Genes and immunity最新文献_第10页

Take my breath away—mitochondrial dysfunction drives CD8+ T cell exhaustion 让我屏住呼吸--线粒体功能障碍导致 CD8+ T 细胞衰竭。

IF 5 3区医学

Genes and immunity Pub Date : 2024-01-22 DOI: 10.1038/s41435-023-00233-8

Felix Clemens Richter, Mariia Saliutina, Ahmed N. Hegazy, Andreas Bergthaler

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Same name, different game?—How ontogeny shapes classical monocyte phenotypes 同样的名字，不同的游戏？--本体如何塑造经典的单核细胞表型

IF 5 3区医学

Genes and immunity Pub Date : 2024-01-20 DOI: 10.1038/s41435-023-00248-1

Lisabeth Pimenov, Azuah Lucrecia Gonzalez, Amanda C. Doran, Sylvia Knapp

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Interleukin-18 produced by gastric epithelial cells protects against pre-neoplastic lesions in Helicobacter pylori infection in mice 胃上皮细胞产生的白细胞介素-18 可保护小鼠免受幽门螺旋杆菌感染的肿瘤前病变的影响。

IF 5 3区医学

Genes and immunity Pub Date : 2024-01-20 DOI: 10.1038/s41435-024-00253-y

Xiaohu Zhao, Dongmei Tong, Richard L. Ferrero

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Prediction of CAF-related genes in immunotherapy and drug sensitivity in hepatocellular carcinoma: a multi-database analysis 肝细胞癌免疫疗法和药物敏感性中 CAF 相关基因的预测：多数据库分析。

IF 5 3区医学

Genes and immunity Pub Date : 2024-01-17 DOI: 10.1038/s41435-024-00252-z

Yi Yao, KaiQing Yang, Qiang Wang, Zeming Zhu, Sheng Li, Bin Li, Bin Feng, Caixi Tang

{"title":"Prediction of CAF-related genes in immunotherapy and drug sensitivity in hepatocellular carcinoma: a multi-database analysis","authors":"Yi Yao, KaiQing Yang, Qiang Wang, Zeming Zhu, Sheng Li, Bin Li, Bin Feng, Caixi Tang","doi":"10.1038/s41435-024-00252-z","DOIUrl":"10.1038/s41435-024-00252-z","url":null,"abstract":"This study aims to identify the cancer-associated fibroblasts (CAF)-related genes that can affect immunotherapy and drug sensitivity in hepatocellular carcinoma (HCC). Expression data and survival data associated with HCC were obtained in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Weighted correlation network analysis (WGCNA) analysis was performed to obtain CAF-related genes. Least Absolute Shrinkage and Selection Operator (LASSO) regression was used for regression analysis and risk models. Subsequently, Gene Set Enrichment Analysis (GSEA) analysis, Gene Set Enrichment Analysis (ssGSEA) analysis, Tumor Immune Dysfunction and Exclusion (TIDE) analysis and drug sensitivity analysis were performed on the risk models. Survival analysis of CAF scores showed that the survival rate was lower in samples with high CAF scores than those with low scores. However, this difference was not significant, suggesting CAF may not directly influence the prognosis of HCC patients. Further screening of CAF-related genes yielded 33 CAF-related genes. Seven risk models constructed based on CDR2L, SPRED1, PFKP, ENG, KLF2, FSCN1 and VCAN, showed significant differences in immunotherapy and partial drug sensitivity in HCC. Seven CAF-related genes may have important roles in immunotherapy, drug sensitivity and prognostic survival in HCC patients.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 1","pages":"55-65"},"PeriodicalIF":5.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41435-024-00252-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139484880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preclinical models of breast cancer: B6BC, a transplantable hormone receptor-positive C57BL/6 mouse cell line 乳腺癌临床前模型：B6BC，一种可移植的激素受体阳性 C57BL/6 小鼠细胞系。

IF 5 3区医学

Genes and immunity Pub Date : 2024-01-13 DOI: 10.1038/s41435-023-00241-8

Maria Perez-Lanzon, Maria Chiara Maiuri, Carlos Lopez-Otin, Guido Kroemer

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Do inhibitory receptors need to be proximal to stimulatory receptors to function? 抑制性受体是否需要靠近刺激性受体才能发挥作用？

IF 5 3区医学

Genes and immunity Pub Date : 2024-01-12 DOI: 10.1038/s41435-023-00251-6

Jonathan D. Worboys, Daniel M. Davis

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Interfer-on time: lessons from genetically diverse mouse models of SARS-CoV-2 infection 干扰开启时间：从感染 SARS-CoV-2 的不同基因小鼠模型中汲取的教训。

IF 5 3区医学

Genes and immunity Pub Date : 2023-12-29 DOI: 10.1038/s41435-023-00250-7

Shelly J. Robertson, Sonja M. Best

引用次数: 0

Spotlight on systems vaccinology: a novel approach to elucidate correlates of protection 聚焦系统疫苗学：阐明保护相关性的新方法。

IF 5 3区医学

Genes and immunity Pub Date : 2023-12-26 DOI: 10.1038/s41435-023-00247-2

Henderson Zhu, Irina Chelysheva, Andrew J. Pollard, Daniel O’Connor

引用次数: 0

Spotlight—author’s view for “Metabolic glycan labeling immobilizes dendritic cell membrane and enhances antitumorefficacy of dendritic cell vaccine” 代谢聚糖标记固定树突状细胞膜并增强树突状细胞疫苗的抗肿瘤功效 "的聚焦-作者观点。

IF 5 3区医学

Genes and immunity Pub Date : 2023-12-26 DOI: 10.1038/s41435-023-00245-4

Jiadiao Zhou, Hua Wang

引用次数: 0

Innate IRE1α-XBP1 activation by viral single-stranded RNA and its influence on lung cytokine production during SARS-CoV-2 pneumonia 病毒单链 RNA 激活先天 IRE1α-XBP1 及其对 SARS-CoV-2 肺炎期间肺细胞因子分泌的影响

IF 5 3区医学

Genes and immunity Pub Date : 2023-12-25 DOI: 10.1038/s41435-023-00243-6

José J. Fernández, Cristina Mancebo, Sonsoles Garcinuño, Gabriel March, Yolanda Alvarez, Sara Alonso, Luis Inglada, Jesús Blanco, Antonio Orduña, Olimpio Montero, Tito A. Sandoval, Juan R. Cubillos-Ruiz, Elena Bustamante-Munguira, Nieves Fernández, Mariano Sánchez Crespo

{"title":"Innate IRE1α-XBP1 activation by viral single-stranded RNA and its influence on lung cytokine production during SARS-CoV-2 pneumonia","authors":"José J. Fernández, Cristina Mancebo, Sonsoles Garcinuño, Gabriel March, Yolanda Alvarez, Sara Alonso, Luis Inglada, Jesús Blanco, Antonio Orduña, Olimpio Montero, Tito A. Sandoval, Juan R. Cubillos-Ruiz, Elena Bustamante-Munguira, Nieves Fernández, Mariano Sánchez Crespo","doi":"10.1038/s41435-023-00243-6","DOIUrl":"10.1038/s41435-023-00243-6","url":null,"abstract":"The utilization of host-cell machinery during SARS-CoV-2 infection can overwhelm the protein-folding capacity of the endoplasmic reticulum and activate the unfolded protein response (UPR). The IRE1α-XBP1 arm of the UPR could also be activated by viral RNA via Toll-like receptors. Based on these premises, a study to gain insight into the pathogenesis of COVID-19 disease was conducted using nasopharyngeal exudates and bronchioloalveolar aspirates. The presence of the mRNA of spliced XBP1 and a high expression of cytokine mRNAs were observed during active infection. TLR8 mRNA showed an overwhelming expression in comparison with TLR7 mRNA in bronchioloalveolar aspirates of COVID-19 patients, thus suggesting the presence of monocytes and monocyte-derived dendritic cells (MDDCs). In vitro experiments in MDDCs activated with ssRNA40, a synthetic mimic of SARS-CoV-2 RNA, showed induction of XBP1 splicing and the expression of proinflammatory cytokines. These responses were blunted by the IRE1α inhibitor MKC8866, the TLR8 antagonist CU-CPT9a, and knockdown of TLR8 receptor. In contrast, the IRE1α-XBP1 activator IXA4 enhanced these responses. Based on these findings, the TLR8/IRE1α system seems to play a significant role in the induction of the proinflammatory cytokines associated with severe COVID-19 disease and might be a druggable target to control cytokine storm.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 1","pages":"43-54"},"PeriodicalIF":5.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139036071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0