Genes and immunity最新文献_第6页

Hspa8 modulation of immune responses mitigates ischemic brain injury Hspa8调节免疫反应减轻缺血性脑损伤。

IF 4.5 3区医学

Genes and immunity Pub Date : 2025-11-01 DOI: 10.1038/s41435-025-00359-x

Xiaokun Wu, Zongkai Wu, Han Yan, Zhe Zu, Hebo Wang

{"title":"Hspa8 modulation of immune responses mitigates ischemic brain injury","authors":"Xiaokun Wu, Zongkai Wu, Han Yan, Zhe Zu, Hebo Wang","doi":"10.1038/s41435-025-00359-x","DOIUrl":"10.1038/s41435-025-00359-x","url":null,"abstract":"Ischemic brain injury triggers complex immune-inflammatory responses that significantly influence disease progression and patient outcomes. This study investigates the role of heat shock protein A8 (Hspa8) in modulating immune cell dynamics following ischemic brain injury. Using single-cell RNA sequencing, bulk RNA sequencing, flow cytometry, and immunofluorescence, we identified significant alterations in T cells, neutrophils, and monocytes within both peripheral blood and brain tissues. Our findings reveal that Hspa8 plays a pivotal role in regulating neutrophil infiltration and reactive oxygen species (ROS) production. Gene silencing of Hspa8 effectively reduced neutrophil accumulation, decreased ROS levels, and mitigated neurological deficits in both in vitro and in vivo ischemic models. Protein-protein interaction (PPI) network analysis further established Hspa8 as a key regulator in immune cell interactions, highlighting its potential as a therapeutic target. These results provide new insights into the immune mechanisms underlying ischemic brain injury and suggest that targeting Hspa8 may offer a promising strategy for reducing inflammation, improving neurological recovery, and enhancing clinical outcomes in affected patients.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"27 1","pages":"13-24"},"PeriodicalIF":4.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Taxonomic variation in immune response strategies among primates 灵长类动物免疫反应策略的分类变异。

IF 4.5 3区医学

Genes and immunity Pub Date : 2025-10-23 DOI: 10.1038/s41435-025-00363-1

Sophie K. Joseph, Jordan M. Lucore, John Lindo, Elizabeth V. Lonsdorf, Marcela E. Benítez

{"title":"Taxonomic variation in immune response strategies among primates","authors":"Sophie K. Joseph, Jordan M. Lucore, John Lindo, Elizabeth V. Lonsdorf, Marcela E. Benítez","doi":"10.1038/s41435-025-00363-1","DOIUrl":"10.1038/s41435-025-00363-1","url":null,"abstract":"In primates, mechanisms of both innate and adaptive immunity are well-studied in just a few species out of this very diverse taxonomic order, especially in relation to specific pathogens like SIV. Recent research has indicated there may be taxon-specific differences across primates in immune response strategies, including relative proportions of immune cell types and whether adaptive or innate responses are favored. It remains unclear which taxonomic level best explains variation in primate immune response strategies. Identifying this is important for understanding when and why these differences evolved. This review synthesizes major recent findings in primate immunology, to connect them to more generalized research on immune response strategies and present hypotheses for future research, focusing on major methodologies in the field. We demonstrate that gaining a better understanding of the evolution of primate immunity has far-reaching implications for our understanding of the evolutionary past of humans, and for present-day global health.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"26 6","pages":"539-548"},"PeriodicalIF":4.5,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41435-025-00363-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145354557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational neoantigen prediction for cancer immunotherapy 肿瘤免疫治疗的计算新抗原预测。

IF 4.5 3区医学

Genes and immunity Pub Date : 2025-10-19 DOI: 10.1038/s41435-025-00365-z

Lakshman Tejaswi, Poornima Ramesh, Shetty Aditya, Rajesh Raju, Thottethodi Subrahmanya Keshava Prasad

{"title":"Computational neoantigen prediction for cancer immunotherapy","authors":"Lakshman Tejaswi, Poornima Ramesh, Shetty Aditya, Rajesh Raju, Thottethodi Subrahmanya Keshava Prasad","doi":"10.1038/s41435-025-00365-z","DOIUrl":"10.1038/s41435-025-00365-z","url":null,"abstract":"Cancer represents a significant global health concern, profoundly affecting morbidity and mortality rates worldwide. Due to cancer-associated genetic changes, cancer cells harbor neoantigens (Tumor-Specific Antigens). They are attractive targets for personalized and generalized cancer therapeutics, including cancer vaccines, T cell adoptive therapy, and immunomonitoring. Such antigens can arise at genomic, transcriptomic, and proteomic levels. The host immune system recognizes neoantigens through their presentation on Major Histocompatibility Complexes (MHC), leading to T cell activation and antitumor response, provided sufficient co-stimulatory signals are provided by antigen-presenting cells, including dendritic cells. Computational tools for neoantigen analysis are rapidly advancing, improving prediction accuracy. Bioinformatics tools aid in identifying somatic mutations and selecting neoantigens based on MHC binding and immunogenicity scores. Cost-efficient computational Human Leukocyte Antigen haplotyping uses sequencing data, while proteogenomic strategies, integrating immunopeptidomics, validate neoantigens by detecting peptides naturally presented by tumor cells. Integrating proteome-based validation provides experimental confirmation, strengthening confidence in predictions. Ongoing developments in bioinformatics and multi-omics integration contribute to neoantigen identification, enabling personalized cancer immunotherapies. This review discusses various computational tools/pipelines, their implementation, clinical trials on neoantigenic vaccines, and the limitations/prospects of neoantigen prediction.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"26 6","pages":"531-538"},"PeriodicalIF":4.5,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal activation of platelets and inflammation in smoking-induced rheumatoid arthritis is alleviated by 3,3′-diindolylmethane 3,3′-二吲哚基甲烷可减轻吸烟引起的类风湿关节炎的血小板异常活化和炎症。

IF 4.5 3区医学

Genes and immunity Pub Date : 2025-10-11 DOI: 10.1038/s41435-025-00360-4

Bo Cai, Yizheng You, Longbo Huang, Cheng Zhu, Haofeng Lin, Jinyang Chen, Ruitao Ye, Zhou Zhou, Yibin Huang, Longying Zha, Ligang Jie, Du Hongyan

{"title":"Abnormal activation of platelets and inflammation in smoking-induced rheumatoid arthritis is alleviated by 3,3′-diindolylmethane","authors":"Bo Cai, Yizheng You, Longbo Huang, Cheng Zhu, Haofeng Lin, Jinyang Chen, Ruitao Ye, Zhou Zhou, Yibin Huang, Longying Zha, Ligang Jie, Du Hongyan","doi":"10.1038/s41435-025-00360-4","DOIUrl":"10.1038/s41435-025-00360-4","url":null,"abstract":"Rheumatoid arthritis (RA) is generally recognized as a complex disease initiated by environmental factors in the context of genetic susceptibility, among which smoking is one of the independent risk factors for RA. Smoking exposure would promote RA inflammation amplification probably because of platelet abnormal activation. This study aims to discover the preventive bioactivities of 3,3′-diindolylmethane (DIM) against RA with smoke exposure and explore the mechanisms by targeting platelet. The findings demonstrate that DIM can ameliorate smoking induced inflammation amplification in CIA mice through diverse of pathology analysis. Notably, the platelet abnormal activation was observed in CIA mice with smoke exposure and it was indeed inhibited by DIM treatment. Additionally, in vitro cigarette smoke extract (CSE) promoted platelet abnormal activation and aggregation characterizing by up-regulation of CD62p expression, Ca2+ mobilization, ROS release and down-regulation of mitochondrial membrane potential (ΔΨm), while DIM could suppress these processes. We verified DIM could mitigate RA inflammation amplification induced by smoking and smoke exposure via inhibiting MAPK/NF-κB and PI3K/Akt/mTOR pathways phosphorylation during platelets abnormal activation. Our research provided a scientific basis for the rational use of DIM and other phytochemicals in the prevention and treatment of RA with smoking and smoke exposure from the perspective of nutrition.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"26 6","pages":"613-625"},"PeriodicalIF":4.5,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-translational acylation modulates immunosuppression and immunotherapy efficacy in hepatocellular carcinoma 翻译后酰化调节肝癌的免疫抑制和免疫治疗效果。

IF 4.5 3区医学

Genes and immunity Pub Date : 2025-10-04 DOI: 10.1038/s41435-025-00362-2

Yunjie Li, Shuya Bai, Jichang Hu, Heli Li, Chen Hu, Jinzhu Zhao, Hong Qian, Zhouping Tang, Yangyang Feng

{"title":"Post-translational acylation modulates immunosuppression and immunotherapy efficacy in hepatocellular carcinoma","authors":"Yunjie Li, Shuya Bai, Jichang Hu, Heli Li, Chen Hu, Jinzhu Zhao, Hong Qian, Zhouping Tang, Yangyang Feng","doi":"10.1038/s41435-025-00362-2","DOIUrl":"10.1038/s41435-025-00362-2","url":null,"abstract":"Acylation modification plays a crucial role in modulating hepatocellular carcinoma (HCC) progression, and their specific prognostic implications in HCC have not been thoroughly investigated. Eleven acylation modifications (crotonylation, lactylation, succinylation, benzoylation, butyrylation, malonylation, glutarylation, 2-hydroxyisobutyrylation, β-hydroxybutyrylation, palmitoylation, myristoylation, and prenylation) were generated consensus cluster. Then, WGCNA was utilized to identify module genes. Finally, machine learning approach was employed to create acylation modification related genes.score (AMRG.score). This analysis revealed two distinct subtypes of AMRG, each characterized by unique molecular signatures. Through the combination of DEGs, DEGs associated with prognosis, and WGCNA, a total of 21 key genes were identified, leading to the creation of AMRG.score. AMRG.score was rigorously validated across independent external cohorts (TCGA-LIHC, LIRI-JP, GSE10143, GSE14520, GSE27150, GSE36376, and GSE76427) and an in-house cohort, demonstrating its reliability and potential applicability. The AMRG.score serves a dual purpose in its application, as it encapsulates essential the clinical context and offers valuable insights regarding the immunotherapy. In particular, patients categorized with a high AMRG.score displayed an active TME and sensitive to immunotherapy. This novel acylation modification-related prognostic signature could effectively assess the prognosis and therapeutic responses of HCC patients, providing new perspectives for individualized treatment for the patient population.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"26 6","pages":"599-612"},"PeriodicalIF":4.5,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Annexin A1 regulates inflammatory-immune response and reduces pancreatic and extra- pancreatic injury during severe acute pancreatitis 更正：在严重急性胰腺炎中，膜联蛋白A1调节炎症免疫反应并减少胰腺和胰腺外损伤。

IF 4.5 3区医学

Genes and immunity Pub Date : 2025-09-29 DOI: 10.1038/s41435-025-00348-0

Shizhao Lin, Feihong Liang, Changgan Chen, Jiajing Lin, Yuwei Wu, Zelin Hou, Heguang Huang, Haizong Fang, Yu Pan

引用次数: 0

αCGRP deficiency aggravates pulmonary fibrosis by promoting senescence in alveolar type 2 cells α - cgrp缺乏通过促进肺泡2型细胞衰老而加重肺纤维化。

IF 4.5 3区医学

Genes and immunity Pub Date : 2025-09-29 DOI: 10.1038/s41435-025-00361-3

Xiaoting Lv, Qingquan Chen, Ziying Zhou, Weijing Wu, Xingliang Yu, Yiming Zeng

{"title":"αCGRP deficiency aggravates pulmonary fibrosis by promoting senescence in alveolar type 2 cells","authors":"Xiaoting Lv, Qingquan Chen, Ziying Zhou, Weijing Wu, Xingliang Yu, Yiming Zeng","doi":"10.1038/s41435-025-00361-3","DOIUrl":"10.1038/s41435-025-00361-3","url":null,"abstract":"To investigate whether αCGRP (Calca) deficiency exacerbates pulmonary fibrosis (PF) by promoting alveolar type 2 (AT2) cell senescence, we retrospectively analyzed clinical data and lung biopsy samples from PF patients (n = 15). In vivo, lung tissues from Calca-knockout (KO) rats and D-galactose (D-gal)-induced senescence models were analyzed using immunohistochemistry, single-cell RNA sequencing (scRNA-seq), and label-free proteomics. PF patient samples showed low αCGRP expression, AT2 subtype differentiation, and high Calca promoter methylation. In Calca-/- rats, AT2 differentiation and oxidative lipid metabolism were enhanced, with increased senescence gene signatures. scRNA-seq revealed upregulation of linoleic, α-linolenic, and arachidonic acid metabolism, alongside suppression of oxidative stress responses in AT2 of the Calca-/- group. D-gal treatment induced alveolitis, fibrotic changes and AT2 subtype differentiation, and the most severe alveolar inflammation was found in Calca-/-+D-gal rats. Proteomics revealed distinct metabolic pathway alterations between WT + D-gal and Calca-/-+D-gal, and Calca-/- and WT + D-gal rats. Differences in metabolic and PPAR pathways were observed between Calca-/- and Calca-/-+D-gal rats. Additionally, both D-gal treatment and Calca-/- affect oxidative phosphorylation. Overall, αCGRP deficiency disrupts AT2 lipid metabolism, and accelerates AT2 inflammatory senescence, ultimately promoting pulmonary fibrosis.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"26 6","pages":"589-598"},"PeriodicalIF":4.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41435-025-00361-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: A scan of pleiotropic immune mediated disease genes identifies novel determinants of baseline FVIII inhibitor status in hemophilia A 更正：多效性免疫介导疾病基因扫描确定了血友病A中FVIII抑制剂基线状态的新决定因素。

IF 4.5 3区医学

Genes and immunity Pub Date : 2025-09-25 DOI: 10.1038/s41435-025-00345-3

Marcio A. Almeida, Vincent P. Diego, Kevin R. Viel, Bernadette W. Luu, Karin Haack, Raja Rajalingam, Afshin Ameri, Meera Chitlur, Natalia Rydz, David Lillicrap, Raymond G. Watts, Craig M. Kessler, Christopher Ramsey, Long V. Dinh, Benjamin Kim, Jerry S. Powell, Eron G. Manusov, Juan M. Peralta, Ruayda Bouls, Shirley M. Abraham, Yu-Min Shen, Carlos M. Murillo, Henry Mead, Paul V. Lehmann, Eli J. Fine, Miguel A. Escobar, Satish Kumar, Barbara A. Konkle, Sarah Williams-Blangero, Carol K. Kasper, Laura Almasy, Shelley A. Cole, John Blangero, Tom E. Howard

引用次数: 0

Dexmedetomidine relieves LPS-induced acute lung injury by boosting HIF-1a/ACOD1 driven anti-inflammatory macrophage polarization 右美托咪定通过增强HIF-1a/ACOD1驱动的抗炎巨噬细胞极化来缓解lps诱导的急性肺损伤。

IF 4.5 3区医学

Genes and immunity Pub Date : 2025-09-24 DOI: 10.1038/s41435-025-00355-1

Ning Zhang, Tangbing Chen, Yintao Chang, Mingzhi Cao, Huan Wang, Chengli Wu, Hong Jiang

{"title":"Dexmedetomidine relieves LPS-induced acute lung injury by boosting HIF-1a/ACOD1 driven anti-inflammatory macrophage polarization","authors":"Ning Zhang, Tangbing Chen, Yintao Chang, Mingzhi Cao, Huan Wang, Chengli Wu, Hong Jiang","doi":"10.1038/s41435-025-00355-1","DOIUrl":"10.1038/s41435-025-00355-1","url":null,"abstract":"Acute lung injury (ALI) is a common and life-threatening lung disease. This study investigated the mechanism by which dexmedetomidine (Dex) alleviates lipopolysaccharide (LPS)-induced ALI, focusing on its regulation of macrophage autophagy and polarization. Initially, a mouse model of LPS-induced ALI was pretreated with Dex. Pulmonary function, histopathological changes, apoptosis, macrophage numbers in bronchoalveolar lavage fluid (BALF), M1/M2 macrophage ratios, iNOS/Arg-1/LC3/P62 fluorescence intensity, and autophagy flux were assessed. Subsequently, RAW264.7 macrophages were treated with LPS and Dex, transfected with si-ACOD1 or si-HIF-1α, and co-cultured with mouse pulmonary microvessel endothelial cells (MPMVECs). The results showed that Dex relieved autophagy flux blockage and promoted autophagy in ALI mice. LPS promoted ACOD1 and HIF-1α levels, and Dex further enhanced their levels to boost macrophage autophagy and M2 polarization. ACOD1 was transcriptionally regulated by HIF-1α. Collectively, Dex mitigated LPS-induced MPMVEC injury and ALI by enhancing HIF-1α-mediated ACOD1 transcription, thus promoting macrophage autophagy and M2 polarization.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"26 6","pages":"561-576"},"PeriodicalIF":4.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity 支气管上皮细胞的表观基因组景观揭示了训练免疫的建立。

IF 4.5 3区医学

Genes and immunity Pub Date : 2025-09-24 DOI: 10.1038/s41435-025-00357-z

Jeanne Bigot, Rachel Legendre, Juliette Hamroune, Sébastien Jacques, Mathieu Le Gars, Nicolas Millet, Loïc Guillot, Harriet Corvol, Christophe Hennequin, Juliette Guitard, Jean-Yves Coppée, Viviane Balloy, Claudia Chica

{"title":"The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity","authors":"Jeanne Bigot, Rachel Legendre, Juliette Hamroune, Sébastien Jacques, Mathieu Le Gars, Nicolas Millet, Loïc Guillot, Harriet Corvol, Christophe Hennequin, Juliette Guitard, Jean-Yves Coppée, Viviane Balloy, Claudia Chica","doi":"10.1038/s41435-025-00357-z","DOIUrl":"10.1038/s41435-025-00357-z","url":null,"abstract":"Innate immune memory, also called trained immunity, refers to the ability of innate immune cells to gain memory characteristics after transient stimulation, resulting in a nonspecific modified inflammatory response upon secondary remote challenge. Bronchial epithelial cells (BECs) participate in innate immune defence and are the first cells of the lower respiratory tract to encounter inhaled pathogens. We recently showed that BECs are capable of innate immune memory after preexposure to Pseudomonas aeruginosa flagellin through epigenetic mechanisms. In the present study, we investigated such mechanisms through the modification of chromatin architecture induced by flagellin preexposure that results in subsequent changes of gene expression. By conducting an unsupervised approach to jointly analyse chromatin accessibility and gene expression, we mapped the remodelling of the epigenomic and transcriptomic profiles during the establishment of BECs memory. We identified a Memory regulatory profile induced by flagellin exposure. It includes clusters of upregulated genes related to inflammation that are linked to a sustainable gain in chromatin accessibility and with an increased activity of specific transcription factors (TFs) whose binding may drive this process. In summary, we demonstrated that flagellin exposure induced changes in chromatin condensation in BECs, which sustains the reprogramming of transcriptional patterns.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"26 6","pages":"577-588"},"PeriodicalIF":4.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41435-025-00357-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0