Sex as a biological variable (SABV) modulates the consequences of sleep disturbance on hippocampal memory and synaptic plasticity

IF 6.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Frontiers in Neuroendocrinology Pub Date : 2025-07-01 DOI:10.1016/j.yfrne.2025.101205

Camilla Paraciani, Robbert Havekes, Peter Meerlo, Nicole J. Gervais

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Abstract

Sleep disturbance affects brain health, with research in rodents showing that both hippocampal memory and synaptic plasticity are impaired following sleep deprivation (SD). However, most studies have used males, overlooking sex as a biological variable (SABV). Given estradiol’s neuroprotective role in the female hippocampus, we hypothesized that the consequences of SD on memory and synaptic plasticity are modulated by sex and/or sex hormones. This review compares SD effects in males to 1) the limited findings in sleep-deprived females, and 2) the effects of estradiol in non-sleep deprived females. The few studies conducted in females suggest that memory deficits post-SD depend on hormonal state. Estradiol in non-sleep-deprived females also modulates hippocampal mechanisms of synaptic plasticity that are impaired by SD in males. While the currently available data is limited, it does hint towards sex-specific effects of SD, and emphasizes the importance of incorporating SABV in future research.

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性别作为一个生物变量（SABV）调节睡眠障碍对海马记忆和突触可塑性的影响。

睡眠障碍会影响大脑健康，对啮齿动物的研究表明，睡眠剥夺（SD）会损害海马记忆和突触可塑性。然而，大多数研究都使用了男性，忽略了性别作为生物变量（SABV）。鉴于雌二醇在雌性海马中的神经保护作用，我们假设SD对记忆和突触可塑性的影响是由性别和/或性激素调节的。这篇综述比较了SD对男性的影响，1)在睡眠不足的女性中发现的有限结果，以及2)雌二醇对非睡眠不足女性的影响。在女性中进行的少数研究表明，sd后的记忆缺陷取决于激素状态。雌二醇在未被剥夺睡眠的女性体内也能调节海马突触可塑性机制，而这种机制在男性中因SD而受损。虽然目前可用的数据有限，但它确实暗示了SD的性别特异性影响，并强调了在未来研究中纳入SABV的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neuroendocrinology 医学-内分泌学与代谢

CiteScore

13.30

自引率

6.80%

发文量

审稿时长

68 days

期刊介绍： Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.