，这一争论已经形成了当前的基本概念，并获得了几项诺贝尔奖。

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A brief history of the CNS cholinergic transmission.

This chapter provides a concise narrative of the evolution of events that have led to the current widely accepted concept of cholinergic neurotransmission. It recounts the saga of a century of intense research, technologic innovations, and fundamental discoveries, highlighting the contributions of key figures who have provoked ongoing intellectual challenges and scientific disputes regarding the physiologic significance of cholinergic transmission. Additionally, the chapter describes the resolution of decades-old debates surrounding the hypothesis of electrical vs chemical neurotransmission-a debate that has shaped current fundamental concepts and garnered several Nobel Prizes.

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来源期刊

Handbook of clinical neurology Medicine-Neurology (clinical)

CiteScore

4.10

自引率

0.00%

发文量

302

期刊介绍： The Handbook of Clinical Neurology (HCN) was originally conceived and edited by Pierre Vinken and George Bruyn as a prestigious, multivolume reference work that would cover all the disorders encountered by clinicians and researchers engaged in neurology and allied fields. The first series of the Handbook (Volumes 1-44) was published between 1968 and 1982 and was followed by a second series (Volumes 45-78), guided by the same editors, which concluded in 2002. By that time, the Handbook had come to represent one of the largest scientific works ever published. In 2002, Professors Michael J. Aminoff, François Boller, and Dick F. Swaab took on the responsibility of supervising the third (current) series, the first volumes of which published in 2003. They have designed this series to encompass both clinical neurology and also the basic and clinical neurosciences that are its underpinning. Given the enormity and complexity of the accumulating literature, it is almost impossible to keep abreast of developments in the field, thus providing the raison d''être for the series. The series will thus appeal to clinicians and investigators alike, providing to each an added dimension. Now, more than 140 volumes after it began, the Handbook of Clinical Neurology series has an unparalleled reputation for providing the latest information on fundamental research on the operation of the nervous system in health and disease, comprehensive clinical information on neurological and related disorders, and up-to-date treatment protocols.