Genes and immunity最新文献_第6页

HER2-targeting CAR-T cells show highly efficient anti-tumor activity against glioblastoma both in vitro and in vivo HER2靶向CAR-T细胞在体外和体内对胶质母细胞瘤都显示出高效的抗肿瘤活性。

IF 5 3区医学

Genes and immunity Pub Date : 2024-05-03 DOI: 10.1038/s41435-024-00275-6

Xueying Li, Lifen Zhao, Wenzhe Li, Peng Gao, Nianzhu Zhang

{"title":"HER2-targeting CAR-T cells show highly efficient anti-tumor activity against glioblastoma both in vitro and in vivo","authors":"Xueying Li, Lifen Zhao, Wenzhe Li, Peng Gao, Nianzhu Zhang","doi":"10.1038/s41435-024-00275-6","DOIUrl":"10.1038/s41435-024-00275-6","url":null,"abstract":"Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor in adults. Current treatment options for GBM include surgical resection, radiation, and chemotherapy, which predominantly slow cancer growth and reduce symptoms, resulting in a 5-year survival rate of no more than 10%. Chimeric antigen receptor (CAR) T-cell therapy is a new class of cellular immunotherapy that has made great progress in treating malignant tumors. Human epidermal growth factor receptor 2 (HER2) is overexpressed in GBM and may provide a potential therapeutic target for GBM treatment. In this study, we constructed third-generation CAR-T cells targeting the HER2 antigen in GBM. HER2-CAR-T cells showed effective anti-tumor activity both in vitro and in vivo. Furthermore, HER2-specific CAR-T cells exhibited strong cytotoxicity and cytokine-secreting abilities against GBM cells in vitro. Anti-HER2 CAR-T cells also exhibited increased cytotoxicity with increasing effector-to-target ratios. Anti-HER2 CAR-T cells delivered via peritumoral injection successfully stunted tumor progression in vivo. Moreover, peritumoral intravenous administration of anti-HER2 CAR-T cells resulted in therapeutic improvement against GBM cells compared with intravenous administration. In conclusion, our study shows that HER2 CAR-T cells represent an emerging immunotherapy for treating GBM.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 3","pages":"201-208"},"PeriodicalIF":5.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41435-024-00275-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidized phospholipids during microbial challenge: friend or foe? 微生物挑战过程中的氧化磷脂：敌还是友？

IF 5 3区医学

Genes and immunity Pub Date : 2024-04-22 DOI: 10.1038/s41435-024-00273-8

Henrique G. Colaço, Kelsey Voss

引用次数: 0

MDSC expansion during HIV infection: regulators, ART and immune reconstitution 艾滋病毒感染期间 MDSC 的扩增：调节器、抗逆转录病毒疗法和免疫重建

IF 5 3区医学

Genes and immunity Pub Date : 2024-04-11 DOI: 10.1038/s41435-024-00272-9

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani

引用次数: 0

Correction: Same name, different game?—How ontogeny shapes classical monocyte phenotypes 更正：同样的名字，不同的游戏？--本体如何塑造经典的单核细胞表型。

IF 5 3区医学

Genes and immunity Pub Date : 2024-04-09 DOI: 10.1038/s41435-024-00269-4

Lisabeth Pimenov, Azuah Lucrecia Gonzalez, Amanda C. Doran, Sylvia Knapp

引用次数: 0

Transcriptomic meta-analysis characterizes molecular commonalities between psoriasis and obesity 转录组元分析描述了银屑病与肥胖之间的分子共性。

IF 5 3区医学

Genes and immunity Pub Date : 2024-04-05 DOI: 10.1038/s41435-024-00271-w

Charalabos Antonatos, Georgios K. Georgakilas, Evangelos Evangelou, Yiannis Vasilopoulos

{"title":"Transcriptomic meta-analysis characterizes molecular commonalities between psoriasis and obesity","authors":"Charalabos Antonatos, Georgios K. Georgakilas, Evangelos Evangelou, Yiannis Vasilopoulos","doi":"10.1038/s41435-024-00271-w","DOIUrl":"10.1038/s41435-024-00271-w","url":null,"abstract":"Despite the abundance of epidemiological evidence for the high comorbid rate between psoriasis and obesity, systematic approaches to common inflammatory mechanisms have not been adequately explored. We performed a meta-analysis of publicly available RNA-sequencing datasets to unveil putative mechanisms that are postulated to exacerbate both diseases, utilizing both late-stage, disease-specific meta-analyses and consensus gene co-expression network (cWGCNA). Single-gene meta-analyses reported several common inflammatory mechanisms fostered by the perturbed expression profile of inflammatory cells. Assessment of gene overlaps between both diseases revealed significant overlaps between up- (n = 170, P value = 6.07 × 10−65) and down-regulated (n = 49, P value = 7.1 × 10−7) genes, associated with increased T cell response and activated transcription factors. Our cWGCNA approach disentangled 48 consensus modules, associated with either the differentiation of leukocytes or metabolic pathways with similar correlation signals in both diseases. Notably, all our analyses confirmed the association of the perturbed T helper (Th)17 differentiation pathway in both diseases. Our novel findings through whole transcriptomic analyses characterize the inflammatory commonalities between psoriasis and obesity implying the assessment of several expression profiles that could serve as putative comorbid disease progression biomarkers and therapeutic interventions.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 3","pages":"179-187"},"PeriodicalIF":5.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140737220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative single-cell transcriptomic profile of hybrid immunity induced by adenovirus vector-based COVID-19 vaccines 基于腺病毒载体的 COVID-19 疫苗诱导的混合免疫的单细胞转录组比较图谱

IF 5 3区医学

Genes and immunity Pub Date : 2024-04-03 DOI: 10.1038/s41435-024-00270-x

Melissa García-Vega, Hui Wan, Mónica Reséndiz-Sandoval, Diana Hinojosa-Trujillo, Olivia Valenzuela, Verónica Mata-Haro, Freddy Dehesa-Canseco, Mario Solís-Hernández, Harold Marcotte, Qiang Pan-Hammarström, Jesús Hernández

{"title":"Comparative single-cell transcriptomic profile of hybrid immunity induced by adenovirus vector-based COVID-19 vaccines","authors":"Melissa García-Vega, Hui Wan, Mónica Reséndiz-Sandoval, Diana Hinojosa-Trujillo, Olivia Valenzuela, Verónica Mata-Haro, Freddy Dehesa-Canseco, Mario Solís-Hernández, Harold Marcotte, Qiang Pan-Hammarström, Jesús Hernández","doi":"10.1038/s41435-024-00270-x","DOIUrl":"10.1038/s41435-024-00270-x","url":null,"abstract":"In this study, antibody response and a single-cell RNA-seq analysis were conducted on peripheral blood mononuclear cells from five different groups: naïve subjects vaccinated with AZD1222 (AZ) or Ad5-nCoV (Cso), individuals previously infected and later vaccinated (hybrid) with AZD1222 (AZ-hb) or Ad5-nCoV (Cso-hb), and those who were infected and had recovered from COVID-19 (Inf). The results showed that AZ induced more robust neutralizing antibody responses than Cso. The single-cell RNA data revealed a high frequency of memory B cells in the Cso and Cso-hb. In contrast, AZ and AZ-hb groups exhibited the highest proportion of activated naïve B cells expressing CXCR4. Transcriptomic analysis of CD4+ and CD8+ T cells demonstrated a heterogeneous response following vaccination, hybrid immunity, or natural infection. However, a single dose of Ad5-nCoV was sufficient to strongly activate CD4+ T cells (naïve and memory) expressing ANX1 and FOS, similar to the hybrid response observed with AZ. An interesting finding was the robust activation of a subset of CD8+ T cells expressing GZMB, GZMH, and IFNG genes in the Cso-hb group. Our findings suggest that both vaccines effectively stimulated the cellular immune response; however, the Ad5-nCoV induced a more robust CD8+ T-cell response in previously infected individuals.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 2","pages":"158-167"},"PeriodicalIF":5.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140559882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: An immunogenomic exome landscape of triple positive primary antiphospholipid patients 更正：三阳性原发性抗磷脂患者的免疫基因组外显子图谱。

IF 5 3区医学

Genes and immunity Pub Date : 2024-03-19 DOI: 10.1038/s41435-024-00261-y

A. Guffroy, L. Jacquel, Y. Seeleuthner, N. Paul, V. Poindron, F. Maurier, V. Delannoy, A. C. Voegeli, P. Zhang, B. Nespola, A. Molitor, M. J. Apithy, P. Soulas-Sprauel, T. Martin, R. E. Voll, S. Bahram, V. Gies, J. L. Casanova, A. Cobat, B. Boisson, R. Carapito, A. S. Korganow

引用次数: 0

Neu5Gc regulates decidual macrophages leading to abnormal embryo implantation Neu5Gc 可调节蜕膜巨噬细胞，导致胚胎异常着床。

IF 5 3区医学

Genes and immunity Pub Date : 2024-03-18 DOI: 10.1038/s41435-024-00268-5

Wu Yue, Zhou Huiling, Liu Yuxin, Wang Ling, Gao Feng, Liu Qicai

引用次数: 0

Chemoimmunotherapy combinations: translating basic knowledge into clinical successes 化学免疫疗法组合：将基础知识转化为临床成功。

IF 5 3区医学

Genes and immunity Pub Date : 2024-03-13 DOI: 10.1038/s41435-024-00264-9

Lionel Apetoh

引用次数: 0

RNA processing modification mediated subtypes illustrate the distinctive features of tumor microenvironment in hepatocellular carcinoma RNA 加工修饰介导的亚型说明了肝细胞癌肿瘤微环境的独特特征。

IF 5 3区医学

Genes and immunity Pub Date : 2024-03-12 DOI: 10.1038/s41435-024-00265-8

Xinhui Li, Shan Liu, Laibin Zou, Min Dai, Chaobei Zhu

{"title":"RNA processing modification mediated subtypes illustrate the distinctive features of tumor microenvironment in hepatocellular carcinoma","authors":"Xinhui Li, Shan Liu, Laibin Zou, Min Dai, Chaobei Zhu","doi":"10.1038/s41435-024-00265-8","DOIUrl":"10.1038/s41435-024-00265-8","url":null,"abstract":"Multiple transcript isoforms of genes can be formed by processing and modifying the 5′ and 3′ ends of RNA. Herein, the aim of this study is to uncover the characteristics of RNA processing modification (RPM) in hepatocellular carcinoma (HCC), and to identify novel biomarkers and potential targets for treatment. Firstly, integrated bioinformatics analysis was carried out to identify risk prognostic RPM regulators (RPMRs). Then, we used these RPMRs to identify subtypes of HCC and explore differences in immune microenvironment and cellular function improvement pathways between the sub-types. Finally, we used the principal component analysis algorithms to estimate RPMscore, which were applied to 5 cohorts. Lower RPMscore among patients correlated with a declined survival rate, increased immune infiltration, and raised expression of immune checkpoints, aligning with the “immunity tidal model theory”. The RPMscore exhibited robust, which was validated in multiple datasets. Mechanistically, low RPMscore can create an immunosuppressive microenvironment in HCC by manipulating tumor-associated macrophages. Preclinically, patients with high RPMscore might benefit from immunotherapy. The RPMscore is helpful in clustering HCC patients with distinct prognosis and immunotherapy. Our RPMscore model can help clinicians to select personalized therapy for HCC patients, and RPMscore may act a part in the development of HCC.","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 2","pages":"132-148"},"PeriodicalIF":5.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0