Genes and immunity最新文献

Butyrate enhances CD56^bright NK cell-driven killing of activated T cells and modulates NK cell chromatin accessibility. 丁酸盐增强CD56bright NK细胞对活化T细胞的杀伤和调节NK细胞染色质的可及性。

IF 5 3区医学

Genes and immunity Pub Date : 2025-06-12 DOI: 10.1038/s41435-025-00338-2

Federico Carlini, Margherita Squillario, Valentina Casella, Matteo Capaia, Valeria Lusi, Davide Bagnara, Monica Colombo, Serena Palmeri, Federico Ivaldi, Fabrizio Loiacono, Antonio Uccelli, Michele Piana, Alice Laroni

{"title":"Butyrate enhances CD56bright NK cell-driven killing of activated T cells and modulates NK cell chromatin accessibility.","authors":"Federico Carlini, Margherita Squillario, Valentina Casella, Matteo Capaia, Valeria Lusi, Davide Bagnara, Monica Colombo, Serena Palmeri, Federico Ivaldi, Fabrizio Loiacono, Antonio Uccelli, Michele Piana, Alice Laroni","doi":"10.1038/s41435-025-00338-2","DOIUrl":"https://doi.org/10.1038/s41435-025-00338-2","url":null,"abstract":"Gut bacteria-derived metabolites, such as butyrate (BUT), induce T regulatory cells through inhibition of histone deacetylases (HDAC). Natural killer (NK) cells are innate lymphocytes with important effector and regulatory functions; little is known on the effect of BUT on NK cells. Here we aimed at evaluating whether BUT affects the epigenetic landscape of human NK cells. We found that BUT inhibits HDAC on human NK cells. Through ATAC sequencing, we demonstrated that BUT affects the chromatin accessibility of human NK cells, influencing, among others, genetic pathways related to immune regulation, response to viruses, chromatin remodeling and genes encoding for micro-RNAs. We identified, through analysis of published transcriptomic data, genes specific for NK-cell functional clusters, and we overlapped results of ATAC-sequencing, finding that BUT activates genes specific for CD56bright and CD69+CD56dim NK cells, and represses genes specific for non-classical NK cells. Through flow cytometry, we observed that BUT induces CD69+CD56dim NK cells. Finally, we found increased cytotoxicity of BUT-treated CD56bright NK cells towards CD25+ and CD69+ T cells, despite a trend towards decreased suppressor function towards total autologous CD4+ T cells. In conclusion, we show that BUT affects the epigenetic landscape of human NK cells, their phenotype and regulatory function.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polygenic prediction of cellular immune responses to mumps vaccine. 流行性腮腺炎疫苗细胞免疫反应的多基因预测。

IF 5 3区医学

Genes and immunity Pub Date : 2025-06-10 DOI: 10.1038/s41435-025-00335-5

Brandon J Coombes, Inna G Ovsyannikova, Daniel J Schaid, Nathaniel D Warner, Gregory A Poland, Richard B Kennedy

引用次数: 0

Mapping the role of cytokine signaling at single-cell and structural resolution in uveal melanoma. 绘制单细胞和结构分辨率在葡萄膜黑色素瘤中细胞因子信号的作用。

IF 5 3区医学

Genes and immunity Pub Date : 2025-06-09 DOI: 10.1038/s41435-025-00337-3

Hongzhan Lin, Zixia Zhou, Hongyan Sun, Cunzi Li, Ying Lu, Zijing Wu, Lan Zhou, Yumo Wang, Zuhui Pu, Lisha Mou, Ming-Ming Yang

{"title":"Mapping the role of cytokine signaling at single-cell and structural resolution in uveal melanoma.","authors":"Hongzhan Lin, Zixia Zhou, Hongyan Sun, Cunzi Li, Ying Lu, Zijing Wu, Lan Zhou, Yumo Wang, Zuhui Pu, Lisha Mou, Ming-Ming Yang","doi":"10.1038/s41435-025-00337-3","DOIUrl":"https://doi.org/10.1038/s41435-025-00337-3","url":null,"abstract":"To better understand the complexity of the tumor microenvironment and to identify novel treatment strategies for uveal melanoma (UVM), we analyzed single-cell RNA sequencing (scRNA-seq) data from eight primary UVM eye tissues and three metastatic UVMs in the liver (GSE139829). We integrated this with bulk RNA-seq data from UVM patients derived from TCGA-UVM and GSE84976 cohorts. Our study focused on cytokine signaling in immune-related genes (CSIRGs), revealing distinct cellular compositions, intercellular interactions, and prognostic implications in UVM. We identified 137 cytokine signaling-related genes in UVM, with ISG20 significantly upregulated and linked to advanced stages and poor prognosis. Recognized for immune regulation, ISG20 emerged as a key survival predictor and therapeutic target from a risk model using Cox regression and LASSO, effectively categorizing patients by survival risk. Furthermore, differential drug response analysis revealed distinct sensitivities to drugs between the risk groups. Immune infiltration analysis showed a diverse immune landscape, potentially influencing response to immunotherapy. Structural prediction using AlphaFold 2 technology and molecular docking analyses revealed interactions between ISG20 and the therapeutic candidate decitabine. This study combines scRNA-seq analysis with structural biology approaches to unravel the molecular complexity of UVM, emphasizing the prognostic and therapeutic relevance of CSIRGs, particularly ISG20.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor-associated macrophages-induced lncRNA RP11-627G18.1 promotes breast cancer metastasis. 肿瘤相关巨噬细胞诱导的lncRNA RP11-627G18.1促进乳腺癌转移。

IF 5 3区医学

Genes and immunity Pub Date : 2025-06-09 DOI: 10.1038/s41435-025-00339-1

Luna Hong, Yijiao Huang, Fengzhan Ye, Shan Wang, Yongqiang Wang, Jie Luo, Zongjiang Zhou, Junpu Wang, Xiaoqing Yuan, Nan Zhou

{"title":"Tumor-associated macrophages-induced lncRNA RP11-627G18.1 promotes breast cancer metastasis.","authors":"Luna Hong, Yijiao Huang, Fengzhan Ye, Shan Wang, Yongqiang Wang, Jie Luo, Zongjiang Zhou, Junpu Wang, Xiaoqing Yuan, Nan Zhou","doi":"10.1038/s41435-025-00339-1","DOIUrl":"https://doi.org/10.1038/s41435-025-00339-1","url":null,"abstract":"Tumor-associated macrophages (TAMs) promote the transition of breast cancer cells from an epithelioid to a mesenchymal phenotype (EMT) and facilitate breast cancer metastasis, but the role of lncRNA in this process is poorly understood. We employed bioinformatics analysis to identify TAMs-related lncRNAs involved in EMT, migration and metastasis of breast cancer cells. LncRNA RP11-627G18.1 was identified as a TAMs-induced lncRNA in breast cancer cells and was further evaluated using RT-qPCR. The roles of lncRNA RP11-627G18.1 in EMT and migration were further explored using RNA interference, western blot, immunofluorescence, wound healing, and transwell assays. We discovered that TAMs-related lncRNA RP11-627G18.1 is positively correlated with EMT, metastasis, and poor prognosis in breast cancer. In vitro studies showed that lncRNA RP11-627G18.1 was induced by TAMs in breast cancer cells, accompanied by enhanced EMT and migration. Knockdown of lncRNA RP11-627G18.1 reversed EMT and inhibited the migration of breast cancer cells. TAMs-induced lncRNA RP11-627G18.1 promoted EMT, migration of breast cancer cells, and tumor metastasis, suggesting it as a promising biomarker and therapeutic target for breast cancer.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel modulation of T effector memory cells-expressing CD45RA by prednisone in inoperable advanced type B thymoma patients. 强的松在不能手术的晚期B型胸腺瘤患者中表达CD45RA的T效应记忆细胞的新调节。

IF 5 3区医学

Genes and immunity Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1038/s41435-025-00329-3

Xin-Tao Yu, Jian Cui, Xing-Guo Yang, Xiang Gao, Lei Yu

{"title":"Novel modulation of T effector memory cells-expressing CD45RA by prednisone in inoperable advanced type B thymoma patients.","authors":"Xin-Tao Yu, Jian Cui, Xing-Guo Yang, Xiang Gao, Lei Yu","doi":"10.1038/s41435-025-00329-3","DOIUrl":"10.1038/s41435-025-00329-3","url":null,"abstract":"Due to the covert onset of thymoma, nearly 30% of patients are diagnosed at stage III or IV, losing the opportunity for surgical treatment. We have initiated the application of prednisone in treating refractory thymoma and explored biomarkers to identify potential cases that might benefit from prednisone treatment. In a study involving 96 patients with thymoma, we confirmed a significant tumor shrinkage with prednisone acetate treatment. A reduced diameter ratio indicated that type B1 and B2 thymomas exhibited the most obvious response to prednisone acetate, especially type B2 thymoma. However, the reduced diameter ratio was < 30% in type A, AB, and B3 thymomas. Immunofluorescence and flow cytometry of tumor tissues indicated that TEMRA (T Effector Memory-Expressing CD45RA) cells primarily exist in type B thymoma. However, the percentage of interleukin-8 + TEMRA cells decreased only in B1 and B2 thymoma tissues after prednisone acetate treatment. These findings are particularly significant for patients with type B thymoma with stage III or IV.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":" ","pages":"222-228"},"PeriodicalIF":5.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing the immune landscape of tumor-infiltrating lymphocytes in non-small cell lung cancer. 非小细胞肺癌肿瘤浸润淋巴细胞的免疫景观特征

IF 5 3区医学

Genes and immunity Pub Date : 2025-06-01 Epub Date: 2025-05-05 DOI: 10.1038/s41435-025-00330-w

Jin-Guo Liu, Lin Yu, Xian-Ling Guo, Xue-Min He, Man Li, Ren-Yuan Gao, Bing-Hui Zhao, Qian-Yu Li, Wen-Jing Zhu, Ping Xu, Xiao-Hua Gu, Yong-An Chen, Xiao-Lan Yin, Yan Shang, Zhen-Hong Guo, Jia-Hao Mao, Yang-Xi Hu, Li-Ming Lu, Jian Hua, Hua Zhang, Yue Li

{"title":"Characterizing the immune landscape of tumor-infiltrating lymphocytes in non-small cell lung cancer.","authors":"Jin-Guo Liu, Lin Yu, Xian-Ling Guo, Xue-Min He, Man Li, Ren-Yuan Gao, Bing-Hui Zhao, Qian-Yu Li, Wen-Jing Zhu, Ping Xu, Xiao-Hua Gu, Yong-An Chen, Xiao-Lan Yin, Yan Shang, Zhen-Hong Guo, Jia-Hao Mao, Yang-Xi Hu, Li-Ming Lu, Jian Hua, Hua Zhang, Yue Li","doi":"10.1038/s41435-025-00330-w","DOIUrl":"10.1038/s41435-025-00330-w","url":null,"abstract":"Tumor-Infiltrating Lymphocytes (TILs) immunotherapy is a highly promising treatment for Non-small Cell Lung Cancer (NSCLC), which is responsible for 18% of all cancer-related deaths. The heterogeneity of TILs remains poorly understood. Here, we utilized combined single-cell RNA (scRNA)/T cell receptor sequencing (scTCR-seq) data from lung adenocarcinoma (LUAD) patients. Naïve CD4+ and effector memory CD8+ T cells were increased in tumor tissue compared with circulating blood samples. Activated signaling pathways were detected, and GZMA was identified as a potential novel diagnostic biomarker. During the transitional phase, macrophages (FTL) and dendritic (AIF1) cells transported the most CD3 TCR clones to T cells, while cytotoxicity CD8+ T (NKG7) cells transported to terminal exhausted CD8+ T cells. In both transition and expansion phases, T helper cells (CXCL13) are transported to regulatory T cells (Tregs). Additionally, we investigated the expression profiles of key cytokines, checkpoint receptors, and their ligands. Cytotoxicity CD8+ T cells (CCL5 and IFNG), T helper cells (FTL, TNFRSF4, and TIGIT), and regulatory T cells (CTLA4, TIGIT and FTL) exhibited functional roles in both primary and metastatic tumor stages. Taken together, our study provides a single-cell resolution of the TIL immune landscape and suggests potential treatment strategies to overcome drug resistance.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":" ","pages":"229-241"},"PeriodicalIF":5.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review on leptin's role in defining cancer: special emphasis on immunomodulation, inflammation, and therapeutic interventions. 瘦素在癌症定义中的作用的系统综述：特别强调免疫调节、炎症和治疗干预。

IF 5 3区医学

Genes and immunity Pub Date : 2025-06-01 Epub Date: 2025-05-15 DOI: 10.1038/s41435-025-00333-7

Snehashish Modak, Tamanna Aktar, Debabrata Majumder, Ashish Kr Singha, Debasish Maiti

{"title":"A systematic review on leptin's role in defining cancer: special emphasis on immunomodulation, inflammation, and therapeutic interventions.","authors":"Snehashish Modak, Tamanna Aktar, Debabrata Majumder, Ashish Kr Singha, Debasish Maiti","doi":"10.1038/s41435-025-00333-7","DOIUrl":"10.1038/s41435-025-00333-7","url":null,"abstract":"Leptin, an adipokine related to obesity, is mainly known for its role in regulating energy homeostasis and appetite by working via the leptin receptor. Recently, different groups have demonstrated that apart from adipocytes, specific cell types associated with cancer and tumor microenvironments express leptin and leptin receptors. This tumor microenvironment-associated leptin-leptin receptor signaling contributes to the different hallmarks of cancer, ranging from inflammatory changes to metastasis. Eventually, it has also been reported that high serum level of leptin, a characteristic of obese people, is linked to enhanced tumor growth. On the other hand, leptin can influence both innate as well as adaptive immunity related to cancer. Overall, leptin's role in modulating cancer is controversial. So, in this review, we summarized the role of leptin in shaping different forms of cancer that are influenced by leptin-leptin receptor signaling with special emphasis on immunomodulation and inflammatory events and also discussed the possible therapeutic interventions to date. As this review work, with the collection of different updated knowledge, has summarized the role of leptin on cancer, it would be useful material to have on hand for both beginners as well as pioneers of these and related fields.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":" ","pages":"266-286"},"PeriodicalIF":5.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive analysis of heat shock proteins in glioma revealed the association with glioma-associated myeloid cells. 对胶质瘤中热休克蛋白的综合分析揭示了其与胶质瘤相关髓样细胞的关联。

IF 5 3区医学

Genes and immunity Pub Date : 2025-06-01 Epub Date: 2025-04-15 DOI: 10.1038/s41435-025-00327-5

Jiacheng Xu, Yuduo Guo, Weihai Ning, Jun Wang, Yujia Chen, Deshan Liu, Jingjing Yang, Yongmei Song, Hongwei Zhang

{"title":"Comprehensive analysis of heat shock proteins in glioma revealed the association with glioma-associated myeloid cells.","authors":"Jiacheng Xu, Yuduo Guo, Weihai Ning, Jun Wang, Yujia Chen, Deshan Liu, Jingjing Yang, Yongmei Song, Hongwei Zhang","doi":"10.1038/s41435-025-00327-5","DOIUrl":"10.1038/s41435-025-00327-5","url":null,"abstract":"In the central nervous system, glioma stands as the predominant primary brain tumor. Heat shock proteins exerted a critical influence on tumor progression and tumor immune microenvironment. However, research on heat shock proteins in glioma remained ambiguous. We analyzed data from the CPTAC, TCGA, and GTEx databases, identifying seven heat shock protein genes critical to glioma prognosis. Subsequently, through Lasso regression, a model based on heat shock protein genes (DNAJC7, DNAJC12, HSPB2, HSP90B1, HSPA5) was constructed. And the risk score showed a positive correlation to the immune score. Further investigation into immune cells revealed that HSPA5 and HSP90B1 were expressed at higher levels in glioma and significantly linked to M2 macrophage infiltration. Considering the limited research on HSP90B1 in glioma, we further revealed that HSP90B1 might have a connection with two crucial signaling pathways within tumors: PI3K/AKT and Wnt/β-catenin. Given that lactate could promote the M2 polarization of macrophages, we further found that HSP90B1 could enhance the transcription of glycolysis-related genes, including LDHA. Overall, our study demonstrated that heat shock protein genes were significantly linked to glioma patient prognosis. Additionally, we observed that HSP90B1 had a significant relationship with M2 macrophage infiltration and potentially regulated LDHA level in glioma.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":" ","pages":"200-212"},"PeriodicalIF":5.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of B cell immunity in lung adenocarcinoma. B细胞免疫在肺腺癌中的作用。

IF 5 3区医学

Genes and immunity Pub Date : 2025-06-01 Epub Date: 2025-05-13 DOI: 10.1038/s41435-025-00331-9

Long Shu, Tania Tao, Desheng Xiao, Shuang Liu, Yongguang Tao

{"title":"The role of B cell immunity in lung adenocarcinoma.","authors":"Long Shu, Tania Tao, Desheng Xiao, Shuang Liu, Yongguang Tao","doi":"10.1038/s41435-025-00331-9","DOIUrl":"10.1038/s41435-025-00331-9","url":null,"abstract":"Lung cancer is the deadliest cancer globally. Non-small cell lung cancer (NSCLC), including adenocarcinoma, squamous cell carcinoma, and large cell carcinoma, constitutes a significant portion of cases. Adenocarcinoma, the most prevalent type, has seen a rising incidence. Immune checkpoint inhibitors (ICIs) have improved outcomes in lung adenocarcinoma (LUAD), yet response rates remain unsatisfactory. PD-1/PD-L1 inhibitors are primary ICIs for LUAD, targeting the PD-1/PD-L1 pathway between CD8+ T cells and tumor cells. However, LUAD presents a \"cold tumor\" phenotype with fewer CD8+ T cells and lower PD-1 expression, leading to resistance to ICIs. Thus, understanding the function of other immune cell in tumor microenvironment is crucial for developing novel immunotherapies for LUAD. B cells, which is part of the adaptive immune system, have gained attention for its role in cancer immunology. While research on B cells lags behind T cells, recent studies reveal their close correlation with prognosis and immunotherapy effectiveness in various solid tumors, including lung cancer. B cells show higher abundance, activity, and prognostic significance in LUAD than that in LUSC. This review summarizes the difference of B cell immunity between LUAD and other lung cancers, outlines the role of B cell immunity in LUAD.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":" ","pages":"253-265"},"PeriodicalIF":5.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Golgi apparatus-related signature predicts the immune microenvironment and prognosis of gastric cancer. 高尔基体相关特征预测胃癌的免疫微环境和预后。

IF 5 3区医学

Genes and immunity Pub Date : 2025-06-01 Epub Date: 2025-05-07 DOI: 10.1038/s41435-025-00332-8

Changlei Wu, Liang Sun, Wenjie Zhu, Chao Huang, Zhengming Zhu, Zitao Liu

{"title":"A Golgi apparatus-related signature predicts the immune microenvironment and prognosis of gastric cancer.","authors":"Changlei Wu, Liang Sun, Wenjie Zhu, Chao Huang, Zhengming Zhu, Zitao Liu","doi":"10.1038/s41435-025-00332-8","DOIUrl":"10.1038/s41435-025-00332-8","url":null,"abstract":"In recent years, numerous studies have provided evidence of the involvement of the Golgi apparatus (GA) in various stages of cancer development. Nonetheless, the specific impact of GA-related characteristics on gastric cancer (GC) progression remains ambiguous. We utilized LASSO and multivariate COX regression methods to develop a GA-associated risk score (GARS). The GARS is constructed from seven signature genes, which are highly expressed in tumors. In our research, we have found that GARS is an effective indicator for predicting the prognosis of GC, chemotherapy sensitivity, and immune therapy response. Patients in the low GARS group exhibit characteristics such as a good prognosis, increased sensitivity to immune therapy, 5-fluorouracil, and paclitaxel. Finally, our experimental results confirm that knocking down F2R significantly reduces the proliferation and migration abilities of GC cells. This study highlights the importance of GA characteristics in predicting the prognosis of GC and in developing personalized treatment strategies. The experimental findings on F2R offer valuable theoretical insights for the diagnosis and management of GC.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":" ","pages":"242-252"},"PeriodicalIF":5.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0