Genes and immunity最新文献_第10页

MDSC expansion during HIV infection: regulators, ART and immune reconstitution 艾滋病毒感染期间 MDSC 的扩增：调节器、抗逆转录病毒疗法和免疫重建

IF 5 3区医学

Genes and immunity Pub Date : 2024-04-11 DOI: 10.1038/s41435-024-00272-9

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani

引用次数: 0

Correction: Same name, different game?—How ontogeny shapes classical monocyte phenotypes 更正：同样的名字，不同的游戏？--本体如何塑造经典的单核细胞表型。

IF 5 3区医学

Genes and immunity Pub Date : 2024-04-09 DOI: 10.1038/s41435-024-00269-4

Lisabeth Pimenov, Azuah Lucrecia Gonzalez, Amanda C. Doran, Sylvia Knapp

引用次数: 0

Transcriptomic meta-analysis characterizes molecular commonalities between psoriasis and obesity 转录组元分析描述了银屑病与肥胖之间的分子共性。

IF 5 3区医学

Genes and immunity Pub Date : 2024-04-05 DOI: 10.1038/s41435-024-00271-w

Charalabos Antonatos, Georgios K. Georgakilas, Evangelos Evangelou, Yiannis Vasilopoulos

{"title":"Transcriptomic meta-analysis characterizes molecular commonalities between psoriasis and obesity","authors":"Charalabos Antonatos, Georgios K. Georgakilas, Evangelos Evangelou, Yiannis Vasilopoulos","doi":"10.1038/s41435-024-00271-w","DOIUrl":"10.1038/s41435-024-00271-w","url":null,"abstract":"Despite the abundance of epidemiological evidence for the high comorbid rate between psoriasis and obesity, systematic approaches to common inflammatory mechanisms have not been adequately explored. We performed a meta-analysis of publicly available RNA-sequencing datasets to unveil putative mechanisms that are postulated to exacerbate both diseases, utilizing both late-stage, disease-specific meta-analyses and consensus gene co-expression network (cWGCNA). Single-gene meta-analyses reported several common inflammatory mechanisms fostered by the perturbed expression profile of inflammatory cells. Assessment of gene overlaps between both diseases revealed significant overlaps between up- (n = 170, P value = 6.07 × 10−65) and down-regulated (n = 49, P value = 7.1 × 10−7) genes, associated with increased T cell response and activated transcription factors. Our cWGCNA approach disentangled 48 consensus modules, associated with either the differentiation of leukocytes or metabolic pathways with similar correlation signals in both diseases. Notably, all our analyses confirmed the association of the perturbed T helper (Th)17 differentiation pathway in both diseases. Our novel findings through whole transcriptomic analyses characterize the inflammatory commonalities between psoriasis and obesity implying the assessment of several expression profiles that could serve as putative comorbid disease progression biomarkers and therapeutic interventions.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 3","pages":"179-187"},"PeriodicalIF":5.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140737220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative single-cell transcriptomic profile of hybrid immunity induced by adenovirus vector-based COVID-19 vaccines 基于腺病毒载体的 COVID-19 疫苗诱导的混合免疫的单细胞转录组比较图谱

IF 5 3区医学

Genes and immunity Pub Date : 2024-04-03 DOI: 10.1038/s41435-024-00270-x

Melissa García-Vega, Hui Wan, Mónica Reséndiz-Sandoval, Diana Hinojosa-Trujillo, Olivia Valenzuela, Verónica Mata-Haro, Freddy Dehesa-Canseco, Mario Solís-Hernández, Harold Marcotte, Qiang Pan-Hammarström, Jesús Hernández

{"title":"Comparative single-cell transcriptomic profile of hybrid immunity induced by adenovirus vector-based COVID-19 vaccines","authors":"Melissa García-Vega, Hui Wan, Mónica Reséndiz-Sandoval, Diana Hinojosa-Trujillo, Olivia Valenzuela, Verónica Mata-Haro, Freddy Dehesa-Canseco, Mario Solís-Hernández, Harold Marcotte, Qiang Pan-Hammarström, Jesús Hernández","doi":"10.1038/s41435-024-00270-x","DOIUrl":"10.1038/s41435-024-00270-x","url":null,"abstract":"In this study, antibody response and a single-cell RNA-seq analysis were conducted on peripheral blood mononuclear cells from five different groups: naïve subjects vaccinated with AZD1222 (AZ) or Ad5-nCoV (Cso), individuals previously infected and later vaccinated (hybrid) with AZD1222 (AZ-hb) or Ad5-nCoV (Cso-hb), and those who were infected and had recovered from COVID-19 (Inf). The results showed that AZ induced more robust neutralizing antibody responses than Cso. The single-cell RNA data revealed a high frequency of memory B cells in the Cso and Cso-hb. In contrast, AZ and AZ-hb groups exhibited the highest proportion of activated naïve B cells expressing CXCR4. Transcriptomic analysis of CD4+ and CD8+ T cells demonstrated a heterogeneous response following vaccination, hybrid immunity, or natural infection. However, a single dose of Ad5-nCoV was sufficient to strongly activate CD4+ T cells (naïve and memory) expressing ANX1 and FOS, similar to the hybrid response observed with AZ. An interesting finding was the robust activation of a subset of CD8+ T cells expressing GZMB, GZMH, and IFNG genes in the Cso-hb group. Our findings suggest that both vaccines effectively stimulated the cellular immune response; however, the Ad5-nCoV induced a more robust CD8+ T-cell response in previously infected individuals.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 2","pages":"158-167"},"PeriodicalIF":5.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140559882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: An immunogenomic exome landscape of triple positive primary antiphospholipid patients 更正：三阳性原发性抗磷脂患者的免疫基因组外显子图谱。

IF 5 3区医学

Genes and immunity Pub Date : 2024-03-19 DOI: 10.1038/s41435-024-00261-y

A. Guffroy, L. Jacquel, Y. Seeleuthner, N. Paul, V. Poindron, F. Maurier, V. Delannoy, A. C. Voegeli, P. Zhang, B. Nespola, A. Molitor, M. J. Apithy, P. Soulas-Sprauel, T. Martin, R. E. Voll, S. Bahram, V. Gies, J. L. Casanova, A. Cobat, B. Boisson, R. Carapito, A. S. Korganow

引用次数: 0

Neu5Gc regulates decidual macrophages leading to abnormal embryo implantation Neu5Gc 可调节蜕膜巨噬细胞，导致胚胎异常着床。

IF 5 3区医学

Genes and immunity Pub Date : 2024-03-18 DOI: 10.1038/s41435-024-00268-5

Wu Yue, Zhou Huiling, Liu Yuxin, Wang Ling, Gao Feng, Liu Qicai

引用次数: 0

Chemoimmunotherapy combinations: translating basic knowledge into clinical successes 化学免疫疗法组合：将基础知识转化为临床成功。

IF 5 3区医学

Genes and immunity Pub Date : 2024-03-13 DOI: 10.1038/s41435-024-00264-9

Lionel Apetoh

引用次数: 0

RNA processing modification mediated subtypes illustrate the distinctive features of tumor microenvironment in hepatocellular carcinoma RNA 加工修饰介导的亚型说明了肝细胞癌肿瘤微环境的独特特征。

IF 5 3区医学

Genes and immunity Pub Date : 2024-03-12 DOI: 10.1038/s41435-024-00265-8

Xinhui Li, Shan Liu, Laibin Zou, Min Dai, Chaobei Zhu

{"title":"RNA processing modification mediated subtypes illustrate the distinctive features of tumor microenvironment in hepatocellular carcinoma","authors":"Xinhui Li, Shan Liu, Laibin Zou, Min Dai, Chaobei Zhu","doi":"10.1038/s41435-024-00265-8","DOIUrl":"10.1038/s41435-024-00265-8","url":null,"abstract":"Multiple transcript isoforms of genes can be formed by processing and modifying the 5′ and 3′ ends of RNA. Herein, the aim of this study is to uncover the characteristics of RNA processing modification (RPM) in hepatocellular carcinoma (HCC), and to identify novel biomarkers and potential targets for treatment. Firstly, integrated bioinformatics analysis was carried out to identify risk prognostic RPM regulators (RPMRs). Then, we used these RPMRs to identify subtypes of HCC and explore differences in immune microenvironment and cellular function improvement pathways between the sub-types. Finally, we used the principal component analysis algorithms to estimate RPMscore, which were applied to 5 cohorts. Lower RPMscore among patients correlated with a declined survival rate, increased immune infiltration, and raised expression of immune checkpoints, aligning with the “immunity tidal model theory”. The RPMscore exhibited robust, which was validated in multiple datasets. Mechanistically, low RPMscore can create an immunosuppressive microenvironment in HCC by manipulating tumor-associated macrophages. Preclinically, patients with high RPMscore might benefit from immunotherapy. The RPMscore is helpful in clustering HCC patients with distinct prognosis and immunotherapy. Our RPMscore model can help clinicians to select personalized therapy for HCC patients, and RPMscore may act a part in the development of HCC.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 2","pages":"132-148"},"PeriodicalIF":5.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pivotal role of BCL11B in the immune, hematopoietic and nervous systems: a review of the BCL11B-associated phenotypes from the genetic perspective BCL11B 在免疫、造血和神经系统中的关键作用：从遗传角度回顾 BCL11B 相关表型。

IF 5 3区医学

Genes and immunity Pub Date : 2024-03-12 DOI: 10.1038/s41435-024-00263-w

José María García-Aznar, Sara Alonso Alvarez, Teresa Bernal del Castillo

{"title":"Pivotal role of BCL11B in the immune, hematopoietic and nervous systems: a review of the BCL11B-associated phenotypes from the genetic perspective","authors":"José María García-Aznar, Sara Alonso Alvarez, Teresa Bernal del Castillo","doi":"10.1038/s41435-024-00263-w","DOIUrl":"10.1038/s41435-024-00263-w","url":null,"abstract":"The transcription factor BCL11B plays an essential role in the development of central nervous system and T cell differentiation by regulating the expression of numerous genes involved in several pathways. Monoallelic defects in the BCL11B gene leading to loss-of-function are associated with a wide spectrum of phenotypes, including neurological disorders with or without immunological features and susceptibility to hematological malignancies. From the genetic point of view, the landscape of BCL11B mutations reported so far does not fully explain the genotype-phenotype correlation. In this review, we sought to compile the phenotypic and genotypic variables associated with previously reported mutations in this gene in order to provide a better understanding of the consequences of deleterious variants. We also highlight the importance of a careful evaluation of the mutation type, its location and the pattern of inheritance of the variants in order to assign the most accurate pathogenicity and actionability of the genetic findings.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 3","pages":"232-241"},"PeriodicalIF":5.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41435-024-00263-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intratumoral NK cell delivery combined with neutralization of the NKG2A pathway as treatment for solid cancer 瘤内 NK 细胞递送结合中和 NKG2A 途径治疗实体瘤。

IF 5 3区医学

Genes and immunity Pub Date : 2024-03-09 DOI: 10.1038/s41435-024-00267-6

Ignacio Melero, Carmen Molina, Cristina Eguizabal, Maite Alvarez

引用次数: 0