Frontiers in Neuroendocrinology最新文献

Semaglutide and the pathogenesis of progressive neurodegenerative disease: the central role of mitochondria Semaglutide与进行性神经退行性疾病的发病机制：线粒体的核心作用

IF 6.7 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-10-01 DOI: 10.1016/j.yfrne.2025.101217

George B. Stefano , Pascal Büttiker , Simon Weissenberger , Jiri Raboch , Martin Anders

{"title":"Semaglutide and the pathogenesis of progressive neurodegenerative disease: the central role of mitochondria","authors":"George B. Stefano , Pascal Büttiker , Simon Weissenberger , Jiri Raboch , Martin Anders","doi":"10.1016/j.yfrne.2025.101217","DOIUrl":"10.1016/j.yfrne.2025.101217","url":null,"abstract":"<div><div>While mitochondria provide critical energy resources, mitochondrial dysfunction can lead to both metabolic and neurodegenerative disorders. Primary mitochondrial disorders (e.g., Leigh syndrome) are uniformly associated with profound neurodegeneration. Recent studies have also implicated mitochondrial dysfunction as a central feature of progressive neurodegenerative diseases, notably Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis, and Huntington’s Disease. In addition to its profound impact on metabolic disease, the glucagon-like peptide-1 receptor agonist, semaglutide, has significant neuroprotective features and may limit the progression of one or more of these disorders. These observations might be explained at least in part by the impact of this drug on mitochondrial function and energy production. Collectively, these observations highlight disrupted energy homeostasis as a critical feature of neurodegenerative disease and suggest novel targets for the development of much-needed new neuropharmaceutical strategies.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"79 ","pages":"Article 101217"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145216979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How the diffuse neuroendocrine system shapes health, homeostasis, and cancer 弥漫性神经内分泌系统如何影响健康、体内平衡和癌症

IF 6.7 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-08-23 DOI: 10.1016/j.yfrne.2025.101216

Michel Salzet

{"title":"How the diffuse neuroendocrine system shapes health, homeostasis, and cancer","authors":"Michel Salzet","doi":"10.1016/j.yfrne.2025.101216","DOIUrl":"10.1016/j.yfrne.2025.101216","url":null,"abstract":"<div><div>The diffuse neuroendocrine system (DNES) consists of dispersed neuroendocrine (NE) cells that bridge nervous, immune, and endocrine pathways across organs. Evolutionarily, DNES traces to primitive metazoans where single cells combined neural and immune roles, later diversifying into specialized vertebrate NE cells. Hallmark traits include dense-core granules, amine metabolism, “salt-and-pepper” chromatin, and regulation by ASCL1, NEUROG3, and INSM1. Remarkable plasticity allows immune and epithelial cells to acquire NE features under stress, while carcinomas exploit this program to form aggressive neuroendocrine tumors (NETs) and resist therapy. Canonical neuroimmune circuits, the Vagus-driven inflammatory reflex and hypothalamic–pituitary–adrenal stress axis, illustrate DNES coordination of systemic responses. Clinically, DNES-derived neoplasms span multiple organs, produce diverse hormonal syndromes, and are managed with somatostatin analogues, epigenetic drugs, and emerging immunotherapies. Recognizing DNES as a diffuse, integrative regulatory network clarifies mechanisms of chronic inflammation and cancer evolution and offers novel therapeutic entry points for disorders ranging from asthma to pancreatic neuroendocrine carcinomas.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"79 ","pages":"Article 101216"},"PeriodicalIF":6.7,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in the acute effects of cannabis on human cognition: A systematic review 大麻对人类认知急性效应的性别差异：系统综述

IF 6.7 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-08-15 DOI: 10.1016/j.yfrne.2025.101215

Justin Matheson , Danial Behzad , Christina Zakala , Thomas Hawken , Bruna Brands , Bernard Le Foll , Christine M. Wickens , Anthony C. Ruocco , Terri Rodak , Patricia Di Ciano

{"title":"Sex differences in the acute effects of cannabis on human cognition: A systematic review","authors":"Justin Matheson , Danial Behzad , Christina Zakala , Thomas Hawken , Bruna Brands , Bernard Le Foll , Christine M. Wickens , Anthony C. Ruocco , Terri Rodak , Patricia Di Ciano","doi":"10.1016/j.yfrne.2025.101215","DOIUrl":"10.1016/j.yfrne.2025.101215","url":null,"abstract":"<div><div>Acute cannabis exposure can transiently impair cognitive performance, increasing the risk of accidental injury and potentially disrupting activities of daily living. Although sex differences in responses to cannabis have been reported, no systematic review has examined whether these extend to acute cognitive effects. Our primary aim was to examine sex differences in the acute effects of cannabis (including isolated delta-9-tetrahydrocannabinol [THC]) on cognition in humans. Our secondary aim was to determine if sex differences in the acute effects of cannabis vary by cognitive domain, route of administration, or dosing paradigm. Following PRISMA guidelines, we conducted a comprehensive literature search across Embase, MEDLINE, APA PsycInfo, Cochrane Library, and Web of Science databases. Of 1,625 unique records, 169 underwent full-text screening, and 29 studies met inclusion criteria. Six of 29 articles (20.7 %), representing eight of 216 cognitive outcomes (3.7 %), found statistical evidence of sex differences in acute cognitive effects of cannabis/THC. All six found increased effects in female participants in at least one cognitive variable; one study additionally found increased effects in male participants, and one study found divergent cognitive effects in male and female participants. There were no clear patterns by cannabis dosing paradigm, route of administration, or cognitive domain. Overall, we found limited evidence that sex significantly influences the acute cognitive effects of cannabis, though methodological heterogeneity precludes any firm conclusions. Future studies should prioritize the measurement of sex-related factors, such as hormonal modulation of cannabinoid pharmacokinetics and pharmacodynamics.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"79 ","pages":"Article 101215"},"PeriodicalIF":6.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial – Addiction in females 编辑-女性成瘾。

IF 6.7 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-08-08 DOI: 10.1016/j.yfrne.2025.101214

Kimberly Nixon, J. Leigh Leasure

引用次数: 0

Oxytocin and dopamine in psychostimulant-induced changes in social behaviour 催产素和多巴胺在精神兴奋剂引起的社会行为改变中的作用。

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-07-01 DOI: 10.1016/j.yfrne.2025.101200

Fernando Castillo Díaz, Inga D. Neumann, Virginie Rappeneau

{"title":"Oxytocin and dopamine in psychostimulant-induced changes in social behaviour","authors":"Fernando Castillo Díaz, Inga D. Neumann, Virginie Rappeneau","doi":"10.1016/j.yfrne.2025.101200","DOIUrl":"10.1016/j.yfrne.2025.101200","url":null,"abstract":"<div><div>Oxytocin (OXT) plays a significant role in regulating social behaviour across various species, making it a key focus in neuroscience. Recent research has expanded beyond the established prosocial effects of OXT to explore its complex interplay with dopamine (DA), a key regulator of both reward processing and social behaviour. DA influences these behaviours both independently and in coordination with OXT. Emerging evidence highlights how psychostimulants disrupt OXT-DA interaction, exacerbating maladaptive social behaviours. This narrative review synthesises findings from pharmacological, optogenetic, and chemogenetic studies to elucidate mechanistic insights into OXT-DA crosstalk in both healthy and drug-compromised social functioning. We examined OXT-DA interaction in non-reproductive social behaviours, such as social approach and aggression, as well as reproductive behaviours, including parental care, offspring attachment, and pair bonding, both in the presence and absence of drugs of abuse. Understanding OXT-DA interaction offers important insights into the neurobiological mechanisms underlying both healthy and pathological social functioning.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"78 ","pages":"Article 101200"},"PeriodicalIF":6.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The overlooked mental health burden of polycystic ovary syndrome: neurobiological insights into PCOS-related depression 多囊卵巢综合征被忽视的心理健康负担：多囊卵巢综合征相关抑郁的神经生物学见解

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-07-01 DOI: 10.1016/j.yfrne.2025.101203

Eleni Dubé-Zinatelli , Freya Anderson , Nafissa Ismail

{"title":"The overlooked mental health burden of polycystic ovary syndrome: neurobiological insights into PCOS-related depression","authors":"Eleni Dubé-Zinatelli , Freya Anderson , Nafissa Ismail","doi":"10.1016/j.yfrne.2025.101203","DOIUrl":"10.1016/j.yfrne.2025.101203","url":null,"abstract":"<div><div>Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting 6–13% of reproductive-aged women worldwide. It is primarily characterized by ovarian dysfunction, hyperandrogenism, and metabolic disturbances. However, women with PCOS also face a heightened risk of depression, possibly due to dysregulation in endocrine and immune systems and gut microbiome disturbances. Symptoms of PCOS such as infertility, obesity, and hirsutism can also cause psychological distress and further exacerbate depression symptoms. Despite this comorbidity, mental health aspects of PCOS are often overlooked in the medical field, leading to insufficient support and negative impacts on the quality of life of PCOS patients. This review explores how distinct PCOS phenotypes influence physiological and psychological outcomes and the possible biological mechanisms involved. We also examine the effects of existing treatments on PCOS symptoms and depression. Addressing both physiological and psychological challenges is crucial for developing targeted, personalized interventions that improve outcomes for individuals diagnosed with PCOS.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"78 ","pages":"Article 101203"},"PeriodicalIF":6.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex as a biological variable (SABV) modulates the consequences of sleep disturbance on hippocampal memory and synaptic plasticity 性别作为一个生物变量（SABV）调节睡眠障碍对海马记忆和突触可塑性的影响。

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-07-01 DOI: 10.1016/j.yfrne.2025.101205

Camilla Paraciani, Robbert Havekes, Peter Meerlo, Nicole J. Gervais

引用次数: 0

The role of the stress adaptive response in multiple sclerosis 应激适应反应在多发性硬化症中的作用。

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-07-01 DOI: 10.1016/j.yfrne.2025.101204

Evangelia Zapanti , Alexandros Dermentzoglou , Paraskevi Kazakou , Konstantinos Kilindireas , George Mastorakos

{"title":"The role of the stress adaptive response in multiple sclerosis","authors":"Evangelia Zapanti , Alexandros Dermentzoglou , Paraskevi Kazakou , Konstantinos Kilindireas , George Mastorakos","doi":"10.1016/j.yfrne.2025.101204","DOIUrl":"10.1016/j.yfrne.2025.101204","url":null,"abstract":"<div><div>Multiple sclerosis (MS) is the commonest autoimmune inflammatory neurological disease presenting multifocal demyelinating lesions in the white matter of the central nervous system (CNS). Its pathogenesis involves genetic and environmental mechanisms which lead to immune cell-mediated destruction of myelin and axonal damage and glial scars in CNS. Stress adaptive response might cause MS exacerbation by triggering release of hormones and neuropeptides leading to immune dysregulation and altered cytokine production. The exact link between the stress adaptive response and MS physiopathology is not clear, although neuro-immunological studies have shown alterations in cytokines and lymphocytes in MS patients, under stress, which might have clinical significance. Dysregulation of the principal components of the stress system, i.e. the hypothalamic–pituitary–adrenal axis, the sympathetic nervous system and the dopaminergic system, have been described in MS patients. In this critical review the role of the stress adaptive response in the manifestation and exacerbation of MS is described.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"78 ","pages":"Article 101204"},"PeriodicalIF":6.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal effects on externalizing problems in females across the lifespan 荷尔蒙对女性一生中外化问题的影响

IF 6.7 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-07-01 DOI: 10.1016/j.yfrne.2025.101206

Michelle M. Martel , Ashley G. Eng , Urveesha Nirjar , Madeline K. Petersen , Miranda P. Ramirez , Carleigh A. Litteral , Layne E. Robinson

{"title":"Hormonal effects on externalizing problems in females across the lifespan","authors":"Michelle M. Martel , Ashley G. Eng , Urveesha Nirjar , Madeline K. Petersen , Miranda P. Ramirez , Carleigh A. Litteral , Layne E. Robinson","doi":"10.1016/j.yfrne.2025.101206","DOIUrl":"10.1016/j.yfrne.2025.101206","url":null,"abstract":"<div><div>Developmental transdiagnostic externalizing problems—including harmful substance use, conduct issues, oppositional-defiance, and ADHD-related hyperactivity-impulsivity—have significant societal impacts, contributing to high costs in areas such as incarceration, delinquency, unemployment, and relationship challenges. These issues also exhibit notable sex differences: males tend to show higher prevalence, while females, though less affected overall, often face more severe outcomes. Despite these public health and personal costs, research on externalizing problems in females remains limited, particularly regarding the biological and hormonal factors driving these sex differences. The current paper explores how female hormonal influences across developmental stages may affect externalizing behaviors, highlighting the role ovarian hormones may play in shaping these externalizing problems. During puberty, estradiol and progesterone shifts contribute to risk-taking behaviors in females, who show distinct vulnerability patterns from males. Other important and understudied reproductive periods include puberty, pregnancy and postpartum, and perimenopause and menopause, and the menstrual cycle, overall. However, most population-level studies overlook the role of ovarian hormone fluctuations. This review advocates for the integration of hormonal phases in assessments, as hormonal shifts may exacerbate symptoms or modify treatment responses. Cycle-aligned interventions and hormone stabilization strategies could improve treatment outcomes, addressing gaps in male-focused treatment models and enhancing care for females with these disorders.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"78 ","pages":"Article 101206"},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A scoping review of functional genomics in perinatal depression 围产期抑郁症功能基因组学研究综述

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-06-26 DOI: 10.1016/j.yfrne.2025.101202

Silvia Elisabetta Portis Bruzzone , Victoria Frederikke S. Garre , Stinne Høgh , Vibe G. Frokjaer , Kieran J. O’Donnell , Rand S. Eid

{"title":"A scoping review of functional genomics in perinatal depression","authors":"Silvia Elisabetta Portis Bruzzone , Victoria Frederikke S. Garre , Stinne Høgh , Vibe G. Frokjaer , Kieran J. O’Donnell , Rand S. Eid","doi":"10.1016/j.yfrne.2025.101202","DOIUrl":"10.1016/j.yfrne.2025.101202","url":null,"abstract":"<div><div>Perinatal depression (PD) is a major public mental health problem affecting 10–20% of pregnant women. Women undergo profound biological and psychosocial adaptations during pregnancy and the postpartum period. Measures of genomic function can reveal pregnancy-associated adaptations, and may also illuminate mechanisms underlying PD, offering potential for clinically useful biomarkers. A systematic overview of functional genomic signatures of PD is currently lacking. We conducted a scoping review of the current literature on two aspects of genomic function: DNA methylation and gene expression. Literature was reviewed through May 2024. Thirty-three studies met inclusion criteria. Altered genomic function related to estrogen signaling and immune function were most consistently associated with PD. However, the reviewed studies used heterogeneous molecular profiling methods, were based on small sample sizes, largely used candidate-gene approaches, and reported mixed findings. The lack of replicated signatures underscores the need for a more comprehensive assessment of genomic function in PD.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"78 ","pages":"Article 101202"},"PeriodicalIF":6.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0