Frontiers in Neuroendocrinology最新文献_第2页

From menarche to menopause: estrogenic influences on stroke-related depression in women 从月经初潮到更年期：雌激素对女性卒中相关抑郁的影响。

IF 6.7 1区医学

Frontiers in Neuroendocrinology Pub Date : 2026-01-01 Epub Date: 2026-01-19 DOI: 10.1016/j.yfrne.2026.101232

Lauren Kelly Tierney , Indy Cabeda Diaz , Shahil H. Patel , Ami P. Raval

{"title":"From menarche to menopause: estrogenic influences on stroke-related depression in women","authors":"Lauren Kelly Tierney , Indy Cabeda Diaz , Shahil H. Patel , Ami P. Raval","doi":"10.1016/j.yfrne.2026.101232","DOIUrl":"10.1016/j.yfrne.2026.101232","url":null,"abstract":"<div><div>Post-stroke depression (PSD) is a common and debilitating complication that disproportionately affects women, yet the underlying risk factors remain incompletely understood. Hormonal fluctuations across a woman’s lifespan, including those naturally occurring during puberty, pregnancy, and menopause, as well as exposures to exogenous hormones, such as oral contraceptives, assisted reproductive technologies, and hormonal replacement therapies, profoundly influence neurobiological pathways, potentially modulating both stroke risk and subsequent depressive disorders. Female-specific or female-predominant patient factors, including polycystic ovary syndrome, migraine, autoimmune disease, and breast cancer may exacerbate susceptibility to depression after stroke. Behavioral factors, such as smoking, substance use, and stress, further interact with biological predispositions to impact PSD outcomes. Our review presents current evidence on the intersection of hormonal fluctuations, patient factors, and behavioral influences in shaping the stroke risk and manifestation of PSD in women. Addressing the intersecting influences on PSD offers a promising pathway to improve post-stroke mental health outcomes and enhance quality of life for women.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"80 ","pages":"Article 101232"},"PeriodicalIF":6.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The genetic architecture of reproductive subtypes of depression in females 女性抑郁症生殖亚型的遗传结构。

IF 6.7 1区医学

Frontiers in Neuroendocrinology Pub Date : 2026-01-01 Epub Date: 2025-12-16 DOI: 10.1016/j.yfrne.2025.101230

Arielle Crestol , Hannah Oppenheimer , Carina J. Koeppel , Claudia Barth

{"title":"The genetic architecture of reproductive subtypes of depression in females","authors":"Arielle Crestol , Hannah Oppenheimer , Carina J. Koeppel , Claudia Barth","doi":"10.1016/j.yfrne.2025.101230","DOIUrl":"10.1016/j.yfrne.2025.101230","url":null,"abstract":"<div><div>Reproductive subtypes of depression, including premenstrual dysphoric disorder, postpartum depression, and perimenopausal depression are tightly linked to hormonal fluctuations, presenting as windows of vulnerability in females. While it is suggested that these reproductive subtypes present as a stable trait, it remains unclear whether they share an underlying genetic architecture. In this review, we summarize the known genetic etiology of each reproductive subtype of depression, contrast the findings between subtypes, and highlight existing knowledge gaps, challenges, and ways forward. We found that while postpartum depression has been comparatively more studied, genetic studies on premenstrual dysphoric disorder and perimenopausal depression are scarce. Candidate genes commonly studied in major depressive disorder (<em>5-HTT, COMT, MAO-A,</em> and <em>TPH1</em>) as well as <em>ESR1</em> have been studied across the reproductive subtypes, however, showing inconsistent patterns. No genome-wide association studies currently exist for premenstrual dysphoric disorder or perimenopausal depression. Genome-wide association studies on postpartum depression, although underpowered, point to unique and shared genetic components with other psychiatric disorders, which should be further explored across all reproductive subtypes of depression. To advance this field, well-powered studies with consistent diagnostic criteria across diverse ancestry groups are needed. Identifying whether overlap exists in the genetic architecture of premenstrual dysphoric disorder, postpartum depression, and perimenopausal depression could enhance our understanding of their pathogenesis and foster the development of new therapeutic targets.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"80 ","pages":"Article 101230"},"PeriodicalIF":6.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145780420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in the acute effects of cannabis on human cognition: A systematic review 大麻对人类认知急性效应的性别差异：系统综述

IF 6.7 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-10-01 Epub Date: 2025-08-15 DOI: 10.1016/j.yfrne.2025.101215

Justin Matheson , Danial Behzad , Christina Zakala , Thomas Hawken , Bruna Brands , Bernard Le Foll , Christine M. Wickens , Anthony C. Ruocco , Terri Rodak , Patricia Di Ciano

{"title":"Sex differences in the acute effects of cannabis on human cognition: A systematic review","authors":"Justin Matheson , Danial Behzad , Christina Zakala , Thomas Hawken , Bruna Brands , Bernard Le Foll , Christine M. Wickens , Anthony C. Ruocco , Terri Rodak , Patricia Di Ciano","doi":"10.1016/j.yfrne.2025.101215","DOIUrl":"10.1016/j.yfrne.2025.101215","url":null,"abstract":"<div><div>Acute cannabis exposure can transiently impair cognitive performance, increasing the risk of accidental injury and potentially disrupting activities of daily living. Although sex differences in responses to cannabis have been reported, no systematic review has examined whether these extend to acute cognitive effects. Our primary aim was to examine sex differences in the acute effects of cannabis (including isolated delta-9-tetrahydrocannabinol [THC]) on cognition in humans. Our secondary aim was to determine if sex differences in the acute effects of cannabis vary by cognitive domain, route of administration, or dosing paradigm. Following PRISMA guidelines, we conducted a comprehensive literature search across Embase, MEDLINE, APA PsycInfo, Cochrane Library, and Web of Science databases. Of 1,625 unique records, 169 underwent full-text screening, and 29 studies met inclusion criteria. Six of 29 articles (20.7 %), representing eight of 216 cognitive outcomes (3.7 %), found statistical evidence of sex differences in acute cognitive effects of cannabis/THC. All six found increased effects in female participants in at least one cognitive variable; one study additionally found increased effects in male participants, and one study found divergent cognitive effects in male and female participants. There were no clear patterns by cannabis dosing paradigm, route of administration, or cognitive domain. Overall, we found limited evidence that sex significantly influences the acute cognitive effects of cannabis, though methodological heterogeneity precludes any firm conclusions. Future studies should prioritize the measurement of sex-related factors, such as hormonal modulation of cannabinoid pharmacokinetics and pharmacodynamics.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"79 ","pages":"Article 101215"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Impact of statins on mortality and disease progression in patients with Alzheimer’s disease: a nationwide cohort study 他汀类药物对阿尔茨海默病患者死亡率和疾病进展的影响：一项全国性队列研究

IF 6.7 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-10-01 Epub Date: 2025-10-15 DOI: 10.1016/j.yfrne.2025.101218

Yoonjung Park , Hyun Woo Lee , Byoung Seok Ye , Seungyeon Kim , Yun Mi Yu

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Editorial – Addiction in females 编辑-女性成瘾。

IF 6.7 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-10-01 Epub Date: 2025-08-08 DOI: 10.1016/j.yfrne.2025.101214

Kimberly Nixon, J. Leigh Leasure

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How the diffuse neuroendocrine system shapes health, homeostasis, and cancer 弥漫性神经内分泌系统如何影响健康、体内平衡和癌症

IF 6.7 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-10-01 Epub Date: 2025-08-23 DOI: 10.1016/j.yfrne.2025.101216

Michel Salzet

{"title":"How the diffuse neuroendocrine system shapes health, homeostasis, and cancer","authors":"Michel Salzet","doi":"10.1016/j.yfrne.2025.101216","DOIUrl":"10.1016/j.yfrne.2025.101216","url":null,"abstract":"<div><div>The diffuse neuroendocrine system (DNES) consists of dispersed neuroendocrine (NE) cells that bridge nervous, immune, and endocrine pathways across organs. Evolutionarily, DNES traces to primitive metazoans where single cells combined neural and immune roles, later diversifying into specialized vertebrate NE cells. Hallmark traits include dense-core granules, amine metabolism, “salt-and-pepper” chromatin, and regulation by ASCL1, NEUROG3, and INSM1. Remarkable plasticity allows immune and epithelial cells to acquire NE features under stress, while carcinomas exploit this program to form aggressive neuroendocrine tumors (NETs) and resist therapy. Canonical neuroimmune circuits, the Vagus-driven inflammatory reflex and hypothalamic–pituitary–adrenal stress axis, illustrate DNES coordination of systemic responses. Clinically, DNES-derived neoplasms span multiple organs, produce diverse hormonal syndromes, and are managed with somatostatin analogues, epigenetic drugs, and emerging immunotherapies. Recognizing DNES as a diffuse, integrative regulatory network clarifies mechanisms of chronic inflammation and cancer evolution and offers novel therapeutic entry points for disorders ranging from asthma to pancreatic neuroendocrine carcinomas.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"79 ","pages":"Article 101216"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Semaglutide and the pathogenesis of progressive neurodegenerative disease: the central role of mitochondria Semaglutide与进行性神经退行性疾病的发病机制：线粒体的核心作用

IF 6.7 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-10-01 Epub Date: 2025-10-03 DOI: 10.1016/j.yfrne.2025.101217

George B. Stefano , Pascal Büttiker , Simon Weissenberger , Jiri Raboch , Martin Anders

{"title":"Semaglutide and the pathogenesis of progressive neurodegenerative disease: the central role of mitochondria","authors":"George B. Stefano , Pascal Büttiker , Simon Weissenberger , Jiri Raboch , Martin Anders","doi":"10.1016/j.yfrne.2025.101217","DOIUrl":"10.1016/j.yfrne.2025.101217","url":null,"abstract":"<div><div>While mitochondria provide critical energy resources, mitochondrial dysfunction can lead to both metabolic and neurodegenerative disorders. Primary mitochondrial disorders (e.g., Leigh syndrome) are uniformly associated with profound neurodegeneration. Recent studies have also implicated mitochondrial dysfunction as a central feature of progressive neurodegenerative diseases, notably Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis, and Huntington’s Disease. In addition to its profound impact on metabolic disease, the glucagon-like peptide-1 receptor agonist, semaglutide, has significant neuroprotective features and may limit the progression of one or more of these disorders. These observations might be explained at least in part by the impact of this drug on mitochondrial function and energy production. Collectively, these observations highlight disrupted energy homeostasis as a critical feature of neurodegenerative disease and suggest novel targets for the development of much-needed new neuropharmaceutical strategies.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"79 ","pages":"Article 101217"},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145216979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “A scoping review of functional genomics in perinatal depression”. [Front. Neuroendocrinol. 78 (2025) 101202] “围产期抑郁症功能基因组学范围综述”的勘误表。(前面。[j].中国生物医学工程学报，2016,32(1):1 - 2。

IF 6.7 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-10-01 Epub Date: 2025-11-01 DOI: 10.1016/j.yfrne.2025.101219

Silvia Elisabetta Portis Bruzzone , Victoria Frederikke S. Garre , Stinne Høgh , Vibe G. Frokjaer , Kieran J. O’Donnell , Rand S. Eid

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A scoping review of functional genomics in perinatal depression 围产期抑郁症功能基因组学研究综述

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-07-01 Epub Date: 2025-06-26 DOI: 10.1016/j.yfrne.2025.101202

Silvia Elisabetta Portis Bruzzone , Victoria Frederikke S. Garre , Stinne Høgh , Vibe G. Frokjaer , Kieran J. O’Donnell , Rand S. Eid

{"title":"A scoping review of functional genomics in perinatal depression","authors":"Silvia Elisabetta Portis Bruzzone , Victoria Frederikke S. Garre , Stinne Høgh , Vibe G. Frokjaer , Kieran J. O’Donnell , Rand S. Eid","doi":"10.1016/j.yfrne.2025.101202","DOIUrl":"10.1016/j.yfrne.2025.101202","url":null,"abstract":"<div><div>Perinatal depression (PD) is a major public mental health problem affecting 10–20% of pregnant women. Women undergo profound biological and psychosocial adaptations during pregnancy and the postpartum period. Measures of genomic function can reveal pregnancy-associated adaptations, and may also illuminate mechanisms underlying PD, offering potential for clinically useful biomarkers. A systematic overview of functional genomic signatures of PD is currently lacking. We conducted a scoping review of the current literature on two aspects of genomic function: DNA methylation and gene expression. Literature was reviewed through May 2024. Thirty-three studies met inclusion criteria. Altered genomic function related to estrogen signaling and immune function were most consistently associated with PD. However, the reviewed studies used heterogeneous molecular profiling methods, were based on small sample sizes, largely used candidate-gene approaches, and reported mixed findings. The lack of replicated signatures underscores the need for a more comprehensive assessment of genomic function in PD.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"78 ","pages":"Article 101202"},"PeriodicalIF":6.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seasonal variation in hair cortisol concentration: A systematic review 毛发皮质醇浓度的季节变化：一项系统综述。

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2025-07-01 Epub Date: 2025-05-23 DOI: 10.1016/j.yfrne.2025.101199

Anja C. Feneberg , Susanne Fischer , Nadine Skoluda

{"title":"Seasonal variation in hair cortisol concentration: A systematic review","authors":"Anja C. Feneberg , Susanne Fischer , Nadine Skoluda","doi":"10.1016/j.yfrne.2025.101199","DOIUrl":"10.1016/j.yfrne.2025.101199","url":null,"abstract":"<div><div>Hair cortisol concentration (HCC) is a crucial biomarker in psychoneuroendocrinological research, offering unique insights into long-term hypothalamic–pituitary–adrenal axis activity. Season has repeatedly shown associations with HCC. However, as of yet, no systematic attempt at quantifying season’s influence on HCC has been undertaken. We conducted a systematic search of the bibliographic databases PubMed and PsycINFO. Twenty-nine between- and within-person studies fulfilled all eligibility criteria (N = 10,520 participants in total). Overall, 22 studies (76%) reported significant differences in HCC across seasons. Most between-personstudies reported lower HCC in winter/spring than in summer/autumn (10/15). This pattern was supported by 2/14 within-person studies, whereas others reported lower HCC in summer than in autumn (6/14). The remaining studies reported other patterns or no seasonal variations in HCC. In conclusion, there is accumulating evidence for seasonal variations in HCC, highlighting the need to consider the seasons in future research on HCC and health. Mechanisms related to meteorological, ecological, sociocultural, and lifestyle factors may underlie seasonal rhythmicity in cortisol secretion and accumulation in hair.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"78 ","pages":"Article 101199"},"PeriodicalIF":6.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0