Unraveling sex differences in maternal and paternal care impacts on social behaviors and neurobiological responses to early-life adversity

IF 6.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Frontiers in Neuroendocrinology Pub Date : 2024-11-17 DOI:10.1016/j.yfrne.2024.101162

Shakeera L. Walker , Erica R. Glasper

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引用次数: 0

Abstract

Early-life stress (ELS) affects the development of prosocial behaviors and social-cognitive function, often leading to structural brain changes and increased psychosocial disorders. Recent studies suggest that mother- and father-child relationships independently influence social development in a sex-specific manner, but the effects of impaired father-child relationships are often overlooked. This review examines preclinical rodent studies to explore how parental neglect impacts neuroplasticity and social behaviors in offspring. We highlight that disruptions in maternal interactions may affect male pups more in uniparental rodents, while impaired paternal interactions in biparental rodents tend to impact female pups more. Due to limited research, the separate effects of maternal and paternal neglect on brain development and social behaviors in biparental species remain unclear. Addressing these gaps could clarify the sex-specific mechanisms underlying social and neurobiological deficits following parental neglect.

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揭示母爱和父爱的性别差异对早年逆境中的社会行为和神经生物学反应的影响。

早期生活压力（ELS）会影响亲社会行为和社会认知功能的发展，往往会导致大脑结构的改变和社会心理障碍的增加。最近的研究表明，母子关系和父子关系以性别特异性的方式独立地影响着儿童的社会性发展，但父子关系受损的影响往往被忽视。本综述通过临床前啮齿动物研究，探讨父母的忽视如何影响后代的神经可塑性和社会行为。我们强调，在单亲啮齿类动物中，母性互动的中断可能会对雄性幼崽产生更大的影响，而在双亲啮齿类动物中，父性互动的受损往往会对雌性幼崽产生更大的影响。由于研究有限，母性和父性忽视对双亲啮齿动物大脑发育和社会行为的不同影响仍不清楚。填补这些空白可以阐明父母忽视造成的社会和神经生物学缺陷的性别特异性机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neuroendocrinology 医学-内分泌学与代谢

CiteScore

13.30

自引率

6.80%

发文量

审稿时长

68 days

期刊介绍： Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.