Frontiers in Bioengineering and Biotechnology最新文献

{"title":"Comprehensive insights of pretreatment strategies on the structures and bioactivities variation of lignin-carbohydrate complexes.","authors":"Chen Su, Xiu Wang, Yongjun Deng, Zhongjian Tian, Chen Huang, Guigan Fang","doi":"10.3389/fbioe.2024.1465328","DOIUrl":"10.3389/fbioe.2024.1465328","url":null,"abstract":"<p><p><b>Introduction:</b> Due to its unique structural features and bioactivities, the lignin-carbohydrate complex (LCC) displays great potential in vast industrial applications. However, the elucidation of how various pretreatment methods affect the structure and bioactivities remains unaddressed. <b>Method:</b> The three pretreatment methods were systematically studied on the variations of structures and bioactivities, and the Gramineae plant, i.e., wheat straw, was adopted in this study. The structures and bioactivities variation caused by different pretreatments were studied in detail. <b>Result and Discussion:</b> The results showed that compared to physical or chemical pretreatments, biological pretreatment was the most effective approach in improving the bioactivities of LCC. The LCC from biological pretreatment (enzymatic hydrolysis, ELCC4) had more functional groups while the lower weight-average molecular weight (<i>Mw</i>) and polydispersity index (PDI) were well-endowed. The highest antioxidant abilities against ABTS and DPPH of ELCC4 were high up to 95% and 84%, respectively. Furthermore, ELCC4 also showed the best ultraviolet (UV)-blocking rate of 96%, which was increased by 6% and 2% compared to LCC8 (physical pretreatment) and LLCC4 (chemical pretreatment). This work prospectively boosts the understanding of pretreatment strategies on the structures and bioactivities variation of LCC and facilitates its utilization as sustainable and biologically active materials in various fields.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovations in ion-selective optodes: a comprehensive exploration of modern designs and nanomaterial integration.","authors":"Ahmed Barhoum, Yaser Alhashemi, Yomna M Ahmed, Mahmoud S Rizk, Mikhael Bechelany, Fatehy M Abdel-Haleem","doi":"10.3389/fbioe.2024.1397587","DOIUrl":"10.3389/fbioe.2024.1397587","url":null,"abstract":"<p><p>In recent years, ion-selective optodes (ISOs) have remarkably progressed, driven by innovative modern designs and nanomaterial integration. This review explored the development of modern ISO by describing state-of-the-art strategies to improve their sensitivity, selectivity, and real-time monitoring capacity. The review reported the traditional membrane based-optodes, and investigated the latest research, current design principles, and the use of essential components, such as ionophores, indicator dyes, polymer membranes, and nanomaterials, in ISO fabrication. Special attention was given to nanomaterials (e.g., quantum dots, polymer dots, nanospheres, nanorods and nanocapsules) and particularly on how rare earth elements can further enhance their potential. It also described innovative ISO designs, including wearable optodes, smartphone-based optodes, and disposable paper-based optodes. As the pursuit of highly sensitive, selective, and adaptable ion sensing devices continues, this summary of the current knowledge sets the stage for upcoming innovations and applications in different domains (pharmaceutical formulations, medical diagnosis, environmental monitoring, and industrial applications).</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of antimicrobial peptides buCaTHL4B and Im-4 on infectious root canal biofilms.","authors":"Ziqiu Hu, Haixia Ren, Yifan Min, Yixin Li, Yuyuan Zhang, Min Mao, Weidong Leng, Lingyun Xia","doi":"10.3389/fbioe.2024.1409487","DOIUrl":"10.3389/fbioe.2024.1409487","url":null,"abstract":"<p><strong>Purpose: </strong>The primary cause of pulp and periapical diseases is the invasion of bacteria into the root canal, which results from the continuous destruction of dental hard tissues. Effective management of infections during root canal therapy necessitates effectively irrigation. This study aims to investigate the effects of two antimicrobial peptides (AMPs), buCaTHL4B and Im-4, on root canal biofilms <i>in vitro</i>.</p><p><strong>Methods: </strong>Two-species biofilms (<i>Enterococcus faecalis</i> and <i>Fusobacterium nucleatum</i>) were selected and anaerobically cultivated. The following treatments were applied: 10 μg/mL buCaTHL4B, 10 μg/mL Im-4, 5 μg/mL buCaTHL4B, 5 μg/mL Im-4, 1 μg/mL buCaTHL4B, 1 μg/mL Im-4, 1% NaOCl, and sterile water. Each group was treated for 3 min. Subsequently, the two strains were co-cultured with 10 μg/mL buCaTHL4B, 10 μg/mL Im-4, 1% NaOCl, and sterile water for 24, 48, and 72 h. The biofilms were examined using confocal laser scanning microscopy (CLSM) with fluorescent staining, and the percentages of dead bacteria were calculated. Quantitative real-time PCR (qRT-PCR) was employed to assess the variations in bacterial proportions during biofilm formation.</p><p><strong>Results: </strong>Compared to 1% NaOCl, 10 μg/mL buCaTHL4B or Im-4 exhibited significantly greater bactericidal effects on the two-species biofilms (<i>p</i> < 0.05), leading to their selection for subsequent experiments. Over a 48-hour period, 10 μg/mL Im-4 demonstrated a stronger antibiofilm effect than buCaTHL4B (<i>p</i> < 0.05). Following a 24-hour biofilm formation period, the proportion of <i>F. nucleatum</i> decreased while the proportion of <i>E. faecalis</i> increased in the sterile water group. In the buCaTHL4B and 1% NaOCl groups, the proportion of <i>F. nucleatum</i> was lower than that of <i>E. faecalis</i> (<i>p</i> < 0.05), whereas in the Im-4 group, the proportion of <i>F. nucleatum</i> was higher than that of <i>E. faecalis</i> (<i>p</i> < 0.05). The proportions of bacteria in the two AMPs groups gradually stabilized after 24 h of treatment.</p><p><strong>Conclusion: </strong>buCaTHL4B and Im-4 exhibited remarkable antibacterial and anti-biofilm capabilities against pathogenic root canal biofilms <i>in vitro</i>, indicating their potential as promising additives to optimize the effectiveness of root canal treatment as alternative irrigants.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11361941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142106023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of native and engineered Clostridia for biomass biorefining.","authors":"Paola Ponsetto, Emilia Malgorzata Sasal, Roberto Mazzoli, Francesca Valetti, Gianfranco Gilardi","doi":"10.3389/fbioe.2024.1423935","DOIUrl":"10.3389/fbioe.2024.1423935","url":null,"abstract":"<p><p>Since their first industrial application in the acetone-butanol-ethanol (ABE) fermentation in the early 1900s, Clostridia have found large application in biomass biorefining. Overall, their fermentation products include organic acids (e.g., acetate, butyrate, lactate), short chain alcohols (e.g., ethanol, n-butanol, isobutanol), diols (e.g., 1,2-propanediol, 1,3-propanediol) and H₂ which have several applications such as fuels, building block chemicals, solvents, food and cosmetic additives. Advantageously, several clostridial strains are able to use cheap feedstocks such as lignocellulosic biomass, food waste, glycerol or C1-gases (CO₂, CO) which confer them additional potential as key players for the development of processes less dependent from fossil fuels and with reduced greenhouse gas emissions. The present review aims to provide a survey of research progress aimed at developing <i>Clostridium</i>-mediated biomass fermentation processes, especially as regards strain improvement by metabolic engineering.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142106024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of the microscope incubation system and its application in evaluating tumor treatment effects through real-time live cellular imaging.","authors":"Haiyang Yan, Tong Wu, Xinlu Li, Zhengyang Feng, Mingfeng Ge, Lixing Zhang, Wen-Fei Dong","doi":"10.3389/fbioe.2024.1447265","DOIUrl":"10.3389/fbioe.2024.1447265","url":null,"abstract":"<p><p><b>Introduction:</b> Long-term imaging of live cells is commonly used for the study of dynamic cell behaviors. It is crucial to keep the cell viability during the investigation of physiological and biological processes by live cell imaging. Conventional incubators that providing stable temperature, carbon dioxide (CO₂) concentration, and humidity are often incompatible with most imaging tools. Available commercial or custom-made stage-top incubators are bulky or unable to provide constant environmental conditions during long time culture. <b>Methods:</b> In this study, we reported the development of the microscope incubation system (MIS) that can be easily adapted to any inverted microscope stage. Incremental PID control algorithm was introduced to keep stable temperature and gas concentration of the system. Moreover, efficient translucent materials were applied for the top and bottom of the incubator which make it possible for images taken during culture. <b>Results:</b> The MIS could support cell viability comparable to standard incubators. When used in real time imaging, the MIS was able to trace single cell migration in scratch assay, T cell mediated tumor cells killing in co-culture assay, inflation-collapse and fusion of organoids in 3D culture. And the viability and drug responses of cells cultured in the MIS were able to be calculated by a label-free methods based on long term imaging. <b>Discussion:</b> We offer new insights into monitoring cell behaviors during long term culture by using the stage adapted MIS. This study illustrates that the newly developed MIS is a viable solution for long-term imaging during in vitro cell culture and demonstrates its potential in cell biology, cancer biology and drug discovery research where long-term real-time recording is required.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142106019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and modeling of diaphragm displacement using ultrasound imaging for wearable respiratory assistive robot.","authors":"Yan Zhang, Danye Li, Fengyao Zhang, Zongyu Wang, Lei Xue, Xiaolu Nan, Nianming Li, Xilai Tan, Weidong Guo, Yuru Zhang, Hongmei Zhao, Qinggang Ge, Dangxiao Wang","doi":"10.3389/fbioe.2024.1436702","DOIUrl":"10.3389/fbioe.2024.1436702","url":null,"abstract":"<p><strong>Introduction: </strong>Assessing the influence of respiratory assistive devices on the diaphragm mobility is essential for advancing patient care and improving treatment outcomes. Existing respiratory assistive robots have not yet effectively assessed their impact on diaphragm mobility. In this study, we introduce for the first time a non-invasive, real-time clinically feasible ultrasound method to evaluate the impact of soft wearable robots on diaphragm displacement.</p><p><strong>Methods: </strong>We measured and compared diaphragm displacement and lung volume in eight participants during both spontaneous and robotic-assisted respiration. Building on these measurements, we proposed a human-robot coupled two-compartment respiratory mechanics model that elucidates the underlying mechanism by which our extracorporeal wearable robots augments respiration. Specifically, the soft robot applies external compression to the abdominal wall muscles, inducing their inward movement, which consequently pushes the diaphragm upward and enhances respiratory function. Finally, we investigated the level and shape of various robotic assistive forces on diaphragm motion.</p><p><strong>Results: </strong>This robotic intervention leads to a significant increase in average diaphragm displacement by 1.95 times and in lung volume by 2.14 times compared to spontaneous respiration. Furthermore, the accuracy of the proposed respiratory mechanics model is confirmed by the experimental results, with less than 7% error in measurements of both diaphragm displacement and lung volume. Finally, the magnitude of robotic assistive forces positively correlates with diaphragm movement, while the shape of the forces shows no significant relationship with diaphragm activity.</p><p><strong>Conclusion: </strong>Our experimental findings validate the effective assistance mechanism of the proposed robot, which enhances diaphragm mobility and assists in ventilation through extracorporeal robotic intervention. This robotic system can assist with ventilation while increasing diaphragm mobility, potentially resolving the issue of diaphragm atrophy. Additionally, this work paves the way for improved robotic designs and personalized assistance, tailored to the dynamics of the diaphragm in respiratory rehabilitation.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11361991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142106020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of CRISPR/Cas-based gene-editing for developing better banana.","authors":"Leena Tripathi, Valentine O Ntui, Jaindra N Tripathi","doi":"10.3389/fbioe.2024.1395772","DOIUrl":"10.3389/fbioe.2024.1395772","url":null,"abstract":"<p><p>Banana (<i>Musa</i> spp.), including plantain, is one of the major staple food and cash crops grown in over 140 countries in the subtropics and tropics, with around 153 million tons annual global production, feeding about 400 million people. Despite its widespread cultivation and adaptability to diverse environments, banana production faces significant challenges from pathogens and pests that often coexist within agricultural landscapes. Recent advancements in CRISPR/Cas-based gene editing offer transformative solutions to enhance banana resilience and productivity. Researchers at IITA, Kenya, have successfully employed gene editing to confer resistance to diseases such as banana Xanthomonas wilt (BXW) by targeting susceptibility genes and banana streak virus (BSV) by disrupting viral sequences. Other breakthroughs include the development of semi-dwarf plants, and increased β-carotene content. Additionally, non-browning banana have been developed to reduce food waste, with regulatory approval in the Philippines. The future prospects of gene editing in banana looks promising with CRISPR-based gene activation (CRISPRa) and inhibition (CRISPRi) techniques offering potential for improved disease resistance. The Cas-CLOVER system provides a precise alternative to CRISPR/Cas9, demonstrating success in generating gene-edited banana mutants. Integration of precision genetics with traditional breeding, and adopting transgene-free editing strategies, will be pivotal in harnessing the full potential of gene-edited banana. The future of crop gene editing holds exciting prospects for producing banana that thrives across diverse agroecological zones and offers superior nutritional value, ultimately benefiting farmers and consumers. This article highlights the pivotal role of CRISPR/Cas technology in advancing banana resilience, yield and nutritional quality, with significant implications for global food security.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142106012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional biomechanical characterization of the spinal cord tissue: dynamic mechanical response.","authors":"Chen Jin, Jiang-Ming Yu, Ran Li, Xiao-Jian Ye","doi":"10.3389/fbioe.2024.1439323","DOIUrl":"10.3389/fbioe.2024.1439323","url":null,"abstract":"<p><p>Characterizing the dynamic mechanical properties of spinal cord tissue is deemed important for developing a comprehensive knowledge of the mechanisms underlying spinal cord injury. However, complex viscoelastic properties are vastly underexplored due to the spinal cord shows heterogeneous properties. To investigate regional differences in the biomechanical properties of spinal cord, we provide a mechanical characterization method (i.e., dynamic mechanical analysis) that facilitates robust measurement of spinal cord <i>ex vivo</i>, at small deformations, in the dynamic regimes. Load-unload cycles were applied to the tissue surface at sinusoidal frequencies of 0.05, 0.10, 0.50 and 1.00 Hz <i>ex vivo</i> within 2 h <i>post mortem</i>. We report the main response features (e.g., nonlinearities, rate dependencies, hysteresis and conditioning) of spinal cord tissue dependent on anatomical origin, and quantify the viscoelastic properties through the measurement of peak force, moduli, and hysteresis and energy loss. For all three anatomical areas (cervical, thoracic, and lumbar spinal cord tissues), the compound, storage, and loss moduli responded similarly to increasing strain rates. Notably, the complex modulus values of <i>ex vivo</i> spinal cord tissue rose nonlinearly with rising test frequency. Additionally, at every strain rate, it was shown that the tissue in the thoracic spinal cord was significantly more rigid than the tissue in the cervical or lumbar spinal cord, with compound modulus values roughly 1.5-times that of the lumbar region. At strain rates between 0.05 and 0.50 Hz, tan δ values for thoracic (that is, 0.26, 0.25, 0.06, respectively) and lumbar (that is, 0.27, 0.25, 0.07, respectively) spinal cord regions were similar, respectively, which were higher than cervical (that is, 0.21, 0.21, 0.04, respectively) region. The conditioning effects tend to be greater at relative higher deformation rates. Interestingly, no marked difference of conditioning ratios is observed among all three anatomical regions, regardless of loading rate. These findings lay a foundation for further comparison between healthy and diseased spinal cord to the future development of spinal cord scaffold and helps to advance our knowledge of neuroscience.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11361947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142106022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DDS-type near-infrared light absorber enables deeper lesion treatment in laser photothermal therapy while avoiding damage to surrounding organs.","authors":"Masataka Takahashi, Jun Fujishiro, Shinsuke Nomura, Manabu Harada, Akinari Hinoki, Masashi Arake, Eiichi Ozeki, Isao Hara, Ayano Satoh, Takahisa Tainaka, Hiro-O Uchida, Yuji Morimoto","doi":"10.3389/fbioe.2024.1444107","DOIUrl":"https://doi.org/10.3389/fbioe.2024.1444107","url":null,"abstract":"<p><p>The efficacy of drug delivery system (DDS)-type near-infrared (NIR) absorbing agents in enhancing laser photothermal therapy is widely acknowledged. Despite the acknowledged efficacy, the therapeutic advantages of photothermal therapy using DDS-type NIR-absorbing agents over simple photothermal therapy without such agents have not been fully elucidated. This study was designed to investigate two primary objectives: firstly, the ability of DDS-type NIR-absorbing agents to induce cell death at greater depths within tumors, and secondly, their capacity to minimize collateral damage to adjacent healthy organs. To investigate these objectives, we employed a combination of indocyanine green lactosome-a DDS-type NIR-absorbing agent-and a precision-controlled laser hyperthermia system. An orthotopic neuroblastoma tumor model was used to closely simulate clinical conditions. The findings revealed that photothermal therapy using the DDS-type NIR-absorbing agent not only facilitates deeper penetration of cell death within tumors but also significantly mitigates thermal damage to surrounding healthy tissues, when compared to simple phototherapy without the agent. Furthermore, the combined treatment significantly prolonged the survival periods of the animals involved. This study is the first to analyze these therapeutic efficacies using quantitative data from an orthotopic tumor animal model and substantiated the potential of DDS-type NIR-absorbing agents to deepen the therapeutic impact of photothermal therapy while safeguarding vital organs, thereby enhancing overall treatment outcomes.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11357940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142106018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac tissue engineering: an emerging approach to the treatment of heart failure.","authors":"Hossein Rayat Pisheh, Fatemeh Sadat Nojabaei, Ahmad Darvishi, Ali Rayat Pisheh, Mahsa Sani","doi":"10.3389/fbioe.2024.1441933","DOIUrl":"https://doi.org/10.3389/fbioe.2024.1441933","url":null,"abstract":"<p><p>Heart failure is a major health problem in which the heart is unable to pump enough blood to meet the body's needs. It is a progressive disease that becomes more severe over time and can be caused by a variety of factors, including heart attack, cardiomyopathy and heart valve disease. There are various methods to cure this disease, which has many complications and risks. The advancement of knowledge and technology has proposed new methods for many diseases. One of the promising new treatments for heart failure is tissue engineering. Tissue engineering is a field of research that aims to create living tissues and organs to replace damaged or diseased tissue. The goal of tissue engineering in heart failure is to improve cardiac function and reduce the need for heart transplantation. This can be done using the three important principles of cells, biomaterials and signals to improve function or replace heart tissue. The techniques for using cells and biomaterials such as electrospinning, hydrogel synthesis, decellularization, etc. are diverse. Treating heart failure through tissue engineering is still under development and research, but it is hoped that there will be no transplants or invasive surgeries in the near future. In this study, based on the most important research in recent years, we will examine the power of tissue engineering in the treatment of heart failure.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11357970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142106014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}