Genes and immunity最新文献_第10页

An adjunct microbiome therapy to enhance immunotherapy efficacy in melanoma patients 增强黑色素瘤患者免疫疗法疗效的辅助微生物组疗法

IF 5 3区医学

Genes and immunity Pub Date : 2023-12-13 DOI: 10.1038/s41435-023-00240-9

John G. Lenehan, Saman Maleki Vareki

引用次数: 0

Antibodies target intracellular oncodrivers through PIGR-mediated transcytosis 抗体通过 PIGR 介导的转囊作用靶向细胞内肿瘤驱动因子

IF 5 3区医学

Genes and immunity Pub Date : 2023-12-13 DOI: 10.1038/s41435-023-00239-2

Subir Biswas, Carmen M. Anadon, Jose R. Conejo-Garcia

引用次数: 0

Metformin facilitates anti-PD-L1 efficacy through the regulation of intestinal microbiota 二甲双胍通过调节肠道微生物群促进抗PD-L1的疗效

IF 5 3区医学

Genes and immunity Pub Date : 2023-12-13 DOI: 10.1038/s41435-023-00234-7

Xiaopeng Zhao, Chuang Liu, Licheng Peng, Hongyan Wang

{"title":"Metformin facilitates anti-PD-L1 efficacy through the regulation of intestinal microbiota","authors":"Xiaopeng Zhao, Chuang Liu, Licheng Peng, Hongyan Wang","doi":"10.1038/s41435-023-00234-7","DOIUrl":"10.1038/s41435-023-00234-7","url":null,"abstract":"Metformin is a synthetic biguanide proven to have beneficial effects against various human diseases. Research has confirmed that metformin exerts its effects by regulating the composition of intestinal microbiota. The composition of intestinal microbiota influences the efficacy of anti-PD-L1 immunotherapy. We assume that the regulation of metformin on intestinal microbiota could enhance the therapeutic efficiency of anti-PD-L1 antibodies. In Lewis lung cancer-bearing C57BL/6J mice, we find that metformin enhances PD-L1 antibody efficacy mainly depending on the existence of gut microbiota, and metformin increases the anti-tumor immunity through modulation of intestinal microbiota and affects the integrity of the intestinal mucosa. Antibiotic depletion of gut microbiota abolished the combination efficacy of PD-L1 antibody and metformin, implying the significance of intestinal microbiota in metformin’s antitumor action. Combining anti-PD-L1 antibody with metformin provoked tumor necrosis by causing increased CD8 T-cell infiltration and IFN-γ expression. In conclusion, metformin could be employed as a microecological controller to prompt antitumor immunity and increase the efficacy of anti-PD-L1 antibodies. Our study provided reliable evidence that metformin could be synergistically used with anti-PD-L1 antibody to enhance the anti-cancer effect.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 1","pages":"7-13"},"PeriodicalIF":5.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138630471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From patient tissue correlates to molecular mechanisms of cancer immune evasion: the emerging role of CD58 and PD-L1 co-regulation via CMTM6 从患者组织相关性到癌症免疫逃避的分子机制：CD58 和 PD-L1 通过 CMTM6 共同调控的新作用

IF 5 3区医学

Genes and immunity Pub Date : 2023-12-11 DOI: 10.1038/s41435-023-00224-9

Johannes C. Melms, Patricia Ho, Meri Rogava, Benjamin Izar

{"title":"From patient tissue correlates to molecular mechanisms of cancer immune evasion: the emerging role of CD58 and PD-L1 co-regulation via CMTM6","authors":"Johannes C. Melms, Patricia Ho, Meri Rogava, Benjamin Izar","doi":"10.1038/s41435-023-00224-9","DOIUrl":"10.1038/s41435-023-00224-9","url":null,"abstract":"Immune evasion is a hallmark of cancer, yet the underlying mechanisms are often unknown in many patients. Using single-cell transcriptomics analysis, we previously identified the co-stimulator CD58 as part of a cancer cell-intrinsic immune checkpoint resistance signature in patient melanoma tissue. We subsequently validated CD58 loss as a driver of immune evasion using a patient-derived co-culture model of cancer and cytotoxic tumor-infiltrating lymphocytes in a pooled single-cell perturbation experiment, where we additionally observed concurrent upregulation of PD-L1 protein expression in melanoma cells with CD58 loss. In our most recent study, we uncovered the mechanisms of immune evasion mediated by CD58 loss, including impaired T cell activation and infiltration within tumors, as well as inhibitory signaling by PD-L1 via a shared regulator, CMTM6. Thus, cancer cell-intrinsic reduction of CD58 represents a multi-faceted determinant of immune evasion. Furthermore, its reciprocal interaction with PD-L1 via CMTM6 provides critical insights into how co-inhibitory and co-stimulatory immune cues are regulated.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 1","pages":"82-84"},"PeriodicalIF":5.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138574751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serving up whatever you wish: CRISPR-base editing generates novel cancer-restricted antigens for immunotherapy 随心所欲CRISPR-碱基编辑产生用于免疫疗法的新型癌症限制性抗原

IF 5 3区医学

Genes and immunity Pub Date : 2023-12-11 DOI: 10.1038/s41435-023-00227-6

Ute E. Burkhardt, Edward F. Fritsch

引用次数: 0

Mapping the landscape of T cell-recognized neoantigens in cancer patients 绘制癌症患者 T 细胞识别的新抗原图谱

IF 5 3区医学

Genes and immunity Pub Date : 2023-12-08 DOI: 10.1038/s41435-023-00230-x

Wouter Scheper

引用次数: 0

Targeting CTLA-4: a possible solution for microsatellite-stable colorectal cancer 靶向 CTLA-4：微卫星稳定型结直肠癌的可能解决方案