Genes and immunity最新文献_第9页

Mapping the landscape of T cell-recognized neoantigens in cancer patients 绘制癌症患者 T 细胞识别的新抗原图谱

IF 5 3区医学

Genes and immunity Pub Date : 2023-12-08 DOI: 10.1038/s41435-023-00230-x

Wouter Scheper

引用次数: 0

Targeting CTLA-4: a possible solution for microsatellite-stable colorectal cancer 靶向 CTLA-4：微卫星稳定型结直肠癌的可能解决方案

IF 5 3区医学

Genes and immunity Pub Date : 2023-12-08 DOI: 10.1038/s41435-023-00223-w

François Ghiringhelli, Marion Thibaudin

引用次数: 0

Interleukin-3 gets a fresh start in the brain 白细胞介素-3在大脑中重获新生

IF 5 3区医学

Genes and immunity Pub Date : 2023-12-08 DOI: 10.1038/s41435-023-00231-w

Abi G. Yates, Annie Khamhoung, Cameron S. McAlpine

引用次数: 0

To whom B cells toll extrafollicular responses B 细胞对哪些人产生了滤泡外反应

IF 5 3区医学

Genes and immunity Pub Date : 2023-12-08 DOI: 10.1038/s41435-023-00226-7

Jonathan H. Lam, Nicole Baumgarth

引用次数: 0

RNA modifications—a regulatory dimension yet to be deciphered in immunity RNA修饰——免疫系统中尚待破解的调控维度。

IF 5 3区医学

Genes and immunity Pub Date : 2023-11-20 DOI: 10.1038/s41435-023-00228-5

Cuong Thi Pham, Laurie Rangan, Susan Schlenner

引用次数: 0

Genetic variants of interferon-response factor 5 are associated with the incidence of chronic kidney disease: the D.E.S.I.R. study 干扰素反应因子5的遗传变异与慢性肾脏疾病的发病率相关:D.E.S.I.R.研究

IF 5 3区医学

Genes and immunity Pub Date : 2023-11-17 DOI: 10.1038/s41435-023-00229-4

Frédéric Fumeron, Gilberto Velho, Fawaz Alzaid, Ray El Boustany, Claire Vandiedonck, Amélie Bonnefond, Philippe Froguel, Louis Potier, Michel Marre, Beverley Balkau, Ronan Roussel, Nicolas Venteclef

{"title":"Genetic variants of interferon-response factor 5 are associated with the incidence of chronic kidney disease: the D.E.S.I.R. study","authors":"Frédéric Fumeron, Gilberto Velho, Fawaz Alzaid, Ray El Boustany, Claire Vandiedonck, Amélie Bonnefond, Philippe Froguel, Louis Potier, Michel Marre, Beverley Balkau, Ronan Roussel, Nicolas Venteclef","doi":"10.1038/s41435-023-00229-4","DOIUrl":"10.1038/s41435-023-00229-4","url":null,"abstract":"Inflammation has been associated with renal diseases. The Interferon Regulatory Factor (IRF)-5 is a key transcription factor in the pro-inflammatory polarization of M1-like macrophages. GWAS have reported that the IRF5 locus is associated with autoimmune diseases and with the estimated glomerular filtration rate (eGFR). We study whether allelic variations in IRF5 are associated with the incidence of chronic kidney disease (CKD) in a general population. We genotyped eleven IRF5 SNPs in the French D.E.S.I.R. cohort from the general population (n = 4820). Associations of SNPs with baseline renal parameters were assessed. Data were analyzed for three endpoints during a 9-year follow-up, incidence of:at least stage 3 CKD, the KDIGO criterion “certain drop in eGFR”, and incidence of micro/macro albuminuria. In the cross-sectional analysis, rs10954213 and rs10954214 were associated with eGFR and rs1874328 with urinary albumin/creatinine ratio (ACR). Rs3807306, rs11761199, rs78658945, rs1874328, rs10954213 and rs11770589 were associated with the incidence of stage 3 CKD in multi-adjusted models. Rs4731532, rs3807306, and rs11761199 were associated with the incidence of CKD defined by the KDIGO. Rs4731532, rs3807306, rs11761199 and rs79288514 were associated with the incidence of micro/macro albuminuria. Our results support the hypothesis of the importance of IRF5 mediated macrophage polarization in the etiology of CKD.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"24 6","pages":"303-308"},"PeriodicalIF":5.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10721545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136397136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2) 内质网氨肽酶II（ERAP2）的进化免疫遗传学。

IF 5 3区医学

Genes and immunity Pub Date : 2023-11-04 DOI: 10.1038/s41435-023-00225-8

Aroosha Raja, Jonas J. W. Kuiper

引用次数: 0

Circulating biomarkers at diagnosis correlate with distant metastases of early luminal-like breast cancer 诊断中的循环生物标志物与早期腔样乳腺癌癌症的远处转移相关。

IF 5 3区医学

Genes and immunity Pub Date : 2023-09-27 DOI: 10.1038/s41435-023-00220-z

Yentl Lambrechts, Abhishek D. Garg, Giuseppe Floris, Kevin Punie, Patrick Neven, Ines Nevelsteen, Jannes Govaerts, François Richard, Annouschka Laenen, Christine Desmedt, Hans Wildiers, Sigrid Hatse

{"title":"Circulating biomarkers at diagnosis correlate with distant metastases of early luminal-like breast cancer","authors":"Yentl Lambrechts, Abhishek D. Garg, Giuseppe Floris, Kevin Punie, Patrick Neven, Ines Nevelsteen, Jannes Govaerts, François Richard, Annouschka Laenen, Christine Desmedt, Hans Wildiers, Sigrid Hatse","doi":"10.1038/s41435-023-00220-z","DOIUrl":"10.1038/s41435-023-00220-z","url":null,"abstract":"There is an urgent need for new and better biomarker modalities to estimate the risk of recurrence within the luminal-like breast cancer (BC) population. Molecular diagnostic tests used in the clinic lack accuracy in identifying patients with early luminal BC who are likely to develop metastases. This study provides proof of concept that various liquid biopsy read-outs could serve as valuable candidates to build a multi-modal biomarker model distinguishing, already at diagnosis, between early metastasizing and non-metastasizing patients. All these blood biomarkers (chemokines, microRNAs, leukemia inhibitory factor, osteopontin, and serum-induced functional myeloid signaling responses) can be measured in baseline plasma/serum samples and could be added to the existing prognostic factors to improve risk stratification and more patient-tailored treatment in early luminal BC.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"24 5","pages":"270-279"},"PeriodicalIF":5.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41117550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL-2 immunotherapy for targeting regulatory T cells in autoimmunity “针对自身免疫中调节性T细胞的IL-2免疫疗法”。

IF 5 3区医学

Genes and immunity Pub Date : 2023-09-23 DOI: 10.1038/s41435-023-00221-y

Valentina Lykhopiy, Vanshika Malviya, Stephanie Humblet-Baron, Susan M. Schlenner

{"title":"IL-2 immunotherapy for targeting regulatory T cells in autoimmunity","authors":"Valentina Lykhopiy, Vanshika Malviya, Stephanie Humblet-Baron, Susan M. Schlenner","doi":"10.1038/s41435-023-00221-y","DOIUrl":"10.1038/s41435-023-00221-y","url":null,"abstract":"FOXP3+ regulatory T cells (Treg) are indispensable for immune homoeostasis and for the prevention of autoimmune diseases. Interleukin-2 (IL-2) signalling is critical in all aspects of Treg biology. Consequences of defective IL-2 signalling are insufficient numbers or dysfunction of Treg and hence autoimmune disorders in human and mouse. The restoration and maintenance of immune homoeostasis remain central therapeutic aims in the field of autoimmunity. Historically, broadly immunosuppressive drugs with serious side-effects have been used for the treatment of autoimmune diseases or prevention of organ-transplant rejection. More recently, ex vivo expanded or in vivo stimulated Treg have been shown to induce effective tolerance in clinical trials supporting the clinical benefit of targeting natural immunosuppressive mechanisms. Given the central role of exogenous IL-2 in Treg homoeostasis, a new and promising focus in drug development are IL-2-based approaches for in vivo targeted expansion of Treg or for enhancement of their suppressive activity. In this review, we summarise the role of IL-2 in Treg biology and consequences of dysfunctional IL-2 signalling pathways. We then examine evidence of efficacy of IL-2-based biological drugs targeting Treg with specific focus on therapeutic candidates in clinical trials and discuss their limitations.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"24 5","pages":"248-262"},"PeriodicalIF":5.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41123973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disentangling the complexity of psoriasis in the post-genome-wide association era 解开后全基因组关联时代银屑病的复杂性。

IF 5 3区医学

Genes and immunity Pub Date : 2023-09-16 DOI: 10.1038/s41435-023-00222-x

Charalabos Antonatos, Katerina Grafanaki, Sophia Georgiou, Evangelos Evangelou, Yiannis Vasilopoulos

{"title":"Disentangling the complexity of psoriasis in the post-genome-wide association era","authors":"Charalabos Antonatos, Katerina Grafanaki, Sophia Georgiou, Evangelos Evangelou, Yiannis Vasilopoulos","doi":"10.1038/s41435-023-00222-x","DOIUrl":"10.1038/s41435-023-00222-x","url":null,"abstract":"In recent years, genome-wide association studies (GWAS) have been instrumental in unraveling the genetic architecture of complex diseases, including psoriasis. The application of large-scale GWA studies in psoriasis has illustrated several associated loci that participate in the cutaneous inflammation, however explaining a fraction of the disease heritability. With the advent of high-throughput sequencing technologies and functional genomics approaches, the post-GWAS era aims to unravel the functional mechanisms underlying the inter-individual variability in psoriasis patients. In this review, we present the key advances of psoriasis GWAS in under-represented populations, rare, non-coding and structural variants and epistatic phenomena that orchestrate the interplay between different cell types. We further review the gene-gene and gene-environment interactions contributing to the disease predisposition and development of comorbidities through Mendelian randomization studies and pleiotropic effects of psoriasis-associated loci. We finally examine the holistic approaches conducted in psoriasis through system genetics and state-of-the-art transcriptomic analyses, discussing their potential implication in the expanding field of precision medicine and characterization of comorbidities.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"24 5","pages":"236-247"},"PeriodicalIF":5.0,"publicationDate":"2023-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10262265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0