Frontiers in Neuroendocrinology最新文献_第10页

Metabolic hormones mediate cognition 代谢激素介导认知

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.101009

Olivia R. Ghosh-Swaby , Amy C. Reichelt , Paul A.S. Sheppard , Jeffrey Davies , Timothy J. Bussey , Lisa M. Saksida

引用次数: 4

The underlying sex differences in neuroendocrine adaptations relevant to Myalgic Encephalomyelitis Chronic Fatigue Syndrome 与肌痛性脑脊髓炎慢性疲劳综合征相关的神经内分泌适应的潜在性别差异

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.100995

Natalie Thomas , Caroline Gurvich , Katherine Huang , Paul R. Gooley , Christopher W. Armstrong

{"title":"The underlying sex differences in neuroendocrine adaptations relevant to Myalgic Encephalomyelitis Chronic Fatigue Syndrome","authors":"Natalie Thomas , Caroline Gurvich , Katherine Huang , Paul R. Gooley , Christopher W. Armstrong","doi":"10.1016/j.yfrne.2022.100995","DOIUrl":"10.1016/j.yfrne.2022.100995","url":null,"abstract":"<div><h3>Introduction</h3><p>Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) is a complex multisystem disease characterised by severe and disabling new-onset symptoms of post-exertional malaise (PEM), fatigue, brain fog, and sleep dysfunction that lasts for at least six months. Accumulating evidence suggests that sex and endocrine events have a significant influence on symptom onset and moderation of ME/CFS, with female sex being one of the most consistent and credible predictive risk factors associated with diagnosis. Such sex differences suggest sex chromosomes and sex steroids may play a part in the development of the condition or moderation of symptoms, although this has yet to be explored in detail.</p></div><div><h3>Methods/Aims</h3><p>This narrative review outlines sex differences in ME/CFS in terms of vulnerability factors and clinical phenotype and explores the known sex differences in neuroendocrine systems affected in ME/CFS and how this may relate to disease risk, onset, pathophysiology, and potential treatment avenues.</p></div><div><h3>Conclusions</h3><p>There is clear evidence of a sex dimorphism with regards to prevalence (3:1 female preponderance), clinical phenotypes, and aetiological triggers prior to symptom onset of ME/CFS. Endocrinological events, particularly those throughout the female lifespan, are associated with ME/CFS and include reproductive menstrual cycle fluctuations, pregnancy, post-partum and perimenopause. Further, there is evidence for gonadal sex, adrenal stress and renal neuroendocrine systems as implicated in ME/CFS, including changes in estrogen, progesterone compounds, aldosterone, and cortisol levels, of which there are established sex differences. The broad effects of steroid hormones on the physiological systems may also speak to the diversity of ME/CFS symptomatology observed in patients. Further attention must be paid to sex, age, and steroid biology in ME/CFS.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"66 ","pages":"Article 100995"},"PeriodicalIF":7.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77891173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Timing is everything: Circadian rhythms and their role in the control of sleep 时间决定一切:昼夜节律及其在控制睡眠中的作用

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.100978

Seithikurippu R. Pandi-Perumal , Daniel P. Cardinali , Nevin F.W. Zaki , Ramanujam Karthikeyan , David Warren Spence , Russel J. Reiter , Gregory M. Brown

引用次数: 7

Sex hormone fluctuation and increased female risk for depression and anxiety disorders: From clinical evidence to molecular mechanisms 性激素波动与女性抑郁症和焦虑症风险增加:从临床证据到分子机制

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.101010

Marija Kundakovic, Devin Rocks

{"title":"Sex hormone fluctuation and increased female risk for depression and anxiety disorders: From clinical evidence to molecular mechanisms","authors":"Marija Kundakovic, Devin Rocks","doi":"10.1016/j.yfrne.2022.101010","DOIUrl":"10.1016/j.yfrne.2022.101010","url":null,"abstract":"<div><p>Women are at twice the risk for anxiety and depression disorders as men are, although the underlying biological factors and mechanisms are largely unknown. In this review, we address this sex disparity at both the etiological and mechanistic level. We dissect the role of fluctuating sex hormones as a critical biological factor contributing to the increased depression and anxiety risk in women. We provide parallel evidence in humans and rodents that brain structure and function vary with naturally-cycling ovarian hormones. This female-unique brain plasticity and associated vulnerability are primarily driven by estrogen level changes. For the first time, we provide a sex hormone-driven molecular mechanism, namely chromatin organizational changes, that regulates neuronal gene expression and brain plasticity but may also prime the (epi)genome for psychopathology. Finally, we map out future directions including experimental and clinical studies that will facilitate novel sex- and gender-informed approaches to treat depression and anxiety disorders.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"66 ","pages":"Article 101010"},"PeriodicalIF":7.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715398/pdf/nihms-1848030.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39987173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

In fond memory of professor Kazuyoshi Tsutsui (1952–2021) 怀念冢井和吉教授(1952-2021)

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.100997

George E. Bentley , Lance J. Kriegsfeld , Barney A. Schlinger , Kazuyoshi Ukena

引用次数: 0

HPA axis activity across the menstrual cycle - a systematic review and meta-analysis of longitudinal studies 贯穿月经周期的HPA轴活动——纵向研究的系统回顾和荟萃分析

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.100998

Hannah Klusmann , Lars Schulze , Sinha Engel , Elise Bücklein , Daria Daehn , Serena Lozza-Fiacco , Angelika Geiling , Caroline Meyer , Elizabeth Andersen , Christine Knaevelsrud , Sarah Schumacher

{"title":"HPA axis activity across the menstrual cycle - a systematic review and meta-analysis of longitudinal studies","authors":"Hannah Klusmann , Lars Schulze , Sinha Engel , Elise Bücklein , Daria Daehn , Serena Lozza-Fiacco , Angelika Geiling , Caroline Meyer , Elizabeth Andersen , Christine Knaevelsrud , Sarah Schumacher","doi":"10.1016/j.yfrne.2022.100998","DOIUrl":"10.1016/j.yfrne.2022.100998","url":null,"abstract":"<div><p>Differential HPA axis function has been proposed to underlie sex-differences in mental disorders; however, the impact of fluctuating sex hormones across the menstrual cycle on HPA axis activity is still unclear. This meta<em>-</em>analysis investigated basal cortisol concentrations as a marker for HPA axis activity across the menstrual cycle. Through a systematic literature search of five databases, 121 longitudinal studies were included, summarizing data of 2641 healthy, cycling participants between the ages of 18 and 45. The meta-analysis showed higher cortisol concentrations in the follicular vs. luteal phase (d<sub>SMC</sub> = 0.12, p =.004, [0.04 – 0.20]). Comparisons between more precise cycle phases were mostly insignificant, aside from higher concentrations in the menstrual vs. premenstrual phase (d<sub>SMC</sub> = 0.17, [0.02 – 0.33], p =.03). In all included studies, nine samples used established cortisol parameters to indicate HPA axis function, specifically diurnal profiles (k = 4) and the cortisol awakening response (CAR) (k = 5). Therefore, the meta-analysis highlights the need for more rigorous investigation of HPA axis activity and menstrual cycle phase.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"66 ","pages":"Article 100998"},"PeriodicalIF":7.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10468727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Impairments in intrinsic functional networks in type 2 diabetes: A meta-analysis of resting-state functional connectivity 2型糖尿病内在功能网络的损伤:静息状态功能连接的荟萃分析

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.100992

Jinli Meng , Jing Liu , Hailong Li , Yingxue Gao , Lingxiao Cao , Yuanyuan He , Yongyue Guo , Li Feng , Xin Hu , Hengyan Li , Chenghui Zhang , Wanlin He , Yunhong Wu , Xiaoqi Huang

{"title":"Impairments in intrinsic functional networks in type 2 diabetes: A meta-analysis of resting-state functional connectivity","authors":"Jinli Meng , Jing Liu , Hailong Li , Yingxue Gao , Lingxiao Cao , Yuanyuan He , Yongyue Guo , Li Feng , Xin Hu , Hengyan Li , Chenghui Zhang , Wanlin He , Yunhong Wu , Xiaoqi Huang","doi":"10.1016/j.yfrne.2022.100992","DOIUrl":"10.1016/j.yfrne.2022.100992","url":null,"abstract":"<div><p>Type 2 diabetes mellitus (T2DM) is associated with abnormal communication among large-scale brain networks, revealed by resting-state functional connectivity (rsFC), with inconsistent results between studies. We performed a meta-analysis of seed-based rsFC studies to identify consistent network connectivity alterations. Thirty-three datasets from 30 studies (1014 T2DM patients and 902 healthy controls [HC]) were included. Seed coordinates and between-group effects were extracted, and the seeds were divided into networks based on their location. Compared to HC, T2DM patients showed hyperconnectivity and hypoconnectivity within the DMN, DMN hypoconnectivity with the affective network (AN), ventral attention network (VAN) and frontal parietal network, and DMN hyperconnectivity with the VAN and visual network. T2DM patients also showed AN hypoconnectivity with the somatomotor network and hyperconnectivity with the VAN. T2DM illness durations negatively correlated with within-DMN rsFC. These DMN-centered impairments in large-scale brain networks in T2DM patients may help to explain the cognitive deficits associated with T2DM.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"66 ","pages":"Article 100992"},"PeriodicalIF":7.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82370574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Environmental disruption of reproductive rhythms 环境对生殖节律的破坏

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.100990

Marie-Azélie Moralia, Clarisse Quignon, Marine Simonneaux, Valérie Simonneaux

引用次数: 10

Child maltreatment and hypothalamic-pituitary-adrenal axis functioning: A systematic review and meta-analysis 儿童虐待与下丘脑-垂体-肾上腺轴功能:一项系统回顾和荟萃分析

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.100987

Selina Schär , Ines Mürner-Lavanchy , Stefanie J. Schmidt , Julian Koenig , Michael Kaess

{"title":"Child maltreatment and hypothalamic-pituitary-adrenal axis functioning: A systematic review and meta-analysis","authors":"Selina Schär , Ines Mürner-Lavanchy , Stefanie J. Schmidt , Julian Koenig , Michael Kaess","doi":"10.1016/j.yfrne.2022.100987","DOIUrl":"10.1016/j.yfrne.2022.100987","url":null,"abstract":"<div><p>Alterations in hypothalamic–pituitary–adrenal (HPA) axis and its effector hormone cortisol have been proposed as one possible mechanism linking child maltreatment experiences to health disparities. In this series of meta-analyses, we aimed to quantify the existing evidence on the effect of child maltreatment on various measures of HPA axis activity. The systematic literature search yielded 1,858 records, of which 87 studies (<em>k</em> = 132) were included. Using random-effects models, we found evidence for blunted cortisol stress reactivity in individuals exposed to child maltreatment. In contrast, no overall differences were found in any of the other HPA axis activity measures (including measures of daily activity, cortisol assessed in the context of pharmacological challenges and cumulative measures of cortisol secretion). The impact of several moderators (e.g., sex, psychopathology, study quality), the role of methodological shortcomings of existing studies, as well as potential directions for future research are discussed.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"66 ","pages":"Article 100987"},"PeriodicalIF":7.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302222000103/pdfft?md5=d23ff244d8492737ec53d6739b5d8680&pid=1-s2.0-S0091302222000103-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39826776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

The impact of perceived stress on the hair follicle: Towards solving a psychoneuroendocrine and neuroimmunological puzzle 感知压力对毛囊的影响:解决心理神经内分泌和神经免疫学难题

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI: 10.1016/j.yfrne.2022.101008

James D.B. O'Sullivan , Eva M.J. Peters , Yomna Amer , Pranusha Atuluru , Jérémy Chéret , Ayelet M. Rosenberg , Martin Picard , Ralf Paus

{"title":"The impact of perceived stress on the hair follicle: Towards solving a psychoneuroendocrine and neuroimmunological puzzle","authors":"James D.B. O'Sullivan , Eva M.J. Peters , Yomna Amer , Pranusha Atuluru , Jérémy Chéret , Ayelet M. Rosenberg , Martin Picard , Ralf Paus","doi":"10.1016/j.yfrne.2022.101008","DOIUrl":"10.1016/j.yfrne.2022.101008","url":null,"abstract":"<div><p>While popular belief harbors little doubt that perceived stress can cause hair loss and premature graying, the scientific evidence for this is arguably much thinner. Here, we investigate whether these phenomena are real, and show that the cyclic growth and pigmentation of the hair follicle (HF) provides a tractable model system for dissecting how perceived stress modulates aspects of human physiology. Local production of stress-associated neurohormones and neurotrophins coalesces with neurotransmitters and neuropeptides released from HF-associated sensory and autonomic nerve endings, forming a complex local stress-response system that regulates perifollicular neurogenic inflammation, interacts with the HF microbiome and controls mitochondrial function. This local system integrates into the central stress response systems, allowing the study of systemic stress responses affecting organ function by quantifying stress mediator content of hair. Focusing on selected mediators in this “brain-HF axis” under stress conditions, we distill general principles of HF dysfunction induced by perceived stress.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"66 ","pages":"Article 101008"},"PeriodicalIF":7.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84813118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5