Frontiers in Neuroendocrinology最新文献_第3页

Celebrating 60 years of neuroendocrinology 庆祝神经内分泌学诞生 60 周年

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-04-01 DOI: 10.1016/j.yfrne.2024.101134

Liisa A.M. Galea

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From means to meaning in the study of sex/gender differences and similarities 性/性别异同研究从手段到意义

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-04-01 DOI: 10.1016/j.yfrne.2024.101133

Carla Sanchis-Segura , Rand R. Wilcox

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Editorial- State of the art on steroids and the nervous system: In memory of Giancarlo 社论--类固醇与神经系统的最新研究成果：纪念詹卡洛

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-04-01 DOI: 10.1016/j.yfrne.2024.101135

Roberto Cosimo Melcangi, Silvia Giatti, Stefano Gotti

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Sodium-glucose cotransporter-2 inhibitors and their potential role in dementia onset and cognitive function in patients with diabetes mellitus: a systematic review and meta-analysis 钠-葡萄糖共转运体-2抑制剂及其在糖尿病患者痴呆症发病和认知功能方面的潜在作用：系统综述和荟萃分析。

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-02-16 DOI: 10.1016/j.yfrne.2024.101131

Yea Jin Youn , Seungyeon Kim , Hyun-Jeong Jeong , Young-Mi Ah , Yun Mi Yu

{"title":"Sodium-glucose cotransporter-2 inhibitors and their potential role in dementia onset and cognitive function in patients with diabetes mellitus: a systematic review and meta-analysis","authors":"Yea Jin Youn , Seungyeon Kim , Hyun-Jeong Jeong , Young-Mi Ah , Yun Mi Yu","doi":"10.1016/j.yfrne.2024.101131","DOIUrl":"10.1016/j.yfrne.2024.101131","url":null,"abstract":"<div><p>This systematic review and meta-analysis aimed to determine the association between the use of sodium-glucose cotransporter 2 (SGLT-2) inhibitors and dementia onset as well as cognitive function in patients with diabetes mellitus. We comprehensively searched the MEDLINE, Embase, and CENTRAL databases to select relevant studies published up to August 2023. The use of SGLT-2 inhibitors significantly lowers dementia risk compared to SGLT-2i non-users (Hazard ratio: 0.68, 95 % CI: 0.50–0.92). Furthermore, our findings indicated a positive effect of SGLT-2 inhibitor use on cognitive function score improvement, as demonstrated by the standardized mean difference of 0.88 (95 % CI: 0.32–1.44), particularly among populations with mild cognitive impairment or dementia. This systematic review and meta-analysis indicate a potential role of SGLT-2 inhibitors in reducing the risk of dementia in patients with diabetes mellitus. These findings underscore the need for well-controlled large clinical trials and future research in this field.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"73 ","pages":"Article 101131"},"PeriodicalIF":7.4,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302224000116/pdfft?md5=d705299bbfab00768568ceb8fabe2a5c&pid=1-s2.0-S0091302224000116-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139897928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cholecystokinin (CCK): a neuromodulator with therapeutic potential in Alzheimer’s and Parkinson’s disease 胆囊收缩素（CCK）：一种对阿尔茨海默氏症和帕金森氏症具有治疗潜力的神经调节剂。

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-02-10 DOI: 10.1016/j.yfrne.2024.101122

Niklas Reich , Christian Hölscher

{"title":"Cholecystokinin (CCK): a neuromodulator with therapeutic potential in Alzheimer’s and Parkinson’s disease","authors":"Niklas Reich , Christian Hölscher","doi":"10.1016/j.yfrne.2024.101122","DOIUrl":"10.1016/j.yfrne.2024.101122","url":null,"abstract":"<div><p>Cholecystokinin (CCK) is a neuropeptide modulating digestion, glucose levels, neurotransmitters and memory. Recent studies suggest that CCK exhibits neuroprotective effects in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Thus, we review the physiological function and therapeutic potential of CCK. The neuropeptide facilitates hippocampal glutamate release and gates GABAergic basket cell activity, which improves declarative memory acquisition, but inhibits consolidation. Cortical CCK alters recognition memory and enhances audio-visual processing. By stimulating CCK-1 receptors (CCK-1Rs), sulphated CCK-8 elicits dopamine release in the substantia nigra and striatum. In the mesolimbic pathway, CCK release is triggered by dopamine and terminates reward responses via CCK-2Rs. Importantly, activation of hippocampal and nigral CCK-2Rs is neuroprotective by evoking AMPK activation, expression of mitochondrial fusion modulators and autophagy. Other benefits include vagus nerve/CCK-1R-mediated expression of brain-derived neurotrophic factor, intestinal protection and suppression of inflammation. We also discuss caveats and the therapeutic combination of CCK with other peptide hormones.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"73 ","pages":"Article 101122"},"PeriodicalIF":7.4,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302224000025/pdfft?md5=8a955eedbbebcc2aefde97b57dfdc255&pid=1-s2.0-S0091302224000025-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: A conceptual model for the study of sex and gender differences 早期生活压力、情感和青少年药物使用之间联系的神经内分泌机制：研究性和性别差异的概念模型

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-01-20 DOI: 10.1016/j.yfrne.2024.101121

Alexandra Donovan , Shervin Assari , Christine Grella , Magda Shaheen , Linda Richter , Theodore C. Friedman

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Sex differences in cortisol levels in depression: A systematic review and meta-analysis 抑郁症患者皮质醇水平的性别差异：系统综述与荟萃分析

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-01-01 DOI: 10.1016/j.yfrne.2023.101118

Rui Wang , Lydia Kogler , Birgit Derntl

{"title":"Sex differences in cortisol levels in depression: A systematic review and meta-analysis","authors":"Rui Wang , Lydia Kogler , Birgit Derntl","doi":"10.1016/j.yfrne.2023.101118","DOIUrl":"10.1016/j.yfrne.2023.101118","url":null,"abstract":"<div><p>Higher prevalence of depression in females might be associated with sex-specific cortisol levels. Evidence exists that cortisol levels differ between healthy females and males, however a sex-specific association in depression has not been systematically assessed. Thus, the current study quantifies the existing literature on different cortisol parameters, i.e., basal cortisol, hair cortisol, cortisol awakening response (CAR), and cortisol stress reactivity comparing depressed females and males as well as sex-specific comparisons with healthy controls. Following an extensive literature research, fifty original articles were included. Depressed females had significantly higher hair cortisol, higher CAR, and lower cortisol stress reactivity compared to depressed males. In comparison with sex-matched controls, female patients had significantly higher evening basal cortisol, higher CAR and lower cortisol stress reactivity, and male patients had significantly higher general, morning and evening basal cortisol. Overall, sex as a fundamental driver of cortisol levels in depression needs to be taken into account.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"72 ","pages":"Article 101118"},"PeriodicalIF":7.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139084487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The role of stress in perinatal depression and anxiety – A systematic review 压力在围产期抑郁和焦虑中的作用 - 系统综述

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-01-01 DOI: 10.1016/j.yfrne.2023.101117

MA. Schalla , A. Stengel

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Electroencephalography findings in menstrually-related mood disorders: A critical review 月经相关情绪障碍的脑电图检查结果：批判性评论

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-01-01 DOI: 10.1016/j.yfrne.2023.101120

Elisavet Kaltsouni , Felix Schmidt , Rachel G. Zsido , Allison Eriksson , Julia Sacher , Inger Sundström-Poromaa , Rachael L. Sumner , Erika Comasco

{"title":"Electroencephalography findings in menstrually-related mood disorders: A critical review","authors":"Elisavet Kaltsouni , Felix Schmidt , Rachel G. Zsido , Allison Eriksson , Julia Sacher , Inger Sundström-Poromaa , Rachael L. Sumner , Erika Comasco","doi":"10.1016/j.yfrne.2023.101120","DOIUrl":"10.1016/j.yfrne.2023.101120","url":null,"abstract":"<div><p>The female reproductive years are characterized by fluctuations in ovarian hormones across the menstrual cycle, which have the potential to modulate neurophysiological and behavioral dynamics. Menstrually-related mood disorders (MRMDs) comprise cognitive-affective or somatic symptoms that are thought to be triggered by the rapid fluctuations in ovarian hormones in the luteal phase of the menstrual cycle. MRMDs include premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and premenstrual exacerbation (PME) of other psychiatric disorders. Electroencephalography (EEG) non-invasively records <em>in vivo</em> synchronous activity from populations of neurons with high temporal resolution. The present overview sought to systematically review the current state of task-related and resting-state EEG investigations on MRMDs. Preliminary evidence indicates lower alpha asymmetry at rest being associated with MRMDs, while one study points to the effect being luteal-phase specific. Moreover, higher luteal spontaneous frontal brain activity (slow/fast wave ratio as measured by the delta/beta power ratio) has been observed in persons with MRMDs, while sleep architecture results point to potential circadian rhythm disturbances. In this review, we discuss the quality of study designs as well as future perspectives and challenges of supplementing the diagnostic and scientific toolbox for MRMDs with EEG.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"72 ","pages":"Article 101120"},"PeriodicalIF":7.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302223000687/pdfft?md5=7d42373733a3221ea792628ecfc63b05&pid=1-s2.0-S0091302223000687-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139084483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Modulatory role of neurosteroidogenesis in the spinal cord during peripheral nerve injury-induced chronic pain 周围神经损伤诱发慢性疼痛期间脊髓中神经类固醇生成的调节作用

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-01-01 DOI: 10.1016/j.yfrne.2023.101116

Ayikoe-Guy Mensah-Nyagan, Laurence Meyer , Christine Patte-Mensah

{"title":"Modulatory role of neurosteroidogenesis in the spinal cord during peripheral nerve injury-induced chronic pain","authors":"Ayikoe-Guy Mensah-Nyagan, Laurence Meyer , Christine Patte-Mensah","doi":"10.1016/j.yfrne.2023.101116","DOIUrl":"10.1016/j.yfrne.2023.101116","url":null,"abstract":"<div><p>The brain and spinal cord (SC) are both targeted by various hormones, including steroid hormones. However, investigations of the modulatory role of hormones on neurobiological functions usually focus only on the brain. The SC received little attention although this structure pivotally controls motor and sensory functions. Here, we critically reviewed key data showing that the process of neurosteroid biosynthesis or neurosteroidogenesis occurring in the SC plays a pivotal role in the modulation of peripheral nerve injury-induced chronic pain (PNICP) or neuropathic pain. Indeed, several active steroidogenic enzymes expressed in the SC produce endogenous neurosteroids that interact with receptors of neurotransmitters controlling pain. The spinal neurosteroidogenesis is differentially regulated during PNICP condition and its blockade modifies painful sensations. The paper suggests that future investigations aiming to develop effective strategies against PNICP or neuropathic pain must integrate in a gender or sex dependent manner the regulatory effects exerted by spinal neurosteroidogenesis.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"72 ","pages":"Article 101116"},"PeriodicalIF":7.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139093971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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