Frontiers in Neuroendocrinology最新文献

Oxytocin and dopamine in psychostimulant-induced changes in social behaviour 催产素和多巴胺在精神兴奋剂引起的社会行为改变中的作用。

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-07-01 DOI: 10.1016/j.yfrne.2025.101200

Fernando Castillo Díaz, Inga D. Neumann, Virginie Rappeneau

{"title":"Oxytocin and dopamine in psychostimulant-induced changes in social behaviour","authors":"Fernando Castillo Díaz, Inga D. Neumann, Virginie Rappeneau","doi":"10.1016/j.yfrne.2025.101200","DOIUrl":"10.1016/j.yfrne.2025.101200","url":null,"abstract":"<div><div>Oxytocin (OXT) plays a significant role in regulating social behaviour across various species, making it a key focus in neuroscience. Recent research has expanded beyond the established prosocial effects of OXT to explore its complex interplay with dopamine (DA), a key regulator of both reward processing and social behaviour. DA influences these behaviours both independently and in coordination with OXT. Emerging evidence highlights how psychostimulants disrupt OXT-DA interaction, exacerbating maladaptive social behaviours. This narrative review synthesises findings from pharmacological, optogenetic, and chemogenetic studies to elucidate mechanistic insights into OXT-DA crosstalk in both healthy and drug-compromised social functioning. We examined OXT-DA interaction in non-reproductive social behaviours, such as social approach and aggression, as well as reproductive behaviours, including parental care, offspring attachment, and pair bonding, both in the presence and absence of drugs of abuse. Understanding OXT-DA interaction offers important insights into the neurobiological mechanisms underlying both healthy and pathological social functioning.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"78 ","pages":"Article 101200"},"PeriodicalIF":6.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The overlooked mental health burden of polycystic ovary syndrome: neurobiological insights into PCOS-related depression 多囊卵巢综合征被忽视的心理健康负担：多囊卵巢综合征相关抑郁的神经生物学见解

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-07-01 DOI: 10.1016/j.yfrne.2025.101203

Eleni Dubé-Zinatelli , Freya Anderson , Nafissa Ismail

{"title":"The overlooked mental health burden of polycystic ovary syndrome: neurobiological insights into PCOS-related depression","authors":"Eleni Dubé-Zinatelli , Freya Anderson , Nafissa Ismail","doi":"10.1016/j.yfrne.2025.101203","DOIUrl":"10.1016/j.yfrne.2025.101203","url":null,"abstract":"<div><div>Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting 6–13% of reproductive-aged women worldwide. It is primarily characterized by ovarian dysfunction, hyperandrogenism, and metabolic disturbances. However, women with PCOS also face a heightened risk of depression, possibly due to dysregulation in endocrine and immune systems and gut microbiome disturbances. Symptoms of PCOS such as infertility, obesity, and hirsutism can also cause psychological distress and further exacerbate depression symptoms. Despite this comorbidity, mental health aspects of PCOS are often overlooked in the medical field, leading to insufficient support and negative impacts on the quality of life of PCOS patients. This review explores how distinct PCOS phenotypes influence physiological and psychological outcomes and the possible biological mechanisms involved. We also examine the effects of existing treatments on PCOS symptoms and depression. Addressing both physiological and psychological challenges is crucial for developing targeted, personalized interventions that improve outcomes for individuals diagnosed with PCOS.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"78 ","pages":"Article 101203"},"PeriodicalIF":6.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex as a biological variable (SABV) modulates the consequences of sleep disturbance on hippocampal memory and synaptic plasticity 性别作为一个生物变量（SABV）调节睡眠障碍对海马记忆和突触可塑性的影响。

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-07-01 DOI: 10.1016/j.yfrne.2025.101205

Camilla Paraciani, Robbert Havekes, Peter Meerlo, Nicole J. Gervais

引用次数: 0

The role of the stress adaptive response in multiple sclerosis 应激适应反应在多发性硬化症中的作用。

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-07-01 DOI: 10.1016/j.yfrne.2025.101204

Evangelia Zapanti , Alexandros Dermentzoglou , Paraskevi Kazakou , Konstantinos Kilindireas , George Mastorakos

{"title":"The role of the stress adaptive response in multiple sclerosis","authors":"Evangelia Zapanti , Alexandros Dermentzoglou , Paraskevi Kazakou , Konstantinos Kilindireas , George Mastorakos","doi":"10.1016/j.yfrne.2025.101204","DOIUrl":"10.1016/j.yfrne.2025.101204","url":null,"abstract":"<div><div>Multiple sclerosis (MS) is the commonest autoimmune inflammatory neurological disease presenting multifocal demyelinating lesions in the white matter of the central nervous system (CNS). Its pathogenesis involves genetic and environmental mechanisms which lead to immune cell-mediated destruction of myelin and axonal damage and glial scars in CNS. Stress adaptive response might cause MS exacerbation by triggering release of hormones and neuropeptides leading to immune dysregulation and altered cytokine production. The exact link between the stress adaptive response and MS physiopathology is not clear, although neuro-immunological studies have shown alterations in cytokines and lymphocytes in MS patients, under stress, which might have clinical significance. Dysregulation of the principal components of the stress system, i.e. the hypothalamic–pituitary–adrenal axis, the sympathetic nervous system and the dopaminergic system, have been described in MS patients. In this critical review the role of the stress adaptive response in the manifestation and exacerbation of MS is described.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"78 ","pages":"Article 101204"},"PeriodicalIF":6.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal effects on externalizing problems in females across the lifespan 荷尔蒙对女性一生中外化问题的影响

IF 6.7 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-07-01 DOI: 10.1016/j.yfrne.2025.101206

Michelle M. Martel , Ashley G. Eng , Urveesha Nirjar , Madeline K. Petersen , Miranda P. Ramirez , Carleigh A. Litteral , Layne E. Robinson

{"title":"Hormonal effects on externalizing problems in females across the lifespan","authors":"Michelle M. Martel , Ashley G. Eng , Urveesha Nirjar , Madeline K. Petersen , Miranda P. Ramirez , Carleigh A. Litteral , Layne E. Robinson","doi":"10.1016/j.yfrne.2025.101206","DOIUrl":"10.1016/j.yfrne.2025.101206","url":null,"abstract":"<div><div>Developmental transdiagnostic externalizing problems—including harmful substance use, conduct issues, oppositional-defiance, and ADHD-related hyperactivity-impulsivity—have significant societal impacts, contributing to high costs in areas such as incarceration, delinquency, unemployment, and relationship challenges. These issues also exhibit notable sex differences: males tend to show higher prevalence, while females, though less affected overall, often face more severe outcomes. Despite these public health and personal costs, research on externalizing problems in females remains limited, particularly regarding the biological and hormonal factors driving these sex differences. The current paper explores how female hormonal influences across developmental stages may affect externalizing behaviors, highlighting the role ovarian hormones may play in shaping these externalizing problems. During puberty, estradiol and progesterone shifts contribute to risk-taking behaviors in females, who show distinct vulnerability patterns from males. Other important and understudied reproductive periods include puberty, pregnancy and postpartum, and perimenopause and menopause, and the menstrual cycle, overall. However, most population-level studies overlook the role of ovarian hormone fluctuations. This review advocates for the integration of hormonal phases in assessments, as hormonal shifts may exacerbate symptoms or modify treatment responses. Cycle-aligned interventions and hormone stabilization strategies could improve treatment outcomes, addressing gaps in male-focused treatment models and enhancing care for females with these disorders.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"78 ","pages":"Article 101206"},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A scoping review of functional genomics in perinatal depression 围产期抑郁症功能基因组学研究综述

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-06-26 DOI: 10.1016/j.yfrne.2025.101202

Silvia Elisabetta Portis Bruzzone , Victoria Frederikke S. Garre , Stinne Høgh , Vibe G. Frokjaer , Kieran J. O’Donnell , Rand S. Eid

{"title":"A scoping review of functional genomics in perinatal depression","authors":"Silvia Elisabetta Portis Bruzzone , Victoria Frederikke S. Garre , Stinne Høgh , Vibe G. Frokjaer , Kieran J. O’Donnell , Rand S. Eid","doi":"10.1016/j.yfrne.2025.101202","DOIUrl":"10.1016/j.yfrne.2025.101202","url":null,"abstract":"<div><div>Perinatal depression (PD) is a major public mental health problem affecting 10–20% of pregnant women. Women undergo profound biological and psychosocial adaptations during pregnancy and the postpartum period. Measures of genomic function can reveal pregnancy-associated adaptations, and may also illuminate mechanisms underlying PD, offering potential for clinically useful biomarkers. A systematic overview of functional genomic signatures of PD is currently lacking. We conducted a scoping review of the current literature on two aspects of genomic function: DNA methylation and gene expression. Literature was reviewed through May 2024. Thirty-three studies met inclusion criteria. Altered genomic function related to estrogen signaling and immune function were most consistently associated with PD. However, the reviewed studies used heterogeneous molecular profiling methods, were based on small sample sizes, largely used candidate-gene approaches, and reported mixed findings. The lack of replicated signatures underscores the need for a more comprehensive assessment of genomic function in PD.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"78 ","pages":"Article 101202"},"PeriodicalIF":6.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Binge alcohol and the neuroendocrinology of the aging female 酗酒与老年女性的神经内分泌学

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-06-04 DOI: 10.1016/j.yfrne.2025.101201

J. Leigh Leasure , Catherine E. Van Doorn , Kimberly Nixon

{"title":"Binge alcohol and the neuroendocrinology of the aging female","authors":"J. Leigh Leasure , Catherine E. Van Doorn , Kimberly Nixon","doi":"10.1016/j.yfrne.2025.101201","DOIUrl":"10.1016/j.yfrne.2025.101201","url":null,"abstract":"<div><div>Aging and alcohol exert marked effects on the endocrine system – in particular the hypothalamic-pituitary–gonadal (HPG) and hypothalamic–pituitary–adrenal (HPA) axes. The aging female brain represents a unique substrate for alcohol effects, given that both the HPG and HPA undergo significant changes with aging in women, making this demographic notably different from both males and younger females. Little attention has been directed at alcohol effects in this group but changing trends in women’s drinking have brought these issues to the forefront. Major gaps in our understanding of aging females include how stressors common to middle and older aged women impact alcohol consumption, and how alcohol consumption in older women impacts brain health and aging. Thus, here we review the current state of knowledge concerning the unique neuroendocrinology of aging females, their stressors and pharmacokinetic reactions to alcohol, and their interactions as causes and neurotoxic consequences of excessive alcohol drinking. We highlight the role of the neuroimmune system at the intersection of aging, alcohol and stress effects, and brain endocrine systems. We conclude that therapeutic interventions should be aimed at managing alcohol-induced neuroimmune responses and their downstream effects on vulnerable white matter. In addition, mid-life represents a window of opportunity in which to introduce strategies to limit alcohol consumption and its consequences for the aging female brain. As so little is known about how alcohol intake impacts brain health in females, let alone in aging females, we assert the need for further investigation of middle-aged and aged females in human and preclinical studies.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"78 ","pages":"Article 101201"},"PeriodicalIF":6.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seasonal variation in hair cortisol concentration: A systematic review 毛发皮质醇浓度的季节变化：一项系统综述。

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-05-23 DOI: 10.1016/j.yfrne.2025.101199

Anja C. Feneberg , Susanne Fischer , Nadine Skoluda

{"title":"Seasonal variation in hair cortisol concentration: A systematic review","authors":"Anja C. Feneberg , Susanne Fischer , Nadine Skoluda","doi":"10.1016/j.yfrne.2025.101199","DOIUrl":"10.1016/j.yfrne.2025.101199","url":null,"abstract":"<div><div>Hair cortisol concentration (HCC) is a crucial biomarker in psychoneuroendocrinological research, offering unique insights into long-term hypothalamic–pituitary–adrenal axis activity. Season has repeatedly shown associations with HCC. However, as of yet, no systematic attempt at quantifying season’s influence on HCC has been undertaken. We conducted a systematic search of the bibliographic databases PubMed and PsycINFO. Twenty-nine between- and within-person studies fulfilled all eligibility criteria (N = 10,520 participants in total). Overall, 22 studies (76%) reported significant differences in HCC across seasons. Most between-personstudies reported lower HCC in winter/spring than in summer/autumn (10/15). This pattern was supported by 2/14 within-person studies, whereas others reported lower HCC in summer than in autumn (6/14). The remaining studies reported other patterns or no seasonal variations in HCC. In conclusion, there is accumulating evidence for seasonal variations in HCC, highlighting the need to consider the seasons in future research on HCC and health. Mechanisms related to meteorological, ecological, sociocultural, and lifestyle factors may underlie seasonal rhythmicity in cortisol secretion and accumulation in hair.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"78 ","pages":"Article 101199"},"PeriodicalIF":6.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

History of hypertensive disorders of pregnancy and risk of Alzheimer’s disease and vascular dementia

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-05-12 DOI: 10.1016/j.yfrne.2025.101198

Simranjit Kaur, Chauncey J. Darden, Goodness M. Adegbola, Junie P. Warrington

引用次数: 0

The medial amygdala’s neural circuitry: Insights into social processing and sex differences 内侧杏仁核的神经回路：对社会处理和性别差异的洞察

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-04-01 DOI: 10.1016/j.yfrne.2025.101190

Benavides Ignacio , Janina Baeza , Bastián Ruiz , Juan Pablo Romero , Paulina Yañez , Camila Ramírez , Teresa Caprile , Carlos Farkas , Antonia Recabal-Beyer

{"title":"The medial amygdala’s neural circuitry: Insights into social processing and sex differences","authors":"Benavides Ignacio , Janina Baeza , Bastián Ruiz , Juan Pablo Romero , Paulina Yañez , Camila Ramírez , Teresa Caprile , Carlos Farkas , Antonia Recabal-Beyer","doi":"10.1016/j.yfrne.2025.101190","DOIUrl":"10.1016/j.yfrne.2025.101190","url":null,"abstract":"<div><div>The amygdala, a critical part of the limbic system, is essential for processing social stimuli and regulating stress responses. Among its various neuronal nuclei, the medial amygdala (MeA) remains one of the least studied in humans. The MeA plays a key role in receiving inputs from the olfactory system through pheromones, as well as from crucial areas such as the hypothalamus, hippocampus, and reward system. This allows the MeA to integrate external stimuli with the organism’s internal state, finetuning social interactions, endocrine responses, and innate behaviors. Recent advances in neuroscience have highlighted the sex differences of the MeA and how they influence behavior and environmental perception. Understanding these sexspecific variations in brain structures, like the MeA in rodents, is vital for applying this knowledge to humans and could help bridge gaps in our understanding and treatment of mental health disorders, which often differ between sexes in both prevalence and presentation.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"77 ","pages":"Article 101190"},"PeriodicalIF":6.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0