Is melanin-concentrating hormone in the medial preoptic area a signal for the decline of maternal care in late postpartum?

IF 6.5 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Ming Li
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Abstract

This manuscript proposes that melanin-concentrating hormone (MCH) in the medial preoptic area (MPOA) is an neurochemical signal evolved to trigger the declining process of maternal care. MCH in the MPOA appears only after parturition and is progressively increased with the progression of lactation, while maternal behavior declines progressively. Intra-MPOA injection of MCH decreases active maternal responses. MCH is also highly responsive to infant characteristics and maternal condition. Behavioral changes induced by MCH in late postpartum period are conducive to the decline of infant-directed maternal behavior. The MPOA MCH system may mediate the maternal behavior decline by suppressing the maternal approach motivation and/or increasing maternal withdrawal via its inhibitory action onto the mesolimbic dopamine D1/D2 receptors and its stimulating action on serotonin 5-HT2C receptors in the ventral tegmental area. Research into the MCH maternal effects will enhance our understanding of the neurochemical mechanisms underlying the maternal behavior decline.

内侧视前区的黑色素浓缩激素是产后晚期母性关怀减少的信号吗?产妇行为中的 MCH。
本手稿提出,内侧视前区(MPOA)中的黑色素浓缩激素(MCH)是一种神经化学信号,它的进化触发了母性关怀的衰退过程。MPOA 中的 MCH 在分娩后才出现,并随着哺乳期的进展而逐渐增加,而母性行为则逐渐减少。在 MPOA 内注射 MCH 会降低母体的主动反应。MCH 对婴儿特征和母体状况的反应也很强烈。产后晚期 MCH 引起的行为变化有利于婴儿引导的母性行为的下降。MPOA MCH 系统可能通过其对间叶多巴胺 D1/D2 受体的抑制作用和对腹侧被盖区血清素 5-HT2C 受体的刺激作用,抑制母性接近动机和/或增加母性退缩,从而介导母性行为的下降。对 MCH 母性效应的研究将加深我们对母性行为衰退的神经化学机制的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Neuroendocrinology
Frontiers in Neuroendocrinology 医学-内分泌学与代谢
CiteScore
13.30
自引率
6.80%
发文量
62
审稿时长
68 days
期刊介绍: Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.
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