Frontiers in Neuroendocrinology最新文献_第3页

Nestorone (segesterone acetate) effects on neuroregeneration Nestorone（醋酸雌甾醇）对神经再生的影响

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-04-01 DOI: 10.1016/j.yfrne.2024.101136

Regine Sitruk-Ware , Heather Sussman , Roberta Brinton , Michael Schumacher , Patrick Singer , Narender Kumar , Alejandro F. De Nicola , Martine El-Etr , Rachida Guennoun , Cesar V Borlongan

{"title":"Nestorone (segesterone acetate) effects on neuroregeneration","authors":"Regine Sitruk-Ware , Heather Sussman , Roberta Brinton , Michael Schumacher , Patrick Singer , Narender Kumar , Alejandro F. De Nicola , Martine El-Etr , Rachida Guennoun , Cesar V Borlongan","doi":"10.1016/j.yfrne.2024.101136","DOIUrl":"10.1016/j.yfrne.2024.101136","url":null,"abstract":"<div><p>Nestorone® (segesterone acetate) is a progestin with a chemical structure closely related to progesterone with high affinity and selectivity for the progesterone receptor without significant interaction with other steroid receptors. It has been developed for female and male contraception and is FDA-approved in a first long-acting contraceptive vaginal system for female contraception. Its safety has been extensively demonstrated in both preclinical and clinical studies for contraceptive indications. Nestorone was found to display neuroprotective and neuroregenerative activity in animal models of various central nervous system diseases, including multiple sclerosis, stroke, and amyotrophic lateral sclerosis. Reviewed herein are neuroprotective and myelin- regenerating properties of Nestorone in various animal models and its translational potential as a therapeutic agent for debilitating neurological diseases for which limited therapeutic options are available (<span>Table 1</span>).</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"73 ","pages":"Article 101136"},"PeriodicalIF":7.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140760970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications 神经类固醇在创伤后应激障碍和酒精使用障碍中的作用：10 年临床文献回顾及治疗意义

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-04-01 DOI: 10.1016/j.yfrne.2023.101119

MacKenzie R. Peltier , Terril L. Verplaetse , Margaret Altemus , Yasmin Zakiniaeiz , Elizabeth A. Ralevski , Yann S. Mineur , Ralitza Gueorguieva , Marina R. Picciotto , Kelly P. Cosgrove , Ismene Petrakis , Sherry A. McKee

{"title":"The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications","authors":"MacKenzie R. Peltier , Terril L. Verplaetse , Margaret Altemus , Yasmin Zakiniaeiz , Elizabeth A. Ralevski , Yann S. Mineur , Ralitza Gueorguieva , Marina R. Picciotto , Kelly P. Cosgrove , Ismene Petrakis , Sherry A. McKee","doi":"10.1016/j.yfrne.2023.101119","DOIUrl":"10.1016/j.yfrne.2023.101119","url":null,"abstract":"<div><p>Rates of alcohol use disorder (AUD) are increasing in men and women and there are high rates of concurrent posttraumatic stress disorder (PTSD) and AUD. AUD and PTSD synergistically increase symptomatology and negatively affect treatment outcomes; however, there are very limited pharmacological treatments for PTSD/AUD. Neurosteroids have been implicated in the underlying neurobiological mechanisms of both PTSD and AUD and may be a target for treatment development. This review details the past ten years of research on pregnenolone, progesterone, allopregnanolone, pregnanolone, estradiol, testosterone and dehydroepiandrosterone/dehydroepiandrosterone-sulfate (DHEA/DHEA-S) in the context of PTSD and AUD, including examination of trauma/alcohol-related variables, such as stress-reactivity. Emerging evidence that exogenous pregnenolone, progesterone, and allopregnanolone may be promising, novel interventions is also discussed. Specific emphasis is placed on examining the application of sex as a biological variable in this body of literature, given that women are more susceptible to both PTSD diagnoses and stress-related alcohol consumption.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"73 ","pages":"Article 101119"},"PeriodicalIF":7.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139105082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The research landscape concerning environmental factors in neurodevelopmental disorders: Endocrine disrupters and pesticides—A review 有关神经发育障碍环境因素的研究概况：内分泌干扰素和杀虫剂--综述。

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-04-01 DOI: 10.1016/j.yfrne.2024.101132

Rebeca Mira Sánchez , Juan Felipe Bermeo Losada , Juan Antonio Marín Martínez

{"title":"The research landscape concerning environmental factors in neurodevelopmental disorders: Endocrine disrupters and pesticides—A review","authors":"Rebeca Mira Sánchez , Juan Felipe Bermeo Losada , Juan Antonio Marín Martínez","doi":"10.1016/j.yfrne.2024.101132","DOIUrl":"10.1016/j.yfrne.2024.101132","url":null,"abstract":"<div><p>In recent years, environmental epidemiology and toxicology have seen a growing interest in the environmental factors that contribute to the increased prevalence of neurodevelopmental disorders, with the purpose of establishing appropriate prevention strategies. A literature review was performed, and 192 articles covering the topic of endocrine disruptors and neurodevelopmental disorders were found, focusing on polychlorinated biphenyls, polybrominated diphenyl ethers, bisphenol A, and pesticides. This study contributes to analyzing their effect on the molecular mechanism in maternal and infant thyroid function, essential for infant neurodevelopment, and whose alteration has been associated with various neurodevelopmental disorders. The results provide scientific evidence of the association that exists between the environmental neurotoxins and various neurodevelopmental disorders. In addition, other possible molecular mechanisms by which pesticides and endocrine disruptors may be associated with neurodevelopmental disorders are being discussed.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"73 ","pages":"Article 101132"},"PeriodicalIF":7.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Celebrating 60 years of neuroendocrinology 庆祝神经内分泌学诞生 60 周年

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-04-01 DOI: 10.1016/j.yfrne.2024.101134

Liisa A.M. Galea

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From means to meaning in the study of sex/gender differences and similarities 性/性别异同研究从手段到意义

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-04-01 DOI: 10.1016/j.yfrne.2024.101133

Carla Sanchis-Segura , Rand R. Wilcox

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Editorial- State of the art on steroids and the nervous system: In memory of Giancarlo 社论--类固醇与神经系统的最新研究成果：纪念詹卡洛

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-04-01 DOI: 10.1016/j.yfrne.2024.101135

Roberto Cosimo Melcangi, Silvia Giatti, Stefano Gotti

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Sodium-glucose cotransporter-2 inhibitors and their potential role in dementia onset and cognitive function in patients with diabetes mellitus: a systematic review and meta-analysis 钠-葡萄糖共转运体-2抑制剂及其在糖尿病患者痴呆症发病和认知功能方面的潜在作用：系统综述和荟萃分析。

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-02-16 DOI: 10.1016/j.yfrne.2024.101131

Yea Jin Youn , Seungyeon Kim , Hyun-Jeong Jeong , Young-Mi Ah , Yun Mi Yu

{"title":"Sodium-glucose cotransporter-2 inhibitors and their potential role in dementia onset and cognitive function in patients with diabetes mellitus: a systematic review and meta-analysis","authors":"Yea Jin Youn , Seungyeon Kim , Hyun-Jeong Jeong , Young-Mi Ah , Yun Mi Yu","doi":"10.1016/j.yfrne.2024.101131","DOIUrl":"10.1016/j.yfrne.2024.101131","url":null,"abstract":"<div><p>This systematic review and meta-analysis aimed to determine the association between the use of sodium-glucose cotransporter 2 (SGLT-2) inhibitors and dementia onset as well as cognitive function in patients with diabetes mellitus. We comprehensively searched the MEDLINE, Embase, and CENTRAL databases to select relevant studies published up to August 2023. The use of SGLT-2 inhibitors significantly lowers dementia risk compared to SGLT-2i non-users (Hazard ratio: 0.68, 95 % CI: 0.50–0.92). Furthermore, our findings indicated a positive effect of SGLT-2 inhibitor use on cognitive function score improvement, as demonstrated by the standardized mean difference of 0.88 (95 % CI: 0.32–1.44), particularly among populations with mild cognitive impairment or dementia. This systematic review and meta-analysis indicate a potential role of SGLT-2 inhibitors in reducing the risk of dementia in patients with diabetes mellitus. These findings underscore the need for well-controlled large clinical trials and future research in this field.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"73 ","pages":"Article 101131"},"PeriodicalIF":7.4,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302224000116/pdfft?md5=d705299bbfab00768568ceb8fabe2a5c&pid=1-s2.0-S0091302224000116-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139897928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cholecystokinin (CCK): a neuromodulator with therapeutic potential in Alzheimer’s and Parkinson’s disease 胆囊收缩素（CCK）：一种对阿尔茨海默氏症和帕金森氏症具有治疗潜力的神经调节剂。

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-02-10 DOI: 10.1016/j.yfrne.2024.101122

Niklas Reich , Christian Hölscher

{"title":"Cholecystokinin (CCK): a neuromodulator with therapeutic potential in Alzheimer’s and Parkinson’s disease","authors":"Niklas Reich , Christian Hölscher","doi":"10.1016/j.yfrne.2024.101122","DOIUrl":"10.1016/j.yfrne.2024.101122","url":null,"abstract":"<div><p>Cholecystokinin (CCK) is a neuropeptide modulating digestion, glucose levels, neurotransmitters and memory. Recent studies suggest that CCK exhibits neuroprotective effects in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Thus, we review the physiological function and therapeutic potential of CCK. The neuropeptide facilitates hippocampal glutamate release and gates GABAergic basket cell activity, which improves declarative memory acquisition, but inhibits consolidation. Cortical CCK alters recognition memory and enhances audio-visual processing. By stimulating CCK-1 receptors (CCK-1Rs), sulphated CCK-8 elicits dopamine release in the substantia nigra and striatum. In the mesolimbic pathway, CCK release is triggered by dopamine and terminates reward responses via CCK-2Rs. Importantly, activation of hippocampal and nigral CCK-2Rs is neuroprotective by evoking AMPK activation, expression of mitochondrial fusion modulators and autophagy. Other benefits include vagus nerve/CCK-1R-mediated expression of brain-derived neurotrophic factor, intestinal protection and suppression of inflammation. We also discuss caveats and the therapeutic combination of CCK with other peptide hormones.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"73 ","pages":"Article 101122"},"PeriodicalIF":7.4,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302224000025/pdfft?md5=8a955eedbbebcc2aefde97b57dfdc255&pid=1-s2.0-S0091302224000025-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: A conceptual model for the study of sex and gender differences 早期生活压力、情感和青少年药物使用之间联系的神经内分泌机制：研究性和性别差异的概念模型

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-01-20 DOI: 10.1016/j.yfrne.2024.101121

Alexandra Donovan , Shervin Assari , Christine Grella , Magda Shaheen , Linda Richter , Theodore C. Friedman

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Sex differences in cortisol levels in depression: A systematic review and meta-analysis 抑郁症患者皮质醇水平的性别差异：系统综述与荟萃分析

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-01-01 DOI: 10.1016/j.yfrne.2023.101118

Rui Wang , Lydia Kogler , Birgit Derntl

{"title":"Sex differences in cortisol levels in depression: A systematic review and meta-analysis","authors":"Rui Wang , Lydia Kogler , Birgit Derntl","doi":"10.1016/j.yfrne.2023.101118","DOIUrl":"10.1016/j.yfrne.2023.101118","url":null,"abstract":"<div><p>Higher prevalence of depression in females might be associated with sex-specific cortisol levels. Evidence exists that cortisol levels differ between healthy females and males, however a sex-specific association in depression has not been systematically assessed. Thus, the current study quantifies the existing literature on different cortisol parameters, i.e., basal cortisol, hair cortisol, cortisol awakening response (CAR), and cortisol stress reactivity comparing depressed females and males as well as sex-specific comparisons with healthy controls. Following an extensive literature research, fifty original articles were included. Depressed females had significantly higher hair cortisol, higher CAR, and lower cortisol stress reactivity compared to depressed males. In comparison with sex-matched controls, female patients had significantly higher evening basal cortisol, higher CAR and lower cortisol stress reactivity, and male patients had significantly higher general, morning and evening basal cortisol. Overall, sex as a fundamental driver of cortisol levels in depression needs to be taken into account.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"72 ","pages":"Article 101118"},"PeriodicalIF":7.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139084487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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