Novel insights into the activating transcription factor 4 in Alzheimer’s disease and associated aging-related diseases: Mechanisms and therapeutic implications

IF 6.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Frontiers in Neuroendocrinology Pub Date : 2024-05-24 DOI:10.1016/j.yfrne.2024.101144

Nan Zhang , Jianfei Nao , Shun Zhang , Xiaoyu Dong

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Abstract

Ageing is inherent to all human beings, most mechanistic explanations of ageing results from the combined effects of various physiological and pathological processes. Additionally, aging pivotally contributes to several chronic diseases. Activating transcription factor 4 (ATF4), a member of the ATF/cAMP response element-binding protein family, has recently emerged as a pivotal player owing to its indispensable role in the pathophysiological processes of Alzheimer’s disease and aging-related diseases. Moreover, ATF4 is integral to numerous biological processes. Therefore, this article aims to comprehensively review relevant research on the role of ATF4 in the onset and progression of aging-related diseases, elucidating its potential mechanisms and therapeutic approaches. Our objective is to furnish scientific evidence for the early identification of risk factors in aging-related diseases and pave the way for new research directions for their treatment. By elucidating the signaling pathway network of ATF4 in aging-related diseases, we aspire to gain a profound understanding of the molecular and cellular mechanisms, offering novel strategies for addressing aging and developing related therapeutics.

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激活转录因子 4 在阿尔茨海默氏症和相关衰老疾病中的新发现：机制和治疗意义

衰老是人类与生俱来的现象，大多数关于衰老的机理解释都是由各种生理和病理过程共同作用的结果。此外，衰老也是导致多种慢性疾病的关键因素。活化转录因子 4（ATF4）是 ATF/cAMP 反应元件结合蛋白家族的成员，由于其在阿尔茨海默病和衰老相关疾病的病理生理过程中扮演着不可或缺的角色，最近已成为一个关键角色。此外，ATF4 与许多生物过程密不可分。因此，本文旨在全面回顾 ATF4 在衰老相关疾病的发生和发展过程中所起作用的相关研究，阐明其潜在机制和治疗方法。我们的目的是为早期识别衰老相关疾病的风险因素提供科学依据，并为治疗这些疾病的新研究方向铺平道路。通过阐明 ATF4 在衰老相关疾病中的信号通路网络，我们希望深入了解其分子和细胞机制，为应对衰老和开发相关疗法提供新的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neuroendocrinology 医学-内分泌学与代谢

CiteScore

13.30

自引率

6.80%

发文量

审稿时长

68 days

期刊介绍： Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.