Nestorone (segesterone acetate) effects on neuroregeneration

IF 6.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Frontiers in Neuroendocrinology Pub Date : 2024-04-01 DOI:10.1016/j.yfrne.2024.101136

Regine Sitruk-Ware , Heather Sussman , Roberta Brinton , Michael Schumacher , Patrick Singer , Narender Kumar , Alejandro F. De Nicola , Martine El-Etr , Rachida Guennoun , Cesar V Borlongan

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Abstract

Nestorone® (segesterone acetate) is a progestin with a chemical structure closely related to progesterone with high affinity and selectivity for the progesterone receptor without significant interaction with other steroid receptors. It has been developed for female and male contraception and is FDA-approved in a first long-acting contraceptive vaginal system for female contraception. Its safety has been extensively demonstrated in both preclinical and clinical studies for contraceptive indications. Nestorone was found to display neuroprotective and neuroregenerative activity in animal models of various central nervous system diseases, including multiple sclerosis, stroke, and amyotrophic lateral sclerosis. Reviewed herein are neuroprotective and myelin- regenerating properties of Nestorone in various animal models and its translational potential as a therapeutic agent for debilitating neurological diseases for which limited therapeutic options are available (Table 1).

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Nestorone（醋酸雌甾醇）对神经再生的影响

Nestorone® （醋酸segesterone）是一种孕激素，其化学结构与黄体酮密切相关，对黄体酮受体具有高亲和力和选择性，与其他类固醇受体无明显相互作用。它已被开发用于女性和男性避孕，并被美国食品及药物管理局批准用于女性避孕的首个长效避孕阴道系统。其安全性已在避孕适应症的临床前研究和临床研究中得到广泛证实。在多种中枢神经系统疾病（包括多发性硬化症、中风和肌萎缩性脊髓侧索硬化症）的动物模型中，发现 Nestorone 具有神经保护和神经再生活性。本文综述了 Nestorone 在各种动物模型中的神经保护和髓鞘再生特性，以及它作为一种治疗剂用于治疗衰弱性神经系统疾病的转化潜力（表 1）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neuroendocrinology 医学-内分泌学与代谢

CiteScore

13.30

自引率

6.80%

发文量

审稿时长

68 days

期刊介绍： Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.