Frontiers in Neuroendocrinology最新文献_第10页

Kisspeptin neuron electrophysiology: Intrinsic properties, hormonal modulation, and regulation of homeostatic circuits Kisspeptin神经元电生理学:内在特性、激素调节和自我平衡回路的调节

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.101006

Bradley B. Jamieson , Richard Piet

引用次数: 5

Exerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity 运动和长期突触增强:运动诱导的神经可塑性机制

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.100993

Wouter A.J. Vints , Oron Levin , Hakuei Fujiyama , Jeanine Verbunt , Nerijus Masiulis

{"title":"Exerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity","authors":"Wouter A.J. Vints , Oron Levin , Hakuei Fujiyama , Jeanine Verbunt , Nerijus Masiulis","doi":"10.1016/j.yfrne.2022.100993","DOIUrl":"10.1016/j.yfrne.2022.100993","url":null,"abstract":"<div><p>Physical exercise may improve cognitive function by modulating molecular and cellular mechanisms within the brain. We propose that the facilitation of long-term synaptic potentiation (LTP)-related pathways, by products induced by physical exercise (i.e., exerkines), is a crucial aspect of the exercise-effect on the brain. This review summarizes synaptic pathways that are activated by exerkines and may potentiate LTP. For a total of 16 exerkines, we indicated how blood and brain exerkine levels are altered depending on the type of physical exercise (i.e., cardiovascular or resistance exercise) and how they respond to a single bout (i.e., acute exercise) or multiple bouts of physical exercise (i.e., chronic exercise). This information may be used for designing individualized physical exercise programs. Finally, this review may serve to direct future research towards fundamental gaps in our current knowledge regarding the biophysical interactions between muscle activity and the brain at both cellular and system levels.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"66 ","pages":"Article 100993"},"PeriodicalIF":7.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302222000164/pdfft?md5=8684c6a3f939fcdf822cd9e3faa94773&pid=1-s2.0-S0091302222000164-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72714497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Methods and considerations for the use of hormonal contraceptives in rat models of neurobehavior 大鼠神经行为模型中使用激素避孕药的方法和考虑

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.101011

Emily N. Hilz

引用次数: 6

Can animal models resemble a premenstrual dysphoric condition? 动物模型能模拟经前烦躁吗?

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.101007

Estrada-Camarena Erika , Carolina López-Rubalcava

引用次数: 5

Metabolic hormones mediate cognition 代谢激素介导认知

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.101009

Olivia R. Ghosh-Swaby , Amy C. Reichelt , Paul A.S. Sheppard , Jeffrey Davies , Timothy J. Bussey , Lisa M. Saksida

引用次数: 4

The underlying sex differences in neuroendocrine adaptations relevant to Myalgic Encephalomyelitis Chronic Fatigue Syndrome 与肌痛性脑脊髓炎慢性疲劳综合征相关的神经内分泌适应的潜在性别差异

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.100995

Natalie Thomas , Caroline Gurvich , Katherine Huang , Paul R. Gooley , Christopher W. Armstrong

{"title":"The underlying sex differences in neuroendocrine adaptations relevant to Myalgic Encephalomyelitis Chronic Fatigue Syndrome","authors":"Natalie Thomas , Caroline Gurvich , Katherine Huang , Paul R. Gooley , Christopher W. Armstrong","doi":"10.1016/j.yfrne.2022.100995","DOIUrl":"10.1016/j.yfrne.2022.100995","url":null,"abstract":"<div><h3>Introduction</h3><p>Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) is a complex multisystem disease characterised by severe and disabling new-onset symptoms of post-exertional malaise (PEM), fatigue, brain fog, and sleep dysfunction that lasts for at least six months. Accumulating evidence suggests that sex and endocrine events have a significant influence on symptom onset and moderation of ME/CFS, with female sex being one of the most consistent and credible predictive risk factors associated with diagnosis. Such sex differences suggest sex chromosomes and sex steroids may play a part in the development of the condition or moderation of symptoms, although this has yet to be explored in detail.</p></div><div><h3>Methods/Aims</h3><p>This narrative review outlines sex differences in ME/CFS in terms of vulnerability factors and clinical phenotype and explores the known sex differences in neuroendocrine systems affected in ME/CFS and how this may relate to disease risk, onset, pathophysiology, and potential treatment avenues.</p></div><div><h3>Conclusions</h3><p>There is clear evidence of a sex dimorphism with regards to prevalence (3:1 female preponderance), clinical phenotypes, and aetiological triggers prior to symptom onset of ME/CFS. Endocrinological events, particularly those throughout the female lifespan, are associated with ME/CFS and include reproductive menstrual cycle fluctuations, pregnancy, post-partum and perimenopause. Further, there is evidence for gonadal sex, adrenal stress and renal neuroendocrine systems as implicated in ME/CFS, including changes in estrogen, progesterone compounds, aldosterone, and cortisol levels, of which there are established sex differences. The broad effects of steroid hormones on the physiological systems may also speak to the diversity of ME/CFS symptomatology observed in patients. Further attention must be paid to sex, age, and steroid biology in ME/CFS.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"66 ","pages":"Article 100995"},"PeriodicalIF":7.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77891173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Timing is everything: Circadian rhythms and their role in the control of sleep 时间决定一切:昼夜节律及其在控制睡眠中的作用

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.100978

Seithikurippu R. Pandi-Perumal , Daniel P. Cardinali , Nevin F.W. Zaki , Ramanujam Karthikeyan , David Warren Spence , Russel J. Reiter , Gregory M. Brown

引用次数: 7

Sex hormone fluctuation and increased female risk for depression and anxiety disorders: From clinical evidence to molecular mechanisms 性激素波动与女性抑郁症和焦虑症风险增加:从临床证据到分子机制

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.101010

Marija Kundakovic, Devin Rocks

{"title":"Sex hormone fluctuation and increased female risk for depression and anxiety disorders: From clinical evidence to molecular mechanisms","authors":"Marija Kundakovic, Devin Rocks","doi":"10.1016/j.yfrne.2022.101010","DOIUrl":"10.1016/j.yfrne.2022.101010","url":null,"abstract":"<div><p>Women are at twice the risk for anxiety and depression disorders as men are, although the underlying biological factors and mechanisms are largely unknown. In this review, we address this sex disparity at both the etiological and mechanistic level. We dissect the role of fluctuating sex hormones as a critical biological factor contributing to the increased depression and anxiety risk in women. We provide parallel evidence in humans and rodents that brain structure and function vary with naturally-cycling ovarian hormones. This female-unique brain plasticity and associated vulnerability are primarily driven by estrogen level changes. For the first time, we provide a sex hormone-driven molecular mechanism, namely chromatin organizational changes, that regulates neuronal gene expression and brain plasticity but may also prime the (epi)genome for psychopathology. Finally, we map out future directions including experimental and clinical studies that will facilitate novel sex- and gender-informed approaches to treat depression and anxiety disorders.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"66 ","pages":"Article 101010"},"PeriodicalIF":7.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715398/pdf/nihms-1848030.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39987173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

In fond memory of professor Kazuyoshi Tsutsui (1952–2021) 怀念冢井和吉教授(1952-2021)

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.100997

George E. Bentley , Lance J. Kriegsfeld , Barney A. Schlinger , Kazuyoshi Ukena

引用次数: 0

HPA axis activity across the menstrual cycle - a systematic review and meta-analysis of longitudinal studies 贯穿月经周期的HPA轴活动——纵向研究的系统回顾和荟萃分析

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.100998

Hannah Klusmann , Lars Schulze , Sinha Engel , Elise Bücklein , Daria Daehn , Serena Lozza-Fiacco , Angelika Geiling , Caroline Meyer , Elizabeth Andersen , Christine Knaevelsrud , Sarah Schumacher

{"title":"HPA axis activity across the menstrual cycle - a systematic review and meta-analysis of longitudinal studies","authors":"Hannah Klusmann , Lars Schulze , Sinha Engel , Elise Bücklein , Daria Daehn , Serena Lozza-Fiacco , Angelika Geiling , Caroline Meyer , Elizabeth Andersen , Christine Knaevelsrud , Sarah Schumacher","doi":"10.1016/j.yfrne.2022.100998","DOIUrl":"10.1016/j.yfrne.2022.100998","url":null,"abstract":"<div><p>Differential HPA axis function has been proposed to underlie sex-differences in mental disorders; however, the impact of fluctuating sex hormones across the menstrual cycle on HPA axis activity is still unclear. This meta<em>-</em>analysis investigated basal cortisol concentrations as a marker for HPA axis activity across the menstrual cycle. Through a systematic literature search of five databases, 121 longitudinal studies were included, summarizing data of 2641 healthy, cycling participants between the ages of 18 and 45. The meta-analysis showed higher cortisol concentrations in the follicular vs. luteal phase (d<sub>SMC</sub> = 0.12, p =.004, [0.04 – 0.20]). Comparisons between more precise cycle phases were mostly insignificant, aside from higher concentrations in the menstrual vs. premenstrual phase (d<sub>SMC</sub> = 0.17, [0.02 – 0.33], p =.03). In all included studies, nine samples used established cortisol parameters to indicate HPA axis function, specifically diurnal profiles (k = 4) and the cortisol awakening response (CAR) (k = 5). Therefore, the meta-analysis highlights the need for more rigorous investigation of HPA axis activity and menstrual cycle phase.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"66 ","pages":"Article 100998"},"PeriodicalIF":7.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10468727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3