Frontiers in Neuroendocrinology最新文献

筛选
英文 中文
Unraveling sex differences in maternal and paternal care impacts on social behaviors and neurobiological responses to early-life adversity. 揭示母爱和父爱的性别差异对早年逆境中的社会行为和神经生物学反应的影响。
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-11-17 DOI: 10.1016/j.yfrne.2024.101162
Shakeera L Walker, Erica R Glasper
{"title":"Unraveling sex differences in maternal and paternal care impacts on social behaviors and neurobiological responses to early-life adversity.","authors":"Shakeera L Walker, Erica R Glasper","doi":"10.1016/j.yfrne.2024.101162","DOIUrl":"https://doi.org/10.1016/j.yfrne.2024.101162","url":null,"abstract":"<p><p>Early-life stress (ELS) affects the development of prosocial behaviors and social-cognitive function, often leading to structural brain changes and increased psychosocial disorders. Recent studies suggest that mother- and father-child relationships independently influence social development in a sex-specific manner, but the effects of impaired father-child relationships are often overlooked. This review examines preclinical rodent studies to explore how parental neglect impacts neuroplasticity and social behaviors in offspring. We highlight that disruptions in maternal interactions may affect male pups more in uniparental rodents, while impaired paternal interactions in biparental rodents tend to impact female pups more. Due to limited research, the separate effects of maternal and paternal neglect on brain development and social behaviors in biparental species remain unclear. Addressing these gaps could clarify the sex-specific mechanisms underlying social and neurobiological deficits from parental neglect.</p>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":" ","pages":"101162"},"PeriodicalIF":6.5,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insulin-like growth factor-1 and cognitive health: Exploring cellular, preclinical, and clinical dimensions 胰岛素样生长因子-1 与认知健康:探索细胞、临床前和临床层面。
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-11-12 DOI: 10.1016/j.yfrne.2024.101161
Cellas A. Hayes , Destiny Wilson , Miguel A. De Leon , Mubarak Jolayemi Mustapha , Sharon Morales , Michelle C. Odden , Nicole M. Ashpole
{"title":"Insulin-like growth factor-1 and cognitive health: Exploring cellular, preclinical, and clinical dimensions","authors":"Cellas A. Hayes ,&nbsp;Destiny Wilson ,&nbsp;Miguel A. De Leon ,&nbsp;Mubarak Jolayemi Mustapha ,&nbsp;Sharon Morales ,&nbsp;Michelle C. Odden ,&nbsp;Nicole M. Ashpole","doi":"10.1016/j.yfrne.2024.101161","DOIUrl":"10.1016/j.yfrne.2024.101161","url":null,"abstract":"<div><div>Age and insulin-like growth factor-1 (IGF-1) have an inverse association with cognitive decline and dementia. IGF-1 is known to have important pleiotropic functions beginning in neurodevelopment and extending into adulthood such as neurogenesis. At the cellular level, IGF-1 has pleiotropic signaling mechanisms through the IGF-1 receptor on neurons and neuroglia to attenuate inflammation, promote myelination, maintain astrocytic functions for homeostatic balances, and neuronal synaptogenesis. In preclinical rodent models of aging and transgenic models of IGF-1, increased IGF-1 improves cognition in a variety of behavioral paradigms along with reducing IGF-1 via knockout models being able to induce cognitive impairment. At the clinical levels, most studies highlight that increased levels of IGF-1 are associated with better cognition. This review provides a comprehensive and up-to-date evaluation of the association between IGF-1 and cognition at the cellular signaling levels, preclinical, and clinical levels.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"76 ","pages":"Article 101161"},"PeriodicalIF":6.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progestagens and progesterone receptor modulation: Effects on the brain, mood, stress, and cognition in females 孕激素和孕酮受体调节:对女性大脑、情绪、压力和认知的影响。
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-11-06 DOI: 10.1016/j.yfrne.2024.101160
Celine Bencker , Laura Gschwandtner , Sibel Nayman , Ramunė Grikšienė , Billie Nguyen , Urs M. Nater , Rachida Guennoun , Inger Sundström-Poromaa , Belinda Pletzer , Marie Bixo , Erika Comasco
{"title":"Progestagens and progesterone receptor modulation: Effects on the brain, mood, stress, and cognition in females","authors":"Celine Bencker ,&nbsp;Laura Gschwandtner ,&nbsp;Sibel Nayman ,&nbsp;Ramunė Grikšienė ,&nbsp;Billie Nguyen ,&nbsp;Urs M. Nater ,&nbsp;Rachida Guennoun ,&nbsp;Inger Sundström-Poromaa ,&nbsp;Belinda Pletzer ,&nbsp;Marie Bixo ,&nbsp;Erika Comasco","doi":"10.1016/j.yfrne.2024.101160","DOIUrl":"10.1016/j.yfrne.2024.101160","url":null,"abstract":"<div><div>Progesterone is a highly lipophilic gonadal hormone that can influence behavior and mental health through its receptors in the brain. Fluctuations in progesterone levels across critical periods of a females life are associated with increased susceptibility to mental conditions.</div><div>This review highlights the effects of progestagens, including progesterone and synthetic progestins, on the brain, mood, stress, and cognition in females. The primary focus is on experimental pharmacological research that teases out the distinct effects of progestagens from those of estrogens. Additionally, the key literature on puberty, the menstrual cycle, pregnancy, perimenopause, hormonal contraceptives, and menopausal hormone therapy is reviewed, although conclusions are limited by the nested effects of progestagens and estrogens.</div><div>Single study-findings suggest an influence of progesterone on amygdala reactivity related to processing of emotional stimuli and memory. In patients with premenstrual dysphoric disorder, progesterone receptor modulation improves premenstrual mood symptoms and potentially enhances fronto-cingulate control over emotion processing. The interaction between progestagens and the systems involved in the regulation of stress seems to influence subjective experiences of mood and stress. Sparse studies investigating the effects of progestin-only contraceptives suggest effects of progestagens on the brain, mood, and stress. Progesterone and progestins used for contraception can influence neural processes as myelination and neuroprotection, exerting protective effects against stroke. Concerning menopausal hormonal therapy, the effects of progestins are largely unknown.</div><div>Levels of progesterone as well as type, administration route, timing, dose regimen, metabolism, and intracellular activity of progestins in hormonal contraceptives and menopausal hormonal therapy are factors whose effects remain to be elucidated. Altogether, current knowledge highlights the potential role of progestagens in females health but also calls for well-designed pharmaco-behavioral studies disentangling the effects of progestagens from those of estrogens.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"76 ","pages":"Article 101160"},"PeriodicalIF":6.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endocrine disrupting effects on morphological synaptic plasticity 内分泌干扰对形态突触可塑性的影响
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-10-01 DOI: 10.1016/j.yfrne.2024.101157
Attila Zsarnovszky , Daiana Alymbaeva , Gergely Jocsak , Csaba Szabo , Boglárka Mária Schilling-Tóth , David Sandor Kiss
{"title":"Endocrine disrupting effects on morphological synaptic plasticity","authors":"Attila Zsarnovszky ,&nbsp;Daiana Alymbaeva ,&nbsp;Gergely Jocsak ,&nbsp;Csaba Szabo ,&nbsp;Boglárka Mária Schilling-Tóth ,&nbsp;David Sandor Kiss","doi":"10.1016/j.yfrne.2024.101157","DOIUrl":"10.1016/j.yfrne.2024.101157","url":null,"abstract":"<div><div>Neural regulation of the homeostasis depends on healthy synaptic function. Adaptation of synaptic functions to physiological needs manifests in various forms of synaptic plasticity (SP), regulated by the normal hormonal regulatory circuits. During the past several decades, the hormonal regulation of animal and human organisms have become targets of thousands of chemicals that have the potential to act as agonists or antagonists of the endogenous hormones. As the action mechanism of these endocrine disrupting chemicals (EDCs) came into the focus of research, a growing number of studies suggest that one of the regulatory avenues of hormones, the morphological form of SP, may well be a neural mechanism affected by EDCs. The present review discusses known and potential effects of some of the best known EDCs on morphological synaptic plasticity (MSP). We highlight molecular mechanisms altered by EDCs and indicate the growing need for more research in this area of neuroendocrinology.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"75 ","pages":"Article 101157"},"PeriodicalIF":6.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain alteration of autoimmune thyroid disease: Neuropsychiatric impact, neuroimaging insights, and neurobiological implications 自身免疫性甲状腺疾病的大脑改变:神经精神影响、神经影像学见解和神经生物学意义。
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-10-01 DOI: 10.1016/j.yfrne.2024.101159
Qin Wei , Haiyang Zhang , Haixia Guan , Xuefei Song , Huifang Zhou
{"title":"Brain alteration of autoimmune thyroid disease: Neuropsychiatric impact, neuroimaging insights, and neurobiological implications","authors":"Qin Wei ,&nbsp;Haiyang Zhang ,&nbsp;Haixia Guan ,&nbsp;Xuefei Song ,&nbsp;Huifang Zhou","doi":"10.1016/j.yfrne.2024.101159","DOIUrl":"10.1016/j.yfrne.2024.101159","url":null,"abstract":"<div><div>Autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disease, characterized by thyroid function disorder and autoimmune imbalance. Previous studies have demonstrated the decreased quality of life and neuropsychiatric manifestations in AITD patients, including anxiety, depression, cognitive impairment and affective disorder. These problems also plague the euthyroid AITD patients. Advanced neuroimaging techniques were well carried out and employed as an explanatory instrument for the above intriguing phenomenon. In recent years, an increasing number of neuroimaging studies have reported that these neuropsychiatric manifestations are accompanied by significant structural and functional brain alterations in AITD patients, mainly involved in neurocognitive and emotional regions, despite the underlying neurobiological mechanism is still unclear. The existing studies suggest that the potential pathogenesis of the neuropsychiatric manifestations and brain alterations does not depend on a single factor, but may result from a combination of thyroid function dysfunction, metabolic disorders, dysregulated autoimmune and <em>trans</em>-synaptic degeneration.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"75 ","pages":"Article 101159"},"PeriodicalIF":6.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Melatonin and brain barriers: The protection conferred by melatonin to the blood-brain barrier and blood-cerebrospinal fluid barrier 褪黑素与脑屏障:褪黑激素对血脑屏障和血脑脊液屏障的保护作用
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-10-01 DOI: 10.1016/j.yfrne.2024.101158
Rafael Mineiro , Maria Rodrigues Cardoso , Ana Catarina Duarte , Cecília Santos , Jose Cipolla-Neto , Fernanda Gaspar do Amaral , Diana Costa , Telma Quintela
{"title":"Melatonin and brain barriers: The protection conferred by melatonin to the blood-brain barrier and blood-cerebrospinal fluid barrier","authors":"Rafael Mineiro ,&nbsp;Maria Rodrigues Cardoso ,&nbsp;Ana Catarina Duarte ,&nbsp;Cecília Santos ,&nbsp;Jose Cipolla-Neto ,&nbsp;Fernanda Gaspar do Amaral ,&nbsp;Diana Costa ,&nbsp;Telma Quintela","doi":"10.1016/j.yfrne.2024.101158","DOIUrl":"10.1016/j.yfrne.2024.101158","url":null,"abstract":"<div><div>The blood–brain barrier and the blood-cerebrospinal fluid barrier separate the blood from brain tissue and cerebrospinal fluid. These brain barriers are important to maintain homeostasis and complex functions by protecting the brain from xenobiotics and harmful endogenous compounds. The disruption of brain barriers is a characteristic of neurologic diseases. Melatonin is a lipophilic hormone that is mainly produced by the pineal gland. The blood–brain barrier and the blood-cerebrospinal fluid barriers are melatonin-binding sites. Among the several melatonin actions, the most characteristic one is the regulation of sleep-wake cycles, melatonin has anti-inflammatory and antioxidant properties. Since brain barriers disruption can arise from inflammation and oxidative stress, knowing the influence of melatonin on the integrity of brain barriers is extremely important. Therefore, the objective of this review is to gather and discuss the available literature about the regulation of brain barriers by melatonin.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"75 ","pages":"Article 101158"},"PeriodicalIF":6.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of 5-alpha reductase inhibitors in animal models of Parkinson’s disease 5-α 还原酶抑制剂对帕金森病动物模型的影响。
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-10-01 DOI: 10.1016/j.yfrne.2024.101156
Mélanie Bourque , Marc Morissette , Amandine Isenbrandt , Silvia Giatti , Roberto Cosimo Melcangi , Manolo Carta , Roberto Frau , Marco Bortolato , Denis Soulet , Thérèse Di Paolo
{"title":"Effect of 5-alpha reductase inhibitors in animal models of Parkinson’s disease","authors":"Mélanie Bourque ,&nbsp;Marc Morissette ,&nbsp;Amandine Isenbrandt ,&nbsp;Silvia Giatti ,&nbsp;Roberto Cosimo Melcangi ,&nbsp;Manolo Carta ,&nbsp;Roberto Frau ,&nbsp;Marco Bortolato ,&nbsp;Denis Soulet ,&nbsp;Thérèse Di Paolo","doi":"10.1016/j.yfrne.2024.101156","DOIUrl":"10.1016/j.yfrne.2024.101156","url":null,"abstract":"<div><div>Parkinson’s disease (PD) is characterized by motor symptoms due to loss of brain dopamine and non-motor symptoms, including gastrointestinal disorders. Although there is no cure for PD, symptomatic treatments are available. L-Dopa is the gold standard PD therapy, but most patients develop dyskinesias (LID), which are challenging to manage. Amantadine is recognized as the most effective drug for LID, but its adverse effects limit the use in patients. Here we review how 5α-reductase inhibitors (5ARIs), drugs used to treat benign prostatic hyperplasia and alopecia, exhibit beneficial effects in PD animal models. 5ARIs show neuroprotective properties in brain and gut dopaminergic systems, and reduce dyskinesias in rodent model of PD. Additionally, the 5ARI finasteride dampened dopaminergic-induced drug gambling in PD patients. Neuroprotection and antidyskinetic activities of 5ARIs in animal models of PD suggest their potential repurposing in men with PD to address gut dysfunction, protect brain DA and inhibit dyskinesias.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"75 ","pages":"Article 101156"},"PeriodicalIF":6.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142368190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is melanin-concentrating hormone in the medial preoptic area a signal for the decline of maternal care in late postpartum? 内侧视前区的黑色素浓缩激素是产后晚期母性关怀减少的信号吗?产妇行为中的 MCH。
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-09-01 DOI: 10.1016/j.yfrne.2024.101155
Ming Li
{"title":"Is melanin-concentrating hormone in the medial preoptic area a signal for the decline of maternal care in late postpartum?","authors":"Ming Li","doi":"10.1016/j.yfrne.2024.101155","DOIUrl":"10.1016/j.yfrne.2024.101155","url":null,"abstract":"<div><p>This manuscript proposes that melanin-concentrating hormone (MCH) in the medial preoptic area (MPOA) is an neurochemical signal evolved to trigger the declining process of maternal care. MCH in the MPOA appears only after parturition and is progressively increased with the progression of lactation, while maternal behavior declines progressively. Intra-MPOA injection of MCH decreases active maternal responses. MCH is also highly responsive to infant characteristics and maternal condition. Behavioral changes induced by MCH in late postpartum period are conducive to the decline of infant-directed maternal behavior. The MPOA MCH system may mediate the maternal behavior decline by suppressing the maternal approach motivation and/or increasing maternal withdrawal via its inhibitory action onto the mesolimbic dopamine D<sub>1</sub>/D<sub>2</sub> receptors and its stimulating action on serotonin 5-HT<sub>2C</sub> receptors in the ventral tegmental area. Research into the MCH maternal effects will enhance our understanding of the neurochemical mechanisms underlying the maternal behavior decline.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"75 ","pages":"Article 101155"},"PeriodicalIF":6.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrogenesis in the hypothalamus: A life-long process contributing to the development and plasticity of neuroendocrine networks 下丘脑的星形成因:促进神经内分泌网络发展和可塑性的终生过程。
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-09-01 DOI: 10.1016/j.yfrne.2024.101154
Ariane Sharif, Vincent Prevot
{"title":"Astrogenesis in the hypothalamus: A life-long process contributing to the development and plasticity of neuroendocrine networks","authors":"Ariane Sharif,&nbsp;Vincent Prevot","doi":"10.1016/j.yfrne.2024.101154","DOIUrl":"10.1016/j.yfrne.2024.101154","url":null,"abstract":"<div><p>Astrocytes are now recognized as integral components of neural circuits, regulating their maturation, activity and plasticity. Neuroendocrinology has provided fertile ground for revealing the diverse strategies used by astrocytes to regulate the physiological and behavioural outcomes of neural circuit activity in response to internal and environmental inputs. However, the development of astrocytes in the hypothalamus has received much less attention than in other brain regions such as the cerebral cortex and spinal cord. In this review, we synthesize our current knowledge of astrogenesis in the hypothalamus across various life stages. A distinctive feature of hypothalamic astrogenesis is that it persists all throughout lifespan, and involves multiple cellular sources corresponding to radial glial cells during early development, followed by tanycytes, parenchymal progenitors and locally dividing astrocytes. Astrogenesis in the hypothalamus is closely coordinated with the maturation of hypothalamic neurons. This coordination is exemplified by recent findings in neurons producing gonadotropin-releasing hormone, which actively shape their astroglial environment during infancy to integrate functionally into their neural network and facilitate sexual maturation, a process vulnerable to endocrine disruption. While hypothalamic astrogenesis shares common principles with other brain regions, it also exhibits specific features in its dynamics and regulation, both at the inter- and intra-regional levels. These unique properties emphasize the importance of further exploration. Additionally, we discuss the experimental strategies used to assess astrogenesis in the hypothalamus and their potential bias and limitations. Understanding the mechanisms of hypothalamic astrogenesis throughout life will be crucial for comprehending the development and function of the hypothalamus under both physiological and pathological conditions.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"75 ","pages":"Article 101154"},"PeriodicalIF":6.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302224000347/pdfft?md5=a32cadde74f9da395b8daf8afbeaeb3d&pid=1-s2.0-S0091302224000347-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypothalamic neurons fully or partially expressing the dopaminergic phenotype: development, distribution, functioning and functional significance. A review 完全或部分表达多巴胺能表型的下丘脑神经元:分布、功能和功能意义。综述。
IF 6.5 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-08-10 DOI: 10.1016/j.yfrne.2024.101153
Michael V. Ugrumov
{"title":"Hypothalamic neurons fully or partially expressing the dopaminergic phenotype: development, distribution, functioning and functional significance. A review","authors":"Michael V. Ugrumov","doi":"10.1016/j.yfrne.2024.101153","DOIUrl":"10.1016/j.yfrne.2024.101153","url":null,"abstract":"<div><p>The hypothalamus is a key link in neuroendocrine regulations, which are provided by neuropeptides and dopamine. Until the late 1980 s, it was believed that, along with peptidergic neurons, hypothalamus contained dopaminergic neurons. Over time, it has been shown that besides dopaminergic neurons expressing the dopamine transporter and dopamine-synthesizing enzymes − tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) − the hypothalamus contains neurons expressing only TH, only AADC, both enzymes or only dopamine transporter. The end secretory product of TH neurons is L-3,4-dihydroxyphenylalanine, while that of AADC neurons and bienzymatic neurons lacking the dopamine transporter is dopamine. During ontogenesis, especially in the perinatal period, monoenzymatic neurons predominate in the hypothalamic neuroendocrine centers. It is assumed that L-3,4-dihydroxyphenylalanine and dopamine are released into the neuropil, cerebral ventricles, and blood vessels, participating in the regulation of target cell differentiation in the perinatal period and the functioning of target cells in adulthood.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"75 ","pages":"Article 101153"},"PeriodicalIF":6.5,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信