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Frontiers in Neuroendocrinology最新文献

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Celebrating 60 years of neuroendocrinology 庆祝神经内分泌学诞生 60 周年
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-04-01 DOI: 10.1016/j.yfrne.2024.101134
Liisa A.M. Galea
{"title":"Celebrating 60 years of neuroendocrinology","authors":"Liisa A.M. Galea","doi":"10.1016/j.yfrne.2024.101134","DOIUrl":"https://doi.org/10.1016/j.yfrne.2024.101134","url":null,"abstract":"","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140605898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From means to meaning in the study of sex/gender differences and similarities 性/性别异同研究从手段到意义
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-04-01 DOI: 10.1016/j.yfrne.2024.101133
Carla Sanchis-Segura , Rand R. Wilcox
{"title":"From means to meaning in the study of sex/gender differences and similarities","authors":"Carla Sanchis-Segura ,&nbsp;Rand R. Wilcox","doi":"10.1016/j.yfrne.2024.101133","DOIUrl":"https://doi.org/10.1016/j.yfrne.2024.101133","url":null,"abstract":"<div><p>The incorporation of sex and gender (S/G) related factors is commonly acknowledged as a necessary step to advance towards more personalized diagnoses and treatments for somatic, psychiatric, and neurological diseases. Until now, most attempts to integrate S/G-related factors have been reduced to identifying average differences between females and males in behavioral/ biological variables. The present commentary questions this traditional approach by highlighting three main sets of limitations: 1) Issues stemming from the use of classic parametric methods to compare means; 2) challenges related to the ability of means to accurately represent the data within groups and differences between groups; 3) mean comparisons impose a results’ binarization and a binary theoretical framework that precludes advancing towards precision medicine. Alternative methods free of these limitations are also discussed. We hope these arguments will contribute to reflecting on how research on S/G factors is conducted and could be improved.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140549959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial- State of the art on steroids and the nervous system: In memory of Giancarlo 社论--类固醇与神经系统的最新研究成果：纪念詹卡洛
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-04-01 DOI: 10.1016/j.yfrne.2024.101135
Roberto Cosimo Melcangi, Silvia Giatti, Stefano Gotti
{"title":"Editorial- State of the art on steroids and the nervous system: In memory of Giancarlo","authors":"Roberto Cosimo Melcangi,&nbsp;Silvia Giatti,&nbsp;Stefano Gotti","doi":"10.1016/j.yfrne.2024.101135","DOIUrl":"https://doi.org/10.1016/j.yfrne.2024.101135","url":null,"abstract":"","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140604493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium-glucose cotransporter-2 inhibitors and their potential role in dementia onset and cognitive function in patients with diabetes mellitus: a systematic review and meta-analysis 钠-葡萄糖共转运体-2抑制剂及其在糖尿病患者痴呆症发病和认知功能方面的潜在作用：系统综述和荟萃分析。
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-02-16 DOI: 10.1016/j.yfrne.2024.101131
Yea Jin Youn , Seungyeon Kim , Hyun-Jeong Jeong , Young-Mi Ah , Yun Mi Yu
{"title":"Sodium-glucose cotransporter-2 inhibitors and their potential role in dementia onset and cognitive function in patients with diabetes mellitus: a systematic review and meta-analysis","authors":"Yea Jin Youn ,&nbsp;Seungyeon Kim ,&nbsp;Hyun-Jeong Jeong ,&nbsp;Young-Mi Ah ,&nbsp;Yun Mi Yu","doi":"10.1016/j.yfrne.2024.101131","DOIUrl":"10.1016/j.yfrne.2024.101131","url":null,"abstract":"<div><p>This systematic review and meta-analysis aimed to determine the association between the use of sodium-glucose cotransporter 2 (SGLT-2) inhibitors and dementia onset as well as cognitive function in patients with diabetes mellitus. We comprehensively searched the MEDLINE, Embase, and CENTRAL databases to select relevant studies published up to August 2023. The use of SGLT-2 inhibitors significantly lowers dementia risk compared to SGLT-2i non-users (Hazard ratio: 0.68, 95 % CI: 0.50–0.92). Furthermore, our findings indicated a positive effect of SGLT-2 inhibitor use on cognitive function score improvement, as demonstrated by the standardized mean difference of 0.88 (95 % CI: 0.32–1.44), particularly among populations with mild cognitive impairment or dementia. This systematic review and meta-analysis indicate a potential role of SGLT-2 inhibitors in reducing the risk of dementia in patients with diabetes mellitus. These findings underscore the need for well-controlled large clinical trials and future research in this field.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302224000116/pdfft?md5=d705299bbfab00768568ceb8fabe2a5c&pid=1-s2.0-S0091302224000116-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139897928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholecystokinin (CCK): a neuromodulator with therapeutic potential in Alzheimer’s and Parkinson’s disease 胆囊收缩素（CCK）：一种对阿尔茨海默氏症和帕金森氏症具有治疗潜力的神经调节剂。
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-02-10 DOI: 10.1016/j.yfrne.2024.101122
Niklas Reich , Christian Hölscher
{"title":"Cholecystokinin (CCK): a neuromodulator with therapeutic potential in Alzheimer’s and Parkinson’s disease","authors":"Niklas Reich ,&nbsp;Christian Hölscher","doi":"10.1016/j.yfrne.2024.101122","DOIUrl":"10.1016/j.yfrne.2024.101122","url":null,"abstract":"<div><p>Cholecystokinin (CCK) is a neuropeptide modulating digestion, glucose levels, neurotransmitters and memory. Recent studies suggest that CCK exhibits neuroprotective effects in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Thus, we review the physiological function and therapeutic potential of CCK. The neuropeptide facilitates hippocampal glutamate release and gates GABAergic basket cell activity, which improves declarative memory acquisition, but inhibits consolidation. Cortical CCK alters recognition memory and enhances audio-visual processing. By stimulating CCK-1 receptors (CCK-1Rs), sulphated CCK-8 elicits dopamine release in the substantia nigra and striatum. In the mesolimbic pathway, CCK release is triggered by dopamine and terminates reward responses via CCK-2Rs. Importantly, activation of hippocampal and nigral CCK-2Rs is neuroprotective by evoking AMPK activation, expression of mitochondrial fusion modulators and autophagy. Other benefits include vagus nerve/CCK-1R-mediated expression of brain-derived neurotrophic factor, intestinal protection and suppression of inflammation. We also discuss caveats and the therapeutic combination of CCK with other peptide hormones.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302224000025/pdfft?md5=8a955eedbbebcc2aefde97b57dfdc255&pid=1-s2.0-S0091302224000025-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: A conceptual model for the study of sex and gender differences 早期生活压力、情感和青少年药物使用之间联系的神经内分泌机制：研究性和性别差异的概念模型
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-01-20 DOI: 10.1016/j.yfrne.2024.101121
Alexandra Donovan , Shervin Assari , Christine Grella , Magda Shaheen , Linda Richter , Theodore C. Friedman
{"title":"Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: A conceptual model for the study of sex and gender differences","authors":"Alexandra Donovan ,&nbsp;Shervin Assari ,&nbsp;Christine Grella ,&nbsp;Magda Shaheen ,&nbsp;Linda Richter ,&nbsp;Theodore C. Friedman","doi":"10.1016/j.yfrne.2024.101121","DOIUrl":"10.1016/j.yfrne.2024.101121","url":null,"abstract":"<div><p>Early life stress (ELS) is defined as an acute or chronic stressor that negatively impacts a child’s development. ELS is associated with substance use and mental health problems. This narrative literature review focuses on sex and gender differences in the effects of ELS on 1) adolescent neuroendocrine development; 2) pubertal brain maturation; and 3) development of internalizing symptoms and subsequent substance use. We posit that ELS may generate larger hormonal dysregulation in females than males during puberty, increasing internalizing symptoms and substance use. Future research should consider sex and gender differences in neuroendocrine developmental processes when studying the link between ELS and negative health outcomes.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302224000013/pdfft?md5=0f2694b96e01bf746f82dc3b9204de9b&pid=1-s2.0-S0091302224000013-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139508148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of stress in perinatal depression and anxiety – A systematic review 压力在围产期抑郁和焦虑中的作用 - 系统综述
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-01-01 DOI: 10.1016/j.yfrne.2023.101117
MA. Schalla , A. Stengel
{"title":"The role of stress in perinatal depression and anxiety – A systematic review","authors":"MA. Schalla ,&nbsp;A. Stengel","doi":"10.1016/j.yfrne.2023.101117","DOIUrl":"10.1016/j.yfrne.2023.101117","url":null,"abstract":"<div><p>Perinatal depression (PND) and anxiety affect around 20% of women, but available pharmacotherapy is not sufficiently effective in 20–60% of them, indicating a need for better understanding of these diseases. Since stress is a significant risk factor for PND, the aim was to examine the role of biological, environmental and psychological stress in PND and anxiety through a systematic literature search. Overall 210 studies were included, among which numerous rodent studies showed that perinatal stress induced depressive-like and anxious behavior, which was associated with HPA-axis alterations and morphological brain changes. Human studies indicated that the relationship between cortisol and perinatal depression/anxiety was not as clear and with many contradictions, although social and psychological stress were clearly positively associated with PND. Finally, oxytocin, synthetic neuroactive steroid and n-3 PUFA diet have been identified as potentially beneficial in the therapy of PND and anxiety, worth to be investigated in the future.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139084484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex differences in cortisol levels in depression: A systematic review and meta-analysis 抑郁症患者皮质醇水平的性别差异：系统综述与荟萃分析
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-01-01 DOI: 10.1016/j.yfrne.2023.101118
Rui Wang , Lydia Kogler , Birgit Derntl
{"title":"Sex differences in cortisol levels in depression: A systematic review and meta-analysis","authors":"Rui Wang ,&nbsp;Lydia Kogler ,&nbsp;Birgit Derntl","doi":"10.1016/j.yfrne.2023.101118","DOIUrl":"10.1016/j.yfrne.2023.101118","url":null,"abstract":"<div><p>Higher prevalence of depression in females might be associated with sex-specific cortisol levels. Evidence exists that cortisol levels differ between healthy females and males, however a sex-specific association in depression has not been systematically assessed. Thus, the current study quantifies the existing literature on different cortisol parameters, i.e., basal cortisol, hair cortisol, cortisol awakening response (CAR), and cortisol stress reactivity comparing depressed females and males as well as sex-specific comparisons with healthy controls. Following an extensive literature research, fifty original articles were included. Depressed females had significantly higher hair cortisol, higher CAR, and lower cortisol stress reactivity compared to depressed males. In comparison with sex-matched controls, female patients had significantly higher evening basal cortisol, higher CAR and lower cortisol stress reactivity, and male patients had significantly higher general, morning and evening basal cortisol. Overall, sex as a fundamental driver of cortisol levels in depression needs to be taken into account.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139084487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electroencephalography findings in menstrually-related mood disorders: A critical review 月经相关情绪障碍的脑电图检查结果：批判性评论
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-01-01 DOI: 10.1016/j.yfrne.2023.101120
Elisavet Kaltsouni , Felix Schmidt , Rachel G. Zsido , Allison Eriksson , Julia Sacher , Inger Sundström-Poromaa , Rachael L. Sumner , Erika Comasco
{"title":"Electroencephalography findings in menstrually-related mood disorders: A critical review","authors":"Elisavet Kaltsouni ,&nbsp;Felix Schmidt ,&nbsp;Rachel G. Zsido ,&nbsp;Allison Eriksson ,&nbsp;Julia Sacher ,&nbsp;Inger Sundström-Poromaa ,&nbsp;Rachael L. Sumner ,&nbsp;Erika Comasco","doi":"10.1016/j.yfrne.2023.101120","DOIUrl":"10.1016/j.yfrne.2023.101120","url":null,"abstract":"<div><p>The female reproductive years are characterized by fluctuations in ovarian hormones across the menstrual cycle, which have the potential to modulate neurophysiological and behavioral dynamics. Menstrually-related mood disorders (MRMDs) comprise cognitive-affective or somatic symptoms that are thought to be triggered by the rapid fluctuations in ovarian hormones in the luteal phase of the menstrual cycle. MRMDs include premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and premenstrual exacerbation (PME) of other psychiatric disorders. Electroencephalography (EEG) non-invasively records <em>in vivo</em> synchronous activity from populations of neurons with high temporal resolution. The present overview sought to systematically review the current state of task-related and resting-state EEG investigations on MRMDs. Preliminary evidence indicates lower alpha asymmetry at rest being associated with MRMDs, while one study points to the effect being luteal-phase specific. Moreover, higher luteal spontaneous frontal brain activity (slow/fast wave ratio as measured by the delta/beta power ratio) has been observed in persons with MRMDs, while sleep architecture results point to potential circadian rhythm disturbances. In this review, we discuss the quality of study designs as well as future perspectives and challenges of supplementing the diagnostic and scientific toolbox for MRMDs with EEG.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302223000687/pdfft?md5=7d42373733a3221ea792628ecfc63b05&pid=1-s2.0-S0091302223000687-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139084483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulatory role of neurosteroidogenesis in the spinal cord during peripheral nerve injury-induced chronic pain 周围神经损伤诱发慢性疼痛期间脊髓中神经类固醇生成的调节作用
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2024-01-01 DOI: 10.1016/j.yfrne.2023.101116
Ayikoe-Guy Mensah-Nyagan, Laurence Meyer , Christine Patte-Mensah
{"title":"Modulatory role of neurosteroidogenesis in the spinal cord during peripheral nerve injury-induced chronic pain","authors":"Ayikoe-Guy Mensah-Nyagan,&nbsp;Laurence Meyer ,&nbsp;Christine Patte-Mensah","doi":"10.1016/j.yfrne.2023.101116","DOIUrl":"10.1016/j.yfrne.2023.101116","url":null,"abstract":"<div><p>The brain and spinal cord (SC) are both targeted by various hormones, including steroid hormones. However, investigations of the modulatory role of hormones on neurobiological functions usually focus only on the brain. The SC received little attention although this structure pivotally controls motor and sensory functions. Here, we critically reviewed key data showing that the process of neurosteroid biosynthesis or neurosteroidogenesis occurring in the SC plays a pivotal role in the modulation of peripheral nerve injury-induced chronic pain (PNICP) or neuropathic pain. Indeed, several active steroidogenic enzymes expressed in the SC produce endogenous neurosteroids that interact with receptors of neurotransmitters controlling pain. The spinal neurosteroidogenesis is differentially regulated during PNICP condition and its blockade modifies painful sensations. The paper suggests that future investigations aiming to develop effective strategies against PNICP or neuropathic pain must integrate in a gender or sex dependent manner the regulatory effects exerted by spinal neurosteroidogenesis.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139093971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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