发布求助
文献互助 智能选刊 最新文献

Genes and immunity最新文献

筛选
英文 中文
Preclinical models of breast cancer: B6BC, a transplantable hormone receptor-positive C57BL/6 mouse cell line 乳腺癌临床前模型：B6BC，一种可移植的激素受体阳性 C57BL/6 小鼠细胞系。
IF 5 3区 医学
Genes and immunity Pub Date : 2024-01-13 DOI: 10.1038/s41435-023-00241-8
Maria Perez-Lanzon, Maria Chiara Maiuri, Carlos Lopez-Otin, Guido Kroemer
{"title":"Preclinical models of breast cancer: B6BC, a transplantable hormone receptor-positive C57BL/6 mouse cell line","authors":"Maria Perez-Lanzon, Maria Chiara Maiuri, Carlos Lopez-Otin, Guido Kroemer","doi":"10.1038/s41435-023-00241-8","DOIUrl":"10.1038/s41435-023-00241-8","url":null,"abstract":"","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 2","pages":"172-174"},"PeriodicalIF":5.0,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do inhibitory receptors need to be proximal to stimulatory receptors to function? 抑制性受体是否需要靠近刺激性受体才能发挥作用？
IF 5 3区 医学
Genes and immunity Pub Date : 2024-01-12 DOI: 10.1038/s41435-023-00251-6
Jonathan D. Worboys, Daniel M. Davis
{"title":"Do inhibitory receptors need to be proximal to stimulatory receptors to function?","authors":"Jonathan D. Worboys, Daniel M. Davis","doi":"10.1038/s41435-023-00251-6","DOIUrl":"10.1038/s41435-023-00251-6","url":null,"abstract":"","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 4","pages":"343-345"},"PeriodicalIF":5.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41435-023-00251-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139432443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interfer-on time: lessons from genetically diverse mouse models of SARS-CoV-2 infection 干扰开启时间：从感染 SARS-CoV-2 的不同基因小鼠模型中汲取的教训。
IF 5 3区 医学
Genes and immunity Pub Date : 2023-12-29 DOI: 10.1038/s41435-023-00250-7
Shelly J. Robertson, Sonja M. Best
{"title":"Interfer-on time: lessons from genetically diverse mouse models of SARS-CoV-2 infection","authors":"Shelly J. Robertson, Sonja M. Best","doi":"10.1038/s41435-023-00250-7","DOIUrl":"10.1038/s41435-023-00250-7","url":null,"abstract":"","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 4","pages":"341-342"},"PeriodicalIF":5.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139073776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spotlight on systems vaccinology: a novel approach to elucidate correlates of protection 聚焦系统疫苗学：阐明保护相关性的新方法。
IF 5 3区 医学
Genes and immunity Pub Date : 2023-12-26 DOI: 10.1038/s41435-023-00247-2
Henderson Zhu, Irina Chelysheva, Andrew J. Pollard, Daniel O’Connor
{"title":"Spotlight on systems vaccinology: a novel approach to elucidate correlates of protection","authors":"Henderson Zhu, Irina Chelysheva, Andrew J. Pollard, Daniel O’Connor","doi":"10.1038/s41435-023-00247-2","DOIUrl":"10.1038/s41435-023-00247-2","url":null,"abstract":"","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 4","pages":"336-337"},"PeriodicalIF":5.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41435-023-00247-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139039739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spotlight—author’s view for “Metabolic glycan labeling immobilizes dendritic cell membrane and enhances antitumorefficacy of dendritic cell vaccine” 代谢聚糖标记固定树突状细胞膜并增强树突状细胞疫苗的抗肿瘤功效 "的聚焦-作者观点。
IF 5 3区 医学
Genes and immunity Pub Date : 2023-12-26 DOI: 10.1038/s41435-023-00245-4
Jiadiao Zhou, Hua Wang
{"title":"Spotlight—author’s view for “Metabolic glycan labeling immobilizes dendritic cell membrane and enhances antitumorefficacy of dendritic cell vaccine”","authors":"Jiadiao Zhou, Hua Wang","doi":"10.1038/s41435-023-00245-4","DOIUrl":"10.1038/s41435-023-00245-4","url":null,"abstract":"","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 3","pages":"259-260"},"PeriodicalIF":5.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139039740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innate IRE1α-XBP1 activation by viral single-stranded RNA and its influence on lung cytokine production during SARS-CoV-2 pneumonia 病毒单链 RNA 激活先天 IRE1α-XBP1 及其对 SARS-CoV-2 肺炎期间肺细胞因子分泌的影响
IF 5 3区 医学
Genes and immunity Pub Date : 2023-12-25 DOI: 10.1038/s41435-023-00243-6
José J. Fernández, Cristina Mancebo, Sonsoles Garcinuño, Gabriel March, Yolanda Alvarez, Sara Alonso, Luis Inglada, Jesús Blanco, Antonio Orduña, Olimpio Montero, Tito A. Sandoval, Juan R. Cubillos-Ruiz, Elena Bustamante-Munguira, Nieves Fernández, Mariano Sánchez Crespo
{"title":"Innate IRE1α-XBP1 activation by viral single-stranded RNA and its influence on lung cytokine production during SARS-CoV-2 pneumonia","authors":"José J. Fernández, Cristina Mancebo, Sonsoles Garcinuño, Gabriel March, Yolanda Alvarez, Sara Alonso, Luis Inglada, Jesús Blanco, Antonio Orduña, Olimpio Montero, Tito A. Sandoval, Juan R. Cubillos-Ruiz, Elena Bustamante-Munguira, Nieves Fernández, Mariano Sánchez Crespo","doi":"10.1038/s41435-023-00243-6","DOIUrl":"10.1038/s41435-023-00243-6","url":null,"abstract":"The utilization of host-cell machinery during SARS-CoV-2 infection can overwhelm the protein-folding capacity of the endoplasmic reticulum and activate the unfolded protein response (UPR). The IRE1α-XBP1 arm of the UPR could also be activated by viral RNA via Toll-like receptors. Based on these premises, a study to gain insight into the pathogenesis of COVID-19 disease was conducted using nasopharyngeal exudates and bronchioloalveolar aspirates. The presence of the mRNA of spliced XBP1 and a high expression of cytokine mRNAs were observed during active infection. TLR8 mRNA showed an overwhelming expression in comparison with TLR7 mRNA in bronchioloalveolar aspirates of COVID-19 patients, thus suggesting the presence of monocytes and monocyte-derived dendritic cells (MDDCs). In vitro experiments in MDDCs activated with ssRNA40, a synthetic mimic of SARS-CoV-2 RNA, showed induction of XBP1 splicing and the expression of proinflammatory cytokines. These responses were blunted by the IRE1α inhibitor MKC8866, the TLR8 antagonist CU-CPT9a, and knockdown of TLR8 receptor. In contrast, the IRE1α-XBP1 activator IXA4 enhanced these responses. Based on these findings, the TLR8/IRE1α system seems to play a significant role in the induction of the proinflammatory cytokines associated with severe COVID-19 disease and might be a druggable target to control cytokine storm.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 1","pages":"43-54"},"PeriodicalIF":5.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139036071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spotlight: “Human STAT2 deficiency: a severe defect of antiviral immunity” 聚焦："人类 STAT2 缺乏症：抗病毒免疫的严重缺陷"
IF 5 3区 医学
Genes and immunity Pub Date : 2023-12-25 DOI: 10.1038/s41435-023-00246-3
Giorgia Bucciol, Isabelle Meyts
{"title":"Spotlight: “Human STAT2 deficiency: a severe defect of antiviral immunity”","authors":"Giorgia Bucciol, Isabelle Meyts","doi":"10.1038/s41435-023-00246-3","DOIUrl":"10.1038/s41435-023-00246-3","url":null,"abstract":"","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 3","pages":"261-263"},"PeriodicalIF":5.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139035890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmental variation and genetic diversity contribute to population differences in immune responses to SARS-CoV-2 and COVID-19 risk 环境变异和遗传多样性导致人群对 SARS-CoV-2 和 COVID-19 风险的免疫反应存在差异
IF 5 3区 医学
Genes and immunity Pub Date : 2023-12-23 DOI: 10.1038/s41435-023-00249-0
Maxime Rotival, Lluis Quintana-Murci
{"title":"Environmental variation and genetic diversity contribute to population differences in immune responses to SARS-CoV-2 and COVID-19 risk","authors":"Maxime Rotival, Lluis Quintana-Murci","doi":"10.1038/s41435-023-00249-0","DOIUrl":"10.1038/s41435-023-00249-0","url":null,"abstract":"","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 4","pages":"338-340"},"PeriodicalIF":5.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139028186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uncovering intestinal macrophages through the integration of single-cell and spatial transcriptomics 通过整合单细胞和空间转录组学发现肠道巨噬细胞
IF 5 3区 医学
Genes and immunity Pub Date : 2023-12-23 DOI: 10.1038/s41435-023-00242-7
Alba Garrido-Trigo, Marisol Veny, Azucena Salas
{"title":"Uncovering intestinal macrophages through the integration of single-cell and spatial transcriptomics","authors":"Alba Garrido-Trigo, Marisol Veny, Azucena Salas","doi":"10.1038/s41435-023-00242-7","DOIUrl":"10.1038/s41435-023-00242-7","url":null,"abstract":"","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 3","pages":"254-255"},"PeriodicalIF":5.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139028235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The genomics revolution comes to the immunopeptidome 免疫肽组迎来基因组学革命。
IF 5 3区 医学
Genes and immunity Pub Date : 2023-12-22 DOI: 10.1038/s41435-023-00244-5
Peter M. Bruno
{"title":"The genomics revolution comes to the immunopeptidome","authors":"Peter M. Bruno","doi":"10.1038/s41435-023-00244-5","DOIUrl":"10.1038/s41435-023-00244-5","url":null,"abstract":"","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 3","pages":"256-258"},"PeriodicalIF":5.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41435-023-00244-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138884811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信