Frontiers in Neuroendocrinology最新文献

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Endocrine disrupting effects on morphological synaptic plasticity 内分泌干扰对形态突触可塑性的影响
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-10-01 DOI: 10.1016/j.yfrne.2024.101157
Attila Zsarnovszky , Daiana Alymbaeva , Gergely Jocsak , Csaba Szabo , Boglárka Mária Schilling-Tóth , David Sandor Kiss
{"title":"Endocrine disrupting effects on morphological synaptic plasticity","authors":"Attila Zsarnovszky ,&nbsp;Daiana Alymbaeva ,&nbsp;Gergely Jocsak ,&nbsp;Csaba Szabo ,&nbsp;Boglárka Mária Schilling-Tóth ,&nbsp;David Sandor Kiss","doi":"10.1016/j.yfrne.2024.101157","DOIUrl":"10.1016/j.yfrne.2024.101157","url":null,"abstract":"<div><div>Neural regulation of the homeostasis depends on healthy synaptic function. Adaptation of synaptic functions to physiological needs manifests in various forms of synaptic plasticity (SP), regulated by the normal hormonal regulatory circuits. During the past several decades, the hormonal regulation of animal and human organisms have become targets of thousands of chemicals that have the potential to act as agonists or antagonists of the endogenous hormones. As the action mechanism of these endocrine disrupting chemicals (EDCs) came into the focus of research, a growing number of studies suggest that one of the regulatory avenues of hormones, the morphological form of SP, may well be a neural mechanism affected by EDCs. The present review discusses known and potential effects of some of the best known EDCs on morphological synaptic plasticity (MSP). We highlight molecular mechanisms altered by EDCs and indicate the growing need for more research in this area of neuroendocrinology.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain alteration of autoimmune thyroid disease: Neuropsychiatric impact, neuroimaging insights, and neurobiological implications 自身免疫性甲状腺疾病的大脑改变:神经精神影响、神经影像学见解和神经生物学意义。
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-10-01 DOI: 10.1016/j.yfrne.2024.101159
Qin Wei , Haiyang Zhang , Haixia Guan , Xuefei Song , Huifang Zhou
{"title":"Brain alteration of autoimmune thyroid disease: Neuropsychiatric impact, neuroimaging insights, and neurobiological implications","authors":"Qin Wei ,&nbsp;Haiyang Zhang ,&nbsp;Haixia Guan ,&nbsp;Xuefei Song ,&nbsp;Huifang Zhou","doi":"10.1016/j.yfrne.2024.101159","DOIUrl":"10.1016/j.yfrne.2024.101159","url":null,"abstract":"<div><div>Autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disease, characterized by thyroid function disorder and autoimmune imbalance. Previous studies have demonstrated the decreased quality of life and neuropsychiatric manifestations in AITD patients, including anxiety, depression, cognitive impairment and affective disorder. These problems also plague the euthyroid AITD patients. Advanced neuroimaging techniques were well carried out and employed as an explanatory instrument for the above intriguing phenomenon. In recent years, an increasing number of neuroimaging studies have reported that these neuropsychiatric manifestations are accompanied by significant structural and functional brain alterations in AITD patients, mainly involved in neurocognitive and emotional regions, despite the underlying neurobiological mechanism is still unclear. The existing studies suggest that the potential pathogenesis of the neuropsychiatric manifestations and brain alterations does not depend on a single factor, but may result from a combination of thyroid function dysfunction, metabolic disorders, dysregulated autoimmune and <em>trans</em>-synaptic degeneration.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Melatonin and brain barriers: The protection conferred by melatonin to the blood-brain barrier and blood-cerebrospinal fluid barrier 褪黑素与脑屏障:褪黑激素对血脑屏障和血脑脊液屏障的保护作用
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-10-01 DOI: 10.1016/j.yfrne.2024.101158
Rafael Mineiro , Maria Rodrigues Cardoso , Ana Catarina Duarte , Cecília Santos , Jose Cipolla-Neto , Fernanda Gaspar do Amaral , Diana Costa , Telma Quintela
{"title":"Melatonin and brain barriers: The protection conferred by melatonin to the blood-brain barrier and blood-cerebrospinal fluid barrier","authors":"Rafael Mineiro ,&nbsp;Maria Rodrigues Cardoso ,&nbsp;Ana Catarina Duarte ,&nbsp;Cecília Santos ,&nbsp;Jose Cipolla-Neto ,&nbsp;Fernanda Gaspar do Amaral ,&nbsp;Diana Costa ,&nbsp;Telma Quintela","doi":"10.1016/j.yfrne.2024.101158","DOIUrl":"10.1016/j.yfrne.2024.101158","url":null,"abstract":"<div><div>The blood–brain barrier and the blood-cerebrospinal fluid barrier separate the blood from brain tissue and cerebrospinal fluid. These brain barriers are important to maintain homeostasis and complex functions by protecting the brain from xenobiotics and harmful endogenous compounds. The disruption of brain barriers is a characteristic of neurologic diseases. Melatonin is a lipophilic hormone that is mainly produced by the pineal gland. The blood–brain barrier and the blood-cerebrospinal fluid barriers are melatonin-binding sites. Among the several melatonin actions, the most characteristic one is the regulation of sleep-wake cycles, melatonin has anti-inflammatory and antioxidant properties. Since brain barriers disruption can arise from inflammation and oxidative stress, knowing the influence of melatonin on the integrity of brain barriers is extremely important. Therefore, the objective of this review is to gather and discuss the available literature about the regulation of brain barriers by melatonin.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of 5-alpha reductase inhibitors in animal models of Parkinson’s disease 5-α 还原酶抑制剂对帕金森病动物模型的影响。
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-10-01 DOI: 10.1016/j.yfrne.2024.101156
Mélanie Bourque , Marc Morissette , Amandine Isenbrandt , Silvia Giatti , Roberto Cosimo Melcangi , Manolo Carta , Roberto Frau , Marco Bortolato , Denis Soulet , Thérèse Di Paolo
{"title":"Effect of 5-alpha reductase inhibitors in animal models of Parkinson’s disease","authors":"Mélanie Bourque ,&nbsp;Marc Morissette ,&nbsp;Amandine Isenbrandt ,&nbsp;Silvia Giatti ,&nbsp;Roberto Cosimo Melcangi ,&nbsp;Manolo Carta ,&nbsp;Roberto Frau ,&nbsp;Marco Bortolato ,&nbsp;Denis Soulet ,&nbsp;Thérèse Di Paolo","doi":"10.1016/j.yfrne.2024.101156","DOIUrl":"10.1016/j.yfrne.2024.101156","url":null,"abstract":"<div><div>Parkinson’s disease (PD) is characterized by motor symptoms due to loss of brain dopamine and non-motor symptoms, including gastrointestinal disorders. Although there is no cure for PD, symptomatic treatments are available. L-Dopa is the gold standard PD therapy, but most patients develop dyskinesias (LID), which are challenging to manage. Amantadine is recognized as the most effective drug for LID, but its adverse effects limit the use in patients. Here we review how 5α-reductase inhibitors (5ARIs), drugs used to treat benign prostatic hyperplasia and alopecia, exhibit beneficial effects in PD animal models. 5ARIs show neuroprotective properties in brain and gut dopaminergic systems, and reduce dyskinesias in rodent model of PD. Additionally, the 5ARI finasteride dampened dopaminergic-induced drug gambling in PD patients. Neuroprotection and antidyskinetic activities of 5ARIs in animal models of PD suggest their potential repurposing in men with PD to address gut dysfunction, protect brain DA and inhibit dyskinesias.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142368190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is melanin-concentrating hormone in the medial preoptic area a signal for the decline of maternal care in late postpartum? 内侧视前区的黑色素浓缩激素是产后晚期母性关怀减少的信号吗?产妇行为中的 MCH。
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-09-01 DOI: 10.1016/j.yfrne.2024.101155
Ming Li
{"title":"Is melanin-concentrating hormone in the medial preoptic area a signal for the decline of maternal care in late postpartum?","authors":"Ming Li","doi":"10.1016/j.yfrne.2024.101155","DOIUrl":"10.1016/j.yfrne.2024.101155","url":null,"abstract":"<div><p>This manuscript proposes that melanin-concentrating hormone (MCH) in the medial preoptic area (MPOA) is an neurochemical signal evolved to trigger the declining process of maternal care. MCH in the MPOA appears only after parturition and is progressively increased with the progression of lactation, while maternal behavior declines progressively. Intra-MPOA injection of MCH decreases active maternal responses. MCH is also highly responsive to infant characteristics and maternal condition. Behavioral changes induced by MCH in late postpartum period are conducive to the decline of infant-directed maternal behavior. The MPOA MCH system may mediate the maternal behavior decline by suppressing the maternal approach motivation and/or increasing maternal withdrawal via its inhibitory action onto the mesolimbic dopamine D<sub>1</sub>/D<sub>2</sub> receptors and its stimulating action on serotonin 5-HT<sub>2C</sub> receptors in the ventral tegmental area. Research into the MCH maternal effects will enhance our understanding of the neurochemical mechanisms underlying the maternal behavior decline.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrogenesis in the hypothalamus: A life-long process contributing to the development and plasticity of neuroendocrine networks 下丘脑的星形成因:促进神经内分泌网络发展和可塑性的终生过程。
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-09-01 DOI: 10.1016/j.yfrne.2024.101154
Ariane Sharif, Vincent Prevot
{"title":"Astrogenesis in the hypothalamus: A life-long process contributing to the development and plasticity of neuroendocrine networks","authors":"Ariane Sharif,&nbsp;Vincent Prevot","doi":"10.1016/j.yfrne.2024.101154","DOIUrl":"10.1016/j.yfrne.2024.101154","url":null,"abstract":"<div><p>Astrocytes are now recognized as integral components of neural circuits, regulating their maturation, activity and plasticity. Neuroendocrinology has provided fertile ground for revealing the diverse strategies used by astrocytes to regulate the physiological and behavioural outcomes of neural circuit activity in response to internal and environmental inputs. However, the development of astrocytes in the hypothalamus has received much less attention than in other brain regions such as the cerebral cortex and spinal cord. In this review, we synthesize our current knowledge of astrogenesis in the hypothalamus across various life stages. A distinctive feature of hypothalamic astrogenesis is that it persists all throughout lifespan, and involves multiple cellular sources corresponding to radial glial cells during early development, followed by tanycytes, parenchymal progenitors and locally dividing astrocytes. Astrogenesis in the hypothalamus is closely coordinated with the maturation of hypothalamic neurons. This coordination is exemplified by recent findings in neurons producing gonadotropin-releasing hormone, which actively shape their astroglial environment during infancy to integrate functionally into their neural network and facilitate sexual maturation, a process vulnerable to endocrine disruption. While hypothalamic astrogenesis shares common principles with other brain regions, it also exhibits specific features in its dynamics and regulation, both at the inter- and intra-regional levels. These unique properties emphasize the importance of further exploration. Additionally, we discuss the experimental strategies used to assess astrogenesis in the hypothalamus and their potential bias and limitations. Understanding the mechanisms of hypothalamic astrogenesis throughout life will be crucial for comprehending the development and function of the hypothalamus under both physiological and pathological conditions.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302224000347/pdfft?md5=a32cadde74f9da395b8daf8afbeaeb3d&pid=1-s2.0-S0091302224000347-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypothalamic neurons fully or partially expressing the dopaminergic phenotype: development, distribution, functioning and functional significance. A review 完全或部分表达多巴胺能表型的下丘脑神经元:分布、功能和功能意义。综述。
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-08-10 DOI: 10.1016/j.yfrne.2024.101153
Michael V. Ugrumov
{"title":"Hypothalamic neurons fully or partially expressing the dopaminergic phenotype: development, distribution, functioning and functional significance. A review","authors":"Michael V. Ugrumov","doi":"10.1016/j.yfrne.2024.101153","DOIUrl":"10.1016/j.yfrne.2024.101153","url":null,"abstract":"<div><p>The hypothalamus is a key link in neuroendocrine regulations, which are provided by neuropeptides and dopamine. Until the late 1980 s, it was believed that, along with peptidergic neurons, hypothalamus contained dopaminergic neurons. Over time, it has been shown that besides dopaminergic neurons expressing the dopamine transporter and dopamine-synthesizing enzymes − tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) − the hypothalamus contains neurons expressing only TH, only AADC, both enzymes or only dopamine transporter. The end secretory product of TH neurons is L-3,4-dihydroxyphenylalanine, while that of AADC neurons and bienzymatic neurons lacking the dopamine transporter is dopamine. During ontogenesis, especially in the perinatal period, monoenzymatic neurons predominate in the hypothalamic neuroendocrine centers. It is assumed that L-3,4-dihydroxyphenylalanine and dopamine are released into the neuropil, cerebral ventricles, and blood vessels, participating in the regulation of target cell differentiation in the perinatal period and the functioning of target cells in adulthood.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The emerging role of rapid corticosteroid actions on excitatory and inhibitory synaptic signaling in the brain 皮质类固醇对大脑兴奋性和抑制性突触信号传递的快速作用。
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-07-01 DOI: 10.1016/j.yfrne.2024.101146
Marian Joëls , Henk Karst , Jeffrey G. Tasker
{"title":"The emerging role of rapid corticosteroid actions on excitatory and inhibitory synaptic signaling in the brain","authors":"Marian Joëls ,&nbsp;Henk Karst ,&nbsp;Jeffrey G. Tasker","doi":"10.1016/j.yfrne.2024.101146","DOIUrl":"10.1016/j.yfrne.2024.101146","url":null,"abstract":"<div><p>Over the past two decades, there has been increasing evidence for the importance of rapid-onset actions of corticosteroid hormones in the brain. Here, we highlight the distinct rapid corticosteroid actions that regulate excitatory and inhibitory synaptic transmission in the hypothalamus, the hippocampus, basolateral amygdala, and prefrontal cortex. The receptors that mediate rapid corticosteroid actions are located at or close to the plasma membrane, though many of the receptor characteristics remain unresolved. Rapid-onset corticosteroid effects play a role in fast neuroendocrine feedback as well as in higher brain functions, including increased aggression and anxiety, and impaired memory retrieval. The rapid non-genomic corticosteroid actions precede and complement slow-onset, long-lasting transcriptional actions of the steroids. Both rapid and slow corticosteroid actions appear to be indispensable to adapt to a continuously changing environment, and their imbalance can increase an individual’s susceptibility to psychopathology.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302224000268/pdfft?md5=ed5c2dd9ec5d11f96ed806ffed5069e1&pid=1-s2.0-S0091302224000268-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emotion recognition and regulation in males: Role of sex and stress steroids 男性的情绪识别和调节:性别和应激类固醇的作用
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-06-09 DOI: 10.1016/j.yfrne.2024.101145
Erik Ilkevič , Markus Hausmann , Ramunė Grikšienė
{"title":"Emotion recognition and regulation in males: Role of sex and stress steroids","authors":"Erik Ilkevič ,&nbsp;Markus Hausmann ,&nbsp;Ramunė Grikšienė","doi":"10.1016/j.yfrne.2024.101145","DOIUrl":"10.1016/j.yfrne.2024.101145","url":null,"abstract":"<div><p>Understanding emotions in males is crucial given their higher susceptibility to substance use, interpersonal violence, and suicide compared to females. Steroid hormones are assumed to be critical biological factors that affect and modulate emotion-related behaviors, together with psychological and social factors. This review explores whether males‘ abilities to recognize emotions of others and regulate their own emotions are associated with testosterone, cortisol, and their interaction. Higher levels of testosterone were associated with improved recognition and heightened sensitivity to threatening faces. In contrast, higher cortisol levels positively impacted emotion regulation ability. Indirect evidence from neuroimaging research suggested a link between higher testosterone levels and difficulties in cognitive emotion regulation. However, this notion must be investigated in future studies using different emotion regulation strategies and considering social status. The present review contributes to the understanding of how testosterone and cortisol affect psychological well-being and emotional behavior in males.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel insights into the activating transcription factor 4 in Alzheimer’s disease and associated aging-related diseases: Mechanisms and therapeutic implications 激活转录因子 4 在阿尔茨海默氏症和相关衰老疾病中的新发现:机制和治疗意义
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-05-24 DOI: 10.1016/j.yfrne.2024.101144
Nan Zhang , Jianfei Nao , Shun Zhang , Xiaoyu Dong
{"title":"Novel insights into the activating transcription factor 4 in Alzheimer’s disease and associated aging-related diseases: Mechanisms and therapeutic implications","authors":"Nan Zhang ,&nbsp;Jianfei Nao ,&nbsp;Shun Zhang ,&nbsp;Xiaoyu Dong","doi":"10.1016/j.yfrne.2024.101144","DOIUrl":"10.1016/j.yfrne.2024.101144","url":null,"abstract":"<div><p>Ageing is inherent to all human beings, most mechanistic explanations of ageing results from the combined effects of various physiological and pathological processes. Additionally, aging pivotally contributes to several chronic diseases. Activating transcription factor 4 (ATF4), a member of the ATF/cAMP response element-binding protein family, has recently emerged as a pivotal player owing to its indispensable role in the pathophysiological processes of Alzheimer’s disease and aging-related diseases. Moreover, ATF4 is integral to numerous biological processes. Therefore, this article aims to comprehensively review relevant research on the role of ATF4 in the onset and progression of aging-related diseases, elucidating its potential mechanisms and therapeutic approaches. Our objective is to furnish scientific evidence for the early identification of risk factors in aging-related diseases and pave the way for new research directions for their treatment. By elucidating the signaling pathway network of ATF4 in aging-related diseases, we aspire to gain a profound understanding of the molecular and cellular mechanisms, offering novel strategies for addressing aging and developing related therapeutics.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141142024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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