Genes and immunity最新文献_第8页

Interferon-γ and its response are determinants of antibody-mediated rejection and clinical outcomes in patients after renal transplantation 干扰素-γ及其反应是肾移植术后抗体介导的排斥反应和临床结果的决定因素。

IF 5 3区医学

Genes and immunity Pub Date : 2024-01-22 DOI: 10.1038/s41435-024-00254-x

Hao Zhang, Di Zhang, Yue Xu, He Zhang, Zijian Zhang, Xiaopeng Hu

{"title":"Interferon-γ and its response are determinants of antibody-mediated rejection and clinical outcomes in patients after renal transplantation","authors":"Hao Zhang, Di Zhang, Yue Xu, He Zhang, Zijian Zhang, Xiaopeng Hu","doi":"10.1038/s41435-024-00254-x","DOIUrl":"10.1038/s41435-024-00254-x","url":null,"abstract":"Interferon-γ (IFN-γ) is an important cytokine in tissue homeostasis and immune response, while studies about it in antibody-mediated rejection (ABMR) are very limited. This study aims to comprehensively elucidate the role of IFN-γ in ABMR after renal transplantation. In six renal transplantation cohorts, the IFN-γ responses (IFNGR) biological process was consistently top up-regulated in ABMR compared to stable renal function or even T cell-mediated rejection in both allografts and peripheral blood. According to single-cell analysis, IFNGR levels were found to be broadly elevated in most cell types in allografts and peripheral blood with ABMR. In allografts with ABMR, M1 macrophages had the highest IFNGR levels and were heavily infiltrated, while kidney resident M2 macrophages were nearly absent. In peripheral blood, CD14+ monocytes had the top IFNGR level and were significantly increased in ABMR. Immunofluorescence assay showed that levels of IFN-γ and M1 macrophages were sharply elevated in allografts with ABMR than non-rejection. Importantly, the IFNGR level in allografts was identified as a strong risk factor for long-term renal graft survival. Together, this study systematically analyzed multi-omics from thirteen independent cohorts and identified IFN-γ and IFNGR as determinants of ABMR and clinical outcomes in patients after renal transplantation.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 1","pages":"66-81"},"PeriodicalIF":5.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139511808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Take my breath away—mitochondrial dysfunction drives CD8+ T cell exhaustion 让我屏住呼吸--线粒体功能障碍导致 CD8+ T 细胞衰竭。

IF 5 3区医学

Genes and immunity Pub Date : 2024-01-22 DOI: 10.1038/s41435-023-00233-8

Felix Clemens Richter, Mariia Saliutina, Ahmed N. Hegazy, Andreas Bergthaler

引用次数: 0

Same name, different game?—How ontogeny shapes classical monocyte phenotypes 同样的名字，不同的游戏？--本体如何塑造经典的单核细胞表型

IF 5 3区医学

Genes and immunity Pub Date : 2024-01-20 DOI: 10.1038/s41435-023-00248-1

Lisabeth Pimenov, Azuah Lucrecia Gonzalez, Amanda C. Doran, Sylvia Knapp

引用次数: 0

Interleukin-18 produced by gastric epithelial cells protects against pre-neoplastic lesions in Helicobacter pylori infection in mice 胃上皮细胞产生的白细胞介素-18 可保护小鼠免受幽门螺旋杆菌感染的肿瘤前病变的影响。

IF 5 3区医学

Genes and immunity Pub Date : 2024-01-20 DOI: 10.1038/s41435-024-00253-y

Xiaohu Zhao, Dongmei Tong, Richard L. Ferrero

引用次数: 0

Prediction of CAF-related genes in immunotherapy and drug sensitivity in hepatocellular carcinoma: a multi-database analysis 肝细胞癌免疫疗法和药物敏感性中 CAF 相关基因的预测：多数据库分析。

IF 5 3区医学

Genes and immunity Pub Date : 2024-01-17 DOI: 10.1038/s41435-024-00252-z

Yi Yao, KaiQing Yang, Qiang Wang, Zeming Zhu, Sheng Li, Bin Li, Bin Feng, Caixi Tang

{"title":"Prediction of CAF-related genes in immunotherapy and drug sensitivity in hepatocellular carcinoma: a multi-database analysis","authors":"Yi Yao, KaiQing Yang, Qiang Wang, Zeming Zhu, Sheng Li, Bin Li, Bin Feng, Caixi Tang","doi":"10.1038/s41435-024-00252-z","DOIUrl":"10.1038/s41435-024-00252-z","url":null,"abstract":"This study aims to identify the cancer-associated fibroblasts (CAF)-related genes that can affect immunotherapy and drug sensitivity in hepatocellular carcinoma (HCC). Expression data and survival data associated with HCC were obtained in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Weighted correlation network analysis (WGCNA) analysis was performed to obtain CAF-related genes. Least Absolute Shrinkage and Selection Operator (LASSO) regression was used for regression analysis and risk models. Subsequently, Gene Set Enrichment Analysis (GSEA) analysis, Gene Set Enrichment Analysis (ssGSEA) analysis, Tumor Immune Dysfunction and Exclusion (TIDE) analysis and drug sensitivity analysis were performed on the risk models. Survival analysis of CAF scores showed that the survival rate was lower in samples with high CAF scores than those with low scores. However, this difference was not significant, suggesting CAF may not directly influence the prognosis of HCC patients. Further screening of CAF-related genes yielded 33 CAF-related genes. Seven risk models constructed based on CDR2L, SPRED1, PFKP, ENG, KLF2, FSCN1 and VCAN, showed significant differences in immunotherapy and partial drug sensitivity in HCC. Seven CAF-related genes may have important roles in immunotherapy, drug sensitivity and prognostic survival in HCC patients.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 1","pages":"55-65"},"PeriodicalIF":5.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41435-024-00252-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139484880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preclinical models of breast cancer: B6BC, a transplantable hormone receptor-positive C57BL/6 mouse cell line 乳腺癌临床前模型：B6BC，一种可移植的激素受体阳性 C57BL/6 小鼠细胞系。

IF 5 3区医学

Genes and immunity Pub Date : 2024-01-13 DOI: 10.1038/s41435-023-00241-8

Maria Perez-Lanzon, Maria Chiara Maiuri, Carlos Lopez-Otin, Guido Kroemer

引用次数: 0

Do inhibitory receptors need to be proximal to stimulatory receptors to function? 抑制性受体是否需要靠近刺激性受体才能发挥作用？

IF 5 3区医学

Genes and immunity Pub Date : 2024-01-12 DOI: 10.1038/s41435-023-00251-6

Jonathan D. Worboys, Daniel M. Davis

引用次数: 0

Interfer-on time: lessons from genetically diverse mouse models of SARS-CoV-2 infection 干扰开启时间：从感染 SARS-CoV-2 的不同基因小鼠模型中汲取的教训。