microRNA 在缺血/再灌注炎症途径中调节免疫反应的能力。

IF 5 3区医学 Q1 GENETICS & HEREDITY

Genes and immunity Pub Date : 2024-06-22 DOI:10.1038/s41435-024-00283-6

Peter Artimovič, Ivana Špaková, Ema Macejková, Timea Pribulová, Miroslava Rabajdová, Mária Mareková, Martina Zavacká

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引用次数: 0

摘要

微RNA在调节缺血/再灌注损伤诱导的免疫反应中发挥着至关重要的作用。通过调节基因表达的能力，microRNA 通过靶向特定基因和信号通路来调整免疫反应。本综述重点探讨 microRNA 对缺血/再灌注损伤过程中触发的炎症通路的影响，并强调其调节炎症的能力在缺血/再灌注损伤的病理生理学中发挥着关键作用。微小RNA表达失调是缺血再灌注损伤的发病机制之一，因此靶向特定的微小RNA为恢复免疫平衡和改善患者预后提供了机会。了解免疫调节microRNAs的复杂网络可以提供新的治疗干预措施，以减轻过度炎症反应并保护组织完整性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The ability of microRNAs to regulate the immune response in ischemia/reperfusion inflammatory pathways

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The ability of microRNAs to regulate the immune response in ischemia/reperfusion inflammatory pathways

MicroRNAs play a crucial role in regulating the immune responses induced by ischemia/reperfusion injury. Through their ability to modulate gene expression, microRNAs adjust immune responses by targeting specific genes and signaling pathways. This review focuses on the impact of microRNAs on the inflammatory pathways triggered during ischemia/reperfusion injury and highlights their ability to modulate inflammation, playing a critical role in the pathophysiology of ischemia/reperfusion injury. Dysregulated expression of microRNAs contributes to the pathogenesis of ischemia/reperfusion injury, therefore targeting specific microRNAs offers an opportunity to restore immune homeostasis and improve patient outcomes. Understanding the complex network of immunoregulatory microRNAs could provide novel therapeutic interventions aimed at attenuating excessive inflammation and preserving tissue integrity.

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来源期刊

Genes and immunity 医学-免疫学

CiteScore

8.90

自引率

4.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Genes & Immunity emphasizes studies investigating how genetic, genomic and functional variations affect immune cells and the immune system, and associated processes in the regulation of health and disease. It further highlights articles on the transcriptional and posttranslational control of gene products involved in signaling pathways regulating immune cells, and protective and destructive immune responses.